Technology Description:
The invention relates to novel pseudopeptide analogs of the insect allatostatin neuropeptide family, which possessbiological activity mimicking that of the naturally occurring neuropeptides. By addition of a hydrophobic moiety to anactive portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which arecapable of penetrating the insect cuticle while still retaining biological activity. By substituting sterically hindered aminoacids or aromatic acids for any or all of the second, third, or fifth amino acid residues of the allatostatic C-terminalpentapeptide, analogs have been produced which are resistant to degradation by insect peptidases while still retainingbiological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmentalprocesses normally regulated by allatostatins in insects.
Reference:
Please refer to patent application S.N. 10/385,317 (Docket #0062.03), "Mimetic Insect Allatostatin Analogs for Insect Control," which was filed on March 10, 2003, and is a divisional of USPN 6,664,371 (Docket #0239.00), which issued on December 17, 2003, and is a divisional of USPN 6,207,643 (Docket #0047.99), which issued on March 27, 2001.
Foreign rights are not available.
Inventors:
Ronald J. Nachman Areawide Pest Management Research 2881 F&B Road College Station, TX 77845 (979) 260-9315 / Fax: (979) 260-9386 nachman@tamu.edu
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Peter E. A. Teal Chemistry Research 1600-1700 S.W. 23rd Drive Gainesville, FL 32604 (352) 374-5788 / Fax: (352) 374-5707
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Christopher S. Garside University of Toronto Toronto, Canada (416) 978-3517 / Fax: (416) 978-3522 |
Stephen S. Tobe University of Toronto Toronto, Canada (416) 978-3517 / Fax: (416) 978-3522 |
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