NINDS Neuroscience Funding Announcements

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Understanding Hopoglycemia Unawareness in Patients with Diabetes
Release Date: July 27, 2001
Announcement Number: RFA-DK-01-031
Application Receipt Date:
November 21, 2001   
Letter of Intent Date: October 14, 2001

Funding Contact: NINDS Funding
Program Area: Neural Environment

Brief Description:
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Child Health and Human Development (NICHD), the National Institute of Nursing Research (NINR) and the Juvenile Diabetes Research Foundation International (JDRF) invite applications to address the problem of hypoglycemia unawareness in patients with diabetes. Episodes of severe hypoglycemia are a major obstacle to the achievement of euglycemia and the prevention of long-term complications in patients with diabetes. Many individuals with diabetes develop hypoglycemia unawareness, which prevents institution of intensified blood glucose control and puts patients at risk for hypoglycemia-related complications. This RFA solicits basic and clinical studies to 1) define the mechanisms underlying the loss of hypoglycemia awareness in patients with diabetes, and 2) develop novel approaches to prevent or reverse hypoglycemia unawareness.

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