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University of Iowa Children's Environmental Airway Disease Center

Grant Number R826711


Other views: Selected publication types Journal articles Publications submitted after final report Redisplay this page with Reference Title, Journal, and Author Columns Display this page in RIS format

  • Journal Article (32)
  • Presentation (1)
  • Reference Type Citation Progress Report Year Document Sources
    Journal Article

    Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genetics 2000;25(2):187-191.

    R826711 (Final)
    R826711C001 (2000)
    R826711C002 (2000)
    R826711C004 (Final)
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    Journal Article

    Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA. Subchronic endotoxin inhalation causes chronic airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(6):L755-L761.

    R826711 (Final)
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    Journal Article

    Butler NS, Monick MM, Yarovinsky TO, Powers LS, Hunninghake GW. Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. Journal of Immunology 2002;169(7):3700-3709.

    R826711 (Final)
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    Journal Article Carter AB, Donohue MR, Knudtson KL, Gudmundsson G, Monick MM, Hunninghake GW. Endotoxin augments viral replication and the inflammatory response in respiratory syncytial virus-infected epithelium. Journal of Immunology. R826711C001 (2000)
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    Journal Article

    Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J. Asthma prevalence and morbidity among rural Iowa schoolchildren. Journal of Allergy and Clinical Immunology 2004;113(1):66-71 and erratum in Journal of Allergy and Clinical Immunology 113(3):391.

    R826711 (Final)
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    Journal Article

    George CL, Jin H, Wohlford-Lenane CL, O’Neill ME, Phipps JC, O’Shaughnessy P, Kline JN, Thorne PS, Schwartz DA. Endotoxin responsiveness and subchronic grain dust-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Biology 2001;280(2):L203-L213.

    R826711 (Final)
    R826711C001 (2000)
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    Journal Article

    George CL, White M, O’Neill ME, Thorne PS, Schwartz DA, Snyder JM. Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(6):L1337-L1344.

    R826711 (Final)
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    Journal Article

    Hollingsworth JW, Cook DN, Brass DM, Walker JK, Morgan DL, Foster WM, Schwartz DA. The role of toll-like receptor 4 in environmental airway injury in mice. American Journal of Respiratory and Critical Care Medicine 2004;170(2):106-107.

    R826711 (Final)
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    Journal Article Kline JN, Jagielo PJ, Watt JL, Schwartz DA. Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. Journal of Applied Physiology 2000;89(3):1172-1178. R826711 (Final)
    R826711C001 (2000)
    R826711C002 (2000)
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    Journal Article Kline JN, Cowden JD, Hunninghake GW, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA. Variable airway responsiveness to inhaled lipopolysaccharide. American Journal of Respiratory and Critical Care Medicine 1999;160(1):297-303, 1999. R826711C001 (2000)
    R826711C002 (2000)
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    Journal Article

    Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA. Genes other than TLR4 are involved in the response to inhaled LPS. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;281(5):L1106-L1114.

    R826711 (Final)
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    Journal Article

    Monick MM, Staber JM, Thomas KW, Hunninghake GW. Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. Journal of Immunology 2001;166(4):2681-2687.

    R826711 (Final)
    R826711C001 (2000)
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    Journal Article

    Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. Journal of Biological Chemistry 2003;278(52):53035-53044.

    R826711 (Final)
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    Journal Article

    Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA. TNF-α and IL-1β are not essential to the inflammatory response in LPS -induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Biology 2001;280(1):L173-L180.

    R826711 (Final)
    R826711C001 (2000)
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    Journal Article

    Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA. CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease. American Journal of Respiratory Cell and Molecular Biology 2002;27(4):474-480.

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    Journal Article

    Moreland JG, Bailey G, Nauseef WM, Weiss JP. Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. Journal of Immunology 2004;172(1):426-432.

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    Journal Article

    Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA. IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. Journal of Applied Physiology 2000;88(1):173-179.

    R826711 (Final)
    R826711C001 (2000)
    R826711C002 (2000)
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    Journal Article

    Savov JD, Gavett SH, Brass DM, Costa DL, Schwartz DA. Neutrophils play a critical role in the development of LPS-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2002;283(5):L952-L962.

    R826711 (Final)
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    Journal Article

    Savov JD, Brass DM, Berman KG, McElvania E, Schwartz DA. Fibrinolysis in LPS -induced chronic airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(4):L940-L948.

    R826711 (Final)
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    Journal Article

    Savov JD, Whitehead GS, Wang J, Liao G, Usuka J, Peltz G, Foster WM, Schwartz DA. Ozone-induced acute pulmonary injury in inbred mouse strains. American Journal of Respiratory Cell and Molecular Biology 2004;31(1):69-77.

    R826711 (Final)
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    Journal Article Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize LPS-induced inflammation in the lower respiratory tract through an IL-12 dependent pathway. Journal of Immunology 1999;163:224-231. R826711C001 (2000)
    R826711C002 (2000)
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    Journal Article Schwartz DA. Etiology and pathogenesis of airway disease in children and adults from rural communities. Environmental Health Perspectives, 1999; 107 (Suppl 3):393-401. R826711C001 (2000)
    R826711C002 (2000)
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    Journal Article

    Schwartz DA. Does inhalation of endotoxin cause asthma? American Journal of Respiratory and Critical Care Medicine 2001;163(2):305-306.

    R826711 (Final)
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    Journal Article

    Schwartz DA, Christ WJ, Kleeberger SR, Wohlford-Lenane CL. Inhibition of LPS -induced airway hyperresponsiveness and airway inflammation by LPS antagonists. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;280(4):L771-L778.

    R826711 (Final)
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    Journal Article

    Thomas KW, Monick MM, Staber JM, Yarovinsky TO, Carter AB, Hunninghake GW. RSV inhibits apoptosis and induces NF-κB activity through a PI-3K dependent pathway. Journal of Biological Chemistry 2002;277(1):492-501.

    R826711 (Final)
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    Journal Article

    Walker JK , Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ. Beta-arrestin-2 regulates the development of allergic asthma. The Journal of Clinical Investigation 2003;112(4):566-574.

    R826711 (Final)
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    Journal Article

    Warshamana GS, Pociask DA, Sime P, Schwartz DA, Brody AR. Susceptibility to asbestos-induced and transforming growth factor-beta 1-induced fibroproliferative lung disease in two strains of mice. American Journal of Respiratory Cell and Molecular Biology 2002;27(6):705-713.

    R826711 (Final)
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    Journal Article

    Whitehead GS, Walker JK , Berman KG, Foster WM, Schwartz DA. Allergen -induced airway disease is mouse strain dependent. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(1):L32-L42.

    R826711 (Final)
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    Journal Article Wohlford-Lenane CL, Deetz DC, Schwartz DA. Cytokine gene expression following inhalation of corn dust. American Journal of Physiology: Lung Cell Molecular Biology 1999;276:L736-L743. R826711C001 (2000)
    R826711C002 (2000)
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    Journal Article

    Zeldin DC, Wohlford-Lenane C, Chulada P, Bradbury JA, Scarborough PE, Roggli V, Langenbach R, Schwartz DA. Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. American Journal of Respiratory Cell and Molecular Biology 2001;25(4):457-465.

    R826711 (Final)
    R826711C004 (Final)
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    Journal Article

    Chen W, Monica MM, Carter AB, Hunninghake GW. Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8. Experimental Lung Research 2000;6(1):13-26.

    R826711 (Final)
    R826711C001 (2000)
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    Journal Article

    Chen W, Hunninghake GW. Effects of ragweed and Th-2 cytokines on the secretion of IL-8 in human airway epithelial cells. Experimental Lung Research 2000;26(4):229-239.

    R826711 (Final)
    R826711C001 (2000)
    R826711C003 (Final)
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    Presentation

    Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J. Management of childhood asthma in the rural setting. Presented at the 60th American Academy of Allergy Asthma and Immunology Workshop on Asthma Care for the Medically Underserved, March 8, 2003.

    R826711 (Final)
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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.


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