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Longitudinal Study of Children's Exposure to Permethrin

EPA Grant Number: R829397
Title: Longitudinal Study of Children's Exposure to Permethrin
Investigators: Hu, Y. , Akland, Gerald G. , Raymer, James H.
Current Investigators: Raymer, James H. , Hu, Y. , Michael, L. C. , Studabaker, W.
Institution: Research Triangle Institute
EPA Project Officer: Deener, Kacee
Project Period: February 18, 2002 through February 17, 2005 (Extended to July 17, 2006)
Project Amount: $754,664
RFA: Children's Vulnerability to Toxic Substances in the Environment (2001)
Research Category: Children's Health , Health Effects

Description:

The specific aims for the proposed research program are to: (1) investigate the time course of the redistribution of permethrin in various media following application and factors affecting the redistribution; (2) investigate the functional relationships across time between environmental media, personal measurements and biological media; (3) estimate aggregate exposure after application and the importance of each exposure pathway; and (4) investigate the difference between the time course of permethrin metabolism between adults and children.

Approach:

We will investigate 15 homes that uses permethrin indoors and with stay home children younger than 3 years old. Each of the homes will be followed intensively for 7 days after application. Then they will be followed once a week in the first month after application and every other a month in the following 11 months. Environmental samples, food samples, personal samples (hand wipes, whole body dosimeter) and urine samples will be collected from children and one stay-home parent. The samples will be analyzed in our laboratory following stand operating procedures and analysis protocols. Data will be analyzed to meet the objectives.

Expected Results:

The anticipated results of this study include: (1) a longitudinal characterization of permethrin concentrations in a multipathway study of young children;(2) an information base from which to develop a relationship of within and across home variation; (3) field testing of new sample collection methods, including whole body dosimeter, urine collection technique for children, and baby wipes for collecting surface samples; (4) development of a time series statistical model which can be used to describe the temporal characteristics of the permethrin decay pattern, as well as the age-specific exposure related behavior patterns observed over the study period; and (5) development of adult-child urinary metabolite profiles over time. The relationship between these profiles over time may improve our understanding of permethrin exposures and behaviors affecting these exposures.

Publications and Presentations:

Publications have been submitted on this project: View all 7 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 1 journal articles for this project

Supplemental Keywords:

multi-media exposure analysis; longitudinal exposure; urinary pesticide metabolite. , Scientific Discipline, Health, RFA, Biology, Risk Assessments, Disease & Cumulative Effects, Health Risk Assessment, Chemistry, Children's Health, exposure assessment, multi-pathway study, metabolism, human health risk, longitudinal study, exposure pathways, children, pesticides, body dosimeter, exposure, functional relationships, human exposure, permethrin

Progress and Final Reports:
2002 Progress Report
2003 Progress Report
2004 Progress Report
2005 Progress Report
Final Report

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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