NINDS Neuroscience Funding Announcements

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Neurovascular Mechanisms of Brain Function and Disease (R21)
Release Date: March 7, 2006
Announcement Number: PAS-06-200
Application Receipt Date:
June 1, 2006
October 1, 2006
February 16, 2007   

Funding Contact: Thomas Jacobs, Ph.D.
Program Area: Neural Environment

Brief Description:
The goal of this Program Announcement with set-aside funds (PAS) is to invite applications for studying the integration of neurobiological and cerebrovascular mechanisms in the adult, aged and pediatric brain in health and disease. This PAS encourages studies focused on improving our understanding of the dynamic interactions within the neurovascular unit (NVU), a construct consisting of brain microvascular endothelium, glia, neurons and the extracellular matrix that maintains spatial relations among them. Knowledge of these interactions has the potential to stimulate new strategies for basic, translational and clinical research in many neurological disorders, including stroke, vascular dementia, and intracerebral hemorrhage. Among the challenges to be addressed are: generate new hypotheses and conduct exploratory work on microvessel–neuron communication; increase our knowledge about cell-cell signaling and how insults to the endothelium affect parenchymal cell damage, which applies not only to stroke, but may also contribute to understanding neurological disorders in which vascular changes are observed; and, elucidate mechanisms by which neurons communicate with blood vessels through interactions with non-neuronal cells in the microenvironment including endothelium, pericytes, astrocytes, oligodendrocytes and microglia.

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