Chemical Sampling Information
	Dipropyl ketone
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Butyrone; DPK; 4-Heptanone; Heptan-4-one; Propyl ketone OSHA IMIS Code Number: D178 Chemical Abstracts Service (CAS) Registry Number: 123-19-3 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: MJ5600000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2710 128 [27 KB, PDF] NIOSH Pocket Guide to Chemical Hazards, Dipropyl ketone: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm, 235 mg/m3 TWA National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 50 ppm, 235 mg/m3 TWA Health Factors Potential symptoms: Irritation of eyes, skin; cough, sore throat; headache; CNS depression, dizziness, drowsiness, decreased breathing; dry skin; in animals: liver injury; narcosis; INGES. ACUTE: Nausea, vomiting, diarrhea. Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8) Affected organs: Eyes, skin, CNS, respiratory system; liver Notes: OSHA does not have a PEL for dipropyl ketone, and no reports of occupational exposure or biomonitoring were found in the literature. Above 49ºC, explosive vapor/air mixtures of dipropyl ketone may be formed. Dipropyl ketone (4-heptanone) is listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515), and it occurs naturally in certain foods (e.g., bread, chicken fat, coffee, baked potatoes). Although dipropyl ketone is found in human urine, its reported elevation in diabetics was not caused by diabetes, but was due to its being a metabolite of di(2-ethylhexyl)phthalate, a leachable plasticizer used in various medical devices and other vinyl materials. Date Last Revised: 02/13/2007 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: Dipropyl ketone. International Chemical Safety Cards (WHO/IPCS/ILO): Dipropyl ketone. Pohanish, R.P. (editor): Dipropyl Ketone. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 983-985. Wahl, H.G., Hong, Q., Hildenbrand, S., Risler, T., Luft, D. and Liebich, H.: 4-Heptanone is a metabolite of the plasticizer di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients. Nephrol. Dial. Transplant. 19(10): 2576-2583, 2004. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Carbosieve S-III Tube (130/65 mg sections; 60/80 mesh) analytical solvent: Carbon Disulfide maximum volume: 10 Liters   maximum flow rate: 0.1 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA SLTC In-House File method classification: Partially Validated All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.