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Chemical Sampling Information |
Butyl Carbitol |
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General Description
Synonyms: 2-(2-Butoxyethoxy)ethanol; Butoxydiethylene glycol; Butoxydiglycol; Diethylene Glycol Monobutyl Ether; Diethylene Glycol n-Butyl Ether; Dowanol DB
OSHA IMIS Code Number: 0471
Chemical Abstracts Service (CAS) Registry Number: 112-34-5
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KJ9100000
Chemical Description and Physical Properties: Colorless liquid
molecular formula: C8H18O3
molecular weight: 162.26
boiling point: 230.4°C
vapor pressure: 3 Pa @ 20°C
flash point: 78°C
melting point: -68°C
Health Factors
Potential symptoms: Eye, skin irritation; high systemic doses in animals caused small decreases in red blood cell count, hemoglobin, hematocrit; enlarged livers and kidney damage
Health Effects: Irritation-Eyes---Moderate (HE15)
Affected organs: Eyes, skin, liver, kidneys
Notes:
- OSHA does not have a PEL for butyl carbitol, which can form explosive vapor/air mixtures at temperatures above 78°C.
- Measurement of the metabolite in human urine, 2-(2-butoxyethoxy)acetic acid, has been used for biomonitoring the exposure of floor lacquerers to butyl carbitol. An 8-hr exposure to 0.05 ± 0.03 ppm butyl carbitol resulted in a urinary metabolite concentration of 9.2 ± 7.4 mmol/mol creatinine.
- A NOAEL of 250 mg/kg/day for butyl carbitol was reported for 13-week oral toxicity studies in rats.
- Rare cases of allergic contact dermatitis have been reported for individuals exposed to butyl carbinol in printing inks, water-based paints, or disinfectants.
Date Last Revised: 09/25/2006
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): Diethylene glycol monobutyl ether.
- NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: KJ9100000: Ethanol, 2-(2-butoxyethoxy)-.
- Berlin, K., Johanson, G. and Lindberg, M.: Hypersensitivity to 2-(2-butoxyethoxy)ethanol. Contact Dermatitis 32(1): 54, 1995.
- Dawson, T.A.J., Black, R.J., Strang, W.C., Millership, J.S. and Davies, I.A.I.: Delayed and immediate hypersensitivity to carbitols. Contact Dermatitis 21(1): 52-53, 1989.
- Johnson, K.A., Baker, P.C., Kan, H.L., Maurissen, J.P., Spencer, P.J., Marty, M.S.: Diethylene glycol monobutyl ether (DGBE): two- and thirteen-week oral toxicity studies in Fischer 344 rats. Food Chem. Toxicol. 43(3) 467-481, 2005.
- Laitinen, J. and Pulkkinen, J.: Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids. Toxicol. Lett. 156(1): 117-126, 2005.
- Schliemann-Willers, S., Bauer, A. and Elsner, P.: Occupational contact dermatitis from diethylene glycol monobutyl ether in a podiatrist. Contact Dermatitis 43(4): 225, 2000.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tubes (100/50 mg sections; 20/40 mesh)
analytical solvent: (95:5) Methylene Chloride:Methanol
maximum volume: 10 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA PV2095)
method classification: Partially Validated
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