Espey MG, Vasudevachari MB, Longava S, Namboodiri M; National Conference on Human Retroviruses and Related Infections.
Program Abstr First Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 1st 1993 Wash DC. 1993 Dec 12-16; 117.
Georgetown University, Washington, DC.
Quinolinic acid (QUIN) is an endogenous neurotoxin that increases significantly in the CNS during the latter stages of HIV infection and is correlated with the severity of cognitive and motor dysfunction in ADC patients. Recent immunohistochemical studies reveal that QUIN is localized in cells macrophage and dendritic morphology. Macrophages and dendritic cells have been shown to be a reservoir for HIV sequestered in lymphoid organs and possibly are an agent for transport of virus into the CNS. In the present study, QUIN was co-cultured with acutely HIV-1 infected T cell (MT2) or monocytic (U937) cell lines. We demonstrate that 10 micromolar QUIN enhances HIV replication 7-fold in acutely infected U937 cells as measured by p24 assay. QUIN slightly decreased replication in the MT2 cells. These data suggest a role for QUIN in the macrophage mediated pathogenesis of HIV infection. These findings indicate that treatments which block QUIN may reduce HIV reservoirs and decrease HIV associated neuropathological complications.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- HIV
- HIV Antigens
- HIV Core Protein p24
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Macrophages
- Monocytes
- Neurotoxins
- Quinolinic Acid
- immunology
Other ID:
UI: 102214309
From Meeting Abstracts