NAME: Disulfiram
SYNONYM(s): Tetraethylthiuram Disulfide; TETD; Tetraethylthioperoxydicarbonicdiamide
IMIS: 2682
CAS: 97-77-8
NIOSH: RTECS J01225000; 32331
DESCRIPTION:
Solid. Gray powder, yellow-white crystals.
MW: 296.56
MP: 66.5 C
Exposure Limits
ACGIH TLV: 2 mg/m3 TWA
NIOSH REL: 2 mg/m3 TWA
Health Factors
IARC: Group 3, not classifiable as to its carcinogenicity to humans
HEALTH EFFECTS: Acute Toxicity-Antabuse effects with alcohol (HE4) LD50 (oral, rat) 8600 mg/kg
Monitoring
PRIMARY SAMPLING/ANALYTICAL METHOD (SLC1):
MEDIA: Glass Fiber Filter (37 mm)
MAX V: 120 Liters MAX F: 1.0 L/min
ANL 1: High Performance Liquid Chromatography; HPLC/UV
REF: 2 (OSHA In-House File)
CLASS: Partially Validated
NOTE: Sample must be analyzed as soon as possible after sampling.
COND: 1) Methanol extraction; C18 column; 75% methanol 25% water; 1 mL/min; UV det: 220, 254; Retention time, 8.2 min; DL 10 ng/inj; C/P KJC 9/78 2) Methanol extraction; Nucleosil C18; 80% acetonitrile 20% water; 1 m:/min; UV det: 254, 280; Retention time, 9.3 min; DL 2.4 ng/inj ext. eff. = 100%; C/P DBA
WIPE:
Yes
BULK METHOD:
Limit the amount of bulk submitted to one gram or one mL.
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