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Volume 17(4);  April 2008
Accelerated Communication
Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design
Yechun Xu, Jacques Ph. Colletier, Hualiang Jiang, Israel Silman, Joel L. Sussman, and Martin Weik
Protein Sci. 2008 April; 17(4): 601–605. doi: 10.1110/ps.083453808.
PMCID: PMC2271175
Articles
The epitope space of the human proteome
Lisa Berglund, Jorge Andrade, Jacob Odeberg, and Mathias Uhlén
Protein Sci. 2008 April; 17(4): 606–613. doi: 10.1110/ps.073347208.
PMCID: PMC2271163
Design of a highly specific and noninvasive biosensor suitable for real-time in vivo imaging of mercury (II) uptake
Richard R. Chapleau, Rebecca Blomberg, Peter C. Ford, and Martin Sagermann
Protein Sci. 2008 April; 17(4): 614–622. doi: 10.1110/ps.073358908.
PMCID: PMC2271171
Analysis of solvent content and oligomeric states in protein crystals—does symmetry matter?
Maksymilian Chruszcz, Wojciech Potrzebowski, Matthew D. Zimmerman, Marek Grabowski, Heping Zheng, Piotr Lasota, and Wladek Minor
Protein Sci. 2008 April; 17(4): 623–632. doi: 10.1110/ps.073360508.
PMCID: PMC2271157
Design of an engineered N-terminal HIV-1 gp41 trimer with enhanced stability and potency
John J. Dwyer, Karen L. Wilson, Kimberly Martin, Jennifer E. Seedorff, Aisha Hasan, Robyn J. Medinas, Donna K. Davison, Michael D. Feese, Hans-Thomas Richter, Hidong Kim, Thomas J. Matthews, and Mary K. Delmedico
Protein Sci. 2008 April; 17(4): 633–643. doi: 10.1110/ps.073307608.
PMCID: PMC2271165
Side chain burial and hydrophobic core packing in protein folding transition states
Patrick J. Farber and Anthony Mittermaier
Protein Sci. 2008 April; 17(4): 644–651. doi: 10.1110/ps.073105408.
PMCID: PMC2271162
Structural and thermodynamic effects of ANS binding to human interleukin-1 receptor antagonist
Ramil F. Latypov, Dingjiang Liu, Kannan Gunasekaran, Timothy S. Harvey, Vladimir I. Razinkov, and Andrei A. Raibekas
Protein Sci. 2008 April; 17(4): 652–663. doi: 10.1110/ps.073332408.
PMCID: PMC2271160
Substrate specificity of human kallikreins 1 and 6 determined by phage display
Hai-Xin Li, Bum-Yeol Hwang, Gurunathan Laxmikanthan, Sachiko I. Blaber, Michael Blaber, Pavel A. Golubkov, Pengyu Ren, Brent L. Iverson, and George Georgiou
Protein Sci. 2008 April; 17(4): 664–672. doi: 10.1110/ps.073333208.
PMCID: PMC2271166
Engineering membrane protein overproduction in Escherichia coli
Daniel Martinez Molina, Tobias Cornvik, Said Eshaghi, Jesper Z. Haeggström, Pär Nordlund, and Marina Ignatushchenko Sabet
Protein Sci. 2008 April; 17(4): 673–680. doi: 10.1110/ps.073242508.
PMCID: PMC2271156
Nonspecific base recognition mediated by water bridges and hydrophobic stacking in ribonuclease I from Escherichia coli
Sergio Martinez Rodriguez, Santosh Panjikar, Karolien Van Belle, Lode Wyns, Joris Messens, and Remy Loris
Protein Sci. 2008 April; 17(4): 681–690. doi: 10.1110/ps.073420708.
PMCID: PMC2271172
Crystal structure of enoyl–acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor
Jun Saito, Mototsugu Yamada, Takashi Watanabe, Maiko Iida, Hideo Kitagawa, Sho Takahata, Tomohiro Ozawa, Yasuo Takeuchi, and Fukuichi Ohsawa
Protein Sci. 2008 April; 17(4): 691–699. doi: 10.1110/ps.073288808.
PMCID: PMC2271168
The crystal structure of the C45S mutant of annelid Arenicola marina peroxiredoxin 6 supports its assignment to the mechanistically typical 2-Cys subfamily without any formation of toroid-shaped decamers
Aude Smeets, Eléonore Loumaye, André Clippe, Jean-François Rees, Bernard Knoops, and Jean-Paul Declercq
Protein Sci. 2008 April; 17(4): 700–710. doi: 10.1110/ps.073399308.
PMCID: PMC2271159
Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities
Dmitri Tolkatchev, Suneil Malik, Anna Vinogradova, Ping Wang, Zhigang Chen, Ping Xu, Hugh P.J. Bennett, Andrew Bateman, and Feng Ni
Protein Sci. 2008 April; 17(4): 711–724. doi: 10.1110/ps.073295308.
PMCID: PMC2271164
Structure–function studies on the active site of the coelenterazine-dependent luciferase from Renilla
Jongchan Woo, Matthew H. Howell, and Albrecht G. von Arnim
Protein Sci. 2008 April; 17(4): 725–735. doi: 10.1110/ps.073355508.
PMCID: PMC2271170
An efficient on-column expressed protein ligation strategy: Application to segmental triple labeling of human apolipoprotein E3
Wentao Zhao, Yonghong Zhang, Chunxian Cui, Qianqian Li, and Jianjun Wang
Protein Sci. 2008 April; 17(4): 736–747. doi: 10.1110/ps.073383708.
PMCID: PMC2271161
Cu(II) organizes β-2-microglobulin oligomers but is released upon amyloid formation
Kwasi Antwi, Maura Mahar, Rapole Srikanth, Mark R. Olbris, Julian F. Tyson, and Richard W. Vachet
Protein Sci. 2008 April; 17(4): 748–759. doi: 10.1110/ps.073249008.
PMCID: PMC2271169
Zn2+ binding to human calbindin D28k and the role of histidine residues
Mikael C. Bauer, Hanna Nilsson, Eva Thulin, Birgitta Frohm, Johan Malm, and Sara Linse
Protein Sci. 2008 April; 17(4): 760–767. doi: 10.1110/ps.073381108.
PMCID: PMC2271158
Structural dependencies of protein backbone 2JNC′ couplings
Nenad Juranić, J.J. Dannenberg, Gabriel Cornilescu, Pedro Salvador, Elena Atanasova, Hee-Chul Ahn, Slobodan Macura, John L. Markley, and Franklyn G. Prendergast
Protein Sci. 2008 April; 17(4): 768–776. doi: 10.1110/ps.073331608.
PMCID: PMC2271174
Quantitative analysis of multi-protein interactions using FRET: Application to the SUMO pathway
Sarah F. Martin, Michael H. Tatham, Ronald T. Hay, and Ifor D.W. Samuel
Protein Sci. 2008 April; 17(4): 777–784. doi: 10.1110/ps.073369608.
PMCID: PMC2271167
Protein Structure Report
NMR solution structure of KP-TerB, a tellurite-resistance protein from Klebsiella pneumoniae
Sheng-Kuo Chiang, Yuan-Chao Lou, and Chinpan Chen
Protein Sci. 2008 April; 17(4): 785–789. doi: 10.1110/ps.073389408.
PMCID: PMC2271173
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