Puel J, Izopet J, Lheritier D, Tricoire J, Berrebi A; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: C283 (abstract no. PoC 4228).
Department of Virology, C.H.U. Purpan, Toulouse, France.
OBJECTIVE: To correlate the quantitative maternal plasmatic and cell viremia with the transmission of HIV to the newborn. METHODS: Patients: monthly follow-up of 16 pregnant women during pregnancy and follow-up of their newborns. Methods: in pregnant women, quantitative plasmatic and cell viremia in each sample, using consensus technique of AC11 ANRS-FRANCE [C. Rouzioux, J. Puel...AIDS, in press]; in newborns, diagnosis of HIV infection by conventional techniques (coculture, PCR). RESULTS: A plasmatic viremia was observed in three pregnant women: two newborns were infected (pregnant woman 9), one uninfected (pregnant woman 4). Cell viremia was stable and with a low titer in 10 cases: none newborn was infected (pregnant woman 3). Cell viremia was high and variable in six cases (plasmatic viremia associated in three cases): four newborns were infected (three diagnosed at birth, and one at one month of life). CONCLUSIONS: At whatever time of transmission (antenatal or at delivery) the presence of a plasmatic viremia and high titers of cell viremia during pregnancy does not imply transmission to newborn but might be considered as a risk factor. The low titers of cell viremia and the absence of a plasmatic viremia imply discussion about the need of therapeutic interruption of the pregnancy. TABULAR DATA, SEE ABSTRACT VOLUME.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Delivery, Obstetric
- Disease Transmission, Vertical
- Female
- France
- HIV Infections
- HIV Seropositivity
- Humans
- Infant
- Infant, Newborn
- Laboratory Techniques and Procedures
- Mothers
- Pregnancy
- Risk Factors
- Viral Load
- Viremia
- organization & administration
- surgery
- transmission
Other ID:
UI: 102199658
From Meeting Abstracts