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Acceptable Substitutes in Very Low Temperature Refrigeration

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Unacceptable substitutes

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Acceptable Substitutes for CFCs (class I ODS) in Very Low Temp Refrigeration

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HFC-23   12, 13, 13B1, 503 R, N
R-403B Isceon 69-L 13, 13B1, 503 R, N
Note: R-403B is unacceptable as a substitute for R-502.
R-508A (PFC Blend Alpha) Klea 5R3 13, 13B1, 503 R, N
R-508B Suva 95 13, 13B1, 503 R, N
Carbon Dioxide   13, 13B1, 503 R, N
NARM-502   13, 13B1, 503 R, N
HFE-7100 as a secondary heat transfer fluid in not-in-kind systems   13, 13B1, 503 N
HFE-7200 as a secondary heat transfer fluid in not-in-kind systems   13, 13B1, 503 N
PFC-330ST, PFC-550HC, PFC-660HC, PFC-1100HC, PFC-1100LT, PGC-100, PGC-150, PFC-331ST, PFC-551HC, PFC-661HC, PFC-1101HC and PGC-151 PFC-330ST, PFC-550HC, PFC-660HC, PFC-1100HC, PFC-1100LT, PGC-100, PGC-150, PFC-331ST, PFC-551HC, PFC-661HC, PFC-1101HC and PGC-151 13, 113, 114 and blends thereof R, N
PFC-1102HC, PFC-662HC, PFC-552HC and FLC-15 PFC-1102HC, PFC-662HC, PFC-552HC and FLC-15 13, 113, 114, blends thereof N
ISCEON 89 ISCEON 89 R-13B1 R, N
R-422C ICOR XLT1 502 R, N
HFC-245fa Genetron® 245fa 11, 114 R, N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Very Low Temp Refrigeration

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
R-410A AZ-20 22 and HCFC blends N
R-404A HP62 22 and HCFC blends R, N
R-407C Suva 9000, KLEA 66 22 and HCFC blends R, N
Isceon 59, NU-22, R-417A Isceon 59, NU-22 22 and HCFC blends R, N
Hydrofluoroether-7000 HFE-7000 123 R, N
KDD5 KDD5 22 R, N
RS-45 (ASHRAE proposed designation: R-434A) RS-45 22 R, N
HFC-245fa Genetron® 245fa 141b N
R-125/290/134a/600a (55.0/1.0/42.5/1.5) ICOR AT-22 22 R, N
R-422B XAC1, NU-22B 22 R, N
R-422C XLT1 22, 402A, 402B, 408A R, N

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