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Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation
EPA Grant Number: R826711C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R826711
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: University of Iowa Children's Environmental Airway Disease Center
Center Director: Hunninghake, Gary W.
Title: Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation
Investigators: Schwartz, David , Nauseef, William
Current Investigators: Nauseef, William , Denning, Gerene , Hunninghake, Gary W. , Moreland, Jess , Schwartz, David , Weiss, Jerry
Institution: University of Iowa
EPA Project Officer: Fields, Nigel
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Health Effects , Children's Health
Description:
Objective:Airway inflammation reflects a complex and orchestrated series of events, including direct and cytokine-mediated intercellular interactions, which culminate in tissue injury. The inflammation following respiratory challenge with grain dust (GD) elicits a spectrum of clinical responses, from acute and self-limited "grain fever" to chronic airway disease. Epidemiologic studies implicate chronic inhalation of grain dust as a major cause of clinically significant, irreversible airway disease. Although GD is contaminated with bacterial lipopolysaccharide (LPS), not all of the observed responses are attributable to LPS. The overall hypothesis in this study is that mechanisms that initiate, promote, and resolve grain dust induced inflammation may be distinct from those mechanisms involved in LPS induced airway inflammation. We will examine the mechanisms responsible for the initiation, promotion, and resolution of LPS/GD-induced inflammation in order to understand better the pathogenesis of asthma in children from rural communities. Publications and Presentations:
Publications have been submitted on this subproject: View all 14 publications for this subproject | View all 33 publications for this center
Journal Articles:Journal Articles have been submitted on this subproject: View all 14 journal articles for this subproject | View all 32 journal articles for this center
Supplemental Keywords:children, health, asthma, grain dust, rural communities. , ENVIRONMENTAL MANAGEMENT, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessment, Biology, Risk Assessments, genetic susceptability, Health Risk Assessment, Epidemiology, Chemistry, Children's Health, Environmental Chemistry, Allergens/Asthma, exposure assessment, environmentally caused disease, allergen, health effects, rural communities, cytokines, assessment of exposure, childhood respiratory disease, mechanisms, LPS, harmful environmental agents, human health risk, toxics, epidemeology, agricultural community, sensitive populations, biological response, grain dust, airway disease, children, lipopolysaccaride, exposure, children's vulnerablity, tissue reactivity, asthma, human exposure, Human Health Risk Assessment
Progress and Final Reports:
2000 Progress Report
Final Report
Main Center Abstract and Reports:
R826711 University of Iowa Children's Environmental Airway Disease Center
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826711C001 Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation
R826711C002 Multi-component Intervention Study of Asthma in Children from Rural Communities
R826711C003 Role of RSV Infection and Endotoxin in Airway Inflammation
R826711C004 A Model to Study the Development of Persistent Environmental Airway Disease