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Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism
EPA Grant Number: R829388C006Subproject: this is subproject number 006 , established and managed by the Center Director under grant R829388
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: CECEHDPR - University of California at Davis Center for the Study of Environmental Factors in the Etiology of Autism
Center Director: Pessah, Isaac N.
Title: Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism
Investigators: Pessah, Isaac N. , Gershwin, M. Eric , Goth, Samuel R. , Matsumura, Fumio , VanDeWater, Judy
Current Investigators: Pessah, Isaac N. , Goth, Samuel R. , VanDeWater, Judy
Institution: University of California - Davis
EPA Project Officer: Saint, Chris
Project Period: September 30, 2001 through September 29, 2002
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001)
Research Category: Health Effects , Children's Health
Description:
Objective:How thimerosal and polybrominated diphenylethers, major environmental concerns to childhood neurodevelopment, influences peripheral immune cells in the B6 murine model has been a primary focus in year 1. Work has begun on assessing the influence of these xenobiotics on the growth and development of glial/hippocampal neurons in culture. The long-term goal is to define common mechanisms in immune and neural cells responsible for developmental toxicity of these environmental agents. Our specific aims are: 1)To define differences in the response of peripheral immune cells (PMBCs) isolated from autistic and non-autistic children in their sensitivity and/or pattern of cell activation and cytokine secretion when challenged in vitro with vaccine antigens, and xenobiotics of environmental relevance (thimerosal, PCBs, and BDEs), singly and in combination.2) Elucidate the mechanisms by which sub-toxic concentrations of (thimerosal, PCBs, and BDEs), singly and in combination, alter growth and activation properties of immune cells from rodents.3) Elucidate the mechanisms by which sub-toxic concentrations of (thimerosal, PCBs, and BDEs), singly and in combination, influence glia/neural cell interactions leading to altered patterns of dendritic spine growth, dendritic branching and synaptogenesis in hippocampal cells from rodents.
Publications and Presentations:Publications have been submitted on this subproject: View all 23 publications for this subproject | View all 157 publications for this center
Journal Articles:Journal Articles have been submitted on this subproject: View all 20 journal articles for this subproject | View all 139 journal articles for this center
Supplemental Keywords:Autism, thimerosal, halogenated organics, cell signaling, immunotoxicology, neurotoxicology,
,
ENVIRONMENTAL MANAGEMENT, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessment, Biology, Risk Assessments, Disease & Cumulative Effects, genetic susceptability, Health Risk Assessment, Physical Processes, Chemistry, Children's Health, biomarkers, exposure assessment, xenobiotics, neurological development, autism, synergistic interactions, mechanisms, human health risk, susceptibility, halogenated aromatics, etiology, gene-environment interaction, neurotoxic, biological markers, children, neurobehavioral, pesticides, chemical exposure, exposure, biomarker, neurobehavioral effects, neurodevelopmental, neurotoxicity
Progress and Final Reports:
2002 Progress Report
2003 Progress Report
2005 Progress Report
Main Center Abstract and Reports:
R829388 CECEHDPR - University of California at Davis Center for the Study of Environmental Factors in the Etiology of Autism
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829388C001 Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
R829388C002 Environmental Factors in the Etiology of Autism; Cell Activation/Signaling Core
R829388C003 Environmental Factors in the Etiology of Autism; Molecular Biomakers Core
R829388C004 Environmental Factors in the Etiology of Autism; Childhood Autism Risks from Genetics and the Environment (The CHARGE Study)
R829388C005 Environmental Factors in the Etiology of Autism; Animal Models of Autism
R829388C006 Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism