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Instrument Calibration The purpose of instrument calibration is to provide a correlation between the response produced by an instrument and the concentration of silica producing the response. (This correlation is often refered to as calibration or standard curve.) In addition, the accuracy of the calibration during the analysis of samples should be demonstrated. As a minimum, the accuracy should be demonstrated at the beginning and end of each analytical run. Since the concentration of the materials used to produce the calibration curve directly effects the results of the sample analysis, these materials should be characterized as well as possible. Possible sources of calibration materials, in order of preference, are:
Since instrument calibration can change over time, the frequency of calibration and calibration verifications is important.
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