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Volume 10, Number 12, December 2004 Novel Avian Influenza H7N3 Strain Outbreak, British ColumbiaMartin Hirst,* Caroline R. Astell,* Malachi Griffith,* Shaun M. Coughlin,*
Michelle Moksa,* Thomas Zeng,* Duane E. Smailus,* Robert A. Holt,* Steven
Jones,* Marco A. Marra,* Martin Petric,† Mel Krajden,† David Lawrence,†
Annie Mak,† Ron Chow,† Danuta M. Skowronski,† S. Aleina Tweed,† SweeHan
Goh,† Robert C. Brunham,† John Robinson,‡ Victoria Bowes,‡Ken Sojonky,‡
Sean K. Byrne,‡ Yan Li,§ Darwyn Kobasa,§ Tim Booth,§ and Mark Paetzel¶ |
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Appendix Figure 3. A structure-based sequence alignment of the influenza A virus hemagglutinin precursor protein from human A/Canada/504/04 (Hu504) with that of the hemagglutinin precursor protein (HA0) from influenza A virus, human strain CV-1 whose structure was solved by Wiley and colleagues in 1998 (PDBcode 1HAO) (6). The alignment shows 49.9% identity in sequence. Insertions and deletions are highlighted in grey and nonconservative mutations are shown in yellow. Conserved cysteines are boxed. The glycosylated aparagines which are conserved are boxed with thin lines; the glycosylated asparagines that are not conserved are boxed with thick lines. |
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This page last reviewed November 8, 2004 |
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Emerging
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