The Registry of Toxic Effects of Chemical Substances

o - Xylene

RTECS #: ZE2450000

CAS #: 95-47-6

UPDATE: May 2008 MW: 106.18 MF: C8H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Dimethylbenzene
  2. 1,2 - Xylene
  3. o - Dimethylbenzene
  1. o - Methyltoluene
  2. o - Xylene (ACGIH:OSHA)
  3. o - Xylol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 500 mg/m3/12 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ATSUDG 8,425,1985
inhalation
rat 		lowest published toxic concentration: 150 mg/m3/24 hour (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) TXCYAC 18,61,1980
inhalation
rat 		lowest published toxic concentration: 1,500 mg/m3/24 hour (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXCYAC 18,61,1980
inhalation
rat 		lowest published toxic concentration: 3,000 mg/m3/24 hour (7-14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXCYAC 18,61,1980
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg (2 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ARANDR 11,233,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published lethal concentration: 6,125 ppm/12 hour N/R YAKUD5 22,883,1980
inhalation
mouse 		lowest published lethal concentration: 30 gm/m3 Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression

Cardiac: Other changes 		AEPPAE 143,223,1929
inhalation
mouse 		lowest published toxic concentration: 1,000 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
mouse 		lethal concentration (50 percent kill): 4,595 ppm/6 hour N/R VCVGH* -,159,1990
inhalation
rat 		lowest published lethal concentration: 6,125 ppm/12 hour N/R JPBAA7 46,95,1938
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TOXID9 60,427,2001
intraperitoneal
mammal (species unspecified) 		lowest published lethal dose: 1,500 mg/kg N/R JPBAA7 46,95,1938
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,550 µL/kg N/R ARTODN 58,106,1985
oral
rat 		lowest published lethal dose: 5 gm/kg N/R YAKUD5 22,883,1980
oral
rat 		lethal dose (50 percent kill): 3,567 mg/kg N/R VCVGH* -,160,1990
subcutaneous
mammal (species unspecified) 		lowest published lethal dose: 2,500 mg/kg N/R JPBAA7 46,95,1938


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,800 ppm/11 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain PHTOEH 89,6,2001
inhalation
rat 		lowest published toxic concentration: 3,500 ppm/6 hour/6 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGH* -,162,1990
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal) 		FCTOD7 41,415,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 150 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1189,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,1189,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1189,1999
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
ENTOX* -,470,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (440 mg/m3) (skin) DTLVS* 3,281,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (109 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 221 mg/m3 (50 ppm);
short term exposure limit 442 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FRANCE VME 50 ppm (221 mg/m3), VLE 100 ppm (442 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 440 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (217 mg/m3), APR2007
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (435 mg/m3);
short term exposure limit 150 ppm (655 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (217 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (108 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (200 mg/m3);
short term exposure limit 100 ppm (450 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (435 mg/m3),KZG- week 200 ppm (870 mg/m3),Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (220 mg/m3);
short term exposure limit 100 ppm (skin), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-XYLENE-air 10 hour time-weighted average 100 ppm;
short term exposure limit 150 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1026;
Number of Industries 9;
Total Number of Facilities 179;
Number of Occupations 25;
Total Number of Employees Exposed 5,778
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1026;
Number of Industries 30;
Total Number of Facilities 2,608;
Number of Occupations 28;
Total Number of Employees Exposed 25,994;
Total Number of Female Employees Exposed 5,812


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in manufacture of PHTHALIC ANHYDRIDE and in pharmaceutical and insecticide synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #1002


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used in manufacture of PHTHALIC ANHYDRIDE and in pharmaceutical and insecticide synthesis

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data

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