![[logo] US EPA](https://webarchive.library.unt.edu/eot2008/20081106053038im_/http://www.epa.gov/epafiles/images/logo_epaseal.gif){kind=logo}
Research Centers
University of Iowa Children's Environmental Airway Disease Center
University of Iowa
The theme of our SCOR program is to investigate the etiology and pathogenesis of airway disease in children from rural communities. We chose this theme for the following reasons: 1) asthma is the most common chronic illness in children; 2) the rural setting introduces unique environmental exposures that are known to play a role in the development of airway disease; 3) environmental models of asthma provide an ideal opportunity to investigate fundamental issues in childhood asthma such as the biological origin and persistence of airway disease; and 4) this theme builds on existing scientific expertise and ensures a highly interactive program. Since grain dust and endotoxin are common in the rural setting and both are associated with acute and chronic forms of airway disease, we have used these very relevant exposures to further focus the projects in our SCOR program. The end result is a highly integrated and focused program that, in aggregate, will substantially enhance our understanding of airway disease in children. The primary hypothesis unifying this research program is that understanding the etiology and pathogenesis of airway disease in children from rural communities will provide the scientific rationale to develop primary, secondary, and tertiary preventive programs that reduce the morbidity and mortality of asthma in the rural setting.
Center Publications:
| Views: | All publications | Selected publication types | Journal articles | Publications submitted after final report |
| Identifier | Abstract | Principal Investigator | Annual/ Final Reports | Pubs Count | Institution | Grant Representative | Grant Amount | Project Period | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
R826711 Centers - Main center abstract - University of Iowa Children's Environmental Airway Disease Center |
The Etiology and Pathogenesis of Airway Disease in Children from Rural Communities |
Schwartz, David Hunninghake, Gary W. Chrischilles, Elizabeth Denning, Gerene Merchant, James A. Nauseef, William - Principal Investigators listed are sub-PIs determined by the center. |
2000
|
Total Pubs:
28 Journals: 27 -- No Books -- |
University of Iowa |
Fields, Nigel |
$2,660,847 |
August 1998 - July 2003 |
| 2 |
R826711C001 Centers - This is a subproject of the University of Iowa Children's Environmental Airway Disease Center |
Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation |
Schwartz, David Nauseef, William Chrischilles, Elizabeth Hunninghake, Gary W. Denning, Gerene Moreland, Jess Weiss, Jerry - Principal Investigators listed are sub-PIs determined by the center. |
2000
|
Total Pubs:
14 Journals: 14 -- No Books -- |
University of Iowa |
EPA Project Officer(s) for University of Iowa Children's Environmental Airway Disease Center Grant Number R826711: Fields, Nigel |
Refer to main center abstract for funding details. |
January 1998 - January 2002 |
| 3 |
R826711C002 Centers - This is a subproject of the University of Iowa Children's Environmental Airway Disease Center |
Multi-component Intervention Study of Asthma in Children from Rural Communities |
Schwartz, David Chrischilles, Elizabeth Merchant, James W. Hunninghake, Gary W. Nauseef, William Merchant, James A. - Principal Investigators listed are sub-PIs determined by the center. |
2000
|
Total Pubs:
11 Journals: 10 -- No Books -- |
University of Iowa |
EPA Project Officer(s) for University of Iowa Children's Environmental Airway Disease Center Grant Number R826711: Fields, Nigel |
Refer to main center abstract for funding details. |
January 1998 - January 2002 |
| 4 |
R826711C003 Centers - This is a subproject of the University of Iowa Children's Environmental Airway Disease Center |
Role of RSV Infection and Endotoxin in Airway Inflammation |
Schwartz, David Hunninghake, Gary W. - Principal Investigators listed are sub-PIs determined by the center. |
Final
|
Total Pubs:
6 Journals: 6 -- No Books -- |
University of Iowa |
EPA Project Officer(s) for University of Iowa Children's Environmental Airway Disease Center Grant Number R826711: Fields, Nigel |
Refer to main center abstract for funding details. |
January 1998 - January 2002 |
| 5 |
R826711C004 Centers - This is a subproject of the University of Iowa Children's Environmental Airway Disease Center |
A Model to Study the Development of Persistent Environmental Airway Disease |
Schwartz, David Hunninghake, Gary W. - Principal Investigators listed are sub-PIs determined by the center. |
Final
|
Total Pubs:
19 Journals: 19 -- No Books -- |
University of Iowa |
EPA Project Officer(s) for University of Iowa Children's Environmental Airway Disease Center Grant Number R826711: Fields, Nigel |
Refer to main center abstract for funding details. |
January 1998 - January 2002 |