|
[print
friendly page]
Barbiturates
Barbiturates were
first introduced for medical use in the early 1900s. More than 2,500 barbiturates
have been synthesized, and at the height of their popularity, about 50
were marketed for human use. Today, about a dozen are in medical use.
Barbiturates produce a wide spectrum of central nervous system depression,
from mild sedation to coma, and have been used as sedatives, hypnotics,
anesthetics, and anticonvulsants. The primary differences among many of
these products are how fast they produce an effect and how long those
effects last. Barbiturates are classified as ultrashort, short, intermediate,
and long-acting.
The ultrashort-acting
barbiturates produce anesthesia within about one minute after intravenous
administration. Those in current medical use are the Schedule IV drug
methohexital (Brevital®), and the Schedule III drugs thiamyl (Surital®)
and thiopental (Pentothal®). Barbiturate abusers prefer the Schedule
II short-acting and intermediate-acting barbiturates that include amobarbital
(Amyta®), pentobarbital (Nembutal®), secobarbital (Seconal®),
and Tuinal (an amobarbital/secobarbital combination product). Other short
and intermediate-acting barbiturates are in Schedule III and include butalbital
(Fiorina®), butabarbital (Butisol®), talbutal (Lotusate®),
and aprobarbital (Alurate®). After oral administration, the onset
of action is from 15 to 40 minutes, and the effects last up to six hours.
These drugs are primarily used for insomnia and preoperative sedation.
Veterinarians use pentobarbital for anesthesia and euthanasia.
Long-acting barbiturates
include phenobarbital (Luminal®) and mephobarbital (Mebaral®),
both of which are in Schedule IV. Effects of these drugs are realized
in about one hour and last for about 12 hours, and are used primarily
for daytime sedation and the treatment of seizure disorders.
|