| | This journal provides immediate access to some articles. Commentaries Blocking the docking of HIV-1 Áine McKnight and Robin A. Weiss Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10581–10582. Published online 2003 September 8. doi: 10.1073/pnas.2035071100.PMCID: PMC196843 Two distinct roles for terminal uridylyl transferases in RNA editing Jonatha M. Gott Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10583–10584. Published online 2003 September 8. doi: 10.1073/pnas.2035062100.PMCID: PMC196844 From the Cover: Extending the utility of gene profiling data by bridging microarray platforms Gregory Z. Ferl, John M. Timmerman, and Owen N. Witte Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10585–10587. Published online 2003 September 8. doi: 10.1073/pnas.2034937100.PMCID: PMC196845 Endothelin-1 and osteoblastic metastasis Gregory R. Mundy Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10588–10589. Published online 2003 September 8. doi: 10.1073/pnas.2035063100.PMCID: PMC196846 Innovations in the design of bundled-item auctions Charles Noussair Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10590–10591. Published online 2003 September 8. doi: 10.1073/pnas.1934705100.PMCID: PMC196847 Perspective The Trojan exosome hypothesis Stephen J. Gould, Amy M. Booth, and James E. K. Hildreth Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10592–10597. Published online 2003 August 28. doi: 10.1073/pnas.1831413100.PMCID: PMC196848 The entry of entry inhibitors: A fusion of science and medicine John P. Moore and Robert W. Doms Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10598–10602. Published online 2003 September 5. doi: 10.1073/pnas.1932511100.PMCID: PMC196849 Physical Sciences Applied Mathematics Combinatorial auction design David Porter, Stephen Rassenti, Anil Roopnarine, and Vernon Smith Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11153–11157. Published online 2003 July 31. doi: 10.1073/pnas.1633736100.PMCID: PMC196943 Applied Physical Sciences From micro to nano contacts in biological attachment devices Eduard Arzt, Stanislav Gorb, and Ralph Spolenak Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10603–10606. Published online 2003 September 5. doi: 10.1073/pnas.1534701100.PMCID: PMC196850 Smart dust: Self-assembling, self-orienting photonic crystals of porous Si Jamie R. Link and Michael J. Sailor Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10607–10610. Published online 2003 August 28. doi: 10.1073/pnas.1233824100.PMCID: PMC196851 Chemistry Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates John W. Daly, H. Martin Garraffo, Thomas F. Spande, Valerie C. Clark, Jingyuan Ma, Herman Ziffer, and John F. Cover, Jr. Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11092–11097. Published online 2003 September 5. doi: 10.1073/pnas.1834430100.PMCID: PMC196932 Biological Sciences Applied Biological Sciences Polydispersity of a mammalian chaperone: Mass spectrometry reveals the population of oligomers in αB-crystallin J. Andrew Aquilina, Justin L. P. Benesch, Orval A. Bateman, Christine Slingsby, and Carol V. Robinson Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10611–10616. Published online 2003 August 28. doi: 10.1073/pnas.1932958100.PMCID: PMC196852 Biochemistry From the Cover: A tale of two TUTases Ruslan Aphasizhev, Inna Aphasizheva, and Larry Simpson Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10617–10622. Published online 2003 September 3. doi: 10.1073/pnas.1833120100.PMCID: PMC196853 Endothelial cell diversity revealed by global expression profiling Jen-Tsan Chi, Howard Y. Chang, Guttorm Haraldsen, Frode L. Jahnsen, Olga G. Troyanskaya, Dustin S. Chang, Zhen Wang, Stanley G. Rockson, Matt van de Rijn, David Botstein, and Patrick O. Brown Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10623–10628. Published online 2003 September 8. doi: 10.1073/pnas.1434429100.PMCID: PMC196854 Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 Scott Classen, Stephane Olland, and James M. Berger Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10629–10634. Published online 2003 September 8. doi: 10.1073/pnas.1832879100.PMCID: PMC196855 The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies Yutong Xue, Richard Gibbons, Zhijiang Yan, Dafeng Yang, Tarra L. McDowell, Salvatore Sechi, Jun Qin, Sharleen Zhou, Doug Higgs, and Weidong Wang Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10635–10640. Published online 2003 September 2. doi: 10.1073/pnas.1937626100.PMCID: PMC196856 (+)-Larreatricin hydroxylase, an enantio-specific polyphenol oxidase from the creosote bush (Larrea tridentata) Man-Ho Cho, Syed G. A. Moinuddin, Gregory L. Helms, Shojiro Hishiyama, Dietmar Eichinger, Laurence B. Davin, and Norman G. Lewis Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10641–10646. Published online 2003 September 5. doi: 10.1073/pnas.1934562100.PMCID: PMC196857 Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles Christopher M. Adams, Joseph L. Goldstein, and Michael S. Brown Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10647–10652. Published online 2003 September 8. doi: 10.1073/pnas.1534833100.PMCID: PMC196858 Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway Srigiridhar Kotamraju, Yoshiko Tampo, Agnes Keszler, Christopher R. Chitambar, Joy Joseph, Arthur L. Haas, and B. Kalyanaraman Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10653–10658. Published online 2003 September 4. doi: 10.1073/pnas.1933581100.PMCID: PMC196859 De novo synthesis of bacterial glycogen: Agrobacterium tumefaciens glycogen synthase is involved in glucan initiation and elongation Juan E. Ugalde, Armando J. Parodi, and Rodolfo A. Ugalde Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10659–10663. Published online 2003 September 5. doi: 10.1073/pnas.1534787100.PMCID: PMC196860 VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors Junsuke Igarashi, Phillip A. Erwin, Ana Paula V. Dantas, Hongjie Chen, and Thomas Michel Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10664–10669. Published online 2003 September 8. doi: 10.1073/pnas.1934494100.PMCID: PMC196861 Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases Bartosz Szczesny, Tapas K. Hazra, John Papaconstantinou, Sankar Mitra, and Istvan Boldogh Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10670–10675. Published online 2003 September 5. doi: 10.1073/pnas.1932854100.PMCID: PMC196862 Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa Bijay S. Jaiswal and Marco Conti Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10676–10681. Published online 2003 September 4. doi: 10.1073/pnas.1831008100.PMCID: PMC196863 GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits Kisaburo Nagamune, Kazuhito Ohishi, Hisashi Ashida, Yeonchul Hong, Jun Hino, Kenji Kangawa, Norimitsu Inoue, Yusuke Maeda, and Taroh Kinoshita Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10682–10687. Published online 2003 September 4. doi: 10.1073/pnas.1833260100.PMCID: PMC196864 Differential substrate-induced signaling through the TonB-dependent transporter BtuB Nathalie Cadieux, Phu G. Phan, David S. Cafiso, and Robert J. Kadner Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10688–10693. Published online 2003 September 4. doi: 10.1073/pnas.1932538100.PMCID: PMC196865 The first external loop of the metal ion transporter DCT1 is involved in metal ion binding and specificity Adiel Cohen, Yaniv Nevo, and Nathan Nelson Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10694–10699. Published online 2003 September 3. doi: 10.1073/pnas.1934572100.PMCID: PMC196866 Biophysics Funnel sculpting for in silico assembly of secondary structure elements of proteins Boris Fain and Michael Levitt Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10700–10705. Published online 2003 August 18. doi: 10.1073/pnas.1732312100.PMCID: PMC293046 The conformation of neurotensin bound to its G protein-coupled receptor Sorin Luca, Jim F. White, Awinder K. Sohal, Dmitri V. Filippov, Jacques H. van Boom, Reinhard Grisshammer, and Marc Baldus Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10706–10711. Published online 2003 September 5. doi: 10.1073/pnas.1834523100.PMCID: PMC196868 Coarse-grained sequences for protein folding and design Scott Brown, Nicolas J. Fawzi, and Teresa Head-Gordon Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10712–10717. Published online 2003 September 8. doi: 10.1073/pnas.1931882100.PMCID: PMC196869 Engineering asymmetric vesicles Sophie Pautot, Barbara J. Frisken, and D. A. Weitz Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10718–10721. Published online 2003 September 8. doi: 10.1073/pnas.1931005100.PMCID: PMC196870 Brain imaging in awake infants by near-infrared optical topography Gentaro Taga, Kayo Asakawa, Atsushi Maki, Yukuo Konishi, and Hideaki Koizumi Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10722–10727. Published online 2003 September 5. doi: 10.1073/pnas.1932552100.PMCID: PMC196871 Ionizing radiation induces heritable disruption of epithelial cell interactions Catherine C. Park, Rhonda L. Henshall-Powell, Anna C. Erickson, Rabih Talhouk, Bahram Parvin, Mina J. Bissell, and Mary Helen Barcellos-Hoff Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10728–10733. Published online 2003 September 5. doi: 10.1073/pnas.1832185100.PMCID: PMC196872 The role of certain Post classes in Boolean network models of genetic networks Ilya Shmulevich, Harri Lähdesmäki, Edward R. Dougherty, Jaakko Astola, and Wei Zhang Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10734–10739. Published online 2003 September 8. doi: 10.1073/pnas.1534782100.PMCID: PMC202352 Cell Biology Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration M. Okigaki, C. Davis, M. Falasca, S. Harroch, D. P. Felsenfeld, M. P. Sheetz, and J. Schlessinger Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10740–10745. Published online 2003 September 5. doi: 10.1073/pnas.1834348100.PMCID: PMC196873 Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase Kiran N. Mahajan and Beverly S. Mitchell Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10746–10751. Published online 2003 September 5. doi: 10.1073/pnas.1631060100.PMCID: PMC196874 Nuclear actin and protein 4.1: Essential interactions during nuclear assembly in vitro Sharon Wald Krauss, Cynthia Chen, Sheldon Penman, and Rebecca Heald Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10752–10757. Published online 2003 September 5. doi: 10.1073/pnas.1934680100.PMCID: PMC196875 Intra-G1 arrest in response to UV irradiation in fission yeast Esben A. Nilssen, Marianne Synnes, Nancy Kleckner, Beáta Grallert, and Erik Boye Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10758–10763. Published online 2003 September 5. doi: 10.1073/pnas.1833769100.PMCID: PMC196876 A quantitative characterization of the yeast heterotrimeric G protein cycle Tau-Mu Yi, Hiroaki Kitano, and Melvin I. Simon Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10764–10769. Published online 2003 September 5. doi: 10.1073/pnas.1834247100.PMCID: PMC196877 Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter Sunita K. Agarwal, Elizabeth A. Novotny, Judy S. Crabtree, Jonathan B. Weitzman, Moshe Yaniv, A. Lee Burns, Settara C. Chandrasekharappa, Francis S. Collins, Allen M. Spiegel, and Stephen J. Marx Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10770–10775. Published online 2003 September 5. doi: 10.1073/pnas.1834524100.PMCID: PMC196878 The PDZ-binding motif of the β2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes Yang Xiang and Brian Kobilka Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10776–10781. Published online 2003 September 3. doi: 10.1073/pnas.1831718100.PMCID: PMC196879 Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2 Huijun Wei, Seungkirl Ahn, Sudha K. Shenoy, Sadashiva S. Karnik, László Hunyady, Louis M. Luttrell, and Robert J. Lefkowitz Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10782–10787. Published online 2003 August 29. doi: 10.1073/pnas.1834556100.PMCID: PMC196880 Rho-dependent formation of epithelial “leader” cells during wound healing T. Omelchenko, J. M. Vasiliev, I. M. Gelfand, H. H. Feder, and E. M. Bonder Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10788–10793. Published online 2003 September 5. doi: 10.1073/pnas.1834401100.PMCID: PMC196881 Developmental Biology Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice Hwei-Ling Cheng, Raul Mostoslavsky, Shin'ichi Saito, John P. Manis, Yansong Gu, Parin Patel, Roderick Bronson, Ettore Appella, Frederick W. Alt, and Katrin F. Chua Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10794–10799. Published online 2003 September 5. doi: 10.1073/pnas.1934713100.PMCID: PMC196882 Ecology Sporormiella and the late Holocene extinctions in Madagascar David A. Burney, Guy S. Robinson, and Lida Pigott Burney Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10800–10805. Published online 2003 September 5. doi: 10.1073/pnas.1534700100.PMCID: PMC196883 Evolution From micro to nano contacts in biological attachment devices Eduard Arzt, Stanislav Gorb, and Ralph Spolenak Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10603–10606. Published online 2003 September 5. doi: 10.1073/pnas.1534701100.PMCID: PMC196850 Active self-splicing group I introns in 23S rRNA genes of hyperthermophilic bacteria, derived from introns in eukaryotic organelles Camilla L. Nesbø and W. Ford Doolittle Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10806–10811. Published online 2003 August 28. doi: 10.1073/pnas.1434268100.PMCID: PMC196884 Distinct geographic patterns of genetic diversity are maintained in wild barley (Hordeum vulgare ssp. spontaneum) despite migration Peter L. Morrell, Karen E. Lundy, and Michael T. Clegg Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10812–10817. Published online 2003 September 8. doi: 10.1073/pnas.1633708100.PMCID: PMC196885 Semipermeable species boundaries between Anopheles gambiae and Anopheles arabiensis: Evidence from multilocus DNA sequence variation N. J. Besansky, J. Krzywinski, T. Lehmann, F. Simard, M. Kern, O. Mukabayire, D. Fontenille, Y. Touré, and N'F. Sagnon Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10818–10823. Published online 2003 August 28. doi: 10.1073/pnas.1434337100.PMCID: PMC196886 Horizontal gene transfer from flowering plants to Gnetum Hyosig Won and Susanne S. Renner Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10824–10829. Published online 2003 September 8. doi: 10.1073/pnas.1833775100.PMCID: PMC196887 Resistance of virus to extinction on bottleneck passages: Study of a decaying and fluctuating pattern of fitness loss Ester Lázaro, Cristina Escarmís, Juan Pérez-Mercader, Susanna C. Manrubia, and Esteban Domingo Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10830–10835. Published online 2003 September 5. doi: 10.1073/pnas.1332668100.PMCID: PMC196888 Synteny perturbations between wheat homoeologous chromosomes caused by locus duplications and deletions correlate with recombination rates Eduard D. Akhunov, Alina R. Akhunova, Anna M. Linkiewicz, Jorge Dubcovsky, David Hummel, Gerry Lazo, Shiaoman Chao, Olin D. Anderson, Jacques David, Lili Qi, Benjamin Echalier, Bikram S. Gill, Miftahudin, J. Perry Gustafson, Mauricio La Rota, Mark E. Sorrells, Deshui Zhang, Henry T. Nguyen, Venugopal Kalavacharla, Khwaja Hossain, Shahryar F. Kianian, Junhua Peng, Nora L. V. Lapitan, Emily J. Wennerlind, Vivienne Nduati, James A. Anderson, Deepak Sidhu, Kulvinder S. Gill, Patrick E. McGuire, Calvin O. Qualset, and Jan Dvorak Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10836–10841. Published online 2003 September 5. doi: 10.1073/pnas.1934431100.PMCID: PMC196889 Genetics Local Context Finder (LCF) reveals multidimensional relationships among mRNA expression profiles of Arabidopsis responding to pathogen infection Fumiaki Katagiri and Jane Glazebrook Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10842–10847. Published online 2003 September 5. doi: 10.1073/pnas.1934349100.PMCID: PMC196890 Specificity in the activation and control of transcription factor E2F-dependent apoptosis Timothy C. Hallstrom and Joseph R. Nevins Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10848–10853. Published online 2003 September 3. doi: 10.1073/pnas.1831408100.PMCID: PMC196891 Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae Piotr A. Mieczkowski, Joanna O. Mieczkowska, Margaret Dominska, and Thomas D. Petes Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10854–10859. Published online 2003 September 8. doi: 10.1073/pnas.1934561100.PMCID: PMC196892 Mapping Drosophila mutations with molecularly defined P element insertions R. Grace Zhai, P. Robin Hiesinger, Tong-Wey Koh, Patrik Verstreken, Karen L. Schulze, Yu Cao, Hamed Jafar-Nejad, Koenraad K. Norga, Hongling Pan, Vafa Bayat, Michael P. Greenbaum, and Hugo J. Bellen Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10860–10865. Published online 2003 September 5. doi: 10.1073/pnas.1832753100.PMCID: PMC196893 Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy Brian K. Jordan, Jennifer H.-C. Shen, Robert Olaso, Holly A. Ingraham, and Eric Vilain Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10866–10871. Published online 2003 August 29. doi: 10.1073/pnas.1834480100.PMCID: PMC196894 Immunology Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection Kenya Honda, Shinya Sakaguchi, Chigusa Nakajima, Ai Watanabe, Hideyuki Yanai, Misako Matsumoto, Toshiaki Ohteki, Tsuneyasu Kaisho, Akinori Takaoka, Shizuo Akira, Tsukasa Seya, and Tadatsugu Taniguchi Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10872–10877. Published online 2003 September 5. doi: 10.1073/pnas.1934678100.PMCID: PMC196895 CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes E. Allison Green, Leonid Gorelik, Catrin M. McGregor, Elise H. Tran, and Richard A. Flavell Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10878–10883. Published online 2003 August 29. doi: 10.1073/pnas.1834400100.PMCID: PMC196896 Diversity of core antigen epitopes of hepatitis B virus D. M. Belnap, N. R. Watts, J. F. Conway, N. Cheng, S. J. Stahl, P. T. Wingfield, and A. C. Steven Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10884–10889. Published online 2003 September 3. doi: 10.1073/pnas.1834404100.PMCID: PMC196897 Temporal activation of NF-κB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses Santanu Bose, Niladri Kar, Ratan Maitra, Joseph A. DiDonato, and Amiya K. Banerjee Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10890–10895. Published online 2003 September 5. doi: 10.1073/pnas.1832775100.PMCID: PMC196898 HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes Gabriella Pietra, Chiara Romagnani, Paola Mazzarino, Michela Falco, Enrico Millo, Alessandro Moretta, Lorenzo Moretta, and Maria Cristina Mingari Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10896–10901. Published online 2003 September 5. doi: 10.1073/pnas.1834449100.PMCID: PMC196899 CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses Hiroyoshi Nishikawa, Takuma Kato, Koji Tanida, Atsunori Hiasa, Isao Tawara, Hiroaki Ikeda, Yoshinori Ikarashi, Hiro Wakasugi, Mitchell Kronenberg, Toshinori Nakayama, Masaru Taniguchi, Kagemasa Kuribayashi, Lloyd J. Old, and Hiroshi Shiku Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10902–10906. Published online 2003 August 28. doi: 10.1073/pnas.1834479100.PMCID: PMC196900 Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist Hugh Rosen, Christopher Alfonso, Charles D. Surh, and Michael G. McHeyzer-Williams Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10907–10912. Published online 2003 September 3. doi: 10.1073/pnas.1832725100.PMCID: PMC196901 The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion Michael T. Wilson, Cecilia Johansson, Danyvid Olivares-Villagómez, Avneesh K. Singh, Aleksandar K. Stanic, Chyung-Ru Wang, Sebastian Joyce, Mary Jo Wick, and Luc Van Kaer Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10913–10918. Published online 2003 September 5. doi: 10.1073/pnas.1833166100.PMCID: PMC196902 Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice Daisuke Ishida, Hailin Yang, Kyoko Masuda, Kanami Uesugi, Hiroshi Kawamoto, Masakazu Hattori, and Nagahiro Minato Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10919–10924. Published online 2003 September 4. doi: 10.1073/pnas.1834525100.PMCID: PMC196903 A dually active anthrax vaccine that confers protection against both bacilli and toxins Gi-Eun Rhie, Michael H. Roehrl, Michael Mourez, R. John Collier, John J. Mekalanos, and Julia Y. Wang Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10925–10930. Published online 2003 September 5. doi: 10.1073/pnas.1834478100.PMCID: PMC196904 Medical Sciences Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 Scott Classen, Stephane Olland, and James M. Berger Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10629–10634. Published online 2003 September 8. doi: 10.1073/pnas.1832879100.PMCID: PMC196855 A neural survival factor is a candidate oncogene in breast cancer Dale Porter, Stanislawa Weremowicz, Koei Chin, Pankaj Seth, Aparna Keshaviah, Jaana Lahti-Domenici, Young Kyung Bae, Constance L. Monitto, Ana Merlos-Suarez, Jennifer Chan, Christine M. Hulette, Andrea Richardson, Cynthia C. Morton, Jeffrey Marks, Mabel Duyao, Ralph Hruban, Edward Gabrielson, Rebecca Gelman, and Kornelia Polyak Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10931–10936. Published online 2003 September 2. doi: 10.1073/pnas.1932980100.PMCID: PMC196905 Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa Stefano Fiorucci, Luca Santucci, John L. Wallace, Marco Sardina, Mario Romano, Piero del Soldato, and Antonio Morelli Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10937–10941. Published online 2003 September 5. doi: 10.1073/pnas.1933204100.PMCID: PMC196906 Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection Ekaterina Dadachova, Antonio Nakouzi, Ruth A. Bryan, and Arturo Casadevall Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10942–10947. Published online 2003 August 20. doi: 10.1073/pnas.1731272100.PMCID: PMC196907 From the Cover: Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils Scott D. Kobayashi, Kevin R. Braughton, Adeline R. Whitney, Jovanka M. Voyich, Tom G. Schwan, James M. Musser, and Frank R. DeLeo Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10948–10953. Published online 2003 September 5. doi: 10.1073/pnas.1833375100.PMCID: PMC196908 From the Cover: A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases Juan Juan Yin, Khalid S. Mohammad, Sanna M. Käkönen, Stephen Harris, J. Ruth Wu-Wong, Jerry L. Wessale, Robert J. Padley, I. Ross Garrett, John M. Chirgwin, and Theresa A. Guise Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10954–10959. Published online 2003 August 26. doi: 10.1073/pnas.1830978100.PMCID: PMC196909 Repeated challenge with prion disease: The risk of infection and impact on incubation period Mike B. Gravenor, Nigel Stallard, Robert Curnow, and Angela R. McLean Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10960–10965. Published online 2003 September 5. doi: 10.1073/pnas.1833677100.PMCID: PMC198321 Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice Faith M. Harris, Walter J. Brecht, Qin Xu, Ina Tesseur, Lisa Kekonius, Tony Wyss-Coray, Jo Dee Fish, Eliezer Masliah, Paul C. Hopkins, Kimberly Scearce-Levie, Karl H. Weisgraber, Lennart Mucke, Robert W. Mahley, and Yadong Huang Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10966–10971. Published online 2003 August 25. doi: 10.1073/pnas.1434398100.PMCID: PMC196910 Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 Nicolas de Roux, Emmanuelle Genin, Jean-Claude Carel, Fumihiko Matsuda, Jean-Louis Chaussain, and Edwin Milgrom Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10972–10976. Published online 2003 August 27. doi: 10.1073/pnas.1834399100.PMCID: PMC196911 CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques Janet M. Harouse, Clarisa Buckner, Agegnehu Gettie, Ross Fuller, Rudolf Bohm, James Blanchard, and Cecilia Cheng-Mayer Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10977–10982. Published online 2003 September 8. doi: 10.1073/pnas.1933268100.PMCID: PMC196912 Microbiology Genetic identification of a respiratory arsenate reductase Chad W. Saltikov and Dianne K. Newman Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10983–10988. Published online 2003 August 25. doi: 10.1073/pnas.1834303100.PMCID: PMC196913 The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold Sibille Humme, Gilbert Reisbach, Regina Feederle, Henri-Jacques Delecluse, Kristine Bousset, Wolfgang Hammerschmidt, and Aloys Schepers Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10989–10994. Published online 2003 August 28. doi: 10.1073/pnas.1832776100.PMCID: PMC196914 Biofilm dispersal in Xanthomonas campestris is controlled by cell–cell signaling and is required for full virulence to plants J. Maxwell Dow, Lisa Crossman, Kim Findlay, Yong-Qiang He, Jia-Xun Feng, and Ji-Liang Tang Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10995–11000. Published online 2003 September 5. doi: 10.1073/pnas.1833360100.PMCID: PMC196915 The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi Xiaofeng F. Yang, Sophie M. Alani, and Michael V. Norgard Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11001–11006. Published online 2003 August 29. doi: 10.1073/pnas.1834315100.PMCID: PMC196916 Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans Ifat Rubin-Bejerano, Iain Fraser, Paula Grisafi, and Gerald R. Fink Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11007–11012. Published online 2003 September 4. doi: 10.1073/pnas.1834481100.PMCID: PMC196917 From the Cover: A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding Pin-Fang Lin, Wade Blair, Tao Wang, Timothy Spicer, Qi Guo, Nannan Zhou, Yi-Fei Gong, H.-G. Heidi Wang, Ronald Rose, Gregory Yamanaka, Brett Robinson, Chang-Ben Li, Robert Fridell, Carol Deminie, Gwendeline Demers, Zheng Yang, Lisa Zadjura, Nicholas Meanwell, and Richard Colonno Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11013–11018. Published online 2003 August 20. doi: 10.1073/pnas.1832214100.PMCID: PMC196918 Neuroscience Genetic contributions to generalized arousal of brain and behavior J. Garey, A. Goodwillie, J. Frohlich, M. Morgan, J.-A. Gustafsson, O. Smithies, K. S. Korach, S. Ogawa, and D. W. Pfaff Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11019–11022. Published online 2003 August 20. doi: 10.1073/pnas.1633773100.PMCID: PMC196919 Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures Schuichi Koizumi, Kayoko Fujishita, Makoto Tsuda, Yukari Shigemoto-Mogami, and Kazuhide Inoue Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11023–11028. Published online 2003 September 4. doi: 10.1073/pnas.1834448100.PMCID: PMC196920 Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb Fuqiang Xu, Nian Liu, Ikuhiro Kida, Douglas L. Rothman, Fahmeed Hyder, and Gordon M. Shepherd Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11029–11034. Published online 2003 September 8. doi: 10.1073/pnas.1832864100.PMCID: PMC196921 Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons Michel Cyr, Jean-Martin Beaulieu, Aki Laakso, Tatyana D. Sotnikova, Wei-Dong Yao, Laura M. Bohn, Raul R. Gainetdinov, and Marc G. Caron Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11035–11040. Published online 2003 September 4. doi: 10.1073/pnas.1831768100.PMCID: PMC196922 Chronic, multisite, multielectrode recordings in macaque monkeys Miguel A. L. Nicolelis, Dragan Dimitrov, Jose M. Carmena, Roy Crist, Gary Lehew, Jerald D. Kralik, and Steven P. Wise Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11041–11046. Published online 2003 September 5. doi: 10.1073/pnas.1934665100.PMCID: PMC196923 GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations R. D. Traub, M. O. Cunningham, T. Gloveli, F. E. N. LeBeau, A. Bibbig, E. H. Buhl, and M. A. Whittington Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11047–11052. Published online 2003 September 5. doi: 10.1073/pnas.1934854100.PMCID: PMC196924 Electroencephalographic signatures of attentional and cognitive default modes in spontaneous brain activity fluctuations at rest H. Laufs, K. Krakow, P. Sterzer, E. Eger, A. Beyerle, A. Salek-Haddadi, and A. Kleinschmidt Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11053–11058. Published online 2003 September 4. doi: 10.1073/pnas.1831638100.PMCID: PMC196925 The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis Craig S. Clements, Hugh H. Reid, Travis Beddoe, Fleur E. Tynan, Matthew A. Perugini, Terrance G. Johns, Claude C. A. Bernard, and Jamie Rossjohn Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11059–11064. Published online 2003 September 5. doi: 10.1073/pnas.1833158100.PMCID: PMC196926 Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease D. Larry Sparks and Bernard G. Schreurs Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11065–11069. Published online 2003 August 14. doi: 10.1073/pnas.1832769100.PMCID: PMC196927 Reward-dependent plasticity in the primary auditory cortex of adult monkeys trained to discriminate temporally modulated signals Ralph E. Beitel, Christoph E. Schreiner, Steven W. Cheung, Xiaoqin Wang, and Michael M. Merzenich Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11070–11075. Published online 2003 August 26. doi: 10.1073/pnas.1334187100.PMCID: PMC196928 Coordination of central odor representations through transient, non-oscillatory synchronization of glomerular output neurons Thomas A. Christensen, Hong Lei, and John G. Hildebrand Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11076–11081. Published online 2003 September 5. doi: 10.1073/pnas.1934001100.PMCID: PMC196929 Neural image processing by dendritic networks Hermann Cuntz, Jürgen Haag, and Alexander Borst Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11082–11085. Published online 2003 August 28. doi: 10.1073/pnas.1830705100.PMCID: PMC196930 Pharmacology Protean agonism at histamine H3 receptors in vitro and in vivo Florence Gbahou, Agnès Rouleau, Séverine Morisset, Régis Parmentier, Sylvain Crochet, Jian-Sheng Lin, Xavier Ligneau, Joël Tardivel-Lacombe, Holger Stark, Walter Schunack, C. Robin Ganellin, Jean-Charles Schwartz, and Jean-Michel Arrang Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11086–11091. Published online 2003 September 5. doi: 10.1073/pnas.1932276100.PMCID: PMC196931 Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates John W. Daly, H. Martin Garraffo, Thomas F. Spande, Valerie C. Clark, Jingyuan Ma, Herman Ziffer, and John F. Cover, Jr. Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11092–11097. Published online 2003 September 5. doi: 10.1073/pnas.1834430100.PMCID: PMC196932 Physiology Correction of proximal tubule phosphate transport defect in Hyp mice in vivo and in vitro with indomethacin Michel Baum, Samer Loleh, Neel Saini, Mouin Seikaly, Vangipuram Dwarakanath, and Raymond Quigley Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11098–11103. Published online 2003 September 2. doi: 10.1073/pnas.1834060100.PMCID: PMC196933 Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability Alex C. Chin, Nathalie Vergnolle, Wallace K. MacNaughton, John L. Wallace, Morley D. Hollenberg, and Andre G. Buret Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11104–11109. Published online 2003 September 5. doi: 10.1073/pnas.1831452100.PMCID: PMC196934 Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle Shaikh Mizanoor Rahman, Agnieszka Dobrzyn, Pawel Dobrzyn, Seong-Ho Lee, Makoto Miyazaki, and James M. Ntambi Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11110–11115. Published online 2003 September 5. doi: 10.1073/pnas.1934571100.PMCID: PMC196935 Plant Biology Nitric oxide regulates K+ and Cl- channels in guard cells through a subset of abscisic acid-evoked signaling pathways Carlos Garcia-Mata, Robert Gay, Sergei Sokolovski, Adrian Hills, Lorenzo Lamattina, and Michael R. Blatt Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11116–11121. Published online 2003 August 29. doi: 10.1073/pnas.1434381100.PMCID: PMC196936 The plant homolog to the human sodium/dicarboxylic cotransporter is the vacuolar malate carrier Vera Emmerlich, Nicole Linka, Thomas Reinhold, Marco A. Hurth, Michaela Traub, Enrico Martinoia, and H. Ekkehard Neuhaus Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11122–11126. Published online 2003 August 28. doi: 10.1073/pnas.1832002100.PMCID: PMC196937 Localization of a bacterial protein in starch granules of transgenic maize kernels Rachel K. Chikwamba, M. Paul Scott, Lorena B. Mejía, Hugh S. Mason, and Kan Wang Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11127–11132. Published online 2003 September 5. doi: 10.1073/pnas.1836901100.PMCID: PMC196938 Strand-biased DNA methylation associated with centromeric regions in Arabidopsis Song Luo and Daphne Preuss Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11133–11138. Published online 2003 September 5. doi: 10.1073/pnas.1831011100.PMCID: PMC196939 Population Biology El Niño drives timing of breeding but not population growth in the song sparrow (Melospiza melodia) Scott Wilson and Peter Arcese Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11139–11142. Published online 2003 September 5. doi: 10.1073/pnas.1931407100.PMCID: PMC196940 Population dynamics of rapid fixation in cytotoxic T lymphocyte escape mutants of influenza A Julia R. Gog, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, and Bryan T. Grenfell Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11143–11147. Published online 2003 September 3. doi: 10.1073/pnas.1830296100.PMCID: PMC196941 Psychology Affective style and in vivo immune response: Neurobehavioral mechanisms Melissa A. Rosenkranz, Daren C. Jackson, Kim M. Dalton, Isa Dolski, Carol D. Ryff, Burt H. Singer, Daniel Muller, Ned H. Kalin, and Richard J. Davidson Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11148–11152. Published online 2003 September 5. doi: 10.1073/pnas.1534743100.PMCID: PMC196942 Social Sciences Economic Sciences Combinatorial auction design David Porter, Stephen Rassenti, Anil Roopnarine, and Vernon Smith Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11153–11157. Published online 2003 July 31. doi: 10.1073/pnas.1633736100.PMCID: PMC196943 INAUGURAL ARTICLE by a Recently Elected Academy Member: Globalization and the distribution of income: The economic arguments Ronald W. Jones Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11158–11162. Published online 2003 September 5. doi: 10.1073/pnas.1733335100.PMCID: PMC196944 Psychology INAUGURAL ARTICLE by a Recently Elected Academy Member: Culture and point of view Richard E. Nisbett and Takahiko Masuda Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11163–11170. Published online 2003 September 5. doi: 10.1073/pnas.1934527100.PMCID: PMC196945 Dissociable neural mechanisms underlying response-based and familiarity-based conflict in working memory James K. Nelson, Patricia A. Reuter-Lorenz, Ching-Yune C. Sylvester, John Jonides, and Edward E. Smith Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11171–11175. Published online 2003 September 4. doi: 10.1073/pnas.1334125100.PMCID: PMC196946 Social Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: Explaining happiness Richard A. Easterlin Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11176–11183. Published online 2003 September 4. doi: 10.1073/pnas.1633144100.PMCID: PMC196947 Correction Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11184. doi: 10.1073/pnas.1934557100.PMCID: PMC196948 Corrects: Vikas K. Goel, et al. Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes. Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5164–5169. |