• Incidence of atrial tachyarrhythmia recorded by the pacemakers [ Time Frame: At 2-year follow-up ] [ Designated as safety issue: No ]
• Worsening of heart failure [ Time Frame: At 2-year follow-up ] [ Designated as safety issue: No ]
• All cause mortality [ Time Frame: At 2-year follow-up ] [ Designated as safety issue: No ]
• Incidence of stroke [ Time Frame: At 2-year follow-up ] [ Designated as safety issue: No ]
• N-Terminal Brain Natriuretic Peptide (NT-proBNP) levels [ Time Frame: At 2-year follow-up ] [ Designated as safety issue: No ]
• Echocardiographic measures of left ventricular dyssynchrony [ Time Frame: At 2-year follow-up ] [ Designated as safety issue: No ]
• 6 minute Hall-Walk distance [ Time Frame: At 2-year follow-up ] [ Designated as safety issue: No ]

• Incidence of atrial tachyarrhythmia recorded by the pacemakers at 1 and 2 years
• Worsening of heart failure at 1 and 2 years
• All cause mortality at 1 and 2 years
• Incidence of stroke at 1 and 2 years
• Brain Natriuretic Peptide (BNP) levels at 1 and 2 years
• NTproBNP levels at 1 and 2 years
• Echocardiographic measures of cardiac dyssynchrony at 1 and 2 years
• 6 minute walking distances at 1 and 2 years

This study will be done in patients who require the implantation of a cardiac pacemaker (an electronic device that controls the heartbeat) for complete heart block (a heart rhythm abnormality resulting in a slow heart beat). Pacemakers regulate the heart beat by delivering pulses of electricity through special wires (pacing leads) which are placed inside the heart.

This study will compare two groups of pacemaker patients. Each group will have their pacing leads placed in a particular location in the heart. The purpose of the study is to show whether the position used in one group is better for maintaining effective heart function compared to the position used in the other group.

The leads in one group will be placed in a position called the Right Ventricular Apex. This is the traditional and most frequently used position for pacemaker leads.

The leads in the other group will be placed in a position called the Right Ventricular High Septum. This is a less commonly used position, but may result in health benefits for the patients compared with the Right Ventricular Apex.

There is an increasing amount of evidence to suggest that other positions in the heart may be more effective than the conventional Right Ventricular Apex (RVA) position for restoring good heart function. The best site to place a lead has not yet been proven.

This is a study comparing the long term clinical effects of two different lead positions. The measurements taken to assess the clinical effects include:

• the effectiveness of the heart's pumping action (as measured by ultrasound scans)
• measurements of how far patients can walk in 6 minutes
• analysis of blood samples
• collection of information from the pacemaker about heart rhythm problems

Half of the patients in the study will receive conventional leads placed in the more common RVA position in the heart. The other half will receive a relatively new type of lead placed in what is called the Right Ventricular High Septal (RVHS) position.

In order to fairly compare the outcomes of these two different lead positions this study has been designed as a 'randomized', 'blind' trial. This means that the group which patients will be entered into will be chosen at random and patients will not be told which group they are in.

Patients will each have an equal (50:50) chance of being in either group. By carefully comparing the clinical differences between the two groups of patients, the study aims to prove whether or not there are additional benefits for patients when the RVHS lead position is used. All leads used in the study have been shown to be safe for patients and are available commercially for implantation. All of the implanting doctors involved in the study are experienced at implanting the pacemakers and leads that will be used in this study.

Inclusion Criteria:

• Patients with high grade AV block and sinus rhythm, scheduled to undergo dual chamber pacemaker implantation OR patients with high grade AV block and permanent atrial fibrillation, scheduled to undergo single chamber ventricular pacemaker implantation.
• Patients aged 18 years or older.

Exclusion Criteria:

• Patients indicated for an Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy.
• Patients following junctional ablation.
• Patients with a Myocardial Infarction within three months prior to enrollment.
• Patients that received bypass surgery within three months prior to enrollment.
• Patients that had a valve replacement within three months prior to enrollment or patients with a mechanical right heart valve.
• Patients where a right ventricular lead cannot be placed i.e. complex congenital heart disease.
• Patients with hypertrophic obstructive cardiomyopathy.
• Patients with acute coronary syndrome, unstable angina, severe mitral regurgitation and/or hemodynamically significant aortic stenosis.
• Previous implanted pacemaker or cardioverter defibrillator.
• Known paroxysmal atrial fibrillation or a documented episode of atrial fibrillation prior to enrollment.
• Patients on amiodarone therapy within the last six months prior to enrollment.
• Terminal conditions with a life expectancy of less than two years.
• Participation in any other study that would confound the results of this study.
• Psychological or emotional problems that may interfere with the volunteer's ability to provide full consent or fully understand the purposes of the study.
• Pregnant patients or patients who may become pregnant during the time-scale of the study.