HomeResearchIntramural ResearchResearch Branches at NHGRISocial & Behavioral Research Branch Hadley Research

Don Hadley, M.S., C.G.C. Associate Investigator Social and Behavioral Research Branch Staff Scientist (Clinical) Social Network Methods Section Associate Director Office of Clinical Liaison Office of the Clinical Director B.S. Purdue University, 1976 M.S. University of California at Berkeley, 1981 (301) 496-3980 (301) 496-7157 dhadley@mail.nih.gov Building 31, Room B1B37 31 Center Dr, MSC 9999 Bethesda, MD 20892-9999 Selected Publications

Mr. Hadley is a clinical researcher in the Social Network Methods Section of the Social and Behavioral Research Branch and a genetic counselor in the Office of the Clinical Director. In the latter capacity, he provides education and counseling to people participating in NIH clinical protocols that have or are at risk for inherited diseases.

As a researcher, Mr. Hadley focuses on understanding the factors that influence interest in and uptake of genetic services, including genetic education, counseling, and testing; he is particularly interested in psychological and behavioral outcomes. Specifically, his research examines the significant role of the family in influencing an individual's knowledge, attitudes, and behaviors related to genetic testing, with the ultimate goal of defining the individual and family variables affecting the psychological and behavioral impact of such testing. An understanding of these issues will inform the development of clinical interventions aimed at improving family communication related to disease risk and health behaviors, adaptation of those experiencing difficulty, and adherence to recommendations for health screening and disease prevention.

Mr. Hadley's work has focused on studying families with an inherited cancer susceptibility syndrome known as hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch Syndrome). His group collects data from patients who choose to receive genetic counseling services and to consider the option of genetic testing for the disease-causing mutation in their families. Participants complete a baseline questionnaire that assesses their interest in and attitudes toward genetic testing prior to receiving genetic information. This survey documents their gen-eral mood, level of worry about cancer and genetic testing, can-cer screening practices, spiritual beliefs, and feelings about their familial communication practic-es and support. A follow-up ques-tionnaire is administered at six-month, one-year, and three-year intervals after receiving their genetic test results or choosing not to undergo testing.

Using the resulting data, Mr. Hadley's group analyzes the ways in which the genetic counseling and testing process influences participants' psychological well-being and communication about genetic risk, and evaluates how such factors guide their cancer screening choices. As only about half of the eligible family members have chosen to participate in the HNPCC study, Mr. Hadley's group now hopes to detail the perspectives and attitudes of those who opted out of genetic testing and to gain insight into their cancer screening practices.

Mr. Hadley plans to extend his research portfolio to include the study of families with more common diseases that affect larger portions of the population. These include diseases that are known to have genetic contributions but are also influenced by other factors such as environment, lifestyle, and diet. This will be an important arena to explore as research continues to move genomics into the medical and public health arenas.

To extend his research portfolio, Mr. Hadley plans to include the study of families with more common diseases that affect larger segments of the population. His future studies will include diseases with genetic contributions that are also influenced by factors such as the environment, lifestyle and diet.

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Last Updated: March 27, 2009