New susceptibility locus for coronary artery disease on chromosome 3q22.3.
Erdmann J,
Grosshennig A,
Braund PS,
König IR,
Hengstenberg C,
Hall AS,
Linsel-Nitschke P,
Kathiresan S,
Wright B,
Trégouët DA,
Cambien F,
Bruse P,
Aherrahrou Z,
Wagner AK,
Stark K,
Schwartz SM,
Salomaa V,
Elosua R,
Melander O,
Voight BF,
O'Donnell CJ,
Peltonen L,
Siscovick DS,
Altshuler D,
Merlini PA,
Peyvandi F,
Bernardinelli L,
Ardissino D,
Schillert A,
Blankenberg S,
Zeller T,
Wild P,
Schwarz DF,
Tiret L,
Perret C,
Schreiber S,
El Mokhtari NE,
Schäfer A,
März W,
Renner W,
Bugert P,
Klüter H,
Schrezenmeir J,
Rubin D,
Ball SG,
Balmforth AJ,
Wichmann HE,
Meitinger T,
Fischer M,
Meisinger C,
Baumert J,
Peters A,
Ouwehand WH;
Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group;
Myocardial Infarction Genetics Consortium;
Wellcome Trust Case Control Consortium;
Cardiogenics Consortium,
Deloukas P,
Thompson JR,
Ziegler A,
Samani NJ,
Schunkert H.
Medizinische Klinik II, Universität zu Lübeck, 23538 Lübeck, Germany. j.erdmann@cardiogenics.eu
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
PMID: 19198612 [PubMed - indexed for MEDLINE]
PMCID: PMC2695543 [Available on 2009/09/01]