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Temporomandibular Joint and Muscle Disorders: Pathophysiological Mechanisms Linking Comorbid Conditions (R01)
Release Date: December 13, 2006
Announcement Number: PA-07-150
Application Receipt Date:
February 5, 2007
June 5, 2007
October 5, 2007
February 5, 2008
June 5, 2008
October 5, 2008
February 5, 2009
Funding Contact: Linda Porter, Ph.D.
Program Area: Systems and Cognitive Neuroscience
Brief Description:
The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research on discovering etiological and pathophysiological
mechanisms underlying a set of chronic, comorbid conditions associated with temporomandibular joint and muscle disorders (TMJMDs).
TMJMDs are a complex collection of diseases involving one or more tissues of the TMJ and facial musculature. Primary symptoms
include chronic pain in facial muscles and limited and painful movement of the jaw. In addition, these and other symptoms
of TMJMD can occur together with other chronic illnesses such as fibromyalgia, atypical face pain, trigeminal neuralgia, chronic
fatigue syndrome, multiple chemical sensitivity, irritable bowel syndrome, complex regional pain syndrome, migraine headache,
speech hearing, swallowing, balance, smell, and taste disorders, and certain cardiovascular diseases. This program announcement
seeks research applications that use state-of-the-art, multidisciplinary and interdisciplinary approaches to discover molecular,
physiological, and behavioral mechanisms responsible for the overlapping symptoms manifested in the set of disorders that
may co-exist with TMJMD. These applications may have as their research focus the chronic, comorbid conditions themselves or
TMJMDs, provided that the aims and goals of the project are to discover biological mechanisms linking the comorbidities. While
the overarching goal of this announcement is to arrive at a better understanding of potential mechanisms underlying TMJMDs
as related to the variety of comorbidities associated with them, it is expected that no single research project will be able
to accomplish this. Applicants are, therefore, encouraged to focus their attention on a particular pathway and a specific
disease that is comorbid with TMJMD.
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