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Federal Register Notices
Federal Register (FR) notices related to the Endocrine Disruptor Screening Program (EDSP) are provided below. The notices are presented in chronological order, with the most recently published FR notices first.
EPA establishes Dockets when rulemaking or non-rulemaking actions are announced. Dockets may contain Federal Register documents, a variety of supporting documentation, and public comments. You may access www.regulations.gov to search for electronic Dockets established after May 22, 2002.
2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996
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2007 Federal Register Notices
Draft List of Initial Pesticide Active Ingredients and Pesticide Inerts to be Considered for Screening under the Federal Food, Drug, and Cosmetic Act; Extension of Comment Period [Federal Register Notice: December 28, 2007 (Volume 72, Number 248, page 73802)]
SUMMARY: EPA issued a notice in the Federal Register of June 18, 2007, concerning the draft list of the first group of chemicals that will be screened in the Agency's Endocrine Disruptor Screening Program (EDSP). The draft list was produced using the approach described in the September 2005 notice, and includes chemicals that the Agency, in its discretion, has decided should be tested first, based upon exposure potential. The June 18, 2007 Federal Register notice provided for a 90-day public comment period. EPA extended the comment period an additional 60 days in the Federal Register of September 12, 2007, and later extended the comment period for 45 days in the Federal Register of November 15, 2007. This document is extending the comment period for a third time for an additional 42 days. The new comment period closes February 11, 2008.
Endocrine Disruptor Screening
Program (EDSP); Draft Policies and
Procedures for Initial Screening;
Request for Comment (PDF) (21 pp, 144K)
[Federal Register Notice: December 13, 2007 (Volume 72, Number 239, pages 70842-70862)]
SUMMARY: This document announces the availability of and solicits public comment on EPA's draft policies and procedures for initial screening under the Agency's Endocrine Disruptor Screening Program (EDSP). The EDSP is established under section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA), which requires endocrine screening of all pesticide chemicals and was established in response to growing scientific evidence that humans, domestic animals, and fish and wildlife species have exhibited adverse health consequences from exposure to environmental chemicals that interact with their endocrine systems. This document provides specific details on the policies and the related procedures that EPA is considering adopting for initial screening under the EDSP. In general, the Agency has tried to develop policies that could be used in subsequent data collection efforts. However, EPA expects that these policies may be modified as a result of the Agency's experience applying them to the first chemicals to undergo testing. This document also discusses the statutory requirements associated with and format of the test orders, as well as EPA's procedures for fair and equitable sharing of test costs and data confidentiality. EPA will also be holding a public meeting to discuss these policies and procedures. A separate Federal Register document announced the details of the public meeting.
Agency Information Collection Activities; Proposed Collection; Comment Request; Tier 1 Screening of Certain Chemicals Under the Endocrine Disruptor Screening Program (EDSP); EPA ICR No. 2249.01, OMB Control No. 2070-new (PDF) (3 pp, 58K) Federal Register Notice: December 13, 2007 (Volume 72, Number 239, pages 70839-70841)]
SUMMARY: In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request for a new Information Collection Request (ICR) to the Office of Management and Budget (OMB). This ICR is entitled: "Tier 1 Screening of Certain Chemicals Under the Endocrine Disruptor Screening Program (EDSP)" and identified by EPA ICR No. 2249.01 and OMB Control No. 2070-new. Before submitting the ICR to OMB for review and approval under the PRA, EPA is soliciting comments on specific aspects of the proposed information collection.
Endocrine Disruptor Screening Program; Workshop to Discuss Draft Policies and Procedures [Federal Register Notice: November 23, 2007 (Volume 72, Number 225, pages 65732-65733)]
SUMMARY: EPA is convening a 1-day public workshop to discuss the Agency's draft administrative policies and procedures for completing the initial screening and testing under EPA's Endocrine Disruptor Screening Program (EDSP) and the burden and cost estimates for the related information collection activities. In two forthcoming notices in the Federal Register, EPA will announce the availability for public review and comment of: (1) The draft policies and procedures EPA is considering adopting for conducting the initial screening and testing under the EDSP and (2) the draft Information Collection Request (ICR) for the initial screening and testing. The purpose of the public workshop is to allow the public to ask questions and for EPA to provide further explanation about these aspects of the EDSP, which in turn may facilitate the preparation of comments.
Draft List of Initial Pesticide Active Ingredients and Pesticide Inerts to be Considered for Screening under the Federal Food, Drug, and Cosmetic Act; Extension of Comment Period [Federal Register Notice: November, 15, 2007 (Volume 72, Number 220, pages 64218-64219)]
SUMMARY: EPA issued a notice in the Federal Register of June 18, 2007, concerning the draft list of the first group of chemicals that will be screened in the Agency's Endocrine Disruptor Screening Program (EDSP). The draft list was produced using the approach described in the September 2005 notice, and includes chemicals that the Agency, in its discretion, has decided should be tested first, based upon exposure potential. The June 18, 2007 Federal Register notice provided for a 90-day public comment period. EPA extended the comment period an additional 60 days in the Federal Register of September 12, 2007. This document is extending the comment period for a second time for 45 days. The new comment period extends to December 31, 2007.
Draft List of Initial Pesticide Active Ingredients and Pesticide Inerts to be Considered for Screening under the Federal Food, Drug, and Cosmetic Act; Extension of Comment Period [Federal Register Notice: September, 12, 2007 (Volume 72, Number 176, page 52108)]
SUMMARY: EPA issued a notice in the Federal Register of June 18, 2007, concerning the draft list of the first group of chemicals that will be screened in the Agency's Endocrine Disruptor Screening Program (EDSP). The draft list was produced using the approach described in the September 2005 notice, and includes chemicals that the Agency, in its discretion, has decided should be tested first, based upon exposure potential. This document is extending the comment period for 60 days, from September 17, 2007, to November 16, 2007.
Endocrine Disruptor Screening
Program; Assay Peer Review Process [PDF file, 4 pp., 67KB]
[Federal Register Notice: July 13, 2007 (Volume 72, Number 134, pages 38577-38580)]
SUMMARY: The purpose of this notice is to announce the approach EPA intends to take for conducting peer reviews of the Tier 1 screening assays and Tier 2 testing assays that are being validated by the Agency’s Endocrine Disruptor Screening Program (EDSP), as well as EPA’s approach for conducting the peer review of the Tier 1 battery. EPA is also announcing the availability of a listserver (Listserv) that will allow interested parties to sign up to receive email notifications of EDSP peer review updates, including information on the availability of peer review materials to be posted on the EDSP website. These materials may include the documents to be peer reviewed, background documents, the charge to the peer reviewers, and reports that summarize the results of peer reviews.
Draft List of Initial Pesticide Active Ingredients and Pesticide
Inerts to be Considered for Screening under the Federal Food, Drug and
Cosmetic Act [PDF file, 18 pp., 131KB]
[Federal Register Notice: June 18, 2007
(Volume 72, Number 116, pages 33486-33503)]
How to comment.
SUMMARY: Section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA) directs EPA to develop a chemical screening program using appropriate validated test systems and other scientifically relevant information to determine whether certain substances may have hormonal effects. In September 2005, EPA published its approach for selecting the initial list of chemicals for which testing will be required under the Endocrine Disruptor Screening Program (EDSP). This notice presents the draft list of the first group of chemicals that will be screened in the Agency's EDSP.
The draft list was produced using the approach described in the September 2005 Notice, and includes chemicals that the Agency has decided should be tested first, based upon exposure potential. This list should not be construed as a list of known or likely endocrine disruptors. Nothing in the approach for generating the initial list provides a basis to infer that any of the chemicals selected interfere with or are suspected to interfere with the endocrine systems of humans or other species.
The first group of chemicals identified for testing includes pesticide active ingredients and High Production Volume (HPV) chemicals used as pesticide inerts. After considering comments on this draft list of chemicals, EPA will issue a second Federal Register Notice containing the final list of chemicals. This notice does not describe other aspects of the EDSP such as the administrative procedures EPA will use to require testing, the validated tests and battery that will be included in the EDSP, or the timeframe for requiring the testing or receiving the data. These topics will be addressed in subsequent notices published in the Federal Register.
2006 Federal Register Notices
FIFRA Scientific Advisory Panel; Notice of Public Meeting [PDF file, 4 pp., 101KB]
[Federal Register Notice: December 13, 2006 (Volume 71, Number 239, pages 74901-74904)]
SUMMARY: There will be a 2-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) to consider and review the status of the in utero through lactational assay in the Endocrine Disruptor Screening Program (EDSP).
Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC); Notice of Public Meeting [PDF file, 3pp., 94KB]
[Federal Register Notice: March 29, 2006 (Volume 71, Number 60, pages 15724-15726)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation Advisory Committe (EDMVAC) on April 18 through April 20, 2006, in Washington, DC. This meeting, as with all EDMVAC meetings, is open to the public. Seating is on a first-come basis. The purpose of the meeting is to receive advice and input from the EDMVAC on: Male and Female Pubertals Assay Interlaboratory Studies, EDSP’s Applied Approach to Validation, Tier 1 Fish Screen Assay Validation Status, updates on Tier 1 Aromatase Assay, and Tier 1 Steroidogenesis Cell Based H295R Assay.
2005 Federal Register Notices
Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC); Notice of Public Meeting [PDF file, 3pp., 81KB]
[Federal Register Notice: November 8, 2005 (Volume 70, Number 215, pages 67700-67702)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC) on November 30 through December 2, 2005, in Raleigh, NC. This meeting, as with all EDMVAC meetings, is open to the public. Seating is on a first-come basis. The purpose of the meeting is to receive advice and input from the EDMVAC on: EPA’s Applied Approach to Validation, OECD Uterotrophic Peer Review Report, Steroidogenesis Using the H295R Cell Line, Avian Studies, and an update on the Pubertal Assays.
Endocrine Disruptor Screening Program; Chemical Selection
Approach for Initial Screening [PDF file, 17pp., 125KB]
[Federal Register Notice: September 27, 2005 (Volume 70, Number 186, pages 56449-56465)]
SUMMARY: This notice describes the approach EPA plans to use for selecting the first group of chemicals to be screened in the Agency’s Endocrine Disruptor Screening Program (EDSP). The Food Quality Protection Act of 1996 (FQPA) amended the Federal Food, Drug, and Cosmetic Act (FFDCA) to direct EPA to develop a chemical screening program using appropriate validated test systems and other scientifically relevant information to determine whether certain substances may have hormonal effects. In December 2002, EPA sought comment on its approach for selecting the initial list of chemicals for which testing will be required under the EDSP. Following review and revision based on the public comments, EPA is now describing the approach that it intends to use for selecting the chemicals for the initial list. For this initial approach, as recommended by scientific advisory committees, EPA will select 50 to 100 chemicals. The chemicals will be selected based on their relatively high potential for human exposure rather than using a combination of exposure- and effects-related factors. The scope of this first group of chemicals to be tested includes pesticide active ingredients and High Production Volume (HPV) chemicals used as pesticide inerts. This will allow EPA to focus its initial screening efforts on a smaller and more manageable universe of chemicals that emphasizes the early attention to the pesticide chemicals that Congress specifically mandated EPA to test for possible endocrine effects. This notice does not identify the initial list of chemicals, nor does it describe other aspects of the EDSP such as the administrative procedures EPA will use to require testing, the validated tests and battery that will be included in the EDSP, or the timeframe for requiring the testing or receiving the data. The initial chemical list and the details of the EDSP process that will apply to the initial chemical list will be addressed in subsequent notices published in the Federal Register.
Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC); Notice of Public Meeting [PDF file, 3pp., 63KB]
[Federal Register Notice: July 11, 2005 (Volume 70, Number 131, pages 39767-39769)]
SUMMARY: There will be a meeting, via teleconference, of the Endocrine Disruptor Methods Validation Advisory Committe (EDMVAC) on August 2, 2005, in Washington, DC. This meeting, as with all EDMVAC meetings, is open to the public. Due to limited phone lines, we encourage all local participants to join us at RESOLVE. Seating will be on a first-come basis. The purpose of the meeting is to receive advice and input from the EDMVAC on the 15-Day Intact Adult Male Assay
Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC); Notice of Public Meeting [PDF file, 3pp., 55KB]
[Federal Register Notice: April 8, 2005 (Volume 70, Number 67, pages 17995-17997)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation Advisory Committe ( EDMVAC ) on April 26-28, 2005, in Washington, DC. This meeting, as with all EDMVAC meetings, is open to the public. Seating is on a first-come basis. The purpose of the meeting is to receive advice and input from the EDMVAC on: Steroidogenesis, Uterotrophic, Fish Screen Studies, and Amphibian Metamorphosis Assays.
2004 Federal Register Notices
Establishment of the Endocrine Disruptor Methods Validation Advisory Committee [PDF file, 2pp., 55KB]
[Federal Register Notice: June 2, 2004 (Volume 69, Number 106, pages 31099-31100)]
SUMMARY: As required by section 9(a)(2) of the Federal Advisory Committee Act (5 U.S.C. App. 2 section 9(a)(2)), we are giving notice that EPA is establishing the Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC). The purpose of this Committee is to provide a forum for a diverse group of individuals representing a broad range of interests and scientific expertise. It will provide advice to the Agency on matters related to the validation of assays under consideration by the Endocrine Disruptor Screening Program (EDSP). The Committee will analyze relevant scientific issues, protocols, review data and interpretations of data for the assays. The major objective of the Committee is to provide advice and recommendations to the EPA Administrator on scientific and technical aspects of the assays as they progress through the validation process. EPA has determined that this advisory committee is in the public interest and will assist the Agency in performing its duties as prescribed by the Food Quality Protection Act of 1996. Copies of the Committee Charter will be filed with the appropriate congressional committees and the Library of Congress.
Request for Nominations to the Proposed Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC); Extension of Time [PDF file, 2pp., 51KB]
[Federal Register Notice: June 1, 2004 (Volume 69, Number 105, pages 30907-30908)]
SUMMARY: In the Federal Register of April 26, 2004 (69 FR 22509) (FRL- 7352-9), EPA issued a notice inviting nominations of qualified candidates to consider for appointment to the proposed Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC), which is replacing the Endocrine Disruptor Methods Validation Subcommittee (EDMVS) under the National Advisory Council for Environmental Policy and Technology (NACEPT). Due to a low number of submissions of nominations the Agency is extending the request for nomination time period to 4 p.m. eastern time on June 18, 2004.
Request for Nominations to the Proposed Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC) [PDF file, 3pp., 64 KB]
[Federal Register Notice: April 26, 2004 (Volume 69, Number 80, pages 22509-22511)]
SUMMARY: EPA is inviting nominations of qualified candidates to consider for appointment to the proposed Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC), which is replacing the Endocrine Disruptor Methods Validation Subcommittee (EDMVS) under the National Advisory Council for Environmental Policy and Technology (NACEPT). EPA will consider nominations submitted in response to this notice as well as nominations received from other outreach efforts in selecting EDMVAC members. The purpose of the proposed EDMVAC will be to provide advice and recommendations to EPA on scientific and technical aspects of the Tier I screens and Tier II assays being considered for the Endocrine Disruptor Screening Program (EDSP). The proposed Committee will evaluate relevant scientific issues, protocols, data and interpretations of the data for the assays during the validation process. The proposed EDMVAC will provide advice on the composition of the Tier I screening battery as well. Nominations will be accepted until 4 p.m. eastern time on May 26, 2004.
2003 Federal Register Notices
Endocrine Disruptor Methods
Validation Subcommittee under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 3pp., 50KB]
[Federal Register
Notice: November 21, 2003 (Volume 68, Number 225, pages 65706-65708)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation
Subcommittee (EDMVS), a subcommittee under the National Advisory Council for Environmental
Policy and Technology (NACEPT), on December 10-12, 2003. The purpose of this meeting is to receive advice and
input from the EDMVS on: The Pubertals assay and Aromatase assay prevalidation results; receive
the introductory presentation on Adult Intact Male assay; and receive updates on: The Androgen
Receptor Binding assay, efforts to finalize reference chemicals, and the Organization for Economic
Cooperation and Development (OECD) fish drafting Group
Endocrine Disruptor Methods
Validation Subcommittee under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 4pp., 50KB]
[Federal Register
Notice: July 30, 2003 (Volume 68, Number 146, pages 44763-44766)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation
Subcommittee (EDMVS), a Subcommittee under the National Advisory Council
for Environmental Policy and Technology (NACEPT), on August 18-20, 2003.
This meeting, as with all EDMVS meetings, is open to the public. Seating
is on a first-come basis.
Endocrine Disruptor Screening
Program; Endocrine Disruptor Methods Validation Subcommittee under the
National Advisory Council for Environmental Policy and Technology; Request
for Nominations for Membership [PDF, 4pp., 50KB]
[Federal Register Notice: May 30, 2003
(Volume 68, Number 104, pages 32482-32485)]
SUMMARY: As mandated by the Federal Food, Drug, and Cosmetic Act (FFDCA),
amended by the Food Quality Protection Act (FQPA) of 1996, EPA implemented
an Endocrine Disruptor Screening Program (EDSP). As part of the EDSP,
the Endocrine Disruptor Methods Validation Subcommittee (EDMVS) was established
in 2001, is a Subcommittee under the National Advisory Council for Environmental
Policy and Technology (NACEPT). The members of the EDMVS may serve up
to three 2-year terms. This notice is a request for nominations for new
members of the EDMVS from interested organizations. NACEPT is a chartered
federal advisory committee subject to the provisions of the Federal Advisory
Committee Act (FACA). Through NACEPT, the EDMVS provides technical advice
and recommendations to EPA regarding validation of the Tier I screening
and Tier II testing methods for the EDSP.
Endocrine Disruptor Methods
Validation Subcommittee under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 3pp., 50KB]
[Federal Register
Notice: May 21, 2003 (Volume 68, Number 98, pages 27797-27799)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation
Subcommittee (EDMVS), a Subcommittee under the National Advisory Council
for Environmental Policy and Technology (NACEPT), on June 5-6, 2003. This
meeting, as with all EDMVS meetings, is open to the public. Seating is
on a first-come basis.
Proposed Chemical Selection Approach
for Initial Screening; Extension of Comment Period [PDF, 2pp., 38KB]
[Federal
Register: February 26, 2003 (Volume 68, Number 38, pages 8901-8902)]
SUMMARY: In a Federal Register notice published on December 30, 2002,
EPA set forth for public comment the approach EPA intends to use for selecting
the first group of chemicals to be screened in the Agency's Endocrine
Disruptor Screening Program (EDSP). EPA requested that comments be submitted
on or before March 1, 2003. In response to several requests to extend
the deadline for submitting comments, EPA is extending the comment period
to April 1, 2003.
2002 Federal Register Notices
Proposed Chemical Selection Approach
for Initial Screening; Request for Comment [PDF, 19pp., 118KB]
[Federal Register:
December 30, 2002 (Volume 67, Number 250, pages 79611-79629)]
SUMMARY: This notice sets forth for public comment the approach EPA plans
to use for selecting the first group of chemicals to be screened in the
Agency's Endocrine Disruptor Screening Program (EDSP). Following consideration
of comments on this draft approach, EPA will issue a second Federal Register
notice setting forth its approach for selecting the first group of chemicals
and the chemicals it proposes for this initial list. Following comment
on the draft list of specific chemicals, EPA will issue the final list.
Endocrine Disruptor Methods
Validation Subcommittee Under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 2pp., 40KB]
[Federal Register
Notice: November 14, 2002 (Volume 67, Number 220, pages 69002-69003)]
SUMMARY: EPA is announcing a 2-hour teleconference meeting of the Endocrine
Disruptor Methods Validation Subcommittee (EDMVS), a subcommittee under
the National Advisory Council for Environmental Policy and Technology
(NACEPT), a Federal advisory committee, on December 4, 2002. The EDMVS
will provide technical advice on a fish lifecycle assay detailed review
paper presented by the Endocrine Disruptor Screening Program (EDSP). The
upcoming teleconference meeting is open to the public.
Endocrine Disruptor Methods
Validation Subcommittee under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 3pp., 44KB]
[Federal Register
Notice: July 10, 2002 (Volume 67, Number 132, pages 45720-45722)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation
Subcommittee (EDMVS), a subcommittee under the National Advisory Council
for Environmental Policy and Technology (NACEPT), a Federal Advisory Committee,
on July 23-24, 2002. The EDMVS will provide technical advice on screening
and testing methods for the Endocrine Disruptor Screening Program (EDSP).
This meeting, as with all EDMVS meetings, is open to the public. Seating
is on a first-come basis.
Endocrine Disruptor Method
Validation Subcommittee under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 2pp., 39KB]
[Federal Register
Notice: May 28, 2002 (Volume 67, Number 67, pages 36878-36879)]
SUMMARY: There will be a meeting, via teleconference, of the Endocrine
Disruptor Methods Validation Subcommittee (EDMVS), a subcommittee under
the National Advisory Council for Environmental Policy and Technology
(NACEPT), a Federal Advisory Committee, on June 11, 2002, to discuss the
steroidogenesis detailed review paper. The meeting is open to the public.
Due to limited phone lines, we encourage all local participants to join
us at RESOLVE. Seating will be on a first-come basis. The EDMVS meeting
originally scheduled for June 10-12, 2002, has been postponed. That meeting
will be rescheduled for late July.
Endocrine Disruptor Method
Validation Subcommittee Under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 3pp., 45KB]
[Federal Register
Notice: March 8, 2002 (Volume 67, Number 46, pages 10715-10717)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation
Subcommittee (EDMVS), a subcommittee under the National Advisory Council
for Environmental Policy and Technology (NACEPT), a Federal Advisory Committee,
on March 25th - 27th, 2002. The EDMVS will provide technical advice on
screening and testing methods for the Endocrine Disruptor Screening Program
(EDSP). The upcoming meeting, as with all EDMVS meetings, is open to the
public. Seating is on a first-come basis.
2001 Federal Register Notices
Endocrine Disruptor Methods
Validation Subcommittee under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 2pp., 39KB]
[Federal Register
Notice: November 21, 2001 (Volume 66, Number 225, pages 58466-58467)]
SUMMARY: As mandated by the Federal Food, Drug, and Cosmetic Act, as amended
by the Food Quality Protection Act of 1996, EPA is implementing an Endocrine
Disruptor Screening Program (EDSP). As part of the implementation of EDSP,
the Endocrine Disruptor Methods Validation Subcommittee (EDMVS) under
the National Advisory Council for Environmental Policy and Technology,
a Federal Advisory Committee NACEPT, has been established. There will
be a 3-day meeting of the EDMVS, December 10 - 12, 2001. EDMVS will provide
technical advice on the Tier 1 screening and Tier 2 testing methods for
its EDSP. The meeting is open to the public. Seating is on a first-come
basis.
Endocrine Disruptor Methods
Validation Subcommittee Under the National Advisory Council for Environmental
Policy and Technology; Notice of Public Meeting [PDF, 2pp., 43KB]
[Federal Register Notice: October 11, 2001 (Volume 66, Number 197, page 51951)]
SUMMARY: As mandated by the Federal Food, Drug, and Cosmetic Act, as amended
by the Food Quality protection Act of 1996, EPA is implementing an Endocrine
Disruptor Screening Program (EDSP). As part of the implementation of EDSP,
the Endocrine Disruptor Methods Validation Subcommittee (EDMVS) has been
established under the National Advisory Council for Environmental Policy
and Technology (NACEPT), a Federal Advisory Committee. EDMVS will have
their first 2-day meeting, October 30-31, 2001. EDMVS will provide technical
advice on the Tier 1 screening and Tier 2 testing methods for EPA's EDSP.
The meeting is open to the public. Seating is on a first-come basis.
National Toxicology Program: Release
of the NTP final report from the Endocrine Disruptors Low-Dose Peer Review
for public comment. [PDF, 1pp., 33KB]
[Federal Register: May 16, 2001 (Volume 66, Number
95, page 27152)]
SUMMARY: The National Toxicology Program (NTP)/National Institute of Environmental
Health Sciences (NIEHS) organized and conducted a scientific peer review
at the request of the EPA to evaluate reported low-dose reproductive and
developmental effects and dose-response relationships for endocrine disrupting
chemicals. The NTP is soliciting public comment prior to transmitting
the final report to the EPA. Public comments received in response to this
solicitation will be included in the final transmittal. The final report
is available on the NTP web site at http://ntp-server.niehs.nih.gov or
by contacting the NTP Office of Liaison and Scientific Review; 919-541-0530
(phone); 919-541-0295 (fax); liaison@starbase.niehs.nih.gov ; 111 T.W.
Alexander Drive, P.O. Box 12233, MD A3-01, Research Triangle Park, NC
27709. Comments are being accepted through July 16, 2001. Instructions
on how to submit comments are in the Federal Register notice.
Endocrine Disruptor Screening
Program; Establishment of an Endocrine Disruptor Methods Validation Subcommittee
under the National Advisory Council for Environmental Policy and Technology;
Request for Nominations for Membership [PDF, 6pp., 57KB]
[Federal Register Notice: May
7, 2001 (Volume 66, Number 88, pages 23022-23027)]
SUMMARY: As mandated by the Federal Food, Drug, and Cosmetic Act, as amended
by the Food Quality Protection Act of 1996, EPA is implementing an Endocrine
Disruptor Screening Program (EDSP). This notice proposes the establishment
of an Endocrine Disruptor Methods Validation Subcommittee (EDMVS) as a
Subcommittee under the National Advisory Council for Environmental Policy
and Technology (NACEPT), and requests nominations for members of the EDMVS
from interested organizations. NACEPT is a chartered federal advisory
committee subject to the provisions of the Federal Advisory Committee
Act. Through NACEPT, the EDMVS will provide technical advice an recommendations
to EPA regarding validation of the Tier 1 Screening and Tier 2 Testing
methods for its Endocrine Disruptor Screening Program (EDSP).
Endocrine Disruptor Screening
Program; Proposed Endocrine Disruptor Methods Validation Subcommittee
under the National Advisory Council for Environmental Policy and Technology;
Notice of Meeting [PDF, 2pp., 38KB]
[Federal Register Notice: March 26, 2001 (Volume
66, Number 58, pages 16466-16467)]
SUMMARY: There will be a meeting of the Endocrine Disruptor Methods Validation
Subcommittee (EDMVS), a subcommittee under the National Advisory Council
for Environmental Policy and Technology (NACEPT), a Federal Advisory Committee,
on April 24, 2001. The EDMVS will provide technical advice on screening
and testing methods for the Endocrine Disruptor Screening Program (EDSP).
The upcoming meeting, as with all EDMVS meetings, is open to the public.
Seating is on a first-come basis.
2000 Federal Register Notices
Priority-Setting Workshop for the
Endocrine Disruptor Screening Program (EDSP); Extension of Comment Period [PDF, 2pp., 129KB]
[Federal Register: July 13, 2000 (Volume 65, Number 135, page 43325)]
SUMMARY: EPA is extending the comment period, announced in the May 19,
2000, Federal Register, for issues discussed at the June 5-7 Priority-Setting
Workshop for the Endocrine Disruptor Screening Program (EDSP), from July
7, 2000 to August 25, 2000.
Priority-Setting Workshop
for the Endocrine Disruptor Screening Program; Notice of Public Meeting [PDF, 3pp., 126KB]
[Federal Register: May 19, 2000 (Volume 65, Number 98, pages 31900-31902)]
SUMMARY: This notice invites public participation in a workshop to discuss
the development of a priority-setting system for the selection of chemicals
for testing in the Endocrine Disruptor Screening Program (EDSP). The Agency's
1998 Proposed Statement of Policy for the EDSP contains a set of principles
and a general strategy for setting priorities for testing. The Agency
has developed a draft version of a priority-setting system and seeks public
input on the further design and implementation of the system. The workshop
will also provide an overall update and invite general comment on other
aspects of the EDSP, including the status of the standardization and validation
efforts and the approach for pesticide active ingredients.
National Institute of Environmental
Health Sciences, NIH; National Toxicology Program; Peer Review Meeting
on Low-Dose Issues for Endocrine Disruptors; Update on Meeting Scope;
Meeting Agenda; and Registration Information [PDF, 3pp., 125KB]
[Federal Register Notice:
September 27, 2000 (Volume 65, Number 188, pages 58097-58099)]
SUMMARY: The National Toxicology Program (NTP) is organizing a Peer Review
to evaluate dose-response relationships for endocrine disrupting chemicals.
In particular, the panel will evaluate whether chemicals can cause hormone-related
effects at doses lower than those typically used in the standard toxicological
dose-setting paradigm. The U.S. Environmental Protection Agency (EPA)
Endocrine Disruptor Screening Program will use the results from this peer
review to assist in determining how to identify and characterize potential
low-dose effects that may arise during endocrine disruptor screening,
testing, and hazard assessment. If the review panel concludes that the
current data on low-dose effects are inconclusive, it will be asked to
describe specific research that would resolve the ambiguities. The Peer
Review will take place October 10-12, 2000 at the Sheraton Imperial Hotel
and Convention Center, Research Triangle Park, NC. This meeting is open
to the public.
National Toxicology Program: Peer
Review Meeting on Low-Dose Issues for Endocrine Disruptors; Scope of Information
Considered for Review Broadened, Deadline for Receipt of Information Extended,
and Date for Meeting Delayed [PDF, 2pp., 120KB]
[Federal Register: April 17, 2000 (Volume
65, Number 74 Pages 20478 - 20479)]
SUMMARY: The National Toxicology Program (NTP) is organizing a Peer Review
to evaluate whether chemicals can cause hormone-related effects at doses
lower than those typically used in the standard toxicological dose-setting
paradigm. On January 6, 2000 the NTP published a Federal Register notice
outlining plans for the Peer Review meeting and soliciting public input
into the process. This notice broadens the request for research studies
and data to be considered and extends previously announced deadlines for
receipt of research information for use in this peer review.
National Toxicology Program: Solicitation
of Comments on Proposed Peer Review of Low-Dose Issues for Endocrine Disruptors [PDF, 4pp., 25KB]
[Federal Register Notice: January 6, 2000 (Volume 65, Number 4, Pages
784-787)]
SUMMARY: NTP is soliciting comments on the planned scope and process for
a proposed peer review of studies bearing on the question of whether endocrine
disruptors may cause effects at doses lower than are tested using standard
toxicological testing procedures. Nominations for peer reviewers, as well
as nominations for studies to be reviewed, are also being solicited. Results
from the peer review will help the U.S. Environmental Protection Agency
(a member agency of the NTP) and, in particular the EPA's Endocrine Disruptor
Screening Program, determine how to address low-dose questions in endocrine
disruptor screening, testing, and hazard assessment.
1999 Federal Register Notices
No Federal Register Notices related to the Endocrine Disruptor Screening Program were published in 1999.
1998 Federal Register Notices
Endocrine Disruptor Screening Program:
Statement of Policy Notice [PDF, 28pp., 228KB]
[Federal Register Notice: December 28,
1998 (Volume 63, Number 248, Page 71541-71568)]
SUMMARY: In this notice, EPA is providing additional details and an opportunity
for public comment on its Endocrine Disruptor Screening Program (EDSP).
The Agency first set forth the basic components of the EDSP in the August
11, 1998, Federal Register. The EDSP is required by the Federal Food,
Drug, and Cosmetics Act (FFDCA), as amended by the Food Quality Protection
Act (FQPA). In developing the EDSP, EPA considered recommendations of
the Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC),
a panel chartered pursuant to the Federal Advisory Committee Act. EDSTAC
recommended expansion of the screening program beyond the statutory minimum
to include not only pesticides but commercial chemicals regulated under
the Toxic substances Control Act (TSCA), certain natural products, non-pesticide
food additives, and cosmetics. EDSTAC also recommended that EPA screen
for effects on the androgen and thyroid systems and for effects on fish
and wildlife. This notice describes the major elements of EPA's EDSP,
as well as its implementation.
Endocrine Disruptor Screening
Program: Priority-Setting Workshop [PDF, 3pp., 26KB]
[Federal Register Notice: December
28, 1998 (Volume 63, Number 248, Page 71568-71570)]
SUMMARY: This notice invites public participation in a workshop to discuss
the development of a priority-setting system for the selection of chemicals
for testing in the Endocrine Disruptor Screening Program (EDSP). The recommendations
of the Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC)
and the Agency's subsequent Statement of Policy contain a set of principles
and a general strategy for setting priorities for testing. The Agency
is now commencing the detailed design phase of the priority-setting system
and seeks public input on the design of the system.
Endocrine Disruptor Screening Program [PDF, 4pp., 34KB]
[Federal Register Notice: August 11, 1998 (Volume 63, Number 154, pages
42852-42855)]
SUMMARY: As mandated by the Federal Food, Drug, and Cosmetic Act, as amended
by the Food Quality Protection Act of 1996, EPA is setting forth its screening
program for determining which pesticide chemicals and other substances
may have an effect in humans that is similar to an effect produced by
a naturally occurring estrogen or other endocrine effects. In developing
the screening program, EPA considered recommendations of the Endocrine
Disruptor Screening and Testing Advisory Committee, a panel chartered
pursuant to the Federal Advisory Committee Act. EPA refers to this program
as the ``Endocrine Disruptor Screening Program'' or the ``Screening Program.''
This document describes the major elements of EPA's Endocrine Disruptor
Screening Program. EPA will provide operational details regarding the
Screening Program, its regulatory implementation, and provide an opportunity
for public comment in a later Federal Register document. After public
comment and before implementation, EPA will submit the Screening Program
for review to a joint panel of the Federal Insecticide, Fungicide, and
Rodenticide Act Scientific Advisory Panel and the EPA Science Advisory
Board.
EPA's Endocrine Disruptor Screening
and Testing Advisory Committee; Notice of Public Meeting [PDF, 2pp., 20KB]
[Federal
Register Notice: June 12, 1998 (Volume 63, Number 113, pages 32209-32210)]
SUMMARY: EPA is announcing the final meeting of the Endocrine Disruptor
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Advisory Committee Act (FACA) to advise
EPA on developing a strategy to screen and test chemicals, including pesticides,
for their potential to disrupt endocrine functions in humans, fish, and
other wildlife.
FIFRA Scientific Advisory Panel
and Science Advisory Board; Open Meeting [PDF, 2pp., 20KB]
[Federal Register Notice:
April 9, 1998 (Volume 63, Number 68, pages 17414-17415)]
SUMMARY: There will be a joint two-day meeting of the Federal Insecticide,
Fungicide, and Rodenticide Act (FIFRA) and Food Quality Protection Act
(FQPA) Scientific Advisory Panel (SAP) and the Agency Science Advisory
Board (SAB) to review a set of scientific issues being considered by the
Agency concerning the development of the Agency's endocrine disruptor
screening and testing program as required by the 1996 Food Quality Protection
Act and the Safe Drinking Water Act. This meeting will focus on scientific
issues identified by the Endocrine Disruptors Screening and Testing Advisory
Committee (EDSTAC) in their draft report. Agenda items include the conceptual
framework for the operation of the EDSTAC, the endocrine disruptors priority
setting process, the proposed endocrine disruptors screening battery and
testing scheme, and a discussion of the near-term endocrine disruptors
program implementation activities. Information from the draft EDSTAC report
and from this meeting as well as public comments will be used by the Agency
to develop the endocrine disruptors program.
Endocrine Disruptors; Notice of
Public Meeting [PDF, 2pp., 13KB]
[Federal Register Notice: March 2, 1998 (Volume 63,
Number 40, pages 10220-10221)]
SUMMARY: EPA is announcing the eighth meeting of the Endocrine Disruptors
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Advisory Committee Act (FACA) to advise
EPA on a strategy for screening chemicals and pesticides for their potential
to disrupt endocrine function in humans and wildlife.
Endocrine Disruptors; Notice of
Public Meeting [PDF, 1pp., 13KB]
[Federal Register Notice: January 23, 1998 (Volume
63, Number 15, page 3565)]
SUMMARY: EPA is announcing the seventh meeting of the Endocrine Disruptors
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Advisory Committee Act (FACA) to advise
EPA on a strategy for screening chemicals and pesticides for their potential
to disrupt endocrine function in humans and wildlife.
1997 Federal Register Notices
Endocrine Disruptors; Notice of
Public Meeting [PDF, 1pp., 13KB]
[Federal Register Notice: November 25, 1997 (Volume
62, Number 227, page 62768]
SUMMARY: EPA is announcing the sixth meeting of the Endocrine Disruptors
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Advisory Committee Act (FACA) to advise
EPA on a strategy for screening chemicals and pesticides for their potential
to disrupt endocrine function in humans and wildlife.
Endocrine Disruptors; Notice of
Public Meeting [PDF, 2pp., 13KB]
[Federal Register Notice: September 3, 1997 (Volume
62, Number 170, pages 46493-46494]
SUMMARY: EPA is announcing the fifth meeting of the Endocrine Disruptors
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Advisory Committee Act (FACA) to advise
EPA on a strategy for screening chemicals and pesticides for their potential
to disrupt endocrine function in humans and wildlife.
Endocrine Disruptors; Notice of
Public Meeting [PDF, 1pp., 12KB]
[Federal Register Notice: July 7, 1997 (Volume 62,
Number 129, page 36279)]
SUMMARY: EPA is announcing the fourth meeting of the Endocrine Disruptors
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Advisory Committee Act (FACA) to advise
EPA on a strategy for screening chemicals and pesticides for their potential
to disrupt endocrine function in humans and wildlife.
Endocrine Disruptors; Notice of
Public Meeting [PDF, 2pp., 12KB]
[Federal Register Notice: April 28, 1997 (Volume 62,
Number 81, pages 22941-22942)]
SUMMARY: EPA is announcing the third meeting of the Endocrine Disruptors
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Advisory Committee Act (FACA) to advise
EPA on a strategy for screening chemicals and pesticides for their potential
to disrupt endocrine function in humans and wildlife.
Special Report on Environmental
Endocrine Disruption: An Effects Assessment and Analysis [PDF, 2pp., 21KB]
[Federal
Register Notice: March 14, 1997 (Volume 62, Number 50, pages 12185-12186)]
SUMMARY: EPA is announcing the availability of the ``Special Report on
Environmental Endocrine Disruption: An Effects Assessment and Analysis.''
The report provides an overview of the current state of the science for
endocrine disruption. The report's major components are an introduction
to the endocrine system and the endocrine disruption hypothesis; a review
of potential human health and ecological risks; and an analysis section,
including an overview of research needs. The report represents an interim
assessment pending a more extensive review expected to be issued by the
National Academy of Sciences later in 1997.
Endocrine Disruptors; Notice of
Public Meeting [PDF, 1pp., 13KB]
[Federal Register Notice: January 27, 1997 (Volume
62, Number 17, page 3894]
SUMMARY: EPA is announcing the second meeting of the Endocrine Disruptors
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Advisory Committee Act (FACA) to advise
EPA on a strategy for screening chemicals and pesticides for their potential
to disrupt endocrine function in humans and wildlife.
1996 Federal Register Notices
1996 Federal Register Notices Back
to Top Endocrine Disruptors; Notice of Public Meeting [PDF, 2pp., 20KB]
[Federal Register
Notice: November 27, 1996 (Volume 61, Number 230, pages 60280-60281)]
SUMMARY: EPA is announcing the first meeting of the Endocrine Disruptors
Screening and Testing Advisory Committee (EDSTAC), a committee established
under the provisions of the Federal Committee Advisory Act (FACA) to advise
EPA on a strategy for screening and testing chemicals and pesticides for
their potential to disrupt endocrine functions in humans and wildlife.
Endocrine Disruptors; Notice of
Public Meeting [PDF, 2pp., 19KB]
[Federal Register Notice: October 17, 1996 (Volume
61, Number 202, pages 54195-54196)]
SUMMARY: EPA is holding a public meeting with interested stakeholder groups
to assist the Agency in forming a committee under the provisions of the
Federal Advisory Committee Act (FACA) to provide advice on the screening
and testing of chemicals and pesticides for their potential to disrupt
endocrine function in humans and wildlife. This is the second of such
meetings. The first meeting was held May 15-16, 1996, in Washington DC.
Persons who attended the first meeting or placed their names on a list
to be kept informed of further developments will be notified of this meeting
by letter, and will receive additional information regarding the formation
of the committee and nominees for committee membership.
Endocrine Disruption by Chemicals:
Next Steps in Chemical Screening and Testing; Open Meeting [PDF, 2pp., 20KB]
[Federal
Register Notice: May 8, 1996 (Volume 61, Number 90, pages 20814-20815)]
SUMMARY: Recent research indicates that environmental endocrine disruptors
need more attention by chemical and pesticide regulators. The EPA will
hold a meeting on May 15 and May 16, 1996 in the Washington, DC metropolitan
area to discuss how EPA can work cooperatively with industry, the environmental
community, academia and others to develop a screening and testing strategy
to identify chemicals that may pose significant risks through endocrine
disruption. This notice announces the location and times for the meeting
and sets forth tentative agenda topics. EPA has invited 20 representatives
of industry, the environmental community, academia, and government to
this meeting. The meeting is open to the public, but space for observers
is limited. The meeting is structured to allow the invited participants
to discuss items on a predetermined agenda. However, at the end of the
first day, there will be thirty minutes of open discussion.