No part of the ancient legacy of Greek medicine enjoyed a more constant transmission than the Aphorisms and Prognostics attributed to Hippocrates of Cos. From the unforgettable opening line, "Life is short, the Art long," the axiomatic and level-headed character of these works made them ideal for teaching, but it also called for elaboration and rationalization. This need was abundantly met by the Greek writings of Galen of Pergamum in the second century C.E. The Hippocratic foundations were complemented, possibly by Byzantine teachers before the eighth century, with Galen's epitome of the "Art of Medicine", Techne iatrike, which became known in the Middle Ages as Tegni or Microtegni, in Latin Ars medica and Ars parva, "The Little Art." The addition of two short treatises on diagnosis, by pulse and urine, resulted in a collection that loosely covered the basics of medical learning. However, one relatively brief and simple text with origins in Baghdad became the catalyst for the development of this collection into the nucleus of the first genuine curriculum.

Hunayn ibn Ishaq al-'Ibadi, 809?-873 (known as Joannitius), the Christian director of the caliph's House of Wisdom, is credited with translating into Arabic more than one hundred Greek writings, the majority by Galen and his Alexandrian commentators. Hunayn abstracted the substance of his library in Questions on Medicine for Scholars. This introduction to Galen's Art came to Latin Christendom, with the author's name suitably baptized, as Isagoge Ioannitii ad Tegni Galieni. It clearly set out the division of medical knowledge into theory and practice, and the classification of learning matter, from the elements as basic building blocks, to uroscopy as the ultimate diagnostic tool. For the twelfth- and thirteenth-century masters of Salerno, the Isagoge of Johannitius was a natural nucleus around which five or six primers coalesced into the foundation of medical education. At the emerging universities, from around 1250, this fundamental "Ars medicine" or "Articella" was at the heart of a growing curriculum, expanded with commentaries, more translations from Greek and Arabic, and, above all, a greater presence of Galen.

Hunayn ibn Ishaq al-'Ibadi, 809?-873 (known as Joannitius). Isagoge Johannitii in Tegni Galeni.
Oxford, 13th century.
(DeRicci NLM [78].) This beautiful manuscript from England contains a model "Articella," decorated with 12 miniature illustrations depicting medical consultation, examination, and instruction. On the page displayed, within the letter M, a master is instructing a student.

Letter O: A physician consulting a book at his patient's bedside. Fol. 32r		Letter T: A master instructing students. Fol. 61r
Letter M: A master with two students. Fol. 61v		Letter U: A physician displaying a flask of urine to a student. Fol. 1r
Letter U: A physician reading a book. Fol. 19v		Letter P: A pregnant woman. Fol. 21v
Letter D: A physician with a flask of urine, possibly comparing it to pictures or descriptions of variously colored urine in a book. Fol. 42v

Hippocrates. Aphorismi. 15th century.
(DeRicci NLM 26; Schullian 510)

Each one of Hippocrates' brief observations or "aphorisms" was treated as a precept, usually numbered and "rubricated," that is, marked by a red or blue initial letter.

Hippocrates. Aphorismi. Armeno [Italy], 1485-Oct. 25, 1486.
(DeRicci NLM 2. Schullian 511)

This small manuscript, containing works of Hippocrates, Galen, and Avicenna, was probably meant to be carried around by the physician, to be referred to at the bedside. The page displayed shows the beginning of of Galen's Tegne or Tegni, as Galen's summary of the Hippocratic works was known in the Middle Ages.

Hunayn ibn Ishaq al-'Ibadi, 809?-873 (known as Joannitius). Isagoge ad Tegni Galieni.
Leipzig : Wolfgang Stockel, May 27, 1497.

An early printed edition of Hunayn's Isagoge [i.e. treatise], a didactic introduction to Galen's Tegne, which was the catalyst for the coalescence of a few texts into the "Articella," the core the medieval medical curriculum.

Articella, seu, Opus artis medicinae.
Venice : Bonetus Locatellus for Octavius Scotus, Dec. 20, 1493.
(Schullian 62.)

The Articella continued in use well into the age of the printed book. This 1493 Venetian edition, with its hand-colored initial letters and marginal decoration, illustrates the attempts of the first printers to make the printed book look like the more familiar manuscript.

Hippocrates. Aphorismi, sive sententiae.
Nuremberg : Caspar Hochfeder, after April 1496.

The "Aphorisms" retained their venerability well into the age of printing. Here, the printer has left space for a hand-written, decorative initial letter of the first Aphorism ([V]ita brevis, ars aut[em] longa), but the letter "V" was never added.