Handbook
of Human Tissue Sources: A National Resource of Human Tissue Samples
Molecular Databases Science and Technology Policy Institute at
RAND.report on human tissue repositories, commissioned by the National
Bioethics Advisory Commission (NBAC), represent the first inventory
of stored tissue sample repositories in the United States
National Institute
on Drug Abuse Center for Genetic Studies The National Institute
on Drug Abuse (NIDA) ( http://www.nida.nih.gov ),
in collaboration with The NIH (http://www.nih.gov ),
has established the Center for Genetic Studies, under a contract to
Rutgers University and its subcontractor, Washington University, to
produce, store, and distribute clinical data and biomaterials (DNA
samples and cell lines) available in the NIDA Genetics Initiative
COGA:
The Collaborative Study on the Genetics of Alcoholism The Collaborative
Study on the Genetics of Alcoholism (COGA) is a multi-site, multi-disciplinary
undertaking with the overall goals of characterizing the familial transmission
of alcoholism and related phenotypes and identifying susceptibility
genes using genetic linkage
National
Institute of Mental Health Center for Collaborative Genetic Studies
on Mental Disorders The National Institute of Mental Health (NIMH)
( http://www.nimh.nih.gov )
has established the Center for Collabortive Genetic Studies with a
grant to Rutgers University and a sub-contract to Washington University,
to produce, store, and distribute clinical data and biomaterials (DNA
samples and cell lines) available in the NIMH Human Genetics Initiative
(www.nimhgenetics.org/NIMH_intiative/NIMH_initiative ).
NIGMS
Human Genetic Cell Repository By providing the resources for human
genome research, the HUMAN GENETIC CELL REPOSITORY , sponsored by the National
Institute of General Medical Sciences (NIGMS), supplies scientists
with the materials for accelerating disease gene discovery. The resources
available include highly-characterized, viable, and contaminant-free
cell cultures and high quality, well-characterized DNA samples derived
from these cultures, both subjected to rigorous quality
control.
CORIELL
CELL REPOSITORIES provide essential research reagents to the scientific
community by establishing, verifying, maintaining, and distributing
cells cultures and DNA derived from cell cultures. These collections,
supported by funds from the National
Institutes of Health (NIH) and several foundations, are extensively
utilized by research scientists around the world
NIA
Cell Repository Sponsored by the National
Institute on Aging (NIA), the AGING CELL REPOSITORY , is a resource
facilitating cellular and molecular research studies on the mechanisms
of aging and the degenerative processes associated with it.
NINDS
Human Genetics Resource Center at the Coriell Institute is a growing
bank for human cells, DNA samples, clinical data, and information sources,
to accelerate research on genetics of disorders of the nervous system
American
Diabetes Association Cell Bank The purpose of the American
Diabetes Association (ADA), GENNID Study (Genetics of non-insulin
dependent diabetes mellitus, NIDDM) is to establish a national database
and cell repository consisting of information and genetic material
from families with well-documented NIDDM. The GENNID Study will provide
investigators with the information and samples necessary to conduct
genetic linkage studies and locate the genes for NIDDM.
The
Autism Research Resource at The Coriell Institute for Medical Research The
State of New Jersey funded the initiation of a genetic resource to
support the study of autism in families where more than one child
is affected or where one child is affected and one demonstrates another
significant and related developmental disorder. This resource
now receives continuing support from the
Coriell Institute for Medical Research. An open bank of anonymously
collected materials documented by a detailed clinical diagnosis forms
the basis of this growing database of information about the disease.
The Autism Resource is housed at the Coriell Institute for Medical
Research in New Jersey , which holds the world's largest collection
of human cells for use in genetic research and where much of the standard
technology of culturing, storing, and distributing cells has been developed
NATIONAL
PATHOLOGY REPOSITORY The National Pathology Repository, located
at the Armed
Forces Institute of Pathology, accessions and stores material coded
by pathologic diagnosis. The National Repository currently stores over
2.8 million cases accessioned and coded since 1917. The material comprises
written records and over 50 million microscopic slides, 30 million
paraffin tissue blocks, and 12 million preserved wet tissue specimens.
Annually, approximately 60,000 new cases are accessioned and coded
into the National Repository. Cases represent both sexes, all races/ethnicities,
all ages, and come from contributors worldwide. These cases represent
the entire spectrum of human and animal disease.
Department
of Defense DNA Registry To provide worldwide scientific consultation,
research, and education services in the field of forensic DNA analysis
to the Department of Defense (DoD) and other agencies. To provide DNA
reference specimen collection, accession, and storage of United States
military and other authorized personnel
P3G
- Public Population Project in Genomics Four different but complementary
population genomics research projects involving whole populations --
Quebec 's CARTaGENE, GenomEUtwin project (involving 8 countries), Estonia
's genome project and the U.K. Biobank -- decided to come together
and create an international consortium: Public Population Project in
Genomics (P3G).
The
Alzheimer's Disease Consortium The AD consortium is a collaborative
effort to develop a shared clinical and genotype database for the study
of late-onset Alzheimer's Disease.
National
Donor Marrow Program Laboratory and Repositories The National Marrow
Donor Program (NMDP) laboratories and repositories play an essential
role in the process of matching donors with patients in need of a stem
cell transplant. Three DNA Repositories store blood samples from potential
donors listed on the Registry. Five contract laboratories perform histocompatibility
testing to determine the donor's tissue type
The
HGDP CEPH diversity Panel A resource of 1064 cultured lymphoblastoid
cell lines (LCLs) from individuals in 51 different world populations
and corresponding milligram quantities of DNA is banked at the Foundation
Jean Dausset (CEPH) in Paris
Harvard
Brain Tissue Resource Center, McLean Hospital The Harvard Brain
Tissue Resource Center has been established at McLean Hospital as a
centralized resource for the collection and distribution of human brain
specimens for brain research
Stanley
Brain Research Laboratory and Brain Collection Begun in 1994, the
Stanley Brain Collection makes postmortem brain tissue from individuals
with schizophrenia, bipolar disorder, major depression, and normal
controls available to researchers without charge. The specimens are
collected with the assistance of participating medical examiners. Permission
of the next-of-kin is obtained in all cases.
Human
Neurospeciment Banks for HIV A brain bank established in 1998 as
a resource for fluids and post-mortem CNS tissue samples from well-characterized
advanced stage, HIV-infected patients.
THE
NHLBI BIOLOGIC SPECIMEN REPOSITORY Since the mid-1970s, the Institute's
Blood Division has established and supported several large blood specimen
repositories to perform prospective and retrospective studies of blood
donors and recipients. Use of these samples has been extensive, and
from 1991-1998, a total of 54,336 specimens from the NHLBI Biological
Specimen Repository were sent to various investigators.
NHLBI
Limited Access Data Sets Data sets generated with NHLBI support
that are available to qualified scientific investigators
Framingham
Heart Study The objective of the Framingham Heart Study was to
identify the common factors or characteristics that contribute to cardiovascular
disease (CVD) by following its development over a long period of time
in a large group of participants who had not yet developed overt symptoms
of CVD or suffered a heart attack or stroke. Genetic material and data
are available to qualified scientific researchers.
NCI
Cooperative Tissue Network The Cooperative Human Tissue Network
(CHTN) specializes
in the prospective procurement, preservation and distribution of
human tissues for research. In addition to normal, benign and malignant
tissues, tissues from patients with specific diseases such as ulcerative
colitis, a premalignant state, are provided. |