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September 2007 Director's Status Report

BUDGET and APPROPRIATIONS

Status of FY 2007, 2008, and 2009 Budgets for NIA

FY 2007
For NIA, the FY 2007 enacted level is $1,047,260 million, an increase of $10.7 million or 1.0 percent over FY 2006. As part of the Joint Funding resolution, funds reserved for roadmap activities were released to the NIH ICs for use in FY 2007. The NIA roadmap allocation was $12.5 million.

In FY 2007, the NIA currently estimates support of 1,518 RPGs, including 433 new and competing projects and a success rate of approximately 17.3 percent. NIA is presently supporting competing RPGs up to the 14.9 percentile. Support levels for other funding mechanisms include 74 research centers for $83 million; 240 other research grants, including 210 research career awards, for a total of $34.5 million; 554 full-time training positions for $23.8 million, and a total of $68.8 million for research and development contracts.

NIA is following the NIH FY 2007 funding policy for non-competing research grants, which is to provide no inflationary increase over FY 2006. In an effort to reinforce its support for new investigators, NIA is supporting a total of 54 new investigators in FY 2007, which is the average number of new investigators NIA supported over the last 5 years.

Beginning in FY 2007, NIH ICs are contributing to the Genes, Environment and Health Initiative (GEI) to support research that will lead to the understanding of genetic contributions and gene-environment interactions in common disease. Approximately $1.8 million is being transferred from the NIA to the National Human Genome Research Institute (NHGRI) for this initiative.

FY 2008
On June 21, the Senate Appropriations Committee on Labor, Health and Human Services (HHS), and Education approved the FY 2008 Labor, HHS, and Education Committee report. For NIH, the Senate Committee mark up provides an additional $1 billion over the FY 2007 enacted level or $29.9 billion, and $1.3 billion over the FY 2008 President’s Budget level for NIH. For NIA, the Senate mark is $1.073 billion, an increase of $26 million, or 2.5 percent, over both the FY 2007 enacted level and the FY 2008 President’s Budget. The Senate mark assumes a 3.0 percent increase in non-competing RPGs and a 3.0 percent increase in the average cost of competing RPGs.

On July 19, the Full House passed the FY 2008 Labor, HHS, and Education Appropriations bill. The bill provides an appropriation for NIH of $29,649,887,000, which would be $750,000,000 above the FY 2007 appropriation and $1,028,646,000 above the President's request. The bill would increase the number of new and competing research grants by approximately 545 over last year’s level and 1,262 over the President’s request; lift a two-year freeze on the average cost of new research grants; help train the next generation of researchers; and provide $110.9 million for the National Children's Study and $300 million for the Global AIDS Fund. For NIA, the FY 2008 House allowance of $1.063 billion was $15.6 million, or 1.5 percent, higher than FY 2007.

A table showing the NIA FY 2006, 2007 and 2008 funding levels by budget mechanism is included on the following page. Please note that the FY 2006 and 2007 columns do not reflect comparability adjustments to the FY 2008 President’s budget that affect the research career, intramural research and research management and support mechanisms.

FY 2009

Preliminary work on the budget for FY 2009 has begun using the FY 2008 President’s budget request as the base. After intermediate stages of review, the President’s budget request for FY 2009 will be presented to Congress in February 2008, at which time it will become available to the public.

MECHANISM FY 2006 Actual FY 2007 Enacted Level FY 2008 President's Budget
Research Grants: No. Amount No. Amount No. Amount
Research Projects:            
Noncompeting 1,058 $506,805,000 1,085 $508,045,000 1,080 $496,921,000
Administrative supplements (115) 13,904,000 (114) 7,150,000 (114) 7,000,000
Competing 409 146,397,000 433 155,062,000 431 154,127,000
Subtotal, RPGs 1,467 667,106,000 1,518 670,257,000 1,511 658,048,000
SBIR/STTR 75 24,977,000 75 25,213,000 74 24,750,000
Subtotal, RPGs 1,542 692,083,000 1,593 695,470,000 1,585 682,798,000
Research Centers:            
Specialized/comprehensive 74 82,378,000 74 82,596,000 74 81,966,000
Clinical research 0 0 0 0 0 0
Biotechnology 0 0 0 0 0 0
Comparative medicine 0 646,000 0 428,000 0 428,000
Research Centers in Minority Institutions 0 0 0 0 0 0
Subtotal, Centers 74 83,024,000 74 83,024,000 74 82,394,000
Other Research:            
Research careers 204 27,028,000 210 28,022,000 217 27,486,000
Cancer education 0 0 0 0 0 0
Cooperative clinical research 0 0 0 0 0 0
Biomedical research support 0 0 0 0 0 0
Minority biomedical research support* 0 1,323,000 0 1,316,000 0 1,316,000
Other 26 5,212,000 30 5,185,000 30 5,185,000
        Subtotal, Other Research 230 33,563,000 240 34,523,000 247 33,987,000
  Total Research Grants 1,846 808,670,000 1,907 813,017,000 1,906 799,179,000
Research Training:  FTTPs    FTTPs    FTTPs  
Individual awards 52 2,378,000 72 3,028,000 55 2,528,000
Institutional awards 482 20,676,000 482 20,776,000 482 20,776,000
Total, Training 534 23,054,000 554 23,804,000 537 23,304,000
             
Research & development contracts 109 63,987,000 108 68,830,000 108 70,318,000
(SBIR/STTR) (0) (55,000) (0) (117,000) (0) (117,000)
  FTEs   FTEs   FTEs  
Intramural research 246 102,607,000 249 102,566,000 251 101,370,000
Research management and support 132 38,241,000 132 39,043,000 135 39,194,000
NIH Roadmap for Medical Research 0 0 0 0 0 13,783,000
Total, NIA 378 1,036,559,000 381 1,047,260,000 386 1,047,148,000
Note:  The FY 2007 column does not reflect the proposed NIA reprogramming and does not include comparable adjustments to the FY 2008 President's budget.  

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LEGISLATIVE UPDATE

  1. Significant Legislative/Executive Action

    1. FY 2008 Appropriations for NIH/NIA

      On July 19, the House passed H.R. 3043, the FY 2008 Labor-HHS Appropriations bill, by a vote of 276 to 140 and with a presidential veto threat for overspending. However, the Senate Appropriations Committee mark-up measure, S. 1710 is not expected to see floor action until September. The Senate and House measures would provide different funding levels for NIH, but both levels are higher than the President’s Budget. H.R. 3043 provides NIH with a funding level of $29,649,887,000, which would be $750,000,000 above the FY 2007 appropriation and $1,028,646,000 above the President's request. The House bill includes several additional NIH provisions not included in S. 1710 (see NIA Budget Report). The FY 2008 House allowance for NIA is $1.063 billion, an increase of $15.6 million, or 1.5 percent, higher than FY 2007. S. 1710 provides an additional $1 billion over the FY 2007 enacted level or $29.9 billion, and $1.3 billion over the FY 2008 President’s Budget level for NIH. For NIA, the Senate mark is $1.073 billion, an increase of $26 million, or 2.5 percent, over both the FY 2007 enacted level and the FY 2008 President’s Budget.

    2. Senate HELP Subcommittee on Retirement and Aging - S. 898 – On July 25, the Senate Committee on Health, Education, Labor and Pensions (HELP) (Senator Edward Kennedy [D-MA], Chair) reported out by unanimous consent S. 898, the Alzheimer’s Breakthrough Act of 2007, with an amendment in the nature of a substitute. S. 898 would increase the authorization level for Alzheimer’s disease (AD) research, and require the Director of the NIA to make supporting AD research a priority for the Institute. In addition, the bill would require an expansion of clinical research on AD with a focus on (1) early diagnosis and detection, (2) the relationship between vascular disease and AD, and (3) expediting the translation of research findings into effective treatments and prevention strategies. S. 898 would require the Secretary, HHS, within 3 years of enactment of the legislation and every 3 years thereafter, to convene a summit on AD for the purpose of providing a detailed overview of current research activities at the NIH, as well as to discuss and solicit input to potential areas of collaboration between the NIH and other Federal agencies related to research, prevention, and treatment of AD.

  2. Committee/Subcommittee Action - Congressional Hearings

    1. Senator Mikulski to Host a Roundtable Discussion on Alzheimer’s Disease – On July 17, the Senate HELP Subcommittee on Retirement Security and Aging (Senator Barbara Mikulski [D-MD], Chair) hosted a roundtable discussion on the “Federal Response to the Epidemic of Alzheimer’s Disease.” Drs. Elias Zerhouni, Director, NIH, and Richard Hodes, Director, NIA, participated in the discussion with Drs. Julie Gerberding, Director, CDC, and Andrew von Eschenbach, Director, FDA.

      (For information, contact Dr. Tamara Jones, NIA/OD, Ph: 401-451-8835)

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STAFF CHANGES

Dr. Robin Barr has been appointed Director of the Office of Extramural Activities (OEA). He brings both expertise and experience to the OEA, which is often grantees’ first point of contact with our Institute, and serves as manager of NIA’s scientific review and grants award process. At NIA, Dr. Barr has served as Deputy Director of OEA and as NIA Training Officer since 1994, following his work as program administrator for cognitive functioning and aging in the Behavioral and Social Research Program. As OEA Director, he will oversee the Scientific Review Office, the National Advisory Council on Aging, and the Grants and Contracts Management Office and through this role will continue to play an invaluable role in laying the foundation for the future of research on aging. He has also been influential in policy development at the NIH level. He was instrumental in changing NIH policy on career awards and is a member of the NIH committee responsible for developing the Pathway to Independence award for new investigators.

Dr. Robert Fenton joined the Intramural Research Program (IRP) as the new Staff Clinician for the Clinical Research Branch (CRB). Prior to accepting his position at the IRP, Dr. Fenton was an Associate Professor in the Department of Medicine, Greenebaum Cancer Center, University of Maryland.

Dr. Wen G. Chen recently joined the Neuroscience and Neuropsychology of Aging (NNA) Program as a Health Scientist Administrator and will be responsible for the Sensory/Motor Disorders of Aging portfolio. Dr. Chen completed her doctorate in Biological Chemistry and Molecular Pharmacology at Harvard University in 2003. Her research focused on the examination of epigenetic mechanisms involved in the regulation of neural activity-dependent gene expression in the central nervous system. She most recently worked in the Office of Cross-cutting Science and Scientific Technology at NIMH. Prior to coming to NIH, she served as Scientific Editor for programs/manuscripts in Systems Neuroscience at Neuron/Cell Press.

Dr. Partha Bhattacharyya, a health economist and health services researcher, joined the Behavioral and Social Research (BSR) Program on July 9 as a Health Program Specialist. While in graduate school, Dr. Bhattacharyya worked as an economist at Academic Analytics, LLC, in Stony Brook, New York, where he managed the process for database construction, integration, and management for FSPINDEX 2005-06, which measures productivity of approximately 180,000 faculty in PhD programs. He earned his doctorate in economics from SUNY Stony Brook in 2007; his dissertation focused on both the supply and demand sides of the healthcare market. He will be working closely with Dr. John Phillips on the BSR economics portfolio, on BSR’s initiatives to develop national health and well-being accounts, and on NIH Roadmap initiatives on burden of illness.

Dr. John Hardy, Senior Investigator and Chief of the Laboratory of Neurogenetics (LNG), accepted a position as Chair of Neuroscience at the Institute of Neurology, University College, in London, England, in May 2007. Dr. Andrew Singleton, Senior Investigator, LNG, will be Acting Chief in the interim.

Dr. Darrell R. Abernethy, Senior Investigator and Chief of the Laboratory of Clinical Investigation (LCI), accepted a position as Chief Science Officer at the United States Pharmacopeia. Dr. Josephine Egan, Senior Investigator, LCI, will be Acting Chief in the interim.

Dr. Susan Molchan recently left the Neuroscience and Neuropsychology of Aging (NNA) program and retired as a Captain from the U.S. Public Health Service (USPHS) Commissioned Corps. Dr. Molchan joined NNA in 2001 following positions at the National Institute on Mental Health intramural program and the Food and Drug Administration (FDA). In NNA, she was initially responsible for assisting with the Alzheimer’s disease clinical trials. A major focus of Dr. Molchan’s responsibilities in NNA was associated with the management of the portfolio of grants on the clinical diagnosis, neuroimaging, and biomarkers of Alzheimer’s disease. She was particularly involved with the development and management of the Alzheimer’s Disease Neuroimaging Initiative (ADNI).

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INSTITUTE-SPONSORED MEETINGS, WORKSHOPS, CONFERENCES, AND PUBLIC INFORMATION ACTIVITIES

I. Meetings Held

Panel to Oversee a Research Program on the Design of National Health Accounts - May 17, 2007
This NIA-funded exploratory meeting, the third in a series, was held at the National Academy of Sciences, Washington, DC. Because health policies can be informed by National Health Accounts, they are particularly important to the well-being of older populations who spend a disproportionate amount of income on health maintenance. Despite concerns about medical costs, relatively little attention has been paid to the issue of health care value. The absence of information about population health in relation to spending could lead to limited access to those benefits made possible through national investments in research and technology. The meeting was organized by the Committee on National Statistics and participants included academics, economists, physicians, health policy researchers, and members of: the Bureau of Economic Analysis, the Centers for Medicare and Medicaid Services, the Agency for Healthcare Research and Quality, the NIH, the National Center on Health Statistics, and the National Institute on Aging. (For more information, contact Dr. John Phillips, BSR, Ph: 301-496-3138.)

Thyroid and Aging Research Summit - May 19, 2007
This exploratory workshop, held in Washington, DC, was sponsored jointly by the NIA Geriatrics and Clinical Gerontology (GCG) Program and the American Thyroid Association. It followed a larger symposium on the previous day by the American Thyroid Association and Johns Hopkins University on the diagnosis, management, and clinical impact of thyroid disease in older adults. Participants at the research summit included leaders in thyroid clinical practice and research, and representatives from the Centers for Disease Control (CDC) and the National Institute on Diabetes and Digestive and Kidney Diseases (NIDDK). This focused and productive meeting identified and prioritized several research areas. It is expected that these outcomes will serve as the basis for a future program announcement on the aging thyroid. (For more information, contact Dr. Basil Eldadah, GCG, Ph: 301-496-6761.)

Meeting of BSR’s Data Priorities Committee - May 21, 2007
This NIA-funded exploratory meeting was held in Bethesda, Maryland. It was a follow-on to the first meeting (September 19-20, 2006, in Washington, DC) of a Special Ad Hoc Committee to review BSR data activities, as recommended in the 2004 NACA review of the BSR Program. The committee, chaired by Lisa Berkman and James P. Smith, was asked to discuss

  • Current data collection, archiving, and dissemination funded by NIA/BSR,
  • Likely needs during the next 10-15 years for data infrastructure for behavioral and social research on aging, and
  • NIA/BSR’s investment in future data collection and archiving.

A draft report has been prepared, based on the discussions at both meetings, and should be completed by September 2007. (For more information, contact Dr. John Haaga, BSR, Ph: 301-496-3131.)

Thymic Atrophy with Aging – June 5-6, 2007
A workshop on Thymic Atrophy with Aging was held on June 5-6, 2007, in Gaithersburg, MD. The purpose of the exploratory workshop was to discuss recent research advances in our understanding of the underlying mechanisms that regulate thymic atrophy during aging. Investigators with scientific expertise in age-related changes in hematopoiesis, regulation of lymphocyte differentiation in the thymus, and the molecular and cellular processes responsible for thymic involution were invited to participate in this workshop. In addition, investigators that have developed and tested strategies to accelerate thymopoiesis and induce T cell recovery in animal models or in clinical settings were invited to discuss their research findings. The goal of the workshop was to identify and discuss the gaps in our understanding of the mechanisms responsible for thymic involution and to assess various strategies that have been tested in the past or are currently being developed to promote immune reconstitution. The workshop is also expected to promote interaction between researchers working in these different areas of research. A report of the meeting will be made available to NIA staff. (For more information, contact: Dr. Rebecca Fuldner, BAP, Ph: 301-496-6402.)

Unexplained Fatigue in the Elderly - June 25-26, 2007
This NIA-sponsored exploratory workshop, held in Bethesda, MD, was led by GCG in collaboration with NNA and BSR. The overarching goal was to conceptualize the area, explore potential mechanisms, to understand approaches to operationalizing these concepts and mechanisms in the setting of observational and interventional studies. The multi-disciplinary group of speakers and participants represented a broad range of clinical and research backgrounds. Presentations outlined the current state of knowledge in selected key areas, and identified several areas of future research needs. (For more information, contact Dr. Basil Eldadah, GCG, Ph: 301-496-6761.)

The Genetics of Alzheimer’s Disease: Where do we go from here? - August 15-16, 2007
A two-day advisory workshop to examine the next steps to be taken in the field of Alzheimer’s disease (AD) genetics and genetic epidemiology was held in Bethesda, MD, August 15-16, 2007. This meeting brought together a group of NIA-funded research scientists, NIH staff, and other select experts to determine the state of research in finding the genes for late onset AD using genome wide association studies, to consider what is needed to move research forward most effectively, and to discuss the formation of a consortium of Alzheimer’s geneticists for a large scale genome wide association study. Discussion topics included (1) the phenotypes and genetic samples that should be included, (2) ways to establish efficient sharing of genetic samples and data that rapidly move the field forward while protecting the research of individual scientists, and (3) the use of large data bases to organize and analyze the data. There was also a discussion of issues regarding informed consent and confidentiality documents. (For more information, contact: Dr. Marilyn Miller, NNA, Ph: 301-496-9350.)

Workshop on Phenotypic Measurement in Individual Differences in Economic Behavior - September 10-11, 2007
The goal of this NIA-supported exploratory workshop, held in Bethesda, MD, was to identify key issues requiring further examination. Recent developments in neuroeconomics linking economic behaviors to neurobiological function open opportunities for measurement of individual differences in economic behavior at both the behavioral and neurobiological level. Of particular relevance to aging are questions regarding (1) whether individual differences in economic behavior at any life stage reliably predict outcomes in older adulthood, (2) whether individual differences in economic behaviors become more or less pronounced with age, and (3) whether measurement of individual differences is reliable at a single life stage, or across life stages. The recent initiation of studies linking molecular genetics and individual differences in economic outcomes has prompted BSR to explore this issue more thoroughly. (For information contact Dr. Erica Spotts, BSR, Ph: 301-496-3138.)

Critical Illness and Critical Care in Older Adults – September 17-18, 2007
This exploratory workshop, held in Bethesda, MD, was sponsored by NIA/GCG. The goals of the workshop were to identify the current state of knowledge, knowledge gaps, research opportunities, and barriers to research on the management of critical illness in the elderly. The workshop was organized around three themes: the intersection of aging and critical illness, new techniques and technologies, and specific clinical issues and applications. It was anticipated that this workshop would draw attention to an existing program announcement co-sponsored by the NIA on multidisciplinary translational research in critical care (PA-07-233). (For more information, contact Dr. Basil Eldadah, GCG, Ph: 301-496-6761.)

II. Upcoming Meetings

The Cognitive Aging Summit - October 10-12, 2007
The Cognitive Aging Summit, an advisory meeting co-sponsored by the NIA and the McKnight Brain Research Foundation (MBRF), will be held October 10-12, 2007, in Washington, DC. The Summit will bring together a range of experts in a variety of research fields to discuss the most cutting edge advances in our understanding of age-related brain and behavioral changes. It is anticipated that recommendations for research directions will emerge from the Summit that could be pursued in future partnerships between the NIA and the MBRF and that this research would lead to practical recommendations and interventions for maintenance of cognitive health throughout life. The goals and objectives of the Cognitive Aging Summit are (1) to assess the status of current scientific knowledge in normal aging and changes in cognition associated with aging; (2) to explore new avenues of potential research within the scientific community which could lead to the development of pharmacological and behavioral interventions and, ultimately, to improved outcomes for older adults; and (3) to raise the level of awareness both within the scientific community and among the public about the importance of this area of research and its tremendous value to society. (For more information, contact: Dr. Molly Wagster, NNA, Ph: 301-496-9360; wagsterm@nia.nih.gov.)

Workshop on National Health Accounts - October 2007
This NIA-supported exploratory workshop will be held in Cambridge, Massachusetts, with an ultimate goal of developing a revised set of National Health Accounts. Since health policies can be informed by National Health Accounts, they are particularly important to the well-being of older populations who spend a disproportionate amount of income on health maintenance. The health and well-being of the elderly is at the core of the NIA mission, and research to support the development of National Health Accounts is a high priority BSR initiative. This workshop will complement the important study on National Health Accounts being conducted by the National Academy of Sciences. The workshop participants will be made up of approximately 12-15 individuals representing a broad spectrum of national policy makers, senior government leaders involved in the production and dissemination of national health account information, and academic thought leaders, all potential users of this information. (For more information, contact Dr. John Phillips, BSR, Ph: 301-496-3138.)

Cell Lineage and Cell Turnover in Tissues of the Aged – November 2007
This exploratory workshop on “Cell Lineage and Cell Turnover in Tissues of the Aged” is being organized by the Biology of Aging Program (BAP) for the week of November 5, 2007. The purpose of the meeting is to examine current methods of cell lineage tracing, quantitative methods for analyzing cellular compositions of tissues by molecular markers and other methods, and the potential experimental barriers to analyzing cell lineages and cell turnover in aged tissues. The workshop was motivated by the fact that cell lineage tracing identifies precursors for the cells that function in different tissues, but such studies have been done primarily in the fields of embryogenesis and developmental biology. However, tissue regeneration and tissue engineering are major areas of research across the NIH and are emerging foci of research on aging, specifically. Therefore, it may be advantageous to better understand the cellular sources for tissue maintenance or repair that function in vivo in aged organisms by extending the methods currently applied to understand these problems in embryogenesis and developmental biology. (For more information, contact Dr. Ron Kohanski, BAP, Ph: 301-496-6402.)

Allostatic Load - November 29-30, 2007
This NIA-supported exploratory workshop, to be held in the Washington, DC, area, will explore theoretical and measurement issues relating to the concept of allostatic load and, more specifically, the question of assessing multiple and cumulative aspects of physiological aging and dysregulation - including its antecedents (e.g., life experiences) and health consequences. The workshop will focus on measurement of cumulative physiological dysregulation in both survey and laboratory contexts and explore how the integration of these approaches and findings from human and animal studies can inform our understanding of these relationships. The goals of the workshop are to identify research needs and strategies for advancing the science in this area. (For more information, contact Dr. Lis Nielsen, BSR, Ph: 301-402-4156.)

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GENERAL INFORMATION/STAFF AWARDS

Biology of Aging Program New Investigators Forum – May 29-31, 2007
The First Annual Biology of Aging Program New Investigators Forum was held in San Antonio, Texas from May 29–31, 2007. The purpose of the forum was one of outreach - to bring together new awardees of grants from BAP in the spring of the year following their award, to encourage their continued success in this field by allowing them to get acquainted with NIA program staff as well as network with each other. New investigators gave talks describing their planned work (or results to date) with an emphasis on how it relates to the area of aging research. This time and venue (rather than meeting in Bethesda) were chosen because the American Aging Association (AGE) was meeting in San Antonio from June 1st through June 4th. (For more information, contact Dr. David Finkelstein, BAP, Ph: 301-496-7847).

NNA First Annual Investigators Meeting for Translational Research - September 17-18, 2007
NNA has an ongoing translational initiative that includes an R21 Early Drug Discovery Program (PAS-06-261), and a U01 Preclinical Drug Development Program (PAR-05-148). In addition, NNA’s investigators involved in drug discovery and drug development can utilize the services of NIA’s Toxicology Contract, “Investigational new Drug Toxicology for Drugs to Treat Alzheimer’s Disease and other Aging-Related Diseases” with SRI International. In order to closely monitor the progress of the translational initiatives, provide guidance, and foster interactions among investigators involved in translational research funded by these programs, NNA staff convened the First Annual Investigators Meeting for Translational Research on September 17-18, 2007. The meeting included investigators who are recipients of grants from the above programs and investigators that use the Toxicology Contract services, program staff from the NIA and the National Institute of Neurological Disorders and Stroke (NINDS), a representative of the Alzheimer’s Drug Discovery Foundation, relevant experts from the Food and Drug Administration (FDA) and several experts on drug discovery for AD from academia and/or industry in the role of expert advisors. These advisors provided immediate feedback and guidance to the investigators and in doing so increased the likelihood of success of these translational projects. (For more information, contact Drs. Neil Buckholtz or Suzana Petanceska, NNA, Ph: 301-496-9350.)

Staff Awards

  • Dr. Stanley Rapoport, Senior Investigator, Brain Physiology and Metabolism Section (BPMS), IRP, received the Chevreul Medal for 2007 from the Association Française pour l’Etude des Corps Gras for his innovative work in lipid signaling in the brain.
  • Dr. Tamara Harris, Senior Investigator and Chief of the Geriatric Epidemiology Section in the Laboratory of Epidemiology, Demography, and Biometry (LEDB), IRP, along with her co-authors, recently received the International Award for Excellence for their paper, “Thiazolidinedione (TZD) Use and Bone Loss in Older Diabetic Adults” (JClin Endocrinol Metab. 91(9):3349-3354, 2006). They received this prestigious award from The Endocrine Society and Pfizer, Inc. The award recognizes the four best clinical research papers published in the Journal of Clinical Endocrinology and Metabolism in 2006.
  • Neuroscience Blueprint Awards:
    • Dr. Brad Wise was awarded an NIH Neuroscience Blueprint Directors’ Individual Award for his continued high level of contributions towards the NIH Blueprint.
    • Dr. Andrew Monjan was awarded an NIH Neuroscience Blueprint Directors’ Group Award for his contributions in supporting the Blueprint Neurodegeneration activities.
    • Dr. Molly Wagster was awarded an NIH Neuroscience Blueprint Directors’ Group Award for her contributions to the Neuroepidemiology Project Team and the development of a contract for the NIH Toolbox for Assessment of Neurological and Behavioral Function. She also was awarded an NIH Neuroscience Blueprint Directors’ Individual Award for her leadership role on the Neuroepidemiology Project Team.
  • Dr. Andrew Monjan made the Keynote Address at the inaugural meeting of the newly formed American Society of Geriatric Otolaryngology.

New Publications Funded by BSR/NIA - These recent publications were wholly or partially funded by NIA/BSR:

  • Growing Older in America: The Health & Retirement Study, NIH Publication No. 07-5757, March 2007.

Every two years, thousand of older Americans tell their stories. Quietly, compellingly, they answer questions about every aspect of their lives – how they are feeling, how they are faring financially, how they are interacting with family and others. They do this as participants in the U.S. Health and Retirement Study (HRS), one of the most innovative studies ever conducted to better understand the nature of health and well-being in later life. The HRS’s purpose is to learn if individuals and families are preparing for the economic and health requirements of advancing age and the types of actions and interventions – at both the individual and societal levels – that can promote or threaten health and wealth in retirement. Now in its second decade, the HRS is the leading resource for data on the combined health and economic circumstances of Americans over age 50.
Adobe PDF (7.1M) (download the Adobe Acrobat Reader here)
Plain HTML version (for screen readers)

  • Twin Research and Human Genetics, Volume 10, Number 2, April 2007. This issue contains a special NIA-sponsored section on “Genetics, Social Behaviors, Social Environments and Aging,” Jennifer R. Harris (NIA/BSR) guest editor.

As outlined in the guest editorial, this represents a high-priority area that is being developed by the Behavioral and Social Research Program at the National Institute on Aging, and three specific directions for portfolio development are described. The special section includes eight commissioned papers that have investigated effects of social behaviors and social environments on outcomes that affect behaviors critical to healthy aging. Several of these papers are based on analyses of NIA-funded studies. Many of these papers were originally presented as part of a symposium organized by BSR (on the same theme as the special section) at the 2006 annual meeting of the Behavior Genetics Association.

  • Ethnicity & Disease, Volume 17, Number 1, Supplement 1, Winter 2007, “Community-based Participatory Research to Reduce Health Disparities Among Minority Elders: The Resource Centers for Minority Aging Research.” Introduction by Dr. Sidney Stahl and Anneliese Hahn of NIA/BSR.

For more than a decade, NIA has funded the Resource Centers for Minority Aging Research (RCMARs). One of the four key components of the RCMARs is a Community Liaison Core whose objectives are to conduct research on recruiting community members for scientific studies and to facilitate working relationships with host communities. The articles in this supplement represent some of the scientific knowledge available on community-based participatory research (CBPR) at the RCMARs. The hope is that this supplement will motivate others involved in CBPR to more fully engage in the conduct of science related to relationships that mutually benefit communities and researchers.

  • Journals of Gerontology, Volume 62B, Special Issue I, June 2007. “Psychological Sciences and Social Sciences,” edited by Neil Charness, Ph.D. Lead article/introduction by Dr. Jeff Elias (recently of NIA/BSR) and Dr. Molly Wagster (NIA/NNA).

This special issue developed out of a symposium on cognitive training for older adults sponsored by NIA in March 2004, with a goal of addressing (a) the state of the art in development of cognitive interventions and the readiness to turn research findings into practice; (b) key research and methodological issues that the consumer, practitioner, and researcher should be aware of when considering the concept of cognitive intervention; and (c) guidelines for judging cognitive intervention as successful.

(For more information on these publications, contact Dr. Richard Suzman, BSR, Ph: 301-496-3131.)

NIA Publications
The following new publications were completed:

  • Why Population Aging Matters: A Global Perspective
  • Global Aging Summit Fact Sheet
  • The Health and Retirement Study: Growing Older in America
  • 2005-2006 Progress Report on Alzheimer’s Disease: Journey to Discovery
  • Links: Minority Research and Training Newsletter, Spring/Summer issue

The following publications were updated or reprinted:

  • Home Safety for People with Alzheimer’s Disease
  • Exercise Guide
  • Safe Use of Medicines
  • ADC Directory
  • English Age Pages: Eyes, Falls, Arthritis, Cancer, Foot Care, Medicines, Online Health, Sleep, Smoking, Considering Surgery
  • Spanish Age Pages: Surgery, Depression
  • Hospitalization Happens
  • Acute Hospitalization and AD
  • Understanding Alzheimer’s Disease
  • Understanding Memory Loss
  • So Far Away: 20 Questions for Long-Distance Caregivers
  • There’s No Place Like Home – For Growing Old Tip Sheet

NIHSeniorHealth -- new topics added to the website: Skin Cancer and Talking with Your Doctor, bringing the total to 33.

(For more information about NIA’s publications or NIHSeniorHealth, Ms. contact Vicky Cahan, Director, OCPL, Ph: 301-496-1752.)

NIA News Releases
News releases were distributed generating 123 clips in print and internet outlets and reaching nearly 64 million people.

  • Tai Chi Boosts Immunity to Shingles Virus in Older Adults, NIH-Sponsored Study Reports (4/6/07). Irwin, M.R., et al. Augmenting immune responses to varicella zoster virus in older adults: A randomized, controlled trial of Tai Chi. Journal of the American Geriatrics Society (2007), 55(4):511-517.
  • Can an Omega-3 Fatty Acid Slow the Progression of Alzheimer’s Disease? (5/10/07)
  • Skin Cancer Information is Newest Offering on NIHSeniorHealth Web Site (5/17/07)
  • Study Finds Mix of Disease Processes at Work in Brains of Most People with Dementia (6/13/07). Schneider, JA, et al. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology (2007). DOI: 10.1212/01.wnl.0000271090.28148.24.

AARP Bulletin article sparks interest in AD clinical trials: The June cover story on Alzheimer’s disease (AD) in the AARP Bulletin, sent to 25 million subscribers, included the ADEAR Web site URL and phone number as resources for more information on participating in AD clinical trials. The mention resulted in more than 5,000 phone inquiries to the ADEAR Center and 26,671 searches of the AD clinical trials database. Alzheimer’s Disease Cooperative Study (ADCS) sites (29 sites responding) reported receiving 1,409 calls as a direct result of the article and ADEAR referrals.

(For more information about NIA’s press releases, contact Ms. Vicky Cahan, Director, Office of Communications and Public Liaison [OCPL], Ph: 301-496-1752.)

Meetings and Exhibits

  • NIA and ADEAR publications were distributed at the following meetings and exhibits: Red Hat Society; NIH booths at Hispanic Health Fairs (multiple cities); Montgomery Hospice conference on Alzheimer’s disease; American Geriatrics Society; American Academy of Physician Assistants; U.S. Department of Labor Mental Health Fair; Medical Library Association; Healthier Black Elders Center – Detroit; NIH Women’s Health Week; NIH booth at National Association of Hispanic Journalists; Alzheimer’s Association Prevention Conference; American Academy of Nurse Practitioners; National Black Nurses Association; National Association of Area Agencies on Aging; Links national conference
  • Dr. Hodes and NIA program staff met with staff from the following professional organizations or associations: the Federation of American Societies for Experimental Biology and their members from the American College of Sports Medicine to discuss older people and research on exercise and physical activity; the National Coalition for Osteoporosis and Related Bone Diseases to discuss needed areas of research and future collaborations; and the Alzheimer’s Association to discuss ongoing partnerships such as the Neuroimaging Initiative and future collaborations.

(For more information about NIA’s exhibits, contact Ms. Vicky Cahan, OCPL, Ph: 301-496-1752. For more information about meetings with professional organizations or associations, contact Dr. Tamara Jones, Legislative Officer, Ph: 301-451-8835.)

Awards

  • “Promoting Successful Eating in Long Term Care” (Connections article):National Association of Government Communicators, Award of Excellence; APEX Award for Publication Excellence
  • Understanding Memory Loss (easy-to-read booklet): National Association of Government Communicators, First Place and National Mature Media Merit Award
  • ADEAR Web site (www.nia.nih.gov/alzheimers): National Association of Government Communicators, Second Place; APEX Grand Award
  • NIA Publications CD: APEX Award of Excellence
  • Prevent Heat Stroke Fan: National Mature Media Merit Award
  • NIHSeniorHealth magazine ad – “At Last, A Medical Website Designed for Grownups”: National Mature Media Merit Award
  • NIA Rolodex Card, Award of Distinction, International Annual Communicator Awards
(For more information about NIA’s awards, contact Ms. Vicky Cahan, OCPL, Ph: 301-496-1752.)

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"New Notices and Initiatives Relevant to National Institute on Aging (NIA)
Excerpts from the NIH GUIDE- April 3, 2007 - August 3, 2007
Includes Notices and Initiatives (Requests for Applications (RFAs) and Program Announcements (PAs), published since the May 2007 Council presentation of the Director’s Status Report (DSR) to the National Advisory Council on Aging (NACA). Also check our NIA website for “Funding Opportunities” at www.nia.nih.gov/GrantsAndTraining/FundingOpportunities/CurrentFundingOpportunities.htm

(Shown here are selected Notices and Initiatives relevant to NIA/National Institutes of Health/DHHS).

FUNDING OPPORTUNITIES – RFAs (NIA's ) - those issued by NIA as the primary IC
(Announcements are sorted by release date. Most recent announcements are at the top of this list.)
# Announcement Number Issuing Organization Release Date Opening Date Expiration
Date
Activity Code(s) Title
1 RFA-AG-08-004 NIA 7/18/2007 n/a 11/24/2007 U01 New Interventions for Menopausal Symptoms (U01)
The purpose of this Request for Applications (RFA) is to establish a Menopausal Symptoms Clinical Research Network that will accelerate the development and testing of promising therapies to provide new options to alleviate the most common, bothersome symptoms of the menopause transition.

Sherry Sherman, Ph.D.
Geriatrics and Clinical Gerontology Program
National Institute on Aging, NIH
Gateway Building, Suite 3C-307
7201 Wisconsin Ave.
Bethesda, MD 20892-9205
(Courier/Express Mail ZIP 20814)
Phone: 301-496-6942
Fax: 301-402-1784
Email: shermans@nia.nih.gov
2 RFA-AG-08-002 NIA 7/17/2007 n/a 10/20/2007 U01 International network for identification, evaluation, and follow-up of families with early onset dominantly inherited Alzheimer’s disease (U01)
The purpose of this announcement is to solicit U01 cooperative agreement applications that will set up an international network consisting of a consortium of scientific investigators that will have the responsibility to identify, recruit, evaluate, and follow-up individuals from families with early onset dominantly inherited Alzheimer's disease [i.e., families with the amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2) mutations or duplications or others still to be discovered].

Neil Buckholtz, Ph.D.
Neuroscience and Neuropsychology of Aging Program
National Institute on Aging
Gateway Building Number, Suite 350
7201 Wisconsin Avenue
Bethesda, MD 20892-9205
Telephone: (301) 496-9350
Fax: (301) 496-1494
Email: buckholn@nia.nih.gov
3 RFA-AG-08-003 NIA 7/17/2007 10/22/2007 11/20/2007 R01 Studies to Identify Possible Juvenile Protective Factors and Their Effects on Aging (R01)
The purpose of this FOA is to solicit both descriptive studies to identify putative juvenile protective
factors and experimental studies to test hypotheses about their effects on aging. Studies in humans
or in animals may be proposed. Studies confined to comparisons of young mature and old mature individuals
will not be considered responsive to this announcement.

Chhanda Dutta, Ph.D.
Chief, Clinical Gerontology Branch
Geriatrics and Clinical Gerontology ProgramÂ
National Institute on Aging
7201 Wisconsin Avenue, Suite 3C-307
Bethesda, MD 20892 (ZIP 20814 for express/courier service)
Telephone: (301) 435-3048
Fax: (301) 402-1784
Email: DuttaC@nia.nih.gov
4 RFA-AG-08-005 NIA 6/28/2007 8/17/2007 9/18/2007 R43, R44 Cost Effective Health Promotion Interventions/Programs for Older Workers (SBIR [R43/44])
The goal of this announcement is to improve the health (including mental health) of older workers, reduce avoidable health care utilization, and be cost-effective for employee insurance plans.

John W. R. Phillips, PhD
Behavioral and Social Research Program
National Institute on Aging
National Institutes of Health
7201 Wisconsin Avenue, Gateway 533
Bethesda, MD 20892
Telephone: (301) 496-3138
Fax: (301) 402-0051
Email: phillipj@mail.nih.gov
5 RFA-AG-08-001 NIA 6/13/2007 9/18/2007 10/19/2007 R21 Protein Homeostasis in Aging: Repair and Degradation (R21)
The goal of this FOA is to promote collaboration among investigators in projects that explore the crosstalk and interplay between protein
quality control systems in aging and age-related diseases. Protein quality control refers to those mechanisms underlying the repair or degradation of damaged, mutated or misfolded proteins. This initiative requires collaborations between two or more investigators at different institutions or in different laboratories within the same institution.

Bradley C. Wise, Ph.D.
Neuroscience and Neuropsychology of Aging Program
National Institute on Aging
Gateway Building, Suite 350
7201 Wisconsin Avenue
Bethesda, MD 20892-9205
Telephone: (301) 496-9350
Fax: (301) 496-1494
Email: wiseb@nia.nih.gov

FUNDING OPPORTUNITIES – RFAs –Issued by NIH with NIA involvement
This list includes Roadmap Initiatives.
(Announcements are sorted by release date. Most recent announcements are at the top of this list.)
# Announcement
Number
Issuing Organization Release Date
Opening Date Expiration Date Activity Code(s) Title
1 RFA-MH-08-060 NIH 7/17/2007 8/17/2007 9/18/2007 R21 Tools and Techniques for Elucidating and Manipulating Neural Circuit Development (R21)
This Funding Opportunity Announcement (FOA) solicits applications directed toward the discovery of novel and/or improved means for precise spatiotemporal analysis or manipulation of circuit assembly in the developing central and peripheral nervous systems. For the purposes of this FOA, neural circuit development is defined as processes occurring during prenatal and postnatal development (through adolescence) that begin with axon and dendrite formation and continue through axon guidance and pathfinding, myelination, synapse formation and synapse refinement.

Andrew A. Monjan, Ph.D.
Chief, Neurobiology of Aging Branch
Neuroscience and Neurophysiology of Aging
National Institute on Aging
Gateway Building, Room 350
7201 Wisconsin Ave.
Bethesda, MD 20892
Telephone: (301) 496-9350
FAX: (301) 402-4740
Email: am39m@nih.gov

FUNDING OPPORTUNITIES – RFAs (NIH's )–issued by Other ICs with NIA involvement,
There are no RFAs from other Ics that NIA joined this council round as of 8/1/2007.
(Announcements are sorted by release date. Most recent announcements are at the top of this list.)

There are no RFAs issued by other ICs with NIA involvement (except for MH-08-060 above) this Council round.

FUNDING OPPORTUNITIES – PAs/PARs/PASs (Other's )–issued by NIA as the Primary IC
(Announcements are sorted by release date. Most recent announcements are at the top of this list.)
# Announcement
Number
Issuing Organization Release Date
Opening Date Expiration Date Activity Code(s) Title
1 PAS-07-387 NIA 6/21/2007 9/16/2007 7/17/2010 R21 Harmonization of Longitudinal Cross-National Surveys of Aging (R21)
The purpose of this FOA is to facilitate the ex-ante and ex-post harmonization of international longitudinal surveys of aging populations to the Health and Retirement Study to maximize cross-national comparability of data. Facilitation will include, but is not limited to, meetings, pilots, and the development of methods to improve cross-national comparability of international aging surveys to the Health and Retirement Study and existing international data files that are harmonized with the HRS: the English Longitudinal Study on Ageing (ELSA); and the Survey of Health, Ageing, and Retirement in Europe (SHARE).

John W. R. Phillips, PhD
Behavioral and Social Research Program
National Institute on Aging
Gateway Building, Room 533
7201 Wisconsin Avenue
Bethesda, MD 20892-NNNN
Telephone: (301) 496-3138
Fax: (301) 402-0051
Email: phillipj@mail.nih.gov

FUNDING OPPORTUNITIES – PAs/PARs/PASs (Other's )–issued by NIH with NIA involvement.
This list includes Roadmap Initiatives.
(Announcements are sorted by release date. Most recent announcements are at the top of this list.)
# Announcement
Number
Issuing Organization Release Date
Opening Date Expiration Date Activity Code(s) Title
1 PA-07-421 NIH 7/27/2007 9/5/2007 9/8/2010 R21 Health Promotion Among Racial and Ethnic Minority Males (R21)
This Funding Opportunity Announcement (FOA) solicits Exploratory/Developmental (R21) grant applications from applicants that propose to stimulate and expand research in the health of minority men. Specifically, this initiative is intended to: 1) enhance our understanding of the numerous factors (e.g., sociodemographic, community, societal, personal) influencing the health promoting behaviors of racial and ethnic minority males and their subpopulations across the life cycle, and 2) solicit applications focusing on the development and testing of culturally and linguistically appropriate health-promoting interventions designed to reduce health disparities among racially and ethnically diverse males and their subpopulations age 21 and older.

Dr. Sidney M. Stahl
Behavioral and Social Research Program
NIH, National Institute on Aging
7201 Wisconsin Ave., Room 533
Bethesda, MD 20892-9205
Telephone: (301) 402-4156
FAX: (301) 402-0051
Email: Sidney_Stahl@nih.gov
2 PAR-07-368 Roadmap 4/30/2007 5/28/2007 6/29/2007 X02 Preapplication for the Molecular Libraries Probe Production Centers Network (MLPCN) [X02]
This announcement was developed as an NIH Roadmap Initiative.
This announcement solicits pre-applications for three types of screening and chemical probe generation centers with complementary capabilities and a high degree of flexibility to address a wide range of biological targets and phenotypes in the production phase of the Molecular Libraries Program (MLP).
3 PAR-07-358 Roadmap 4/19/2007 5/28/2007 9/16/2008 X01 National Institutes of Health Rapid Access to Interventional Development (NIH-RAID Pilot) (X01)
This announcement was developed as an NIH Roadmap Initiative.
Successful projects under this program gain access to government contract resources, and are assisted by the NIH in establishing and implementing a product development plan. Projects are supported by the NIH Roadmap and individual Institutes and Centers within NIH.
4 PAR-07-353 Roadmap 4/13/2007 5/28/2007 6/22/2007 X02 Preapplication for Cheminformatics Research Centers (X02)
This announcement was developed as an NIH Roadmap Initiative.
This announcement is soliciting 20-page preapplications for the establishment of Cheminformatics Research Centers (CRCs), a part of the NIH Molecular Libraries Program (MLP).

FUNDING OPPORTUNITIES – PAs/PARs/PASs (Other's )–issued by Other ICs at NIH with NIA involvement.
(Announcements are sorted by release date. Most recent announcements are at the top of this list.)
# Announcement
Number
Issuing Organization Release Date
Opening Date Expiration Date Activity Code(s) Title
1 PAR-07-417 NIBIB 7/25/2007 8/24/2007 5/15/2010 R03 Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination (R03)
This FOA intends to support modification and enhancement of existing neuroimaging informatics tools and resources that are hosted or being considered for inclusion into the NIH Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC, www.nitrc.org, public release scheduled for October 2007). Examples of such tools include image segmentation, image registration, image processing pipelines, statistical analysis packages, spatial alignment and normalization algorithms, and data format translators.

Neil Buckholtz, Ph.D.
Neuroscience and Neuropsychology of Aging Program
National Institute on Aging
Gateway Building, Suite 350
7201 Wisconsin Avenue Bethesda, MD 20892-9205
Telephone: (301) 496-9350
FAX: (301) 496-1494
Email: buckholn@nia.nih.gov
2 PA-07-395 NINDS 7/12/2007 7/12/2007 4/6/2010 R41, R42 Advanced Tools and Technologies for Deep Brain Stimulation in Movement Disorders – STTR (R41/R42)
3 PA-07-396 NINDS 7/12/2007 7/12/2007 4/6/2010 R43, R44 Advanced Tools and Technologies for Deep Brain Stimulation in Movement Disorders – SBIR (R43/R44)
These Funding Opportunity Announcements (FOAs) invite grant applications from small business concerns (SBCs) for projects to design and develop advanced tools and technologies that will lead to improved clinical treatment for Deep Brain Stimulation (DBS) patients.

Andrew A. Monjan, Ph.D., M.P.H.
Chief, Neurobiology of Aging Branch
Neuroscience and Neuropsychology of Aging Program
National Institute on Aging
Gateway Building, Suite 350
7201 Wisconsin Avenue, MSC 9205
Bethesda, MD 20892-9205 (use 20814 for express mail)
Telephone: (301) 496-9350
FAX: (301) 496-1494
E-Mail: monjana@nia.nih.gov
4 PA-07-389 NINDS 6/29/2007 7/5/2007 5/8/2010 R43, R44 Neurotechnology Research, Development, and Enhancement (SBIR [R43/R44])
5 PA-07-390 NINDS 6/29/2007 7/5/2007 5/8/2010 R41, R42 Neurotechnology Research, Development, and Enhancement (STTR [R41/R42])
These Funding Opportunity Announcements (FOAs) solicit grant applications from small business concerns (SBCs) that propose to enable neuroscience and behavioral research through the development of novel, or the significant enhancement or improvement of currently existing, tools and approaches to be used in brain and behavioral research. Such tools and approaches could include those used in basic or clinical research, or for clinical treatment and care (e.g., assessment, diagnosis, and treatment of brain disorders).

Bradley C. Wise, Ph.D.
Neuroscience and Neuropsychology of Aging Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 350, MSC 9205
Bethesda, MD 20892-9205
Telephone: (301) 496-9350
FAX: (301) 496-1494
Email: wiseb@nia.nih.gov
6 PAS-07-381 ORWH 6/11/2007 8/16/2007 1/8/2010 R21 Advancing Novel Science in Women’s Health Research (ANSWHR) [R21]
7 PAS-07-382 ORWH 6/11/2007 8/16/2007 1/8/2010 R03 Advancing Novel Science in Women’s Health Research (ANSWHR) (R03)
The purpose of these Funding Opportunity Announcements(FOA), issued by the Office of Research on Women's Health (ORWH) and co-sponsoring NIH institutes and centers (ICs), is to promote innovative, interdisciplinary research that will advance new concepts in women's health research and the study of sex/gender differences. Recent research reports have established the importance of studying issues specific to women, including the scientific and clinical importance of analyzing data separately for females and males. ORWH is particularly interested in encouraging extramural investigators to undertake new interdisciplinary research to advance studies on how sex and gender factors affect women's health; however, applications in all areas of women's health and/or sex/gender research are invited.

Sherry Sherman, Ph.D.
Geriatrics and Clinical Gerontology Program
National Institute on Aging
Gateway Building, 3C307
7201 Wisconsin Avenue
Bethesda, MD 20810
Tel: 301 435 3048
Email: shermans@nia.nih.gov
8 PAR-07-379 OBSSR 6/7/2007 7/19/2007 9/19/2009 R01 Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01)
9 PAR-07-380 OBSSR 6/7/2007 7/19/2007 9/19/2009 R21 Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21)
The purpose of this PA is to encourage behavioral and social science research on the causes and solutions to health and disabilities disparities in the U.S. population. Health disparities between, on the one hand, racial/ethnic populations, lower socioeconomic classes, and rural residents and, on the other hand, the overall U.S. population are major public health concerns. Emphasis is placed on research in and among three broad areas of action: 1) Public policy, 2) health care, and 3) disease/disability prevention. Particular attention is given to reducing health gaps among groups. Proposals that utilize an interdisciplinary approach, investigate multiple levels of analysis, incorporate a life-course perspective, and/or employ innovative methods such as system science or community-based participatory research are particularly encouraged.

John W. R. Phillips, Ph.D.
Behavioral and Social Research Program
National Institute on Aging
7201 Wisconsin Avenue, Gateway 533
Bethesda, MD 20892
Tel.: 301.496.3138
Fax: 301.402.0051
E-mail: PhillipJ@mail.nih.gov
10 PA-07-362 NCI 4/23/2007 5/16/2007 3/17/2010 R21 Exploratory Cancer Prevention Studies Involving Molecular Targets for Bioactive Food Components (R21)
The goal of this initiative is to foster exploratory/developmental nutrition and cancer prevention research. Specifically, this initiative seeks to promote cancer prevention research to identify and characterize molecular targets for bioactive food components. A bioactive food component is defined as a dietary constituent that has a health benefit by altering one or more cellular processes when provided in quantities over and beyond that needed for basic nutrition.

Judy Hannah, Ph.D.
National Institute on Aging
7201 Wisconsin Avenue, Suite 3C-307
Bethesda, MD 20892
Phone: (301) 435-0044
Fax: (301) 402-1784
Email: hannahj@nia.nih.gov
11 PA-07-354 NHLBI 4/13/2007 5/5/2007 3/6/2010 R01 Bioengineering and Obesity (R01)
The purpose of this FOA is to solicit applications to develop and validate new and innovative engineering approaches to address clinical problems related to energy balance, intake, and expenditure.

Winifred K. Rossi, MA
Deputy Director
Geriatrics and Clinical Gerontology Program
National Institute on Aging, NIH, DHHS
7201 Wisconsin Avenue, Suite 3C307
Bethesda, MD 20892-9205 (Express: 20814)
Telephone: 301-496-3836
Fax: 301-402-1784
Email: winnie_rossi@nih.gov
11 PA-07-355 NHLBI 4/13/2007 5/5/2007 3/6/2010 R01 Improving Heart Failure Disease Management (R01)
The purpose of this initiative is to stimulate innovative research to address inadequately answered questions about disease management in clinical practice for chronic heart failure (HF). The broader goal is to identify and improve, better implement, and disseminate clinically effective disease management tools into clinical practice to reduce HF morbidity and mortality and improve patient outcomes.

Basil A. Eldadah, MD, PhD
Geriatrics and Clinical Gerontology Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 3C307, MSC 9205
Bethesda, MD 20892
Telephone: 301-496-6761
FAX: 301-402-1784
Email: EldadahB@nia.nih.gov
12 PAR-07-352 NIBIB 4/6/2007 5/5/2007 5/8/2010 R01 Bioengineering Research Partnerships (BRP)[R01]
The primary objective of this program announcement is to encourage basic, applied, and translational bioengineering research that could make a significant contribution to improving human health.

Winifred K. Rossi, M.A.
Special Assistant for Planning
NIA
7201 Wisconsin Avenue - Suite 3E327
Bethesda, MD 20892-9205
TEL: 301-496-3836
FAX: 301-402-1784
Email: rossiw@nia.nih.gov
13 PA-07-199 NINDS 12/18/2006 1/5/2007 7/6/2008 R01 Mechanisms of Transmission and Dissemination of Transmissible Spongiform Encephalopathies (TSEs) (R01)
This PA is intended to expand research on how these diseases can spread within an affected population and how infectious prions are then distributed through the body and ultimately to the CNS.

Andrew A. Monjan, Ph.D.
Chief, Neurobiology of Aging Branch
Neuroscience and Neurophysiology of Aging
National Institute on Aging
Gateway Building, Room 350
7201 Wisconsin Ave.
Bethesda, MD 20892
Telephone: (301) 496-9350
FAX: (301) 402-4740
Email: am39m@nih.gov

NOTICES ISSUED BY NIA
(Notices are sorted by release date. Most recent Notices are at the top of this list.)
# Announcement
Number
Issuing Organization Release Date Title
1 NOT-AG-07-008 NIA 7/27/2007 NIA Announcement: Modified Policy for Program Project Applications
2 NOT-AG-07-007 NIA 7/10/2007 Announcing the NIA Mutant Mouse Aging Colony for Biogerontology Research
3 NOT-AG-07-006 NIA 5/4/2007 Administrative Supplements for Translational Aging Research leading to New Interventions, Health Practices and Policies

NOTICES ISSUED BY NIH (Central)
(Notices are sorted by release date. Most recent Notices are at the top of this list.
# Announcement
Number
Issuing Organization Release Date Title
1 NOT-OD-07-081 NIH 8/3/2007 Notice of Release of the NIH/CDC Small Business Innovation Research (SBIR) Contract Solicitation (PHS 2008-1)
2 NOT-OD-07-082 NIH 8/3/2007 NIH Offers Commercialization Assistance Program to SBIR Phase II Awardees
3 NOT-OD-07-080 NIH 7/31/2007 NIH Offers SBIR Niche Assessment Program to Phase I Awardees
4 NOT-OD-07-078 NIH 7/27/2007 NIH Requiring Mandatory Use of the Electronic Financial Status Report System in the eRA Commons Beginning October 1, 2007
5 NOT-OD-07-076 NIH 7/20/2007 Announcing 2008 NIH Regional Seminars in Program Funding and Grants Administration
6 NOT-RM-07-011 NIH 7/13/2007 The NIH Intramural Research Program and the NIH Director’s Roadmap Initiative – Locus of Review
7 NOT-OD-07-074 NIH 7/6/2007 Request for Information (RFI): NIH System to Support Biomedical and Behavioral Research and Peer Review
8 NOT-OD-07-070 NIH 6/22/2007 NIH/AHRQ/NIOSH Announce Change in Electronic Submission Process – Federal Holidays Excluded from Application Viewing Window
9 NOT-MH-07-114 NIH 6/4/2007 This is a notice related to the Blueprint Initiative issued by NIMH on behalf of NIH involving NIH's intent to publish a Request for Applications for Tools and Techniques for Elucidating and Manipulating Neural Circuit Development.
10 NOT-RM-07-007 NIH 3/30/2007 Notice of Clarification of Application Instructions for NIH Director’s New Innovator Award (DP2)

NOTICES ISSUED BY OTHER INSTITUTES/CENTERS AT NIH (with NIA involvement)
(Notices are sorted by release date. Most recent Notices are at the top of this list.)
# Announcement Number Issuing Organization Release Date Title
1 NOT-MH-07-117 NIMH 7/25/2007 Request for Information (RFI): Creating a Gene Expression Atlas for Developing Rhesus Macaque Brain (Neuroscience Blueprint)
2 NOT-DC-07-003 NIH 5/31/2007 Notice of Extension for Request for Information (RFI): Tools and Resources for Human Embryonic Stem Cell Research in the Nervous System (Neuroscience Blueprint)
3 NOT-NS-07-009 NINDS 5/4/2007 Announcement of the US-JAPAN Brain Research Cooperative Program - US Component

Page last updated Feb 19, 2009