| | This journal provides immediate access to some articles. Commentaries HIV therapy: Managing resistance Dominik Wodarz and Martin A. Nowak Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8193–8195. PMCID: PMC34002 Neural circuits in the 21st century: Synaptic networks of neurons
and glia Joseph J. LoTurco Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8196–8197. PMCID: PMC34003 Bt corn pollen impacts on nontarget Lepidoptera: Assessment of
effects in nature David S. Pimentel and Peter H. Raven Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8198–8199. PMCID: PMC34004 Physical Sciences Applied Mathematics Generalized flows, intrinsic stochasticity, and turbulent transport Weinan E Vanden Eijnden and Eric Vanden Eijnden Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8200–8205. PMCID: PMC26923 The paradox of alloreactivity and self MHC restriction: Quantitative analysis and statistics Vincent Detours and Alan S. Perelson Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8479–8483. PMCID: PMC26973 Applied Physical Sciences Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission Thomas A. Klar, Stefan Jakobs, Marcus Dyba, Alexander Egner, and Stefan W. Hell Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8206–8210. PMCID: PMC26924 Compact stellarators with modular coils P. R. Garabedian Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8211–8215. PMCID: PMC26925 Chemistry The decomposition of peroxynitrite does not yield nitroxyl anion and singlet oxygen Gábor Merényi, Johan Lind, Gidon Czapski, and Sara Goldstein Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8216–8218. Published online 2000 July 4. PMCID: PMC26926 Two-dimensional infrared spectroscopy of peptides by phase-controlled femtosecond vibrational photon echoes M. C. Asplund, M. T. Zanni, and R. M. Hochstrasser Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8219–8224. Published online 2000 July 11. PMCID: PMC26927 Microtubule self-organization is gravity-dependent Cyril Papaseit, Nathalie Pochon, and James Tabony Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8364–8368. Published online 2000 July 4. PMCID: PMC26953 Biological Sciences Anthropology Polynesian origins: Insights from the Y chromosome Bing Su, Li Jin, Peter Underhill, Jeremy Martinson, Nilmani Saha, Stephen T. McGarvey, Mark D. Shriver, Jiayou Chu, Peter Oefner, Ranajit Chakraborty, and Ranjan Deka Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8225–8228. PMCID: PMC26928 Applied Biological Sciences A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program Jörg C. Heinrich and Maxwell J. Scott Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8229–8232. Published online 2000 July 11. PMCID: PMC26929 Biochemistry Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding Julian C.-H. Chen, Jolanta Krucinski, Larry J. W. Miercke, Janet S. Finer-Moore, Ann H. Tang, Andrew D. Leavitt, and Robert M. Stroud Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8233–8238. Published online 2000 July 11. PMCID: PMC26930 A deoxyribonucleotidase in mitochondria: Involvement in regulation of dNTP pools and possible link to genetic disease Chiara Rampazzo, Lisa Gallinaro, Eva Milanesi, Elisabetta Frigimelica, Peter Reichard, and Vera Bianchi Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8239–8244. PMCID: PMC26931 Structure–activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: The proline hinge is responsible for the cell-penetrating ability of buforin II Chan Bae Park, Kwan-Su Yi, Katsumi Matsuzaki, Mi Sun Kim, and Sun Chang Kim Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8245–8250. Published online 2000 July 11. PMCID: PMC26932 Biosynthesis of terpenoids: 4-Diphosphocytidyl-2-C-methyl-d-erythritol kinase from tomato Felix Rohdich, Juraithip Wungsintaweekul, Holger Lüttgen, Markus Fischer, Wolfgang Eisenreich, Christoph A. Schuhr, Monika Fellermeier, Nicholas Schramek, Meinhart H. Zenk, and Adelbert Bacher Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8251–8256. Published online 2000 July 4. PMCID: PMC26933 Crystal structure of the Holliday junction DNA in complex with a single RuvA tetramer Mariko Ariyoshi, Tatsuya Nishino, Hiroshi Iwasaki, Hideo Shinagawa, and Kosuke Morikawa Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8257–8262. Published online 2000 July 11. PMCID: PMC26934 m5C RNA and m5C DNA methyl transferases use different cysteine residues as catalysts Yaoquan Liu and Daniel V. Santi Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8263–8265. PMCID: PMC26935 Memory landscapes of single-enzyme molecules Lars Edman and Rudolf Rigler Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8266–8271. Published online 2000 July 4. PMCID: PMC26936 From the Cover: Sensitive detection of DNA polymorphisms by the serial invasive signal amplification reaction Jeff G. Hall, Peggy S. Eis, Scott M. Law, Luis P. Reynaldo, James R. Prudent, David J. Marshall, Hatim T. Allawi, Andrea L. Mast, James E. Dahlberg, Robert W. Kwiatkowski, Monika de Arruda, Bruce P. Neri, and Victor I. Lyamichev Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8272–8277. Published online 2000 July 11. PMCID: PMC26937 A cytotoxic ribonuclease which specifically cleaves four isoaccepting arginine tRNAs at their anticodon loops Kozo Tomita, Tetsuhiro Ogawa, Takeshi Uozumi, Kimitsuna Watanabe, and Haruhiko Masaki Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8278–8283. Published online 2000 July 4. PMCID: PMC26938 Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids Jennifer M. Parker-Barnes, Tapas Das, Emil Bobik, Amanda E. Leonard, Jennifer M. Thurmond, Lu-Te Chaung, Yung-Sheng Huang, and Pradip Mukerji Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8284–8289. PMCID: PMC26939 Activation of polyamine catabolism in transgenic rats induces acute pancreatitis Leena Alhonen, Jyrki J. Parkkinen, Tuomo Keinänen, Riitta Sinervirta, Karl-Heinz Herzig, and Juhani Jänne Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8290–8295. Published online 2000 July 4. PMCID: PMC26940 A quantitative, high-throughput screen for protein stability S. Ghaemmaghami, M. C. Fitzgerald, and T. G. Oas Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8296–8301. Published online 2000 July 11. PMCID: PMC26941 Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53 Sam W. Lee, Li Fang, Makoto Igarashi, Toru Ouchi, Kun Ping Lu, and Stuart A. Aaronson Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8302–8305. Published online 2000 July 11. PMCID: PMC26942 Biophysics Two-dimensional infrared spectroscopy of peptides by phase-controlled femtosecond vibrational photon echoes M. C. Asplund, M. T. Zanni, and R. M. Hochstrasser Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8219–8224. Published online 2000 July 11. PMCID: PMC26927 Changes in brain cell shape create residual extracellular space volume and explain tortuosity behavior during osmotic challenge Kevin C. Chen and Charles Nicholson Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8306–8311. Published online 2000 July 11. PMCID: PMC26943 NMR investigation of ferricytochrome c unfolding: Detection of an equilibrium unfolding intermediate and residual structure in the denatured state Brandy S. Russell, Rory Melenkivitz, and Kara L. Bren Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8312–8317. Published online 2000 July 4. PMCID: PMC26944 Site-specific conformational determination in thermal unfolding studies of helical peptides using vibrational circular dichroism with isotopic substitution R. A. G. D. Silva, Jan Kubelka, Petr Bour, Sean M. Decatur, and Timothy A. Keiderling Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8318–8323. Published online 2000 July 4. PMCID: PMC26945 Temperature and length scale dependence of hydrophobic effects and their possible implications for protein folding David M. Huang and David Chandler Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8324–8327. Published online 2000 July 11. PMCID: PMC26946 Modeling the dynamics of human hair cycles by a follicular automaton J. Halloy, B. A. Bernard, G. Loussouarn, and A. Goldbeter Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8328–8333. PMCID: PMC26947 NMR structure of the bovine prion protein Francisco López García, Ralph Zahn, Roland Riek, and Kurt Wüthrich Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8334–8339. PMCID: PMC26948 NMR structures of three single-residue variants of the human prion protein Luigi Calzolai, Dominikus A. Lysek, Peter Güntert, Christine von Schroetter, Roland Riek, Ralph Zahn, and Kurt Wüthrich Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8340–8345. PMCID: PMC26949 Cell Biology From the Cover: Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells Takashi Shinohara, Kyle E. Orwig, Mary R. Avarbock, and Ralph L. Brinster Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8346–8351. PMCID: PMC26950 Phosphate is a specific signal for induction of osteopontin gene expression George R. Beck, Jr., Brad Zerler, and Elizabeth Moran Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8352–8357. Published online 2000 July 11. PMCID: PMC26951 Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and Wnt pathways Etienne Labbé, Ainhoa Letamendia, and Liliana Attisano Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8358–8363. Published online 2000 July 11. PMCID: PMC26952 Microtubule self-organization is gravity-dependent Cyril Papaseit, Nathalie Pochon, and James Tabony Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8364–8368. Published online 2000 July 4. PMCID: PMC26953 Localization of α1,3-fucosyltransferase VI in Weibel–Palade bodies of human endothelial cells Silvia Schnyder-Candrian, Lubor Borsig, René Moser, and Eric G. Berger Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8369–8374. PMCID: PMC26954 Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface Sanna Heino, Sari Lusa, Pentti Somerharju, Christian Ehnholm, Vesa M. Olkkonen, and Elina Ikonen Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8375–8380. Published online 2000 July 11. PMCID: PMC26955 Inhibition of proteasomal degradation by the Gly-Ala repeat of Epstein–Barr virus is influenced by the length of the repeat and the strength of the degradation signal Nico P. Dantuma, Stijn Heessen, Kristina Lindsten, Marianne Jellne, and Maria G. Masucci Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8381–8385. Published online 2000 July 11. PMCID: PMC26956 Developmental Biology The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling Jun Peng, Liyong Zhang, Linsay Drysdale, and Guo-Hua Fong Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8386–8391. Published online 2000 July 4. PMCID: PMC26957 Evolution Interpreting the universal phylogenetic tree Carl R. Woese Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8392–8396. PMCID: PMC26958 Genetics Transcription coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences Florence Le Page, Arne Klungland, Deborah E. Barnes, Alain Sarasin, and Serge Boiteux Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8397–8402. Published online 2000 July 11. PMCID: PMC26959 Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine Martijn E. T. Dollé, Wendy K. Snyder, Jan A. Gossen, Paul H. M. Lohman, and Jan Vijg Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8403–8408. PMCID: PMC26960 Fundamental patterns underlying gene expression profiles: Simplicity from complexity Neal S. Holter, Madhusmita Mitra, Amos Maritan, Marek Cieplak, Jayanth R. Banavar, and Nina V. Fedoroff Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8409–8414. Published online 2000 July 11. PMCID: PMC26961 Balancing transcriptional interference and initiation on the
GAL7 promoter of
Saccharomyces cerevisiae Ingo H. Greger, Agustín Aranda, and Nick Proudfoot Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8415–8420. Published online 2000 July 11. PMCID: PMC26962 A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13 Alexander J. Muller, Angelika K. Teresky, and Arnold J. Levine Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8421–8426. Published online 2000 July 11. PMCID: PMC26963 Immunology The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge Laura Stobie, Sanjay Gurunathan, Calman Prussin, David L. Sacks, Nicolas Glaichenhaus, Chang-You Wu, and Robert A. Seder Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8427–8432. Published online 2000 July 11. PMCID: PMC26964 Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: Molecular basis for serotype specificity S. Villeneuve, H. Souchon, M.-M. Riottot, J.-C. Mazié, P.-s. Lei, C. P. J. Glaudemans, P. Kováč, J.-M. Fournier, and P. M. Alzari Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8433–8438. Published online 2000 July 4. PMCID: PMC26965 Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation Hideto Ikushima, Yasuhiko Munakata, Tomonori Ishii, Satoshi Iwata, Masazumi Terashima, Hirotoshi Tanaka, Stuart F. Schlossman, and Chikao Morimoto Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8439–8444. PMCID: PMC26966 CD1c molecules broadly survey the endocytic system Masahiko Sugita, Nicole van der Wel, Rick A. Rogers, Peter J. Peters, and Michael B. Brenner Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8445–8450. Published online 2000 July 11. PMCID: PMC26967 The serine and threonine residues in the Ig-α cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction Ralph Müller, Jürgen Wienands, and Michael Reth Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8451–8454. PMCID: PMC26968 Inhibition of MHC class I-restricted antigen presentation by γ2-herpesviruses Philip G. Stevenson, Stacey Efstathiou, Peter C. Doherty, and Paul J. Lehner Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8455–8460. Published online 2000 July 11. PMCID: PMC26969 α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria Gloria Gonzalez-Aseguinolaza, Camila de Oliveira, Margaret Tomaska, Seokmann Hong, Oscar Bruna-Romero, Toshinori Nakayama, Masaru Taniguchi, Albert Bendelac, Luc Van Kaer, Yasuhiko Koezuka, and Moriya Tsuji Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8461–8466. PMCID: PMC26970 V(D)J recombination is not activated by demethylation of the kappa locus Sara R. Cherry, Caroline Beard, Rudolf Jaenisch, and David Baltimore Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8467–8472. Published online 2000 July 4. PMCID: PMC26971 Comparative T cell receptor repertoire selection by antigen after adoptive transfer: A glimpse at an antigen-specific preimmune repertoire Valérie Attuil, Philipp Bucher, Mauricette Rossi, Mireille Mutin, and Janet L. Maryanski Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8473–8478. PMCID: PMC26972 The paradox of alloreactivity and self MHC restriction: Quantitative analysis and statistics Vincent Detours and Alan S. Perelson Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8479–8483. PMCID: PMC26973 Medical Sciences A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin Kazuhiko Mishima, Andrew P. Mazar, Allen Gown, Marilyn Skelly, Xiang-Dong Ji, Xu-Dong Wang, Terence R. Jones, Webster K. Cavenee, and H.-J. Su Huang Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8484–8489. Published online 2000 July 11. PMCID: PMC26974 Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts Takashi Watanabe and Bruce A. Sullenger Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8490–8494. Published online 2000 July 11. PMCID: PMC26975 High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment Anna M. Wu, Paul J. Yazaki, Shih-wa Tsai, Khoi Nguyen, Anne-Line Anderson, Deborah W. McCarthy, Michael J. Welch, John E. Shively, Lawrence E. Williams, Andrew A. Raubitschek, Jeffrey Y. C. Wong, Tatsushi Toyokuni, Michael E. Phelps, and Sanjiv S. Gambhir Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8495–8500. Published online 2000 July 4. PMCID: PMC26976 Activation of p53 in cervical carcinoma cells by small molecules Sakari Hietanen, Sonia Lain, Eberhard Krausz, Christine Blattner, and David P. Lane Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8501–8506. PMCID: PMC26977 Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products Alan R. Schoenfeld, Eliot J. Davidowitz, and Robert D. Burk Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8507–8512. PMCID: PMC26978 LXRα functions as a cAMP-responsive transcriptional regulator of gene expression Kouichi Tamura, Yuqing E. Chen, Masatsugu Horiuchi, Qin Chen, Laurent Daviet, Zhiyong Yang, Laurent Daviet, Marco Lopez-Ilasaca, Hui Mu, Richard E. Pratt, and Victor J. Dzau Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8513–8518. Published online 2000 July 11. PMCID: PMC26979 Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line Takahiko Kogai, James J. Schultz, Laura S. Johnson, Min Huang, and Gregory A. Brent Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8519–8524. Published online 2000 July 11. PMCID: PMC26980 Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme Wei Yan, Faye Wu, John Morser, and Qingyu Wu Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8525–8529. Published online 2000 July 4. PMCID: PMC26981 Role of cysteines in Plasmodium falciparum circumsporozoite protein: Interactions with heparin can rejuvenate inactive protein mutants Dharmendar Rathore and Thomas F. McCutchan Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8530–8535. Published online 2000 July 11. PMCID: PMC26982 Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets Tetsuya Kakuma, Young Lee, Moritake Higa, Zhuo-wei Wang, Wentong Pan, Iichiro Shimomura, and Roger H. Unger Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8536–8541. PMCID: PMC26983 Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells Debajit K. Biswas, Antonio P. Cruz, Eva Gansberger, and Arthur B. Pardee Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8542–8547. PMCID: PMC26984 Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity Yasuo Tsutsumi, Masanori Onda, Satoshi Nagata, Byungkook Lee, Robert J. Kreitman, and Ira Pastan Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8548–8553. Published online 2000 July 11. PMCID: PMC26985 Microbiology whmD is an essential mycobacterial gene required for proper septation and cell division James E. Gomez and William R. Bishai Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8554–8559. Published online 2000 July 4. PMCID: PMC26986 Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis Igor Kramnik, William F. Dietrich, Peter Demant, and Barry R. Bloom Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8560–8565. Published online 2000 July 11. PMCID: PMC26987 Identification of eIF2Bγ and eIF2γ as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach Martin Krüger, Carmela Beger, Qiang-Xin Li, Peter J. Welch, Richard Tritz, Mark Leavitt, Jack R. Barber, and Flossie Wong-Staal Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8566–8571. PMCID: PMC26988 CTX contains a hybrid genome derived from tandemly integrated elements Brigid M. Davis and Matthew K. Waldor Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8572–8577. Published online 2000 July 4. PMCID: PMC26989 Neurobiology Calcium imaging demonstrates colocalization of calcium influx and extrusion in fly photoreceptors Johannes Oberwinkler and Doekele G. Stavenga Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8578–8583. PMCID: PMC26990 A relationship between behavior, neurotrophin expression, and new neuron survival Xiao-Ching Li, Erich D. Jarvis, Benjamin Alvarez-Borda, Daniel A. Lim, and Fernando Nottebohm Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8584–8589. Published online 2000 July 11. PMCID: PMC26991 Calsenilin reverses presenilin-mediated enhancement of calcium signaling Malcolm A. Leissring, Tritia R. Yamasaki, Wilma Wasco, Joseph D. Buxbaum, Ian Parker, and Frank M. LaFerla Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8590–8593. PMCID: PMC26992 The γ-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse Matthias Kneussel, Silke Haverkamp, Jens C. Fuhrmann, Hongbing Wang, Heinz Wässle, Richard W. Olsen, and Heinrich Betz Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8594–8599. PMCID: PMC26993 An initiator element mediates autologous downregulation of the human type A γ-aminobutyric acid receptor β1 subunit gene Shelley J. Russek, Sabita Bandyopadhyay, and David H. Farb Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8600–8605. PMCID: PMC26994 Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes Silvia Ginés, Joëlle Hillion, Maria Torvinen, Stèphane Le Crom, Vicent Casadó, Enric I. Canela, Sofia Rondin, Jow Y. Lew, Stanley Watson, Michele Zoli, Luigi Francesco Agnati, Philippe Vernier, Carmen Lluis, Sergi Ferré, Kjell Fuxe, and Rafael Franco Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8606–8611. Published online 2000 July 11. PMCID: PMC26995 Reelin controls position of autonomic neurons in the spinal cord Joseph W. Yip, Yee Ping L. Yip, Kazunori Nakajima, and Christine Capriotti Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8612–8616. Published online 2000 July 4. PMCID: PMC26996 Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism Masayuki Sasaki, Mirella Gonzalez-Zulueta, Hui Huang, William J. Herring, Sohyun Ahn, David D. Ginty, Valina L. Dawson, and Ted M. Dawson Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8617–8622. PMCID: PMC26997 Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness J. Preston Van Hooser, Tomas S. Aleman, Yu-Guang He, Artur V. Cideciyan, Vladimir Kuksa, Steven J. Pittler, Edwin M. Stone, Samuel G. Jacobson, and Krzysztof Palczewski Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8623–8628. Published online 2000 June 27. PMCID: PMC26998 From the Cover: Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons Vladimir Parpura and Philip G. Haydon Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8629–8634. PMCID: PMC26999 Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate Samuel S.-H. Wang, Leonard Khiroug, and George J. Augustine Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8635–8640. Published online 2000 July 11. PMCID: PMC27000 Pentameric assembly of a neuronal glutamate transporter Sepehr Eskandari, Michael Kreman, Michael P. Kavanaugh, Ernest M. Wright, and Guido A. Zampighi Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8641–8646. PMCID: PMC27001 Excess “read-through” acetylcholinesterase attenuates but the “synaptic” variant intensifies neurodeterioration correlates Meira Sternfeld, Shai Shoham, Omer Klein, Cesar Flores-Flores, Tamah Evron, Gregory H. Idelson, Dani Kitsberg, James W. Patrick, and Hermona Soreq Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8647–8652. Published online 2000 July 11. PMCID: PMC27002 Pharmacology A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus Pietro Paolo Sanna, Fulvia Berton, Maurizio Cammalleri, Melanie K. Tallent, George R. Siggins, Floyd E. Bloom, and Walter Francesconi Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8653–8657. Published online 2000 July 11. PMCID: PMC27003 Fibroblast growth factors: An epigenetic mechanism of broad spectrum resistance to anticancer drugs SaeHeum Song, M. Guillaume Wientjes, Yuebo Gan, and Jessie L.-S. Au Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8658–8663. Published online 2000 July 11. PMCID: PMC27004 Physiology γ-Aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes Paco Lorente, Alain Lacampagne, Yvan Pouzeratte, Stephen Richards, Barbara Malitschek, Rainer Kuhn, Bernhard Bettler, and Guy Vassort Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8664–8669. PMCID: PMC27005 Mitochondria as ATP consumers: Cellular treason in anoxia Julie St-Pierre, Martin D. Brand, and Robert G. Boutilier Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8670–8674. Published online 2000 July 11. PMCID: PMC27006 Regulation of CFTR Cl− channel gating by ATP binding and hydrolysis Mutsuhiro Ikuma and Michael J. Welsh Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8675–8680. Published online 2000 July 4. PMCID: PMC27007 Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: A possible link between inflammatory cytokines and atherogenesis Ma-Li Wong, Boxun Xie, Nan Beatini, Phan Phu, Sudhir Marathe, Anthony Johns, Philip W. Gold, Emmet Hirsch, Kevin Jon Williams, Julio Licinio, and Ira Tabas Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8681–8686. Published online 2000 July 11. PMCID: PMC27008 Plant Biology From the Cover: Inositol hexakisphosphate is a physiological signal regulating the K+-inward rectifying conductance in guard cells Fouad Lemtiri-Chlieh, Enid A. C. MacRobbie, and Charles A. Brearley Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8687–8692. Published online 2000 July 11. PMCID: PMC27009 Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate Lorella Navazio, Michael A. Bewell, Ashia Siddiqua, George D. Dickinson, Antony Galione, and Dale Sanders Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8693–8698. Published online 2000 July 11. PMCID: PMC27010 Transgenic potato (Solanum tuberosum) tubers synthesize the full spectrum of inulin molecules naturally occurring in globe artichoke (Cynara scolymus) roots Elke M. Hellwege, Sylvia Czapla, Anuschka Jahnke, Lothar Willmitzer, and Arnd G. Heyer Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8699–8704. Published online 2000 July 11. PMCID: PMC27011 Adenosine diphosphate glucose pyrophosphatase: A plastidial phosphodiesterase that prevents starch biosynthesis Milagros Rodríguez-López, Edurne Baroja-Fernández, Aitor Zandueta-Criado, and Javier Pozueta-Romero Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8705–8710. Published online 2000 July 11. PMCID: PMC27012 Enhancement of induced disease resistance by simultaneous activation of salicylate- and jasmonate-dependent defense pathways in Arabidopsis thaliana Saskia C. M. van Wees, Erik A. M. de Swart, Johan A. van Pelt, Leendert C. van Loon, and Corné M. J. Pieterse Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8711–8716. Published online 2000 July 11. PMCID: PMC27013 An ethylene-induced cDNA encoding a lipase expressed at the onset of senescence Yuwen Hong, Tzann-Wei Wang, Katalin A. Hudak, Frank Schade, Carol D. Froese, and John E. Thompson Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8717–8722. Published online 2000 July 11. PMCID: PMC27014 Psychology Orbitofrontal cortex: A key prefrontal region for encoding information Stephen Frey and Michael Petrides Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8723–8727. Published online 2000 July 4. PMCID: PMC27015 Dissociation of response conflict, attentional selection, and expectancy with functional magnetic resonance imaging B. J. Casey, Kathleen M. Thomas, Tomihisa F. Welsh, Rajendra D. Badgaiyan, Clayton H. Eccard, J. Richard Jennings, and Eveline A. Crone Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8728–8733. PMCID: PMC27016 Increased discrimination of “false memories” in autism spectrum disorder David Q. Beversdorf, Brian W. Smith, Gregory P. Crucian, Jeffrey M. Anderson, Jocelyn M. Keillor, Anna M. Barrett, John D. Hughes, Gretchen J. Felopulos, Margaret L. Bauman, Stephen E. Nadeau, and Kenneth M. Heilman Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8734–8737. PMCID: PMC27017 Brain-wave representation of words by superposition of a few sine waves Patrick Suppes and Bing Han Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8738–8743. Published online 2000 July 11. PMCID: PMC27018 Social Sciences Psychology Brain-wave representation of words by superposition of a few sine waves Patrick Suppes and Bing Han Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8738–8743. Published online 2000 July 11. PMCID: PMC27018 Corrections Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8744. Published online 2000 July 4. PMCID: PMC56031 Corrects: Susan Brown, et al. Special Feature: Implications of the Tribolium Deformed mutant phenotype for the evolution of Hox gene function. Proc Natl Acad Sci U S A. 2000 April 25; 97(9): 4510–4514. Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8744. PMCID: PMC56032 Corrects: Yoshihiro Kashiwaya, et al. d-β-Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5440–5444. Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8745. Published online 2000 July 4. PMCID: PMC56033 Corrects: Kamal E. Habib, et al. Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6079–6084. Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8745. PMCID: PMC56034 Corrects: Mary B. Callanan, et al. The IgG Fc receptor, FcγRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma. Proc Natl Acad Sci U S A. 2000 January 4; 97(1): 309–314. |