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Method Modifications Published
analytical methods are written either in light of a specific laboratory's procedures or in
general terminology. It is unlikely that any given laboratory will follow the method
without incorporating some of their own internal procedures. These minor modifications
should not have any significant impact on the performance of the method. These minor
modifications include items such as: Other undesirable modifications may be made which increase laboratory throughput or
reduce costs while compromising the performance of the method. Examples of this type of
modification include: Major modifications to a referenced method significantly alter the performance and
validation of the method. If a laboratory has modified the reference method, the modifications and the purpose of
the modifications should be examined. If the performance of the method is not known (e.g., it is a reference method with
major modifications or is a method from an unproven source) it should be thoroughly
validated through the analysis of samples of known results. |