Chemical Sampling Information
	n-Butyl Acetate
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase ] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Butyl Acetate; Butyl ethanoate; Acetic acid, butyl ester OSHA IMIS Code Number: 0440 Chemical Abstracts Service (CAS) Registry Number: 123-86-4 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: AF7350000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1123 129 [27 KB, PDF] NIOSH Pocket Guide to Chemical Hazards, n-Butyl Acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 150 ppm, 710 mg/m3 TWA OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 150 ppm, 710 mg/m3 TWA OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 150 ppm, 710 mg/m3 TWA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 150 ppm, 713 mg/m3 TWA; 200 ppm, 950 mg/m3 STEL National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 150 ppm, 710 mg/m3 TWA; 200 ppm, 950 mg/m3 STEL Health Factors NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,700 ppm [LEL] Potential symptoms: Irritation of eyes, skin, upper respiratory system; headache, drowsiness, narcosis; INGES. ACUTE: nausea. Health Effects: Irritation-Eye, Nose, Throat---Moderate (HE15); Narcosis (HE8); Explosive, Flammable (HE18) Affected organs: Eyes, skin, respiratory system, CNS Notes: The IDLH is 10% of the lower explosive limit (1.7%). Above 22ºC, explosive vapor/air mixtures may be formed. Listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515). n-Butyl acetate is metabolized in the body sequentially to n-butanol, n-butyraldehyde, and n-butyric acid. The latter can go into fatty acid synthesis via medium chain acyl-CoA synthetase. Rats inhaling n-butyl acetate 6 hr/day, 5 days/week for 13 weeks showed degeneration of the olfactory epithelium, judged to be minimum to mild at 1500 ppm and mild to moderate at 3000 ppm levels of exposure. The NOEL was 500 ppm. Date Last Revised: 02/08/2006 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: n-Butyl Acetate. International Chemical Safety Cards (WHO/IPCS/ILO): n-Butyl acetate. David, R.M., Tyler, T.R., Quellette, R., Faber, W.D. and Banton, M.I.: Evaluation of subchronic toxicity of n-butyl acetate vapor. Food Chem. Toxicol. 39(8): 877-886, 2001. Pohanish, R.P. (editor): Butyl Acetates. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 392-395. Teeguarden, J.G., et al.: Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid. Toxicol. Sci. 85(1): 429-446, 2005. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: Carbon Disulfide maximum volume: 12 Liters   maximum flow rate: 0.05 L/min (TWA) maximum volume: 0.75 Liter   maximum flow rate: 0.05 L/min (STEL) current analytical method: Gas Chromatography; GC/FID method reference: OSHA Analytical Method (OSHA 1009) method classification: Fully Validated sampling media: Diffusive Sampler: 3M 3520 Organic Vapor Monitor; SKC 575-002 Passive Sampler analytical solvent: Carbon Disulfide minimum time: 15 to 240 Minutes current analytical method: Gas Chromatography; GC/FID method reference: OSHA Analytical Method (OSHA 1009) method classification: Fully Validated note: Persons using diffusive samplers to monitor workplace air must ensure that the sampling devices are properly closed before transporting such devices to the laboratory for analysis. The device will continue to sample until properly closed. Diffusive sampler accessories used for analysis of samplers must be included with transported samples. Persons using such devices must provide sampling-site station barometric pressure and temperature to the analytical laboratory to improve accuracy of sampling results. sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: (99:1) Carbon Disulfide:Dimethylformamide maximum volume: 10 Liters   maximum flow rate: 0.2 L/min (TWA) maximum volume: 3 Liters   maximum flow rate: 0.2 L/min (STEL) current analytical method: Gas Chromatography; GC/FID method reference: NIOSH Analytical Method (NIOSH 1450) [107 KB, PDF] method classification: Fully Validated note: Samples should be refrigerated as soon as possible after sampling and sent cold to the laboratory. All Trademarks are the property of their respective owners. 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