NHLBI Workshop on Future Directions for Hypertension
Treatment Trials
Natcher Conference Center
Bethesda, MD
September 17-18, 2003
OBJECTIVES
 Executive
Summary
List of Participants
This workshop will consider the need for further hypertension treatment
trials with clinical event outcomes. Three themes for trials will
be explored:
determining how low a blood pressure level (initially or at goal)
should be targeted for treatment;
determining optimal treatment regimens for a broadly representative
patient population;
assessing the role of treatment guided by non-BP patient characteristics
at initial evaluation or in response to treatment.
Variations on these concepts will be evaluated for importance,
especially potential impact on medical practice, and for feasibility.
They will be prioritized among themselves, and in comparison to
research directed explicitly at practice changes to achieve better
BP control.
AGENDA
Day 1
- 8:30 am
- Opening remarks
- Dr. Califf
- 8:40 am
- Announcements
- Dr. Cutler
- 8:45 am
-
- Charge to participants
- Dr. Califf
- 8:50 am
-
- Keynote: Public health challenges in treating hypertension
- Dr. Furberg
- 9:15 am
-
- Keynote: Pharmacologic issues in treating hypertension
- Dr. Oparil
- 9:40 am
-
- Theme 1: How low to treat blood pressure? Evidence from
epidemiology and clinical trials
- Dr. MacMahon
- 10:05 am
-
- Refreshment Break
- 10:30 am
- Theme 2: Drugs and drug regimens - what are the issues
and how to address them?
- Dr. Black
- 10:55 am
- Theme 3A: Can genetic information help with selecting antihypertensive
treatments?
- Dr. Boerwinkle
- 11:20 am
- Theme 3B: Can sub-clinical disease help with selecting
antihypertensive treatments?
- Dr. Devereux (delivered by Dr. Gottdiener)
- 11:45 am
- Discussion
- 12:30 pm
- Lunch (Natcher Cafeteria)
- 1:30 pm
- Breakout Groups 1-3
- Drs. Cushman, Wright, Svetkey (leaders)
- 5:30 pm
- Adjourn for the day
- Day 2
- Reconvene in plenary session
- 8:30 am
- NHLBI Hypertension Research Initiatives: process and perspectives
- Dr. Cutler
- 8:40 am
- Summary of Breakout 1
- Dr. Cushman
- 9:00 am
- Discussion
- 9:20 am
- Summary of Breakout 2
- Dr. Wright
- 9:40 am
- Discussion
- 10:00 am
- Summary of Breakout 3
- Dr. Svetkey
- 10:20 am
- Discussion
- 10:40 am
- Refreshment Break
- 11:00 am
- Priority-setting exercise
- All
- 11:50 am
- Closing remarks
- Dr. Califf
- Noon
- Adjournment
NOTE: Because of the Hurricane Isabel weather emergency, the
Workshop agenda was accelerated, and was held on September
17 only.
August 2004
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