Award Abstract #0328636
FIBR: Integrated Ecological and Genomic Analysis of Speciation in Mimulus

NSF Org:	EF Emerging Frontiers
Initial Amendment Date:	September 2, 2003
Latest Amendment Date:	July 26, 2007
Award Number:	0328636
Award Instrument:	Continuing grant
Program Manager:	Elizabeth R. Blood EF Emerging Frontiers BIO Directorate for Biological Sciences
Start Date:	September 1, 2003
Expires:	August 31, 2009 (Estimated)
Awarded Amount to Date:	$4999979
Investigator(s):	John Willis jwillis@duke.edu (Principal Investigator)
Sponsor:	Duke University 2200 W. Main St, Suite 710 Durham, NC 27705 919/684-3030
NSF Program(s):	FRONTIERS IN BIO RES (FIBR)
Field Application(s):
Program Reference Code(s):	BIOT, 9183
Program Element Code(s):	7216

ABSTRACT

Biologists have been seeking answers to fundamental questions about how new species arise since the time of Darwin. Speciation is difficult to study because it is a gradual process that generally occurs in a time frame that is longer than a scientist's lifetime. Genomic tools now make it possible to address many of the pivotal questions that have been left unanswered for over a century. This project, involving collaborations between the fields of population biology, genetics, ecology, genome technology, bioinformatics, and computational biology, will investigate how new species arise by elucidating the molecular genetic basis of speciation mechanisms in the Mimulus group. The molecular genetic information will be used to answer specific questions about the role of ecological isolation, mate choice, and genomic incompatibility in speciation events and in maintaining species integrity.

A broader impact of this research is a cross-disciplinary mentoring program involving underrepresented groups that will prepare students for collaborative research. Another significant broader impact of this research is that it will develop genomic tools for a group of plants that are extremely interesting to ecologists and evolutionary biologists because of their diversity of breeding systems, pollinators and habitats. A large community of scientists who have focused their research on this diverse and interesting group will benefit substantially from the development of these tools.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Aagaard, J. E., R. G. Olmstead, J. H. Willis, and P. C. Phillips.  "Duplication of floral regulatory genes in the Lamiales,"  American Journal of Botany,  v.92,  2005,  p. 1284.

Angert, A..  "Demography of central and marginal populations of monkeyflowers (M. cardinalis and M. lewisii).,"  Ecology,  2006, 

Angert, A..  "Growth and leaf physiology of M. cardinalis and M. lewisii under high and low altitude temperature regimes.,"  Oecologia,  v.148,  2006,  p. 183.

Angert, A. L. and D. W. Schemske.  "Local adaptation and the maintenance of geographical species boundaries in Mimulus lewisii and M. cardinalis,"  Evolution,  2005,  p. 1671.

Bouck, A. and T.J. Vision.  "The molecular ecologist's guide to expressed sequence tags.,"  Molecular Ecology,  v.16,  2007,  p. 907.

Fishman, L. and J. H. Willis.  "A cytonuclear incompatibility causes anther sterility in Mimulus hybrids.,"  Evolution,  v.60,  2006,  p. 1372.

Fishman, L., and J. H. Willis.  "A novel meiotic drive locus almost completely distorts segregation in Mimulus (Monkeyflower) hybrids.,"  Genetics,  v.169,  2005,  p. 355.

Hall, M. and J. H. Willis.  "Transmission ratio distortion in intraspecific hybrids of Mimulus guttatus: Implications for genomic divergence.,"  Genetics,  v.170,  2005,  p. 375.

Hall, M. C. and J. H. Willis.  "Pleiotropic quantitative trait loci contribute to population divergence in traits associated with life-history variation in Mimulus guttatus.,"  Genetics,  v.172,  2006,  p. 1829.

Hall, M.C. and J.H. Willis.  "Divergent selection on flowering time contributes of local adaptation in Mimulus guttatus populations.,"  Evolution,  v.60,  2006,  p. 2466.

Martin, N. H., and J. H. Willis.  "ECOLOGICAL DIVERGENCE ASSOCIATED WITH MATING SYSTEM CAUSES NEARLY COMPLETE REPRODUCTIVE ISOLATION BETWEEN SYMPATRIC MIMULUS SPECIES,"  Evolution,  v.61,  2007,  p. 68.

Sweigart, A. L., A. Mason, and J. H. Willis.  "Natural variation for a hybrid incompatiblilty between two species of Mimulus.,"  Evolution,  v.61,  2007,  p. 141.

Sweigart, A. L., L. Fishman, J. H. Willis.  "A simple genetic incompatibility causes hybrid male sterility in Mimulus.,"  Genetics,  v.172,  2006,  p. 2465.

Wu, C.A., D.B. Lowry, A.M. Cooley, K.M. Wright, Y.W. Lee, and J.H. Willis.  "Mimulus is an emerging model system for the integration of ecological and genomic studies.,"  Heredity,  2007, 


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