2007 Annual Report 1a.Objectives (from AD-416) To devise innovative methods for the suppression of insects that transmit diseases to U.S. military deployed abroad. 1b.Approach (from AD-416) Identify and test compounds with insecticidal activity that makes them especially beneficial in the rapid control of mosquitoes, flies, and other arthropods responsible for carrying disease agent. Devise innovative means of applying control agents especially suited for use in combat or deployment conditions. Identify and test new classes of topical and area repellents for use by troops. 3.Progress Report This report serves to document research conducted under a Reimbursable Agreement between ARS and the Department of Defense. Additional details of research can be found in the report for the in-house project 6408-41000-006-00, "Chemistry of Natural Products for Pest Management and Crop Development." Officials from the Department of Defense visited Natural Products Utilization Research Unit (NPURU) on January 29, 2007, to discuss research collaboration. National Program Leader (NPL) joined this meeting. NPURU participating scientists visited facilities of collaborators performing assays to determine insect toxicant or repellent acitivity. Progress of the project is monitored through phone calls. Compounds were isolated and identified from plants that show adulticide activity. These compounds were synthetically modified in order to achieve higher activities. Analogs of piperidine and amides were synthesized and evaluated for activity against adult Aedes aegypti mosquitoes, primary vector for both dengue and yellow fever. Isolation and synthesis of compounds is ongoing in order to obtain and develop compounds that are more active adulticides and/or repellents.