Methamphetamine use is emerging in cities and rural settings previously thought to be largely unaffected by illicit drug use and is increasing among populations not previously known to use this drug. The Methamphetamine Interagency Task Force was established in response to a provision of the Comprehensive Methamphetamine Control Act of 1996. Methamphetamine Interagency Task Force: Final Report issues the findings of a collaborative effort by Federal and non-Federal experts in law enforcement, prevention, education, and treatment. This report presents the principles that guided the Task Force, recommendations from the Task Force, and needs for further research.