Universal Determinants of Alcohol-Induced ToxicityJohn Abrams, Ph.D. Project DescriptionThis grant is focused on studying pathways relevant to alcohol-induced toxicity which is a risk factor relevant to birth defects, cancer, cirrhosis and many other human diseases. The central hypothesis predicts that core effectors of alcohol toxicity are universally shared across the animal kingdom and likely define authentic targets for therapeutic intervention. Conserved pathways relevant to ethanol-induced toxicity and corresponding apoptosis will be compared in human, Zebrafish, and Drosophila systems. This grant is of interest to both the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and NIEHS and will be funded by both institutes. |
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