The Systolic Hypertension in the Elderly Program
(SHEP)
Objectives:
To assess the ability of antihypertensive drug
treatment to reduce the risk of nonfatal and fatal (total) stroke in isolated
systolic hypertension.
Background:
Previous trials have demonstrated beneficial effects
of antihypertensive treatment of diastolic hypertension on major morbidity and
mortality, but none has investigated the ability to influence these events for
persons with isolated systolic hypertension.
Subjects:
4736 persons (1.06%) from 447,921 screenees aged 60
years and above were randomized (2365 to active treatment, 2371 to placebo).
Systolic blood pressure ranged from 160 to 219 mm Hg and diastolic blood
pressure was less than 90 mm Hg. Of the participants, 3161 were not receiving
antihypertensive medication at initial contact, and 1575 were. The average
systolic blood pressure was 170 mm Hg; average diastolic blood pressure, 77 mm
Hg. The mean age was 72 years, 57% were women, and 14% were black.
Conclusions:
In persons aged 60 years and over with isolated
systolic hypertension, antihypertensive stepped-care drug treatment with
low-dose chlorthalidone as step 1 medication reduced the incidence of total
stroke by 36%, with 5-year absolute benefit of 30 events per 1000 participants.
Major cardiovascular events were reduced, with 5-year absolute benefit of 55
events per 1000. (JAMA 1991; June 26:3255-64.).
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Study Website |
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Study Documentation |
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Data Distribution Agreement |
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