FYI from the NHLBI Index

Janauary 2006: Vol. 6, Issue 3
Research and Resources

Anemia in the Elderly
Cardiovascular Cell Therapy Research Network
Clinical Hematology Research Career Development Program (K12)
Community-Responsive Interventions to Reduce Cardiovascular Risk in American Indians and Alaska Natives
Genomics and Proteomics: Short Courses on Applications to Complex HEart, Lung, Blood, and Sleep Disorders
Long-Term Oxygen Treatment Trial
Obese and Diabetic Intrauterine Environment: Long-Term Metabolic or Cardiovascular Consequences in the Offspring
RNA Interference (RNAi): Stability, Delivery, and Processing by Tissues
Short Sleep Duration and Risk of Obesity or Overweight: Linking Mechanisms
Systems Biology Exploratory Program
Type I Diabetes and its Complications: Development of New Therapeutics and Monitoring Technologies (SBIR/STTR)
Weight Loss in Obese Adults with Cardiovascular Risk Factors: Clinical Interventions

NHLBI Research Initiatives

From time to time, the NHLBI invites investigators to submit grant applications or contract proposals for specific research programs. We are currently soliciting applications for the programs described below. Unless a due date is mentioned, applications are accepted for February 1, June 1, and October 1 deadlines each year. For full details of these and other research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm or the Web page that is linked each initiative number.

Anemia in the Elderly

Initiative Number: RFA AG-06-002
Applications due: January 20, 2006
Objective: To explore the epidemiology, pathophysiology, and clinical aspects of anemia in the elderly.

Cardiovascular Cell Therapy Research Network

Initiative Number: RFA HL-06-001
Applications due: March 10, 2006
Objective: To establish a network to conduct multiple, collaborative, proof-of-concept, cell therapy clinical protocols to enhance the repair and regeneration of damaged cardiovascular tissue.

Clinical Hematology Research Career Development Program (K12)

Initiative Number: RFA HL-06-006
Applications due: February 14, 2006
Objective: To develop multidisciplinary career development programs in non-malignant clinical hematology research in order to equip new academic researchers with the knowledge and skills necessary to address complex problems in blood disease, transfusion medicine, and cellular therapies.

Community-Responsive Interventions to Reduce Cardiovascular Risk in American Indians and Alaska Natives

Initiative Number: RFA HL-06-002
Applications due: March 10, 2006
Objective: To test the effectiveness of behavioral interventions such as weight reduction, regular physical activity, and smoking cessation to reduce the risk of cardiovascular disease in American Indians and Alaska Natives.

Genomics and Proteomics: Short Courses on Applications to Complex Heart, Lung, Blood, and Sleep Disorders

Initiative Number: RFA HL-05-012
Applications due: January 17, 2006
Objective: To develop, conduct, evaluate, and disseminate short-term courses on the application of genomics to heart, lung, blood, and sleep disorders.

Long-Term Oxygen Treatment Trial

Initiative Number: RFP HR-06-07
Applications due: January 24, 2006
Objective: To determine the efficacy of continuous long-term oxygen treatment for improving survival in subjects with chronic obstructive pulmonary disease and less-than-severe hypoxemia at rest.

Obese and Diabetic Intrauterine Environment: Long-Term Metabolic or Cardiovascular Consequences in the Offspring

Initiative Number: RFA DK-05-014
Applications due: March 16, 2006
Objective: To investigate the effect of maternal obesity and diabetes on mechanisms that could potentially contribute to obesity, metabolic disease, and cardiovascular disease in the offspring.

RNA Interference (RNAi): Stability, Delivery, and Processing by Tissues

Initiative Number: RFA HL-05-019
Applications due: January 18, 2006
Objective: To increase our understanding of the biology of RNA interference, an effective post-transcriptional strategy for silencing genes, in order to develop its therapeutic potential for a wide range of heart, lung, and blood diseases.

Short Sleep Duration and Risk of Obesity or Overweight: Linking Mechanisms

Initiative Number: RFA HL-06-03
Applications due: January 25, 2006
Objective: To investigate whether metabolic and appetite changes resulting from short sleep duration contribute to weight gain.

Systems Biology Exploratory Program

Initiative Number: RFA HL-06-004
Applications due: March 10, 2006
Objective: To undertake a coordinated "systems biology" approach to understanding the normal physiology and perturbations associated with heart, lung, blood, and sleep disorders in order to develop new high-impact treatments and prevention strategies.

Type I Diabetes and its Complications: Development of New Therapeutics and Monitoring Technologies (SBIR/STTR)

Initiative Number: RFA DK-05-015 and RFA DK-05-016
Applications due: March 15, 2006
Objective: To develop new approaches, through small business innovation research and technology transfer, to prevent, treat, monitor, and cure type 1 diabetes and its macro- and micro-vascular complications.

Weight Loss in Obese Adults with Cardiovascular Risk Factors: Clinical Interventions

Initiative Number: RFA HL-06-007
Applications due: February 15, 2006
Objective: To test the effectiveness in routine clinical practice of interventions for weight loss in obese patients who have other cardiovascular risk factors such as hypertension, dyslipidemia, and diabetes.

Modified 6/20/06
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Director, NHLBI

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