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Chemical Sampling Information: |
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| Rotenone |
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General Description
Synonyms: 1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methyl-ethenyl)-[1]benzopyrano [3,4-b]furo[2,3-h][1] benzopyran-6(6aH)-one; Tubatoxin; Cube; Derris, Prentox; Nicouline
OSHA IMIS Code Number: 2228
Chemical Abstracts Service (CAS) Registry Number: 83-79-4
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: DJ2800000
NIOSH Pocket Guide to Chemical Hazards, Rotenone: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 5 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen; (TLV listed under Rotenone (Commercial))
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 mg/m3 TWA
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 2,500 mg/m3
Potential symptoms: Irritation of eyes, skin, respiratory system; numbness of mucous membrane; nausea, vomiting, abdominal pain; muscle tremors, incoordination, clonic convulsions; stupor; hypoglycemia; headache; confusion; cough; labored breathing; pulmonary edema (may be delayed); eye damage (upon direct eye contact); severe rash (with repeated skin contact); INGES ACUTE: Abdominal cramps, vomiting, diarrhea; convulsions.
Health Effects: Cumulative systemic toxicity (HE3); Irritation-Eye, Nose, Throat, Skin---Mild (HE16)Suspect dopaminergic neurotoxin---parkinsonism (HE7).
Affected organs: Eyes, skin, respiratory system, CNS
Note: Rotenone has been used to produce an animal model of Parkinson's disease due to its ability to cause specific dopaminergic neurotoxicity after parenteral administration. It remains to be determined whether occupational exposure to rotenone increases the risk of parkinsonism.
Date Last Revised: 07/13/2004
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Rotenone.
- International Chemical Safety Cards (WHO/IPCS/ILO): Rotenone.
- Gao, H.M., Hong, J.S., Zhang, W. and Liu, B.: Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J. Neurosci. 23(4): 1228-1236, 2003.
- Pohanish, R.P. (editor): Rotenone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2007-2009.
- Sherer, T.B., et al.: Mechanism of toxicity in rotenone models of Parkinson's disease. J. Neurosci. 23(34): 10756-10764, 2003.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Polytetrafluorethylene (FA) filter, 1.0 micron
maximum volume: 400 Liters maximum flow rate: 3.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: NIOSH Analytical Method (NIOSH 5007)
method classification: Fully Validated
Bulk method: Limit the amount of bulk submitted to one gram or one mL.
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