2008 Annual Report 1a.Objectives (from AD-416) Develop hyperimmuned immunoglobulin for control of coccidiosis. 1b.Approach (from AD-416) Develop vaccines against Eimeria parasites for poultry. 3.Progress Report This develops a hyperimmune antibody-based strategies to control avian pathogens. In this collaboration, ARS provides expertise in studies on the basic immune mechanisms which are involved in hyperimmune antibody-mediated protection against coccidiosis after oral feeding of antibodies to newly hatched birds. In vivo trials using an experimental challenge model developed at ARS had shown clear evidence that long-term feeding of newly hatched birds with IASA’s hyperimmune egg yolk antibodies carrying IgY antibodies against Eimeria oocysts provide significant protection against live Eimeria challenge infections. This was the basis for initiating large field trials which are ongoing in Latin American countries. Progress is monitored by written progress reports, regular teleconferences and meetings.