Chemical Sampling Information
	Arsenic, Inorganic
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Includes Copper Acetoarsenite and all inorganic compounds such as Lead Arsentate containing arsenic except arsine, measured as (As) OSHA IMIS Code Number: 0260 Chemical Abstracts Service (CAS) Registry Number: 7440-38-2 Other Chemical Abstracts Service (CAS) Registry Numbers: 3687-31-8; 7645-25-2; 7748-40-9 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: CG0525000 Department of Transportation Regulation Number (49 CFR 172.101) and guide [2008 Emergency Response Guidebook, 2.5 MB PDF]: 1558 152 (metal); 1562 152 (dust) NIOSH Pocket Guide to Chemical Hazards, Arsenic (Inorganic compounds, as As): chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: Cancer Hazard 29 CFR 1910.1018 -- 0.01 mg/m3 TWA; 0.005 mg/m3 Action Level; NOTE: This section applies to all occupational exposures to inorganic arsenic except employee exposures in agriculture or resulting from pesticide application, the treatment of wood with preservatives or the utilization of arsenically preserved wood. OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.1118 requirements identical to 1910.1018. OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1018 requirements identical to 1910.1018. American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.01 mg/m3 TWA; Appendix A1 - Confirmed Human Carcinogen; BEI National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.002 mg/m3 Ceiling (15 Minutes); Appendix A - NIOSH Potential Occupational Carcinogens Health Factors National Toxicology Program (NTP) carcinogenic classification: Known to be a Human Carcinogen [149 KB, PDF] International Agency for Research on Cancer (IARC) carcinogenic classification: Arsenic in drinking-water - Group 1, carcinogenic to humans [58 KB, Vol. 84, PDF]; Arsenic and Arsenic Compounds - Group 1, carcinogenic to humans [523 KB, Suppl. 7, PDF; 28 KB, Vol. 23, PDF] NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 5 mg As/m3 Potential symptoms: Ulceration of nasal septum; dermatitis; gastrointestinal disturbances; peripheral neuropathy; respiratory irritation, hemolytic anemia, cardiovascular instability (prolonged Q-T interval on EKG; arrhythmias); increased capillary permeability (hematemesis, hematuria; bloody stools); facial and peripheral edema; acute encephalopathy; metallic taste, garlicky breath odor; stomatitis; conjunctivitis; leukopenia, pancytopenia; fatigue, anorexia with weight loss (oral); Mees' lines of the nails; hair loss; hyperpigmentation and hyperkeratosis of skin. Health Effects: Carcinogen (HE1); Cumulative systemic poison, cardiovascular disease, Raynaud's phenomena (HE3); gastrointestinal effects, hematologic effects (HE12), dermatitis (HE14), ocular effects, neurological effects (HE7), genotoxic effects (HE2); Bowen's disease (HE2); INGES ACUTE: Depends on salt, LDLO (man) 1.4 mg/kg Arsenic Trioxide. Affected organs: Liver, kidney, skin, lungs, lymphatic system; blood, CNS, eyes, gastrointestinal tract. Note: Trise (arsenic trioxide) is an FDA approved medication for the treatment of acute promyelocytic leukemia. Date Last Revised: 08/17/2001 Literature Basis: (cardiovascular instability, Mees' lines, metallic taste, garlicky breath odor) Ford, M.D.: Arsenic. In: Goldfrank's Toxicology Emergencies, 6th Ed., Goldfrank, L.R., Flomenbaum, N.E., Lewin, N.A., Weisman, R.S., Howland, M.A., Hoffman, R.S., eds. Connecticut: Appleton & Lange, pp. 1261-1273, 1998. (ACUTE INGES: difficulty in swallowing) Furst, A., Radding, S.B., and Wurzel, K.A.: Arsenic (As). In: Encyclopedia of Toxicology, Vol. 1, Wexler, P. ed. New York: Acedemic Press, pp. 80-82, 1998. (weakness, loss of appetite) Sitting, M.: Arsenic and inorganic arsenic compounds. Handbook of Toxic and Hazardous Chemical and Carcinogens, 3rd Ed., Vol. 1, pp.,157-161, 1991. (Raynaud's phenomena, genotoxic) U.S. Department of Health and Human Services, Public Health Services, Agency for Toxic Substances and Disease Registry. Toxicological profile for arsenic, pp. 15-132, September 2000. (Bowen's disease) Col, M., Col, C., Soran, A., Sayli, B.S., Ozturk, S.: Arsenic-related Bowen's disease, palmar keratosis, and skin cancer. Environmental Health perspectives. 107 (8): 687-689, 1999. (treatment of acute promyelocytic leukemia) Cohen, M.H., Hirschfeld, S., Flamm Honig, S., et al.: Drug approval summaries: arsenic trioxide, tamoxifen citrate, anastrazole, paclitaxel, bexarotene. Oncologist 6(1): 4-11, 2001. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Mixed Cellulose Ester Filter (MCEF) 0.8 microns maximum volume: 960 Liters   minimum volume: 480 Liters   maximum flow rate: 2.0 L/min current analytical method: Atomic Absorption Spectroscopy; AAS/GF method reference: OSHA Manual of Analytical Methods (OSHA ID-105) method classification: Fully Validated NOTE: If the filter is not overloaded, samples may be collected up to an 8-hour period. For volatile arsenic compounds, sample with a MCEF 0.8 microns filter followed by a sodium carbonate treated backup pad. Arsenic and/or any of the following metals may be analyzed from the same full-shift sample: lead, cadmium, iron, zinc, and copper. alternate analytical method: Inductively Coupled Plasma; ICP-MS method reference: OSHA Manual of Analytical Methods (OSHA 1006) method classification: Fully Validated If arsine is suspected to also be present, sample with a MCEF and a sodium carbonate treated backup pad followed by and in series with a large charcoal tube containing 400 mg (front) and 200 mg (backup) sections of activated coconut shell charcoal. This sampling train is described in Section 5.1.2. of OSHA ID-105. The minimum air volume is 120 L and the sampling rate is 0.5 L/min with this sampling train. Wipe Sampling Method: sampling media: Whatman Smear Tab Filter. analytical solvent: Distilled water All Trademarks are the property of their respective owners. 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