The Registry of Toxic Effects of Chemical Substances
Silica, amorphous fumed RTECS #: VV7310000
CAS #: 112945-52-5
The Registry of Toxic Effects of Chemical Substances
Silica, amorphous fumed |
| UPDATE: May 2008 | MW: 60.09 | MF: O2Si |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
|
N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraperitoneal | rat
lowest published lethal dose: 50 mg/kg
|
N/R
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AHBAAM 136,1,1952
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intratracheal | mouse
lowest published lethal dose: 96.77 mg/kg
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Lung, Thorax, or Respiration: Acute pulmonary edema | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes
TOPADD 33,745,2005
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intratracheal | mouse
lowest published toxic dose: 96.77 mg/kg
|
Lung, Thorax, or Respiration: Acute pulmonary edema | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOPADD 33,745,2005
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intratracheal | mouse
lowest published toxic dose: 50 mg/kg
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Lung, Thorax, or Respiration: Changes in lung weight
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TOLED5 175,24,2007
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intratracheal | mouse
lowest published toxic dose: 2 mg/kg
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Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 175,24,2007
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intratracheal | rat
lowest published lethal dose: 10 mg/kg
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N/R
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AHBAAM 136,1,1952
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intravenous | rat
lethal dose (50 percent kill): 15 mg/kg
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Lung, Thorax, or Respiration: Acute pulmonary edema
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BSIBAC 44,1685,1968
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oral | rat
lethal dose (50 percent kill): 3,160 mg/kg
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N/R
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ARSIM* 20,9,1966
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
inhalation | rat
lowest published toxic concentration: 154 mg/m3/6 hour/4 week- intermittent
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Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Other proteins
FAATDF 16,590,1991
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inhalation | rat
lowest published toxic concentration: 5.41 mg/m3/5 day- intermittent
|
Lung, Thorax, or Respiration: Other changes | Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 45,1856,2007
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inhalation | rat
lowest published toxic concentration: 1.39 mg/m3/5 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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FCTOD7 45,1856,2007
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REVIEWS:
ORGANIZATION
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STANDARD
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| REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Inadequate Evidence
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IMEMDT 42,39,1987
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International Agency for Research on Cancer (IARC) Cancer Review
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Human Inadequate Evidence
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IMEMDT 42,39,1987
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International Agency for Research on Cancer (IARC) Cancer Review
|
Human Inadequate Evidence
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IMEMDT 68,41,1997
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 3
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IMEMDT 68,41,1997
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TOXICOLOGY REVIEW
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NTIS** CONF-691001
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TOXICOLOGY REVIEW
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ECRVE8 6,197,1988
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
|
| REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - dust in air
|
time-weighted average 20 million particles per cubic foot
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DTLWS* 3,33,1973
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
|
| REFERENCE
N/R
|
N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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| REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Silica, amorphous, 7501
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OSHA ANALYTICAL METHOD #ID-125G
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REFERENCES:
CODEN
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| REFERENCE
AHBAAM
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Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For
publisher information, see ZHPMAT.
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ARSIM*
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Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
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BSIBAC
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Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de
Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
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DTLWS*
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"Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For
publisher information, see 85INA8.
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ECRVE8
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Environmental Carcinogenesis Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016)
V.3- 1985-
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FAATDF
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Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
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FCTOD7
|
Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford,
NY 10523) V.20- 1982-
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IMEMDT
|
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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TOPADD
|
Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical
Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
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