Acephate Quickview (CASRN 30560-19-1)

Status of Data for Acephate

File First On-Line: 09/07/1988; Last Significant Revision: 05/01/1989

Category (section)	Status	Last Revised
Oral RfD Assessment	On-line	02/01/1990
Inhalation RfC Assessment	No data
Carcinogenicity Assessment	On-line	10/01/1993

Synonyms

30560-19-1 75 sp Acephate Chevron re 12,420 ENT 27822

n-(Methoxy(methylthio)phosphinoyl)acetamide Orthene Orthene-755 Ortho 12420 more...

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect	Point of Departure*	UF	MF	RfD
Inhibition of brain ChE	LEL : 0.12 mg/kg-day	30	1	4 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

• Principal and Supporting Studies (Oral RfD)
  • 90-day rat feeding study (LEL for male subjects), Chevron Chemical Co., 1987a
• Confidence in the Oral RfD
  • Study -- Medium
  • Database -- High
  • RfD -- High

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • C (Possible human carcinogen)
• Weight-of-Evidence Narrative:
  • The classification is based on increased incidence of hepatocellular carcinomas and adenomas in female mice.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)	Extrapolation Method
8.7 x10-3 per mg/kg-day	Linearized multistage procedure, extra risk

Drinking Water Unit Risks
2.5x10-7 per ug/L

Risk Level	Concentration
E-4 (1 in 10,000)	4x102 ug/L
E-5 (1 in 100,000)	4x101 ug/L
E-6 (1 in 1,000,000)	4 ug/L

• Dose-Response Data (Carcinogenicity, Oral Exposure)
  • Tumor Type: Liver adenomas and carcinomas
  • Test Species: Mouse/ CD-1, female
  • Route: Oral, Diet
  • Reference: Chevron Chemical, 1982a

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

• Not Assessed under the IRIS Program.