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Model Detail

Mouse Model Information
Model Name	P53.R270H/K14Cre
Investigator	Harry van Steeg
Status	available
Availability	n/a
Strain	n/a
Species of Origin	Mouse
Mutation Type	Point Mutant
Manipulation Type	targeted
Conditional	Y
Projected Use	SNP assessment, UV skin cancer
Phenotype Summary	Model made at MIT (Tyler Jacks) for reference see De Vries et al. (2002) Proc. Natl. Acad. Sci. USA 99; 2948 - 2953. Model crossed with Keratin14-Cre (origin Anton Berns, Netherlands Cancer Institute)
Genetic Information
Gene Name	tumor protein p53 (Li-Fraumeni syndrome)
Gene Symbol	TP53
Reference Sequence	8400737
MGI Gene Record	TP53 Gene Details
LocusLink	7157
Disease	n/a
OMIM	191170
Gene Models	n/a
Biopathways	KEGG: cell cycle
Gene Ontology
Molecular Function	n/a
Biological Process	DNA repair
Cellular Component	n/a
Publications
Title	n/a

This page URL: http://tools.niehs.nih.gov/genotype/detail.cfm
NIEHS website: http://www.niehs.nih.gov/
Email the Web Manager at webmanager@niehs.nih.gov

Last Reviewed: 21 August 2007