Becker JT, Schaerf FW, Kingsley L, Fox R, Dew MA; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 391 (abstract no. W.B.P.236).
Depts. Psychiatry, Neurology & Epidemiology, Univ. Pittsburgh Sch. Med, Pittsburgh, PA, USA
OBJECTIVES: This study evaluated the relationship between measures of affect and cognitive function in HIV-1+/-) gay/bisexual men. METHODS: HIV-1 seropositive (n=157) and seronegative (n=113) gay/bisexual men from the Pittsburgh and Baltimore MACS sites completed the Beck Depression Inventory (BDI), Spielberger's State/Trait Anxiety Inventory (STAI), and a short battery of neuropsychological tests. RESULTS: Overall, the HIV-1+ men had more symptoms of depression (i.e., BDI), but no increases in either State or Trait Anxiety. Furthermore, when the seropositive men were categorized based on total number of CD4 cells there were significant differences only in terms of the total BDI score, which was elevated in the men with the lowest CD4 counts. This elevation was not due to an increase in the number or severity of symptoms of abnormal affect (e.g., "dissatisfied with life"), but rather an increase in the number and/or severity of physical symptoms (e.g., weight change) reported on the BDI. No differences in performance on the cognitive tests were seen between serostatus groups. Performance was correlated with the BDI but not the STAI. Further analysis revealed that it was the physical symptoms of depression rather than the affective symptoms which were related to cognitive function. CONCLUSIONS: These data indicate that the assessment of mood in HIV-1-infected individuals must take into account physical illness. Consistent with other findings from the MACS, neuropsychological performance was predicted by the presence of physical symptoms, but not by dysphoric mood.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Anxiety
- Baltimore
- Bisexuality
- CD4 Lymphocyte Count
- CD4-CD8 Ratio
- CD4-Positive T-Lymphocytes
- Depression
- HIV Seropositivity
- HIV-1
- Homosexuality
- Homosexuality, Male
- Humans
- Male
- Multicenter Study
- Neuropsychological Tests
- Personality Inventory
- Psychiatric Status Rating Scales
- epidemiology
- immunology
- physiology
Other ID:
UI: 102177868
From Meeting Abstracts