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“The future of genetic studies of complex human diseases”: Drs. Merikangas and Risch talk about that influential paper 13 years later
hum-molgen.org is starting a series of interviews and discussions with authors of recent papers that have been highly influential in human molecular genetics.
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| human genetics and molecular biology news flash
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| 2009-05-07 |
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No Ticket No Entry
A gene 'ticket' that allows cancer cells admittance to the brain is reported in a paper published online.
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Chromatin-Modification Link to Memory
A chromatin-modifying enzyme impairs memory formation in mice.
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A Time to Stress
Exposure to stress affects the brain, but different brain areas are vulnerable at particular times in life.
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The Dangers of Double Dipping
Analyses of data from functional magnetic resonance imaging (fMRI) and studies tracking electrical activity in the brain can generate misleading results, suggests an article online.
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Easing the Way to Pluripotency
Tools to selectively drive the expression of genes in pluripotent stem cells while leaving differentiated cells untouched are reported online.
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A Primate-Specific Potassium Channel in Schizophrenia
A primate-specific variant of a potassium channel affects cerebral cortex function, cognition, neuronal physiology and risk of having schizophrenia.
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High Rate of Chromosomal Instability in Human Embryos
Abnormal chromosome structure in early human embryos is quite common, according to a report online.
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Genetic Factors for Common Traits in Asians
Scientists in Korea have carried out the first large screen of health-related genes in an East Asian population.
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Sleep Disorder Associated With Autoimmune Response
An assault of the immune system on sleep centers of the brain may cause narcolepsy.
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Energized by RNA
Scientists have discovered a new class of enzymes that use a type of RNA to make natural products.
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Fresh Lead for Broad-Spectrum Huntington's Therapy
New findings may catalyze the development of drugs to treat Huntington's and other similar diseases.
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Easing Inflammation
A new type of therapy that targets a key enzyme in a specific type of white blood cell eases inflammation in mice.
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Protein Cocktail Directs Production of New Heart Cells
Researchers have discovered a cocktail of proteins that triggers the production of new heart muscle cells.
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“The future of genetic studies of complex human diseases”: Drs. Merikangas and Risch talk about that influential paper 13 years later
hum-molgen.org is starting a series of interviews and discussions with authors of recent papers that have been highly influential in human molecular genetics.
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| 2009-04-23 |
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Gut Hormone Aids Malnourished Dialysis Patients
Daily treatment with the gut hormone ghrelin is effective in sustaining an improved appetite in patients on dialysis.
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Urine Test for Kidney Disease
Scientists have developed a new test for detecting kidney disease.
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Enzyme Regulator of Attention Provides Insights into ADHD
Scientists have discovered a key enzyme in the brain of rats that helps regulate attention and hyperactivity.
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Assembling Large DNA Molecules in a Test Tube
Scientists have developed a method for assembling short pieces of DNA into one long molecule in a test tube.
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Gene Elements That Control Cell Evolution
Three large studies unravel the network underlying the genetic elements that control how cells transform and evolve from precursors to mature cells.
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Stem Cells Generate New Eggs in Adult Mice
Mammalian ovaries might retain their capacity to generate new eggs during adulthood, suggests a study.
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Cancer Genomics Hits Its Stride
A look back at the achievements of cancer genomics, and forward to the prospect that the complete DNA sequencing of large numbers of cancers will help us move towards a deeper understanding of how to treat cancers.
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New Approach to Cancer Treatment
A new drug that shows robust anti-tumour activity in a preclinical mouse model of cancer, is reported.
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| 2009-04-03 |
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Nature Network: A platform for the interactions of scientists
A new online platform for the interactions between scientists
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Rethinking Tumour Spread
Scientist proposes a drastic change in how we view metastatic spread, which has important implications for the treatment of patients with cancer.
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Pluripotency by Piggybac
Researchers have developed a method to create induced pluripotent stem cells (iPSCs) with an unmodified genome.
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Finding Footprints in the Genome
A method for measuring in vivo protein occupancy in the entire yeast genome is presented in a study.
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Softening Bone
A molecular mechanism that promotes bone destruction could be harnessed to combat osteoporosis.
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A New Treatment for Arrhythmia
A drug currently available in the clinic could be used to treat patients with an inherited form of cardiac arrhythmia.
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Unexpected Tumour Growth?
Blood vessel inhibitors have been pursued as anticancer agents, but in low doses they may actually promote blood-vessel formation and tumour growth in mice.
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A Secret Doorway into the Brain
Scientists have identified how immune cells bypass the blood-brain barrier to enter the brain, which in turn allows other immune cells to enter the brain and cause disease.
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New Genetic Risk Factors for Breast Cancer
Several new regions of the genome that predispose to breast cancer have been identified in two large studies.
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Risk Factors for Cardiovascular Health
Several genetic variants that predispose individuals to sudden cardiac death have been identified in two studies published online.
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Stem Cells Generate Intestine
Cultured intestinal stem cells can be coaxed to produce the many different cell types that make up the intestinal epithelium.
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Peek-A-Boo Perception
From a young age, children with autism have an altered perception of biological motion - an ability that assists interaction with other living beings and is linked to social understanding.
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Molecule Implicated in Stem Cell Engraftment
A signalling pathway that helps to regulate the movement of blood-forming stem cells in the body is revealed.
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Light Switch for Brain Signalling Pathways
A new method uses light to turn specific intracellular signalling pathways on and off in live, behaving animals.
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| 2009-03-23 |
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Effects of Prenatal Drug Exposure
It is important to close the gap between scientific understanding of the effects of drug exposure in the womb on brain development and public perception and policy.
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How Nerve Fibers Degenerate
An enzyme inside nerve cells that is crucial for nerve fibre degeneration in fruit flies and mice is identified.
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Shutting the Door on Obesity
Knocking out an enzyme responsible for the metabolism of fat in the intestine protects mice from obesity.
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A Brain Trauma-Alzheimer's Disease Connection
Two enzymes implicated in Alzheimer's disease may also have a role in traumatic brain injury.
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Risk Factor for Blood Diseases
A common genetic sequence abnormality that enhances the likelihood of acquiring a mutation in a gene linked to blood diseases has been identified.
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A Pancreatic Path
Scientists have found a small compound that could direct stem cells to become insulin-secreting pancreatic beta cells.
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How to Make a Dopamine-Producing Neuron
A 'control switch' that instructs immature cells to become dopamine-expressing neurons is revealed.
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Link between Cancer and Dietary Restriction
A signalling pathway that influences how sensitive cancer cells are to the beneficial effects of dietary restriction (DR) is described.
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| 2009-03-19 |
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The STREGA initiative: Guidelines for the reporting of genetic association studies
A recent paper describes the STREGA initiative and proposes guidelines for the reporting of genetic association studies
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| 2009-03-05 |
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Caffeine Protects From UV Damage
The mechanism by which caffeine may protect the skin against the damage of UV exposure is revealed in a study.
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Antibodies That Neutralize Multiple Flu Strains
Researchers have engineered human antibodies that protect animals against lethal doses of multiple strains of influenza virus.
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Where Decisions Are Made
Scientists have discovered that the process involved in decision making occurs in different areas of the brain's frontal lobe, depending on whether the decision is abstract or more concrete.
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Childhood Abuse Permanently Modifies Stress Genes
Early childhood abuse in humans can change the expression of a gene that is important for responding to stress.
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Managing Iron Overload
A growth factor involved in inducing bone formation has an unsuspected role in iron metabolism.
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