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February 2005 Director's Status Report

Budget and Appropriations

The FY 2005 Appropriation for NIA (including AIDS) is $1,051,990,000, an increase of 3 percent over the FY 2004 actual budget authority of $1,021,381,000. Funding for AIDS-related research, decreases from $5,489,000,000 in FY 2004 to $5,459,000,000 in FY 2005, a decrease of 0.5 percent. The FY 2005 Appropriation includes $6.6M spread across all mechanisms for Roadmap.

Overall Budget Policy

One of NIH’s highest priorities is the funding of medical research through research project grants (RPGs). Support for RPGs allows NIH to sustain the scientific momentum of investigator-initiated research while providing new research opportunities. In FY 2005, total RPGs funded by NIA is estimated to be 1,439 awards, an increase of 49 awards over the FY 2004 actuals.

Promises for advancement in medical research are dependent on a continuing supply of new investigators with new ideas. In the FY 2005 Appropriation, NIA will support 543 pre- and postdoctoral trainees in full-time training positions; this is a decrease of one FTTP from FY 2004.

NIA FY 2005 Appropriation - Mechanism Discussion

The FY 2005 Appropriation includes funding for 1,439 research project grants, compared to 1,390 in FY 2004. Of these 1,439 awards, 349 will be competing research project grants and 1,090 will be noncompeting awards.

The funding for the Centers mechanism increases by 4.6 percent over the FY 2004 level.

The FY 2005 Appropriation includes an increase of 0.8 percent above the FY 2004 level for Other Research.

The funding for Contracts in FY 2005 increases by 9 percent over the FY 2004 level.

The FY 2005 Appropriation includes a 4 percent increase over the FY 2004 level for Intramural Research and a 3.7 percent increase over the FY 2004 level for RMS.

FY 2006 President’s Budget

The President is required to submit a Fiscal Year 2006 President's Budget to Congress during the first week in February 2005.

(Contact: Mr. Patrick Shirdon, FMB, 301-496-9147)

Legislative Update

I. Significant Legislative/Executive Action

  • President’s Proposed FY 2005 Budget and Senate and House Budget Resolutions for NIH/NIA – H.R. 4818, Consolidated Appropriations Act, 2005, was signed into Public Law 108-447 on Dec. 8, 2004. Exact budget distribution has not been finalized.

II. Legislation Tracking

  • S.566/H.R. 1138, the Alzheimer’s Disease, Research, Prevention, and Care Act of 2003 lost momentum when S. 2533/H.R. 4595, the Ronald Reagan Alzheimer’s Breakthrough Act of 2004 was introduced by Senators Barbara Mikulski (D-MD) and Kit Bond (R-MO)/Representative Edward Markey (D-MA). There was no action on these measures before end of 108th Congress and will have to be reintroduced in 109th. NOTE: SEC. 399O. ALZHEIMER'S DISEASE PUBLIC EDUCATION CAMPAIGN of S. 2533 was included in the Consolidated Appropriations conference report and states that:

1. IN GENERAL- The Secretary, acting through the Director of the Centers for Disease Control and Prevention, shall carry out a program to educate the public and public health community regarding—

a. diagnosis and early warning signs of Alzheimer's disease; and
b. how healthy lifestyles could maintain cognitive function and brain health.

  • S.1217, Keeping Seniors Safe from Falls Act – The Senate passed the measure unanimously on November 18, 2004. S. 1217 sponsored by Senators Barbara Mikulski (D-MD) and Mike Enzi (R-WY) focuses on prevention of falls among older adults through four areas: public education campaigns, research initiatives, demonstration projects and a study on the effect of falls on health care costs. H.R. 3513, the Elder Fall Prevention Act of 2003, the House companion bill, did not make it out of committee review.

III. Congressional Briefings and Hearings

  • The October 6 briefing for Congressman John Boozman (R-AR) with Dr. Richard Hodes on Alzheimer’ disease research was postponed until February 3, 2005.
  • On December 2, Dr. Judith Salerno, NIA Deputy Director, participated at the American Federation on Aging Research (AFAR) briefing for Congressional members and staff on Older Adult Obesity held at the Washington D.C. Hyatt.

IV. Congressional Outreach

  • At request of Senator Kay Bailey Hutchinson, Dr. Richard Hodes and NIA Program staff met on October 19 with Dr. Roy Wilson, President, Texas Tech University to discuss their new Aging Institute and aging research.

V. Professional Organization Outreach Activities

  • NIA leadership staff met with the Alzheimer’s Association (AA) on September 15, October 7, and December 8 to discuss ongoing AD projects and collaborations.
  • Jane Shure and Stephanie Dailey of the NIA Communications and Public Liaison Office attended the Meals on Wheels Association of America (MOWAA) Annual Conference held this past September in Colorado Springs. MOWAA members participated in the final input for a health message on Safe Use of Medications. This NIA/AoA/MOWAA brochure designed for Meals on Wheels recipients will be ready for distribution in January 2005.
  • NIA leadership also met with the Ad Hoc Group for Medical Research on October 20 and provided updates for the 2005 NIH Resource Guide.
  • Friends of NIA. Professional and patient advocacy groups have been meeting to consider formation of the “Friends of NIA.” This group would partner to raise public and Congressional awareness of research activities and advocate for the needs of the National Institute on Aging. Daniel Perry, Executive Director of the Alliance for Aging Research will serve as the first chair of the Friends of NIA.

(Contact: Dr. Tamara Jones, NIA/OD, Ph: 401-451-8835)

Staff Changes

U.S. Department of Health and Human Services (HHS) Secretary Tommy G. Thompson announced the appointment of four new members to the National Advisory Council on Aging (NACA). Two-thirds of the 18-member Council are from the health and scientific disciplines, particularly the biological, behavioral, and medical sciences, and one-third from the general public, including public policy, law, health policy, economics, and management. Council members are appointed for overlapping terms of four years. The NIA is the lead federal agency supporting and conducting biomedical, social, and behavioral research and training related to aging and the special needs of older people.

The new members are:

Paul Greengard, Ph.D. Dr. Paul Greengard is the Vincent Astor Professor of Molecular and Cellular Neuroscience at The Rockefeller University. He began his exploration of nerve cells in 1948 when he joined the Johns Hopkins biophysics laboratory then headed by Detlev Bronk. After receiving his Ph.D. from Johns Hopkins in 1953, Greengard spent five years in England receiving advanced training in brain biochemistry at the University of London, at Cambridge University, and at the National Institute of Medical Research.

Upon his return to the United States, Greengard worked as Director of the Department of Biochemistry at Geigy Research Laboratories, in Ardsley, New York for eight years. He has remained intensely interested in the applications of basic scientific knowledge to the development of therapeutic agents for treatment of various neurological and psychiatric diseases. In 1967, he left the pharmaceutical industry to return to academia. He spent one year as Visiting Professor at Albert Einstein College of Medicine and Vanderbilt University School of Medicine. From 1968 to 1983, Greengard served as Professor of Pharmacology and Psychiatry at Yale University, and subsequently moved to his current position at The Rockefeller University.

Over the years, Greengard’s achievements have earned him many distinguished awards including the Metropolitan Life Foundation Award for Medical Research, The Charles A. Dana Award for Pioneering Achievements in Health, the Ralph W. Gerard Prize in Neuroscience from the Society for Neuroscience, The National Academy of Sciences Award in the Neurosciences, the Bristol-Myers Award for Distinguished Achievement in Neuroscience Research, the 3M Life Sciences Award of the Federation of American Societies for Experimental Biology. In the year 2000, Greengard was awarded the Nobel Prize in Physiology or Medicine.

Terry L. Mills, Ph.D. Terry Mills received his Ph.D. in sociology, with an emphasis in gerontology, from the University of Southern California. Currently, an Associate Professor of Sociology, Dr. Mills also is Associate Dean for Minority Affairs in the University of Florida (UF) College of Liberal Arts & Sciences; and Director of the Office for Academic Support and Institutional Services (OASIS). Prior to this appointment he served as Assistant Dean of the UF Graduate School with responsibilities for the Office of Graduate Minority Programs (OGMP), and Director of the Ronald E. McNair Scholars Program. An active researcher, Dr. Mills’ current research focuses on the relationship between social, environmental, and physical health factors that affect self-reports of depressive symptoms among racial/ethnically diverse older adult populations. Additionally, he conducts research on family intergenerational relationships, particularly on factors associated with solidarity and conflict among members of different family generations. A special emphasis is given to the grandparent-grandchild dyad. Mills has been a member of the faculty at the University of Florida since 1996.

Albert L. Siu, M.D., M.S.P.H. Albert L. Siu, M.D., MSPH, is the Chairman of the Brookdale Department of Geriatrics and Adult Development of The Mount Sinai Medical Center, and the Ellen and Howard C. Katz Professor of Geriatrics and Adult Development. He is an internist, geriatrician, and health services and policy researcher. He is currently a Senior Associate Editor of Health Services Research and a member of the U.S. Preventive Services Task Force.

Dr. Siu graduated from Yale Medical School and went on to complete a residency in Internal Medicine and a fellowship as a Robert Wood Johnson Clinical Scholar at UCLA. He joined the UCLA faculty in 1985 in Medicine with a joint appointment at RAND. He served as Chief of the Division of Geriatric Medicine at UCLA from 1989 until his departure in 1993 to become a Deputy Commissioner in the New York State Department of Health. In 1995, he went to Mount Sinai as a Professor in the Department of Health Policy. Before moving into his current role, he was the Clifford Spingarn M.D. Professor and Chief of the Division of General Internal Medicine from 1998-2002.

Mary E. Tinetti, M.D. Mary Tinetti M.D. is the Gladys Phillips Crofoot Professor of Medicine, Epidemiology, and Public Health, and Director of the Program on Aging and Claude Pepper Center for Independence of Older Americans at Yale University School of Medicine. As a physician scientist with clinical training in geriatrics, Dr. Tinetti has published extensively in the area of falls and fall injury risk factors identification and prevention. She determined that older persons at risk for falling and injury could be identified, that falls and injuries were associated with a range of serious adverse outcomes including nursing home placement and functional decline, and that multifactorial risk reduction strategies were effective and cost-effective at reducing the rate of falling. She is now involved in state and national efforts to translate these research findings into clinical and public health practice. She also investigates functional disability, mobility impairment, individual patient preference in the face of multiple health conditions, and the adverse effects of multiple medications. Dr. Tinetti is funded by the NIA and several foundations. She has over 100 original peer reviewed publications as well as several reviews and book chapters. She is an editor for the fifth edition of Principles of Geriatric Medicine and Gerontology.

Dr. Tinetti served as a member of the board of directors of the American Geriatrics Society and currently serves on several national advisory committees including the Beeson Faculty Scholars in Aging Program, the Robert Wood Johnson (RWJ) Generalist Physician Faculty Award Program, and the Nonprescription Drug Advisory Committee of the Food and Drug Administration. She has received numerous awards including the Joseph T. Freeman Award from the Gerontological Society of America, the Irving Wright Award from the American Federation of Research, and the Greppi Prize from the Italian Gerontological and Geriatric Society.

Dr. Huber Warner, Associate Director for BAP, will be leaving the NIA in late May to accept a position as Associate Dean for Research in the College of Biological Sciences at the University of Minnesota where he taught for 20 years before joining the NIA in 1984. During his tenure here he initiated and participated in the development of many research areas including: cellular senescence, oxidative stress, apoptosis, functional genomics, the intervention testing program, and premature aging models. He has published extensively on these and related topics, and he currently serves on the editorial board of Mechanisms of Ageing and Development, the Advisory Board for the Institute of Aging of the Canadian Institutes of Health Research, and is a fellow of the Gerontological Society of America.

Dr. Warner came to the NIA to manage the Molecular Biology Program in NIA's then Molecular and Cell Biology Branch within the Biomedical Research and Clinical Medicine Program (BRCM). While this Branch eventually evolved into the Biology of Aging Program (BAP), he also served as Branch Chief and Deputy Associate Director, and was ultimately named Associate Director of BAP in 2000. Dr. Warner has provided leadership through a time of unprecedented progress and excitement in the field of basic biology of aging, and the positive impact of his efforts will be a long-lasting legacy.

Dr. Richard Havlik, Chief of the Laboratory of Epidemiology, Demography and Biometery, retired in June 2004 after a long career at NIH. Dr. Havlik received his M.D. degree and did training in internal medicine at Northwestern University in Chicago. He then obtained a Masters in Public Health degree from Johns Hopkins School of Hygiene and Public Health. Dr. Havlik first came to NIH in 1968 as a research associate in the Epidemiology Branch at the National Heart, Lung, and Blood Institute (NHLBI). He also worked in the Coronary Drug Project and the Lipid Research Clinics Program. From 1980-1985, he served as the Chief of the Clinical and Genetic Epidemiology Section in NHLBI’s Epidemiology and Biometry Program. From 1985 to 1990, he was Special Assistant for Biomedical Applications at the National Center for Health Statistics. Dr. Havlik came to NIA as the Associate Director of the Epidemiology, Demography, and Biometry Program in 1990. When that program was designated as a Laboratory in 2001, he served as its Chief until his retirement. Dr. Havlik made numerous contributions to the fields of heart disease and aging and was elected to the American Epidemiologic Society in 1988.

At NHLBI, Dr. Havlik and colleagues detected the first signs of the decline in coronary heart disease mortality. He organized a high profile NIH conference on this landmark trend in public health and edited the NIH publication reporting the proceedings of this meeting. He was influential in the development of twins studies to evaluate genetic influences on coronary heart disease risk factors. At NIA, Dr. Havlik led a laboratory with a wide range of research interests in the epidemiology of chronic disease, disability, body composition, and dementia. He supported the development of several large epidemiologic studies that have had a substantial impact on aging research. He also continued to pursue his interest in cardiovascular risk factors in the older population and explored their impact on mortality and dementia. He led a highly innovative study that demonstrated that head trauma in World War II was predictive of Alzheimer’s Disease 50 years later.

Dr. Gerald Medoff has accepted the position of NIA's new Clinical Director. Dr. Medoff is a world renowned infectious disease specialist, with distinction in management of fungal diseases and AIDS. His prior position was with Washington University in St. Louis where he served over the past 30 years as Chief of the Division of Infectious Diseases, Vice-Chairman of the Department of Medicine, Senior Advisor to the Chairman of Medicine, and most recently Associate Chairman of Medicine for Hospital Affairs and Associate Chief Medical Officer of Barnes Jewish Hospital.

Dr. Medoff is a graduate of Columbia University. He attended medical school at Washington University, completed internal medicine training at Tufts and Boston University, and trained in Infectious Diseases at Massachusetts General Hospital. He then joined the senior staff at Washington University. He has a distinguished record of scholarly activity including over 200 papers and book chapters, service on editorial boards and advisory committees, and service on the Infectious Diseases Committee of the American Board of Internal Medicine, the National Institute of Allergy and Infectious Diseases (NIAID) AIDS Research Advisory Committee, and the Pharmacy and Therapeutics Committee of Blue Cross/Blue Shield.

In addition to his interest in infectious diseases and AIDS management, he will be participating in research studies on vaccine development and overseeing the Clinical Research Branch. He is also an outstanding teacher (a past winner of Washington University School of Medicine's Teacher of the Year award) and will assure the adherence to high standards of medical practice in our clinical research studies.

Dr. John Haaga joined the Behavioral and Social Research (BSR) Program as the Deputy Associate Director on October 17, 2004. His prior position was with the Population Reference Bureau where he was Director of the Domestic Programs Department and of the Center for Public Information on Population Research. In these roles he headed the department providing public information on U.S. population trends, including changes in the American family, migration to and within the United States, and the aging of the American population. He had previously served as Director of the National Academy of Sciences (NAS) Committee on Population and led research projects at the International Centre for Diarrhoeal Disease Research, Bangladesh, and the RAND Corporation. Dr. Haaga earned his Ph.D. at The RAND Graduate School of Policy Studies. He served as President of the Association of Population Centers 2003-2004, and as Secretary-Treasurer of the Population Association of America 1999-2002.

Ms. Linda Ingram joined BSR in September 2004 as a contract analyst and writer. She previously worked at the National Academy of Sciences where she analyzed various federal databases for the Committee on National Statistics, and worked with the Doctorate Record File for the Office of Scientific and Engineering Personnel. She has also worked on federal databases on child abuse and drug abuse.

Mr. Patrick Shirdon, has accepted the position as NIA Budget Officer, Financial Management Office. Mr. Shirdon has been NIA’s Acting Budget Officer while also serving as the Special Assistant to the Director, National Institute of Dental and Craniofacial Research (NIDCR). He has an M.S. degree in business from Johns Hopkins University. He was Deputy Budget Officer, NIDCR, and prior to that, he was a Budget Analyst in the NIH Office of Financial Management (OFM). He was recruited to NIH in 1992 through the Outstanding Scholars Program and participated in OFM's intern program.

Ms. Joan Starr joined the NIA Administrative Management Branch (AMB) as an Administrative Officer in October. She worked previously as an Office Manager for the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Office of Science Policy and Public Liaison (OSPPL).

Ms. Jane Shure, Communications Director of the NIA and head of the Institute’s Office of Communications and Public Liaison, left the Institute on November 1 to head communications at the American Chemical Society. Ms. Shure served as the “institutional memory” of NIA, becoming communications chief at the NIA’s founding in 1974. In that role, she informed both the public and the media about aging, about science, and about the implications of research for everyday life. She was at the helm of these outreach activities during both the formative and growth years of NIA, contributing extraordinary vision, intelligence, and energy to NIA’s mission.

Ms. Marta Campbell, Chief, Office of International Activities, left NIA on September 30. Ms. Campbell has been with NIA for more than a decade. She managed NIA’s international program, coordinated NIA’s technical assistance workshops, and represented NIA on women’s health issues trans-NIH.

Dr. Elisabeth Koss left NIA on November 15 to become a Scientific Review Administrator for the Risk, Prevention, and Health behavior Integrated Review Group, Center for Scientific Review. Prior to that, Dr. Koss was the Assistant Director of the Alzheimer’s Disease Centers Research Program in NIA’s NNA Program.

Ms. Arlene Jackson accepted the position as NIA IRP Recruitment Specialist effective December 13. In her new position, she will be responsible for recruitment activities for all pre-doctoral positions, managing the NIA Summer Program, facilitating data collection and analyses relating to IRP student recruitment activities, and developing and implementing trans-NIA workplace diversity initiatives.

Institute-Sponsored Meetings, Workshops, Conferences, and Public Information Activities

I. Meetings Held

Immunity and Aging

An NIA-sponsored exploratory workshop on Immunity and Aging was held on October 2-4, 2004, in Saranac Lake, NY. The purpose of the workshop was to discuss recent research advances in the field of immunosenescence. Gaps in our understanding of the mechanisms responsible for the decline in function of the immune system with age were highlighted and critical research areas that still need to be addressed were discussed during the course of the workshop. The workshop also allowed interactions between researchers working in different areas of immunology and aging. A report of this workshop is being prepared for publication in 2005 in Mechanisms of Aging and Development. (Contact: Dr. Rebecca Fuldner, BAP, Ph: 301-496-6402).

NIA Stem Cell Grantee Meeting

This exploratory meeting was organized by the NIA Stem Cell Working Group and was the second meeting of grantees in stem cell research and aging. The meeting was held November 8-10, 2004, in Bethesda, MD. Investigators exchanged information on recent research progress and discussed current issues in stem cell research as it relates to understanding aging and developing therapies for age-related conditions. Participants included investigators receiving grants awarded under the NIA RFA “Biology of Adult Stem Cells in Aging” as well as other NIA grantees and NIA intramural investigators working in adult stem cell research. (Contact: Dr. Jill L. Carrington, BAP, Ph: 301-496-6402).

Neural Interfaces Workshop

Neural Interfaces Workshop was held November 15-17, 2004, in Bethesda, MD. NIA, the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Institute of Child Health and Human Development (NICHD), and the National Institute on Deafness and Other Communication Disorders (NIDCD) contributed to this National Institute of Neurological Disorders and Stroke (NINDS)-sponsored workshop. This exploratory meeting combined, for the first time, the 35th Annual Neural Prosthesis Workshop and the annual meeting of the NIH Deep Brain Stimulation (DBS) Consortium, of which NIA is a member. The NIH Neural Prosthesis research community consists of investigators working in areas such as functional neuromuscular/electrical stimulation studies, auditory and cortical prostheses, microelectrode array technology, and brain-computer interface. The NIH DBS Consortium is a group of multidisciplinary researchers who explore DBS and its therapeutic applications, especially in relation to Parkinson’s Disease. Because the previous meetings of these two groups of investigators overlapped in both subject matter and attendees, a joint meeting was developed to enhance potential synergies and explore topics of common interest. Plenary sessions addressed Neural Information Processing, Auditory Prosthesis as a Paradigm for Successful Neural Interfaces, Optimal Systems Design for Neural Interfaces, Optimizing Material Tissue Interactions for Neural Interfaces, Deep Brain Stimulation: Theoretical and Clinical Considerations, Practical Considerations for Neural Interfaces, Future Potential for Neural Interfaces. (Contact: Dr. Judith A. Finkelstein, NNA, Ph: 301-496-9350, or jf119k@nih.gov)

The Monkey Caloric Restriction (CR) Grantee Meeting

The third annual exploratory meeting of the NIA monkey caloric restriction (RFA AG-02-002) grantees and Advisory Panel was held on November 18, 2004, in Bethesda. Participants included the grantees, Advisory Panel members, NIA IRP personnel involved with the Poolesville monkey caloric restriction colony, and relevant NIA program administrators from the BAP Systems Branch. The grantees reviewed their progress and discussed common issues, including nomenclature for designating age-groups, and depositing their data into the Primate Aging Database. The grantees and NIA IRP personnel noted excellent progress and collegial interactions in successfully integrating grantee requirements into the NIA monkey caloric restriction colony exam schedule. (Contacts: Dr. Frank Bellino, Dr. Jill Carrington, Dr. David Finkelstein, and Dr. Rebecca Fuldner, BAP, Ph: 301-496-6402).

NIH State-of-the-Science Conference on End-of-Life Research

NIA cosponsored the exploratory NIH State-of-the-Science Conference on End-of-Life Research on December 6-8, 2004. BSR staff collaborated with the Office of the Director’s (OD/NIH) Office of Medical Applications Research (OMAR) to plan and coordinate this conference. The conference addressed these questions: What defines the transition to end of life? What outcome variables are important indicators of the quality of the end-of-life experience for the dying person and for the surviving loved ones? What patient, family, and health care system factors are associated with improved or worsened outcomes? What processes and interventions are associated with improved or worsened outcomes? What are future research directions for improving end-of-life care? (Contact: Dr. Sid Stahl, BSR, Ph: 301-402-4156)

Senescent Cells and Their Environment

The NIA held an exploratory workshop on this topic on January 23-24, in Novato, CA. Issues discussed included the extent to which senescent cells might accumulate in aging organisms, and the role these cells might have on tissue physiology. The subject is particularly relevant at this time because the secretory pattern of senescent cells (at least fibroblasts) is considerably different from that from younger counterparts. In addition, the discovery that the senescent state can be achieved by a variety of means, and not just telomere attrition, indicate that such cells might exist in vivo in large enough numbers to be physiologically relevant. Recent developments in this field were discussed by current NIA grantees and investigators who might be recruited to aging research. The meeting objective was identify high priority and underdeveloped areas of research related to cell biology of aging. (Contact: Dr. Felipe Sierra, BAP, NIA, 301-496-6402).

II. Meetings Planned

NIH State-of-the-Science Conference on Management of Menopause-Related Symptoms

Women going through the menopause transition may experience a variety of symptoms, ranging from hot flashes, night sweats, and problems sleeping to loss of sexual desire, depression, vaginal dryness, and urinary and bleeding complaints. For some, the discomfort of symptoms greatly diminishes their quality of life. A careful examination of commonly used strategies for symptom management is urgently needed to identify options that will best control women’s symptoms and restore their quality of life. To address this need, the National Institute on Aging and the Office of Medical Applications of Research, of the National Institutes of Health, will sponsor an advisory State-of-the-Science Conference on Management of Menopause-Related Symptoms, March 21-23, 2005, in Bethesda, MD.

Objectives are to (1) review the nature of menopause-related symptomatology in the context of ovarian aging and senescence and the surrounding biologic, and psychosocial milieu of the menopause transition, (2) evaluate the efficacy, acceptability, safety and risk/benefit profile of various hormonal and non-hormonal approaches for ameliorating menopause-related symptoms and (3) identify opportunities for future research aimed at developing new strategies to treat menopause-related symptoms. This conference is intended for health care professionals and researchers interested in the aging of women at midlife, reproductive endocrinology, and menopause, as well as general practitioners, patients, their families, and interested members of the public. (Contact: Dr. Sherry Sherman, GCG, Ph: 301-496-6942)

Workshop on Behavioral and Social Multi-Level Interventions, Spring 2005

An exploratory workshop is proposed in preparation for a multi-level intervention initiative spanning a range of disability impacts. The workshop will address the policy areas that can affect the disability decline in the U.S. Scientists who have investigated behavioral change at various levels of analysis will be invited to present brief position papers that look at different levels of investigation, and to suggest research approaches to facilitate the integration of various levels of analysis. It is anticipated that the workshop will encourage participants to apply a broader approach to behavioral change than that of investigators operating independently. The November 2003 Harvard conference on “Small Interventions with Large Effects,” which featured research in economics, social psychology, and public health, will provide input to the proposed workshop. BSR has a tradition of supporting research on social and behavioral interventions, including exercise, cognitive maintenance, caregiving, and nutrition. Most behavior change interventions address the psychological or micro-level of analysis. Micro-level approaches to behavioral change, such as Resources for Enhancing Alzheimer's Caregiver Health (REACH) and Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE), are effective to a certain degree, although expensive to implement. Change induced at the community, institutional, structural, and even the societal level has been less often attempted and rarely combined with the micro approach in a systematic manner. Since the range of behaviors subject to potential multi-level amelioration is broad, BSR will focus on disability as assessed by activities of daily living (ADL) and independent activities of daily living (IADL) measures, an area already well established by ongoing BSR support as subject to potential change. (Contact: Dr. Sid Stahl, BSR, Ph: 301-402-4156)

Signaling Defects in Aging Immune System

An exploratory workshop on Signaling Defects in Aging Immune System is being planned for April, 2005. There have been several reports that noted defects and/or delays in the activation of cell signaling pathways in T lymphocytes as well as other cell types of the immune system with age. The purpose of this workshop is to explore what is known about alterations of the lipid domains of the membrane with aging and how these changes might affect cell signaling pathways in different cell types. Although there have been a few reports in the literature that the plasma membrane microviscosity changes with age, there has not been a focus on how and when such changes occur and how these changes would affect downstream signaling cascades. Therefore, several investigators with expertise in lipid chemistry, membrane lipid domains and signaling pathways will be brought together to discuss the current state of knowledge of the field and research opportunities for the future. (Contact: Dr. Rebecca Fuldner, BAP, NIA, 301-496-6402).

General Information/Staff Awards

New Publications

Federal Interagency Forum on Aging-Related Statistics. Older Americans 2004: Key Indicators of Well-Being. Federal Interagency Forum on Aging-Related Statistics. Washington, DC: USGPO, November 2004.

National Research Council. Critical Perspectives on Racial and Ethnic Differences in Health in Late Life. N.B. Anderson, R.A. Bulatao, and B. Cohen (eds). Panel on Race Ethnicity, and Health in Later Life. Committee on Population, Division of Behavioral and Social Sciences and Education. Washington, DC: The National Academies Press, 2004.

National Research Council. Understanding Racial and Ethnic Differences in Health in Late Life: A Research Agenda. R.A. Bulatao and N.B. Anderson (eds.). Panel on Race, Ethnicity, and Health in Later Life. Committee on Population, Division of Behavioral and Social Sciences and Education. Washington, DC: The National Academies Press, 2004.

Journal of Aging and Health. Supplemental Issue: Increasing the Participation of Older Minorities in Health Research.Supplement to Volume 16, Number 5, November 2004. Sage Publications.

The following new NIA publications were made available:

  • Working with Your Older Patient: A Clinician’s Handbook
  • Shingles Age Page
  • 2003 Progress Report on Alzheimer’s Disease
  • Conversando con su Medico (Talking with your Doctor – Spanish)
  • Connections, Vol. 12, No. 2

The following NIA publications were updated or reprinted:

  • NIA Publications (on CD-ROM)
  • NIA Age Pages (on CD-ROM)
  • ADC Program Directory
  • AD Fact Sheet
  • AD Genetics Fact Sheet
  • Caregiver Guide
  • Exercise Guide
  • Exercise Video
  • Dealing with Diabetes Age Page
  • Depression Age Page
  • Older Drivers Age Page
  • Getting Your Affairs in Order Age Page
  • HIV/AIDS Age Page
  • Preventing Falls and Fractures Age Page
  • Stroke Age Page

NIA publications are available online at www.niapublications.org. (Contact: Ms. Vicky Cahan, OCPL, Ph: 301-496-1752)

NIHSeniorHealth

NIHSeniorHealth was the only web site to receive an Industry Innovators award from the International Council on Active Aging (ICAA). Trophies were presented to NIA and the National Library of Medicine (NLM) at the ICAA’s Active Aging 2004 Conference in Orlando, Florida, on November 11. In December, two new topics were released: Diabetes (in cooperation with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and Taking Medicines (in cooperation with the National Institute of General Medical Sciences [NIGMS]). Visit NIHSeniorHealth online at www.NIHSeniorHealth.gov. (Contact: Ms. Vicky Cahan, OCPL, Ph: 301-496-1752)

Presentations/Exhibits/Projects

On September 28, the Institute sponsored a briefing for health and financial media on the “Health and Wealth in an Aging America.” The briefing, held in NYC, featured research supported by the Behavioral and Social Research Program. Speakers included Dana Goldman of RAND, Anne Case of Princeton, Jonathan Skinner of Dartmouth, James P. Smith of RAND, David Laibson of Harvard, and Nobel Laureate Daniel Kahneman of Princeton. (Contact: Ms. Vicky Cahan, OCPL, Ph: 301-496-1752)

On October 13, the Institute, with private partners under the aegis of the Foundation for NIH, announced to the media and public the start of the Alzheimer’s Disease Neuroimaging Initiative. The event, in conjunction with the annual American Medical Association’s (AMA) Science Reporters Conference, featured remarks by Dr. Hodes and the Principal Investigator of the Initiative, Michael Weiner, from the Veterans Affairs Medical Center and University of California, San Francisco. The announcement was widely covered in the media. (Contact: Ms. Vicky Cahan, OCPL, Ph: 301-496-1752)

Press Releases

From July through November, OCPL distributed 13 press releases on topics ranging from the discovery of gene mutations for Parkinson’s Disease to the establishment of new demography centers. The releases generated over 835 clips in print and internet outlets reaching more than 62.5 million people. The most current NIA press releases can be found online at http://www.nia.nih.gov/NewsAndEvents/PressReleases/. (Contact: Ms. Vicky Cahan, OCPL, Ph: 301-496-1752)

New Notices and Initiatives Relevant to the National Institute on Aging (NIA)

Excerpts from the NIH GUIDE—from September 2, 2004—December 30, 2004 Includes Notices and Initiatives, (Requests for Applications (RFAs) and Program Announcements (PAs), published since the October 2004 Council presentation of the Director’s Status Report (DSR) to the National Advisory Council on Aging (NACA). Also check our NIA website for “Current Funding Opportunities” (Shown here are selected Notices relevant to NIA and selected Initiatives.)

Notices

(Notices are sorted by release date. Most recent notices are at the end of this list.)

  1. NIH Announces New Address for Centralized Receipt of Progress Reports Due on/after October 1, 2004
    Release Date: September 2, 2004
    Notice Number: NOT-OD-04-063 (see follow-up notice, NOT-HS-05-004) http://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-063.html

    This Notice updates Notice OD-04-054 published July 23, 2004. As stated in that Notice, effective with non-competing progress reports due on/after October 1, 2004, NIH is centralizing receipt and initial processing of all NIH non-competing progress reports. The new centralized mailing address for all NIH Institutes/Centers (IC) is now:

    Division of Extramural Activities Support, OER
    National Institutes of Health
    6705 Rockledge Drive, Room 2207, MSC 7987
    Bethesda, MD 20892-7987 (for regular or US Postal Service Express mail)
    Bethesda, MD 20817 (for other courier/express mail delivery only)
    Phone Number: (301) 594-6584

  2. Doubly Labeled Water Central Laboratory for Clinical Trials of Caloric Restriction
    Release Date: September 3, 2004
    Notice Number: NOT-AG-04-007
    http://grants.nih.gov/grants/guide/notice-files/NOT-AG-04-007.html

    The National Institute on Aging (NIA) is conducting a set of human intervention studies collectively titled “Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE).” Measurement of total energy expenditure (TEE) is an important component of CALERIE, and is being performed using the doubly-labeled water (DLW) technique. The NIA is interested in identifying laboratories that are capable of preparing and/or analyzing substantial numbers of samples on an ongoing basis with short turnaround time, experienced in working with outside clinics, and able to provide high quality DLW results. Response Due Date was November 10, 2004. 
  3. Enhanced Public Access to NIH Research Information
    Release Date: September 3, 2004
    Notice Number: NOT-OD-04-064 (Also see NOT-OD-04-070)
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-064.html


    NIH's mission includes a long-standing commitment to share and support public access to the results and accomplishments of the activities that it funds. Establishing a comprehensive, searchable electronic resource of NIH- funded research results and providing free access to all, is perhaps the most fundamental way to collect and disseminate this information. The NIH has established and intends to maintain a dialogue with publishers, investigators, and representatives from scientific associations and the public to ensure the success of this initiative. This notice is to announce and to seek public comments regarding NIH's plans to facilitate enhanced public access to NIH health related research information. The comments period was extended to November 16, 2004 per NOT-OD-04-070.)
  4. Notice on NIA Policies Regarding Acceptance of Applications for Clinical Trials
    Release Date: September 8, 2004
    Notice Number: NOT-AG-04-008
    http://grants.nih.gov/grants/guide/notice-files/NOT-AG-04-008.html

    This notice involves information on the criteria by which the NIA decides to accept or decline clinical trial applications. Potential applicants may not be aware of ongoing similar or identical studies if no reports from these studies have been presented or published, persons considering submission of an application for a Phase 1, 2, or 3 clinical trial in a research area administered by NIA are strongly encouraged to contact NIA staff well in advance of the date that they would wish to submit an application.

  5. Compliance With the NIH Guidelines for Research Involving Recombinant DNA Molecules
    Release Date: September 14, 2004
    Notice Number: NOT-OD-04-067
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-067.html


    The NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines) stipulate biosafety and containment measures for recombinant DNA research. Furthermore, they outline essential ethical principles and key safety reporting requirements for human gene transfer research. Requirements for human gene transfer trials - Investigators conducting human gene transfer research at, or sponsored by, an institution that receives NIH support for recombinant DNA research must comply with Appendix M of the NIH Guidelines. Appendix M outlines points to consider in the design and submission of these protocols to OBA. Under Appendix M, investigators conducting trials subject to the NIH Guidelines must register their protocols with OBA and provide certain information about the trials for review by the NIH and, possibly, the NIH Recombinant DNA Advisory Committee. Questions can be directed to: Allan C. Shipp - Email: oba@od.nih.gov

  6. Extension of Receipt Dates for NIDDK Pilot and Feasibility Program in Kidney Diseases (PA-01-127)
    Release Date: September 22, 2004
    Notice Number: NOT-DK-04-017
    http://grants.nih.gov/grants/guide/notice-files/NOT-DK-04-017.html


    This notice is to inform potential applicants that the program announcement for the NIDDK PILOT AND FEASIBILITY PROGRAM IN KIDNEY DISEASES at http://grants.nih.gov/grants/guide/pa-files/PA-01-127.html will remain active until October 1, 2005, unless replaced prior to that time by a subsequent program announcement.

  7. Addendum to PAR-03-118
    Release Date: September 23, 2004
    Notice Number: NOT-TW-04-003
    http://grants.nih.gov/grants/guide/notice-files/NOT-TW-04-003.html


    PAR-03-118, Global Health Research Initiative Program for New Foreign Investigators (GRIP), was published in the NIH Guide on May 16, 2003. The FIC and partner Institutes and Offices are expanding the eligibility criteria for this announcement.

  8. Extension of Bioengineering Research Grant (BRG) Program Announcement (PA-02-011)
    Release Date: October 08, 2004
    Notice Number: NOT-EB-04-003
    http://grants.nih.gov/grants/guide/notice-files/NOT-EB-04-003.html


    This notice is to inform potential applicants that the program announcement for the BIOENGINEERING RESEARCH GRANTS at http://grants.nih.gov/grants/guide/pa-files/PA-02-011.html will remain active until March 1, 2005, unless replaced prior to that time by a subsequent program announcement. New applications in response to the current Program Announcement will be accepted on the February 1, 2005, deadline. Revised applications will be accepted on the March 1, 2005, deadline.

  9. NIH Announces Updated Criteria for Evaluating Research Grant Applications
    Release Date: October 12, 2004
    Notice Number: NOT-OD-05-002
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-002.html


    The goal of the NIH Roadmap is to accelerate and strengthen biomedical research enterprise. During consultation with the extramural scientific community that led to the development of the NIH Roadmap process, it was frequently mentioned that the criteria used to evaluate research grant applications were not placing appropriate emphasis on some important types of biomedical research (see http://nihroadmap.nih.gov/). The Roadmap Trans-NIH Clinical Research Workforce Committee proposed a modification of the NIH Peer Review Criteria for investigator-initiated research grant applications that would better accommodate interdisciplinary, translational, and clinical projects. The updated review criteria were adopted at the August 5, 2004 meeting of the Directors of the NIH Institutes and Centers. According to the schedule shown below, the updated criteria will replace the review criteria adopted on June 27,1997 (see http://grants.nih.gov/grants/guide/notice-files/not97-010.html).

  10. Review of Ranking Data
    Release Date: October 29, 2004
    Notice Number: NOT-OD-05-008
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-008.html

    Ranking Information: The ranking tables include data from both grants and contracts. Information reflects data available in the NIH system at the end of the fiscal year. This notification is to advise your organization that the National Institutes of Health (NIH) “Awards by State and Foreign Site” Fiscal Year 2004 Grant Data has been expanded to show Medical School detail. The CSV (Comma Separated Value) file format has been updated to include several new columns specific to Medical Schools. A “medical school grant flag” has been created. This column is marked ‘Y' when the grant is attributed to your Medical School for ranking purposes. In some cases Medical School Name and Medical School Location are combined.

  11. NIH Announces Revised Policy: Applications that Include Consortium/Contractual Facilities and Administrative Costs
    Release Date: November 02, 2004
    Notice Number: NOT-OD-05-004
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-004.html

    This Notice supersedes Notice NOT-OD-04-040 “Change in Direct Cost Limitations on Solicited Applications,” and broadens the scope of the policy change to apply to all applications involving consortium/contractual facilities and administrative (F&A) costs, regardless of amount of budget or budget format (e.g., modular and non-modular). This change is effective for applications that have submission/receipt dates on or after December 1, 2004. This policy applies to all solicited and investigator-initiated applications. For solicited applications, this policy change now applies to all currently active announcements (Request for Applications and Program Announcements), regardless of the announcement issue date. This policy is particularly relevant to all applications that include a limitation on direct costs. While consortium F&A costs will continue to be requested and awarded, applicants will now separate these costs when determining if a budget exceeds a direct cost limit. This policy impacts eligibility to submit a modular budget. If you have questions on this Notice, please contact the Grants Management Specialist listed in the RFA/PA, or the Division of Grants Policy at (301) 435-0949.

  12. Revised PHS 2590 (Non-Competing Grant Progress Report) Now Available
    Release Date: November 02, 2004
    Notice Number: NOT-OD-05-007
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-007.html

    Progress Reports using the newly revised “U.S. Department of Health and Human Services Public Health Service Non-Competing Grant Progress Report” (PHS 2590, rev. 9/04) instructions and forms will be accepted immediately. All progress reports received on or after May 1, 2005 must use the new version. The newly revised instructions and forms are available at http://grants.nih.gov/grants/forms.htm. The forms available on the website continue to be provided in two formats—MS Word and PDF-fillable using Adobe Acrobat Reader Software. Free Adobe Software may be accessed at http://www.adobe.com/products/acrobat/readstep.html. Grantees are strongly encouraged to access the instructions and forms via the Internet because they provide valuable links to current policy documents and allow easy navigation of the instructions. For further information, contact GrantsInfo@nih.gov. General inquires about the changes to the actual form pages and instructions may be directed to: Division of Grants Policy, Office of Policy for Extramural Research Administration, Email: GrantsPolicy@od.nih.gov

  13. Revised PHS 2271, PHS 3734, and HHS 568 Forms Now Available
    Release Date: November 02, 2004
    Notice Number: NOT-OD-05-005
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-005.html

    NIH announces the availability of three revised (9/2004) forms: 1) PHS 2271 (Statement of Appointment); 2) PHS 3734 (Official Statement Relinquishing Interest and Rights in a PHS Research Grant); 3) HHS 568 (Final Invention Statement and Certification). The newly revised forms and instructions are available at http://grants.nih.gov/grants/forms.htm. The forms continue to be provided in two electronic formats—MS Word and PDF-fillable using Adobe Acrobat Reader Software. Free Adobe Software may be accessed at http://www.adobe.com/products/acrobat/readstep.html.

  14. Revised PHS 398 (DHHS Public Health Service Grant Application) Now Available
    Release Date: November 02, 2004
    Notice Number: NOT-OD-05-006
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-006.html

    The newly revised “Application for a DHHS Public Health Service Grant” (PHS 398, rev. 9/04) instructions and forms are now available and will be accepted for submission/receipt dates on or after December 1, 2004. All applications received on or after May 10, 2005 must use the new instructions and forms. During the transition period, applications using the previous version (rev. 5/01) of the PHS 398 will be accepted through May 9, 2005. However, after this date, applications submitted using instructions and forms other than the PHS 398 (rev 9/04) will be returned to the applicant.

  15. Prevalence and Co-Occurrence of Conditions Possibly Related to Low Testosterone Levels in Older Men
    Release Date: November 3, 2004
    Notice Number: NOT-AG-05-001
    http://grants.nih.gov/grants/guide/notice-files/NOT-AG-05-001.html

    NIA has issued a Request for Applications (RFA) for planning and protocol development for a coordinated set of clinical trials on the efficacy and safety of testosterone treatment in older men for specific symptomatic conditions that may be related to low testosterone levels. This RFA is available at http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-05-005.html. The planning project will begin in 2005; the trials are expected to begin in 2006. The symptomatic conditions for which efficacy of testosterone treatment may be tested are in four domains: weakness/frailty/disability, sexual dysfunction, cognitive dysfunction, and impaired vitality/well-being/quality of life. Before and during the planning phase for these trials, the NIA is interested in obtaining additional information regarding the availability of data on the prevalence in older men of conditions in these domains, and of specific combinations of conditions in two or more domains (e.g., coexisting sexual dysfunction and cognitive dysfunction). Information on the relationship of these prevalences to differing levels of testosterone (e.g., in men with circulating testosterone levels greater than, vs. less than, 320 ng/dl) would be particularly useful. Response Due Date: January 28, 2005.

  16. Addendum to PAR-03-106: Innovations in Biomedical Computational Science and Technology
    Release Date: November 18, 2004
    Notice Number: NOT-GM-05-101
    http://grants.nih.gov/grants/guide/notice-files/NOT-GM-05-101.html

    The NIA is participating in this announcement. This addendum is to inform potential applicants that the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), is participating in this announcement also.

  17. Reminder: Program Announcement Needed to Identify R03 and R21 Applications
    Release Date: November 24, 2004
    Notice Number: NOT-OD-05-010
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-010.html

    In 2003, NIH standardized many features of the small grant (R03) and exploratory/developmental research grant (R21) to accommodate investigator-initiated applications (websites listed below under Inquiries). However, many Institutes and Centers (ICs) do not accept R03 applications, and many accept R21 applications only in response to specific funding opportunities. Applicants have been advised that R03 or R21 applications assigned to an IC that does not participate may be withdrawn from the review process. The NIH uses the information provided on line 2 of PHS 398 to correctly identify R03 and R21 applications. The cooperation of applicants is needed in providing this important information. The inclusion of this information will also ensure that the text of the appropriate Program Announcement is provided to the review group.

  18. Extension of Expiration Date for Various Research Career Development ("K") Program Announcements
    Release Date: December 2, 2004
    Notice Number: NOT-OD-05-011
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-011.html

    The Office of Extramural Research gives notice of the extension of the expiration dates for the following Program Announcements: PA-00-003 Mentored Clinical Scientist Development Award (K08) published 10/8/99, (http://grants.nih.gov/grants/guide/pa-files/PA-00-003.html) PA-00-004 Mentored Patient-Oriented Research Career Development Award (K23) published 10/8/99, (http://grants.nih.gov/grants/guide/pa-files/PA-00-004.html) PA-00-019 Mentored Research Scientist Development Award (K01) published 12/2/99, (http://grants.nih.gov/grants/guide/pa-files/PA-00-019.html) PA-00-020 Independent Scientist Award (K02) published 12/2/99, (http://grants.nih.gov/grants/guide/pa-files/PA-00-020.html) PA-00-021 Senior Scientist Award (K05) published 12/2/99, (http://grants.nih.gov/grants/guide/pa-files/PA-00-021.html) The above announcements remain active until revisions can be issued in 2005. Please note that the PHS 398 application form has been recently revised. The new form is available at: http://grants.nih.gov/grants/forms.htm. Interested applicants are encouraged to contact the program staff person listed in the relevant announcement prior to submission.

  19. Announcing the NIA Aged Non-Human Primate Tissue Bank
    Release Date: December 3, 2004
    Notice Number: NOT-AG-05-002
    http://grants.nih.gov/grants/guide/notice-files/NOT-AG-05-002.html

    This notice announces a new resource for investigators in the field of aging research. The NIA Aged Non-human Primate Tissue Bank provides a repository of tissue from aged non-human primates (NHP) for use in research. Some tissue from middle-aged and young NHP will also be available soon. The tissues are donated by NIA-supported NHP colonies and other NHP colonies such as the National Primate Research Centers. The goal of the NIA Non-human Primate Tissue Bank is to archive tissue that might otherwise be discarded, and provide that tissue to investigators undertaking research on normal aging and age-related diseases. Further information is available at: http://www.nia.nih.gov/ResearchInformation/ScientificResources/NHPTissueBankHandbook.htm. For information on availability of tissue, contact Tracy Cope, copet@nia.nih.gov.

  20. Reminder of Financial Conflict of Interest Requirements for All NIH-Supported Institutions
    Release Date: December 6, 2004
    Notice Number: NOT-OD-05-013
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-013.html

    This Notice is intended as a reminder of the financial conflict of interest (FCOI) requirements for all institutions and contractors that receive from the National Institutes of Health (NIH) grants or contract support to conduct research. Although the FCOI requirements summarized here are longstanding, the world of scientific collaboration has changed and is continuing to change very quickly. New and more complex types of relationships are emerging and with them potential FCOIs. In light of these evolving financial relationships, institutions and contracting organizations that receive NIH support to conduct research are hereby reminded of the requirement to identify and manage the FCOIs of all NIH-supported investigators and to comply with the associated reporting requirements.

  21. NIH Establishes Website for New Investigators
    Release Date: December 10, 2004
    Notice Number: NOT-OD-05-014
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-014.html

    The Office of Extramural Research (OER), NIH, announces the posting of a new website that articulates NIH's continuing commitment to new investigators (see http://grants.nih.gov/grants/new_investigators/index.htm). The website describes current policies, data related to the influx of new investigators, resources that new investigators can use to understand and work with the NIH, and helpful hints that might be useful in constructing a first application for NIH support. The OER solicits additional suggestions for non-commercial content for this website. Visitors who know of additional resources can send suggestions to OEPMailbox@mail.nih.gov.

  22. Request for Information (RFI): NIH Knockout Mouse Inventory Project
    Release Date: December 10, 2004
    Notice Number: NOT-OD-05-015
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-015.html

    Information Requested An international meeting held in the autumn of 2003 and recently reported in Nature Genetics (Austin et al., Nature Genetics, September 2004; 36(9): 921-924) recommended that a public resource project be initiated to create a null mutation for every protein-coding gene in the mouse genome to take advantage of the demonstrated power of “knockout” mice to elucidate gene function. Investigators who have constructed mouse knockouts and/or mutant ES cell lines are invited to provide the NIH with information about their constructs, and may do so readily at www.informatics.jax.org/mgihome/submissions/knockout_inventory.shtml.

  23. Additional Receipt Dates for Bioengineering Research Partnerships (PAR-04-023)
    Release Date: December 16, 2004
    Notice Number: NOT-EB-04-005
    http://grants.nih.gov/grants/guide/notice-files/NOT-EB-04-005.html

    This notice is to inform potential applicants of a change in receipt dates for applications in response to http://grants.nih.gov/grants/guide/pa-files/PAR-04-023.html, “Bioengineering Research Partnerships.” Beginning with the January 20, 2005, application receipt date, there will be three application receipt dates per year instead of the two specified in the original program announcement. The reasons for this change are to (1) reduce delays between application receipt and advisory council consideration and (2) provide more timely opportunities to revise and resubmit reviewed applications. Receipt dates for letters of intent are two months prior to the application deadlines. New receipt dates for BRP applications and letters of intent are: Application receipt dates: January 20, 2005; May 20, 2005; September 20, 2005; January 20, 2006; and May 22, 2006.

  24. NIH Implementation of Office for Human Research Protections (OHRP) Guidance on Research Involving Coded Private Information or Biological Specimens
    Release Date: December 30, 2004
    Notice Number: NOT-OD-O5-020
    http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-020.html

    On August 10, 2004, the Office for Human Research Protections (OHRP), Department of Health and Human Services, issued Guidance on Research Involving Coded Private Information or Biological Specimens, available at http://www.hhs.gov/ohrp/humansubjects/guidance/cdebiol.pdf. The OHRP guidance, which was addressed to Institutional Review Boards (IRBs), investigators, and funding agencies, affects the way the NIH and applicant institutions process applications involving coded private information or human biological specimens. This Notice explains changes that NIH has made to grant application and contract proposal instructions to reflect the OHRP Guidance. This Notice is a follow-up to NOT-OD-04-069 (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-069.html), published September 17, 2004. Please note that the information in the PHS 398 grant application is to be used by investigators and peer reviewers to help determine the applicability of the OHRP Guidance to the proposed research. The information provided does not redefine or reinterpret OHRP's Guidance. Should questions about the applicability of the OHRP Guidance arise, NIH will consult with OHRP before making a determination. All new and competing continuation grant applications and non-competing grant progress reports (Type 5) involving coded private information or biological specimens submitted to NIH on or after January 10, 2005 should follow the revised instructions outlined in the PHS 398. Although use of the 9/2004 version of the PHS 398 (http://grants.nih.gov/grants/funding/phs398/phs398.html) is not mandatory until May 10, 2005, this version includes detailed instructions to help applicants to apply the OHRP guidance. To minimize confusion in application preparation, applicants are urged to use this new version for applications impacted by this guidance.

Initiatives

(Initiatives are sorted by release date. Most recent initiatives are at the end of this list.)

  1. Collaborative Studies on Alzheimer and Related Diseases
    Release Date: September 2, 2004
    RFA Number: RFA-AG-05-006
    http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-05-006.html

    Application Receipt Date: December 21, 2004

    Research Objectives: The NIA and NINDS encourage wider use of data and samples generated by grants supported by the institute(s) including the Alzheimer’s Disease Centers (ADCs). The purpose of this RFA is to accelerate collaborative cross-disciplinary and multi-institutional approaches that will contribute new and vital information about the clinical and pathological course of normal aging and the neurodegenerative diseases associated with aging. The project must use the National Alzheimer’s Coordinating Center (NACC) http://www.alz.washington.edu/ for expert advice on planning, study design, and also utilize NACC for statistical analyses and data management during conduct of the research projects.

    Direct your questions about scientific/research issues, Alzheimer’s Centers and relationships with NACC to: Creighton H. Phelps, Ph.D.
    Program Director, Alzheimer’s Disease Centers
    Neuroscience and Neuropsychology of Aging
    National Institute on Aging
    Gateway Building, Suite 350
    Bethesda, MD 20892-9205
    Telephone: (301) 496-9350
    FAX: (301) 496-1494
    Email: phelpsc@nia.nih.gov

  2. Bioengineering Approaches to Energy Balanace and Obesity (SBIR/STTR)
    Release Date: September 3, 2004
    PA Number: PA-04-156
    http://grants.nih.gov/grants/guide/pa-files/PA-04-156.html

    Application Receipt Dates: Applications submitted in response to this program announcement will be accepted at the standard application deadlines (April 1, August 1, December 1) through August 1, 2007.

    Research Objectives: The purpose of this PA is to solicit applications to develop and validate new and innovative bioengineering technology to address clinical problems related to energy balance, intake, and expenditure. Novel sensors, devices, imaging, and other approaches are expected to be developed and evaluated by collaborating engineers, physical scientists, and scientists from other relevant disciplines with expertise in obesity and nutrition. The goal is to increase the number of useful technologies and tools available to scientists to facilitate their research in energy balance and health. Eventually these research tools should facilitate therapeutic advances and behavioral changes to address such problems as weight control and obesity.

    Direct your questions about scientific/research issues to:
    Winifred K. Rossi, M.A.
    Special Assistant for Planning Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    NIH, DHHS
    7201 Wisconsin Avenue, Suite 3C307
    Bethesda, Maryland 20892-9205 (Express: 20814)
    Telephone: 301-496-3836
    Fax: 301-402-1784
    Email: rossiw@nia.nih.gov

  3. Ancillary Studies to the AD Neuroimaging Initiative
    Release Date: September 20, 2004
    PA Number: PA-04-158
    http://grants1.nih.gov/grants/guide/pa-files/PA-04-158.html

    Application Receipt Dates: October 1, February 1, June 1 (a month later for amended applications) http://grants1.nih.gov/grants/funding/submissionschedule.htm

    Research Objectives: The purpose of this PA is to invite research grant applications for ancillary studies to the Alzheimer’s Disease Neuroimaging Initiative (ADNI), RFA-AG-04-005. The purpose of the ADNI is to develop a multi-site, longitudinal, prospective, naturalistic study of normal cognitive aging, mild cognitive impairment (MCI), and early Alzheimer's disease (AD) as a public domain research resource to facilitate the scientific evaluation of neuroimaging (magnetic resonance imaging [MRI], positron emission tomography [PET]), and other biomarkers for the onset and progression of MCI and AD. The ADNI will collect, process, and store serial blood, CSF, and urine samples in the three groups of subjects for analyses for potential biomarkers of disease progression, including genomic, proteomic, and metabolomic markers that can be correlated with clinical, neuropsychological, and imaging data. Immortalized cell lines will also be established.

    Direct questions related to NIA interests and issues to:
    Susan Molchan, M.D.
    Program Director, Alzheimer's Disease Clinical Trials
    Neuroscience and Neuropsychology of Aging Program
    National Institute on Aging
    Gateway Bldg., Suite 350
    7201 Wisconsin Ave.
    Bethesda, MD 20892-9205
    Telephone: (301) 496-9350
    FAX: (301) 496-1494
    Email: molchans@mail.nih.gov

  4. Bioengineering Approaches to Energy Balance and Obesity
    RFA Number: RFA-HL-04-022
    http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-04-022.html
    Release Date: September 20, 2004

    Application Receipt Date: February 16, 2005

    Research Objectives: The objective of this RFA is to encourage and enable bioengineering teams to develop and evaluate new technologies, instrumentation, and medical devices to better assess appropriate biomedical parameters and provide feedback and/or therapy to reduce the prevalence of obesity and overweight. Development of new technologies and application of existing technologies may be proposed. Examples of relevant technologies include, but are not limited to, imaging, diagnostic and therapeutic devices, direct and remote sensors, meters, micro-transmitters, and biomaterials. Studies may include use of animal models and/or human participants, but are not required to do so. If appropriate, plans for manufacturing and clinical evaluation of developed instrumentation and medical devices should be included in the application.

    Direct your questions about scientific/research issues to:
    Winifred K. Rossi, M.A.
    Special Assistant for Planning
    Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    7201 Wisconsin Avenue, Suite 3C307
    Bethesda, MD 20892-9205 (Express: 20814)
    Telephone: 301-496-3836
    Fax: 301-402-1784
    Email: rossiw@nia.nih.gov

  5. Manufacturing Processes of Medical, Dental, and Biological Technologies (SBIR/STTR)
    Release Date: September 29, 2004
    PA Number: PA-04-161
    http://grants.nih.gov/grants/guide/pa-files/PA-04-161.html

    Application Receipt Date(s): Applications submitted in response to this program announcement will be accepted at the standard application deadlines [April 1, August 1, December 1]

    Research Objectives: This initiative encourages research related to advanced processing in the manufacture of biomedical products and the implementation of new technologies in medical care. New methods, procedures, measures, and controls are needed for manufacturing a broad range of technologies and products with unsurpassed quality and to lower manufacturing costs for existing and/or new processes. Research is also encouraged that can contribute to the containment and reduction of health care costs and that can improve the cost effectiveness, quality, and accessibility of the health care system.

    Direct your questions about scientific/research issues to:
    Michael-David Kerns, Ph.D.
    National Institute on Aging
    Gateway Building, Room 2C218
    7201 Wisconsin Avenue
    Bethesda, MD 20892-9205
    Telephone: (301) 496-9322
    FAX: (301) 402-2945
    Email: kernsm@mail.nih.gov

  6. Improving Measurement Tools for Sternal Skin Conductance and Hot Flashes: Phase I SBIR
    Release Date: September 29, 2004 (See NOT-AT-05-001)
    RFA Number: RFA-AT-05-005
    http://grants.nih.gov/grants/guide/rfa-files/RFA-AT-05-005.html

    Application Receipt Date: January 25, 2005

    Research Objectives: This initiative invites Phase 1 small business grant applications to conduct research to improve measurement tools or devices for sternal skin conductance. Sternal skin conductance devices have been used to monitor hot flashes, but existing tools are limited in the amount of data that they can collect and their utility under ambulatory conditions. Improved measurement tools that are reliable, user-friendly, reasonably priced, and can collect data for extended periods of time are needed to evaluate the efficacy of various therapies, including complementary and alternative medicine (CAM) modalities, to reduce hot flashes under unsupervised, ambulatory conditions in clinical studies.

    Direct your questions about scientific/research issues to:
    Sherry Sherman, Ph.D.
    Director, Clinical Aging and Reproductive Hormone Research
    National Institute on Aging
    NIH Gateway Building, Suite 3C-307
    7201 Wisconsin Ave.
    Bethesda, MD 10892-9205 (Courier/Express Mail ZIP is 20814)
    Telephone: (301) 435-3048
    FAX: (301) 402-1784
    Email: shermans@mail.nih.gov

  7. Planning Project for Testosterone Trials in Aging Men
    Release Date: October 12, 2004
    RFA Number: RFA-AG-05-005 (See NOT-AG-05-001)
    http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-05-005.html

    Application Receipt Date: January 11, 2005

    Research Objectives This initiative invites applications for planning and protocol development for a coordinated set of clinical trials of the efficacy and safety of testosterone treatment in older men for specific symptomatic conditions that may be related to low testosterone levels, and of effects of testosterone treatment in middle-aged men on outcomes and risk factors possibly related to low testosterone levels. The award will support planning activities, biostatistical and other data.

    Direct your questions about scientific/research issues to:
    Sergei V. Romashkan, M.D., Ph.D.
    Clinical Trials Branch
    Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    7201 Wisconsin Avenue, Suite 525A
    Bethesda, MD 20892-9205 (Fed Ex Packages use ZIP 20814)
    Telephone: 301-435-3047
    Fax: 301-480-1066
    Email: romashks@nia.nih.gov

  8. Research on the Economics of Diet, Activity, and Energy Balance
    Release Date: October 25, 2004
    PA Number: PA-05-009
    http://grants.nih.gov/grants/guide/pa-files/PA-05-009.html

    Application Receipt Dates: http://grants.nih.gov/grants/funding/submissionschedule.htm

    Research Objectives: This PA is intended to make funding opportunities in the area of energy balance (i.e., the relationship between diet, physical activity, and obesity) known to researchers with expertise and experience in health economics and health services research who might otherwise not be aware of the opportunity to apply these disciplines to this area. This PA also aims to foster collaborative activities between researchers from these disciplines and more traditional researchers of cancer and other chronic diseases. Research areas supported by this PA include: consumer economics, industrial organization, community structure, policy, cost-effectiveness/cost benefit studies. A multidisciplinary research approach that integrates economics research in one or more of these areas with knowledge and methodologies from other social and behavioral sciences, and/or with epidemiological and clinical research is strongly encouraged (Hill 2004).

    Direct your questions about scientific/research issues to:
    John W. R. Phillips, Ph.D.
    Behavioral and Social Research Program
    The National Institute on Aging
    7201 Wisconsin Avenue
    Gateway Building, Room 533, MSC 9205
    Bethesda, MD 20892-9205
    Telphone: (301) 496-3138
    Fax: (301) 402-0051
    Email: phillipj@nia.nih.gov

  9. Research Supplements To Promote Diversity in Health-Related Research
    Release Date: November 19, 2004
    PA Number: PA-05-015
    http://grants.nih.gov/grants/guide/pa-files/PA-05-015.html

    Application Receipt Dates(s): Applications can be received at any time Research Objectives

    The NIH hereby notifies all Principal Investigators holding any of the NIH research grants (listed below) that funds are available for administrative supplements to support and recruit students, postdoctorates, and eligible investigators. Administrative supplements must support work within the scope of the original project. Principal Investigators at domestic institutions who hold an active R01, R10, R18, R22, R24, R35, R37, R43, R44, R41, R42, P01, P20, P30, P40, P41, P50, P51, P60, U01, U10, U19, U41, U42, U54, or S06 grant may be eligible to submit a request for an administrative supplement to the awarding component of the parent grant. Because policies may vary among awarding components regarding eligibility of Small Grant Awards (R03), Academic Research Enhancement Awards (R15), or Exploratory/Developmental Grants (R21) for supplements under this program, grantees holding those awards must check with the appropriate awarding component before submitting an application for a supplement.

    For general information about this initiative, contact:
    Michael-David A.R.R. Kerns, M.B.A., M.S., Ph.D.
    Office of Extramural Affairs
    7201 Wisconsin Avenue, Suite 2C218
    Bethesda, MD 20892-9205
    Telephone: (301) 496-9322
    FAX: (301) 402-2945
    E-mail: michael.kerns@nih.hhs.gov
    Web site: http://www.nia.nih.gov

  10. Alzheimer's Disease Pilot Clinical Trials
    Release Date: November 23, 2004
    PA Number: PAR-05-021
    http://grants.nih.gov/grants/guide/pa-files/PAR-05-021.html

    Application Receipt Dates(s): http://grants.nih.gov/grants/funding/submissionschedule.htm

    Research Objectives: The objective of the Alzheimer's Disease Pilot Clinical Trials initiative is to improve the quality of clinical research designed to evaluate interventions for the prevention or treatment of Alzheimer's disease and age-associated cognitive decline by stimulating applications for pilot clinical drug trials to test interventions aimed at delaying the onset of or preventing AD and age-associated cognitive decline, slowing, halting, or, if possible, reversing the progressive decline in cognitive function, and modifying the cognitive and behavioral symptoms in Alzheimer's disease.

    Direct your questions about scientific/research issues to:
    Neil S. Buckholtz, Ph.D.
    Neuroscience and Neuropsychology of Aging Program
    National Institute on Aging
    7201 Wisconsin Avenue, Suite 350, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-9350
    FAX: (301) 496-1494
    Email: Buckholn@nia.nih.gov

  11. R21 Grants for Alzheimer's Disease Drug Discovery
    Release Date: November 24, 2004
    PA Number: PAS-05-022
    http://grants.nih.gov/grants/guide/pa-files/PAS-05-022.html

    Application Receipt Dates(s): http://grants.nih.gov/grants/funding/submissionschedule.htm

    Research Objectives: The objective of this solicitation is to stimulate preclinical research in the discovery, design, development and testing of novel compounds aimed at slowing, halting, or, if possible, reversing the progressive decline in cognitive function and modifying the behavioral symptoms in Alzheimer's disease as well as delaying the onset of or preventing AD. This initiative is intended to stimulate basic research and development efforts. The goal is not to duplicate or compete with pharmaceutical companies but to encourage, complement, and accelerate the process of discovering new, innovative, and effective compounds for the prevention and treatment of the cognitive impairment and behavioral symptoms associated with Alzheimer's disease.

    Direct your questions about scientific/research issues to:
    Neil S. Buckholtz, Ph.D.
    Neuroscience and Neuropsychology of Aging Program
    National Institute on Aging
    7201 Wisconsin Avenue, Suite 350, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-9350
    FAX: (301) 496-1494
    Email: Buckholn@nia.nih.gov

  12. Research on Mind-Body Interactions and Health
    Release Date: December 10, 2004
    PA Number: PA-05-027
    http://grants.nih.gov/grants/guide/pa-files/PA-05-027.html

    Application Receipt Dates(s): http://grants.nih.gov/grants/funding/submissionschedule.htm

    Research Objectives: The Public Health Service has documented that many of the leading causes of morbidity and mortality in the U.S. are attributable to social, behavioral, and lifestyle factors (e.g., tobacco use, lack of exercise, poor diet, and drug and alcohol abuse). Numerous studies have also documented that psychological stress is linked to a variety of health outcomes, and researchers and public health officials are becoming increasingly interested in understanding the nature of this relationship. This initiative invites applications that will deal with these areas.

    Direct your questions about scientific/research issues to:
    Jeffrey W. Elias, Ph.D.
    National Institute on Aging
    Individual Behavioral Processes Branch
    Behavioral & Social Research Program
    National Institute on Aging
    Gateway Bldg., Suite 533
    Bethesda, MD 20892
    Phone: 301-402-4156
    Fax: 301-402-0051
    E-mail: EliasJ@nia.nih.gov

  13. Social and Cultural Dimensions of Health
    Release Date: December 17, 2004
    Program Announcement (PA) Number: PA-05-029
    http://grants.nih.gov/grants/guide/pa-files/PA-05-029.html

    Application Receipt Dates: http://grants.nih.gov/grants/funding/submissionschedule.htm

    Research Objectives: The ultimate goal of this program announcement is to encourage the development of health research that integrates knowledge from the biomedical and social sciences. This involves the further development of health-related social science research relevant to the missions of the NIH Institutes and Centers (ICs) and the development of multi- or inter-disciplinary research that blends the theories and approaches of the social and biomedical sciences. This announcement encourages further development of health-related social sciences research relevant to the missions of the ICs. These missions encompass a broad range of scientific questions related to the health and well-being of our nation's people. Information about the specific missions of the ICs participating in this program announcement is posted at http://www.nih.gov/icd/.

    Direct your questions about scientific/research issues to:
    Sidney Stahl, Ph.D.
    Behavioral and Social Research Program
    National Institute on Aging Gateway
    Building, Room 525 MSC 9205
    7201 Wisconsin Avenue
    Bethesda, MD 20892-9205
    Telephone: 301-402-4156
    Fax: 301-402-0051
    E-mail: stahls@mail.nih.gov

  14. Chronic Fatigue Syndrome: Pathophysiology and Treatment
    Release Date: December 21, 2004
    PA Number: PA-05-030
    http://grants.nih.gov/grants/guide/pa-files/PA-05-030.html

    Application Receipt Dates: Standard http://grants.nih.gov/grants/funding/submissionschedule.htm

    Research Objectives This initiative invites submission of investigator-initiated research grant applications to support research on the epidemiology, diagnosis, pathophysiology, and treatment of chronic fatigue syndrome (CFS) in diverse groups and across the life span. Applications that address gaps in our understanding of the environmental and biological risk factors, the determinants of heterogeneity among patient populations, and the common mediators influencing multiple body systems that are affected in CFS are encouraged. The NIH is interested in funding research that will enhance our knowledge of the disease process and improve the diagnosis, treatment, and quality of life of all persons with CFS.

    Direct your questions about scientific/research issues to:
    Dr. Susan Nayfield
    Chief, Geriatric Branch
    Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    Gateway Building, Suite 3C-307
    7201 Wisconsin Avenue
    Bethesda, MD 20892-9205
    Phone: (301) 496-6761
    Email: nayfiels@mail.nih.gov

  15. Restless Legs Syndrome and Periodic Limb Movement Disorder
    Release Date: December 21, 2004
    PA-05-032
    http://grants.nih.gov/grants/guide/pa-files/PA-05-032.html

    Application Receipt Dates(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm for details

    Purpose: This initiative encourages investigator-initiated research grant applications to study restless legs syndrome and periodic limb movement disorder. Restless legs syndrome (RLS) is a disorder characterized by disagreeable leg sensations, usually prior to sleep onset, that cause an almost irresistible urge to move the legs. The overwhelming majority of patients with RLS also have periodic limb movement disorder. This announcement re-issues PA-01-086. This PA is intended to expand RLS research as well as build upon already funded work addressing the hypotheses that acquired or genetically mediated dysfunctions in dopamine/motor systems and/or iron transport mechanisms are etiologically linked to RLS symptoms. Of particular relevance to this PA are applications that address the sensory gating and circadian timing aspects of RLS which are defining features of the condition.

    Direct your questions about scientific/research issues to:
    Andrew A. Monjan, Ph.D., M.P.H.
    National Institute on Aging
    Gateway Building, Suite C3C07
    7201 Wisconsin Avenue
    Bethesda, MD 20892
    Phone: (301) 496-9350
    Fax: (301) 496-1494
    E-mail: am39m@nih.gov

  16. Retirement Economics
    Release Date: December 29, 2004
    Program Announcement (PA) Number: PA-05-036
    http://grants.nih.gov/grants/guide/pa-files/PA-05-036.html

    Application Receipt Dates(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm for details

    Research Objectives: The importance of studying retirement is heightened by the approaching retirement of the baby boom generation of Americans. In 2008, the first of the baby boom generation reaches age 62. Over the next 30 years, the U.S. population over age 62 is projected to double (from about 40 million to about 80 million people), while the working age population increases by just 13 percent. This announcement encompasses research on the work and retirement decisions that people make at older ages and the health and economic circumstances of individuals as they evolve before retirement, at the time that work transitions take place, and throughout retirement. It is about the complex interrelationships between work, economic circumstances, public policy, health, and other aspects of later life. NIA encourages applicants to discuss their topics with program staff prior to submission.

    Direct your questions about scientific/research issues to:
    John W.R. Phillips, Ph.D.
    Behavioral and Social Research Program
    National Institute on Aging
    7201 Wisconsin Avenue, Suite 533
    Bethesda, MD 20892-9205
    Telephone: (301) 496-3138
    FAX: (301) 402-0051
    Email: phillipj@nia.nih.gov

NIH Roadmap Initiatives

NIH Roadmap Initiatives have been planned to help enable NIH to sustain its historic record of cutting-edge contributions that are central to extending the quality of healthy life for people in this country and around the world. All NIH Institutes and Centers participate in Roadmap initiatives. Below is a list of Roadmap initiatives released since the last presentation of the Director’s Status Report (DSR) at the October 2004 council meeting. Releases are sorted with the most recent ones at the end of the list. (For more information visit the NIH Roadmap Initiatives Web site.)
Announcement Number
Issuing Organization
Release Date
Expiration Date
Activity Code
Title
RFA-RM-04-022
Roadmap
9/28/2004
1/25/2005
U54
National Centers for Biomedical Computing
RFA-RM-05-008
Roadmap
10/1/2004
1/20/2005
P20
Regional Translational Research Center Planning Grants
RFA-RM-04-026
Roadmap
10/22/2004
1/25/2005
P01, R01, R21
Membrane Protein Production and Structure Determination
RFA-RM-04-023
Roadmap
10/27/2004
1/26/2005
R21
Novel Preclinical Tools for Predictive ADME-Toxicology
RFA-RM-05-013
Roadmap
11/17/2004
1/25/2005
R01
New Methodologies for Natural Products Chemistry
RFA-RM-05-014
Roadmap
11/18/2004
2/16/2005
P41
Pilot-Scale Libraries for High-Throughput Screening
RFA-RM-05-010
Roadmap
11/19/2004
2/12/2005
T32
Interdisciplinary Training: Behavior, Environment and Biology
RFA-RM-05-011
Roadmap
12/7/2004
2/15/2005
R03, R21
Assay Development for High Throughput Molecular Screening
RFA-RM-05-012
Roadmap
12/13/2004
3/11/2005
P20
Exploratory Centers for Cheminformatics Research
RFA-RM-05-015
Roadmap
12/17/2004
3/26/2005
T32
Predoctoral Clinical Research Training Programs

Budget Table

National Institute on Aging
FY 2004 Actual/FY 2005 Final Conference
(Dollars in Thousands)

Includes Aids

FY 2004
Budget Authority

FY 2005
Conference
Research Grants
No.
Amount
No.
Amount

Research Projects

Noncompeting
971
$493,437
1,090
$534,499
Administrative Supplement
(103)
7,079
(103)
7,079
Competing
419
166,194
349
139,520
Subtotal
1,390
666,710
1,439
681,098
SBIR/STTR
87
24,535
87
24,927
Subtotal, RPG
1,477
691,245
1,526
706,025
Research Centers
76
82,825
76
86,615
Other Research
Research Careers
192
25,022
204
25,601
Cooperative Clinical Research
3
1,728
2
993
MBRS
1,338
1,390
Other
29
6,561
29
7,332
Subtotal, Other
224
34,649
235
35,316
Total, Research Grants
1,777
808,719
1,837
827,956
Training: FTTP
Individual
62
2,610
62
2,717
Institutional
482
20,847
481
21,666
Total, Training
544
23,457
543
24,383
R&D Contracts
132
56,396
132
61,576
Subtotal, Extramural
888,572
913,915
Intramural Research
99,454
103,491
RMS
33,355
34,584
Total
1,021,381
1,051,990

 


Page last updated Feb 19, 2009