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Model Detail

Mouse Model Information
Model Name	Msh6(T1217D)
Investigator	Peter Stambrook
Status	available
Availability	n/a
Strain	n/a
Species of Origin	None selected
Mutation Type	None selected
Manipulation Type	targeted
Conditional	N
Projected Use	SNP assessment, GI cancer
Phenotype Summary	Mice with this single nucleotide change are viable and fertile. They show loss of DNA repair function while having no effect on the apoptotic response to DNA damaging agents. The mice have a tumor predisposition phenotype.
Genetic Information
Gene Name	mutS homolog 6 (E. coli)
Gene Symbol	MSH6
Reference Sequence	6754743
MGI Gene Record	Msh6 Gene Detail
LocusLink	17688
Disease	n/a
OMIM	600678
Gene Models	n/a
Biopathways	n/a
Gene Ontology
Molecular Function	n/a
Biological Process	n/a
Cellular Component	nucleus
Publications
Title	n/a

This page URL: http://tools.niehs.nih.gov/genotype/detail.cfm
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Last Reviewed: 21 August 2007