NINDS Neuroscience Funding Announcements

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Assay Development for High Throughput Molecular Screening (R21) (NIH Roadmap)
Release Date: July 13, 2006
Announcement Number: RFA-RM-07-001
Application Receipt Date:
September 22, 2006   
Letter of Intent Date: September 8, 2006

Funding Contact: Mark Scheideler, Ph.D.
Program Area: Channels, Synapses and Neural Circuits

Brief Description:
This FOA is one component of the NIH Molecular Libraries and Imaging Roadmap Initiative (http://nihroadmap.nih.gov/molecularlibraries/index.asp), a major NIH effort to broaden access to rapid assay technologies. This program will fund the development and adaptation of biological assays for use in automated high throughput molecular screening (HTS). A further component of this Roadmap Initiative, PAR-06-259 (http://grants.nih.gov/grants/guide/pa-files/PAR-06-259.html), separately recommends biological assay projects that are HTS-ready for screening within the Molecular Libraries Screening Centers Network, which employs a library of chemical compounds that are part of the Molecular Libraries Small Molecule Repository. It is intended that this FOA promote the development of automated screening projects that can be submitted to the MLSCN, although this is not a requirement. The overall goal of the initiative is to facilitate the creation of a public database of biological information about small molecule chemical structures, which then seeds the further development of small molecule pharmacological tools for biological research. Other efforts within the Initiative also supporting this objective include the development of HTS-related technologies, Informatic applications and Preclinical tools.

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