| | This journal provides immediate access to some articles. Commentaries Horizontal gene transfer in eukaryotic algal evolution Jason Raymond and Robert E. Blankenship Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7419–7420. Published online 2003 June 16. doi: 10.1073/pnas.1533212100.PMCID: PMC164597 What happens if the room at the bottom runs out? A close look at small water pores Helmut Grubmüller Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7421–7422. Published online 2003 June 16. doi: 10.1073/pnas.1533175100.PMCID: PMC164598 Bacterial cell division spirals into control Zemer Gitai and Lucy Shapiro Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7423–7424. Published online 2003 June 16. doi: 10.1073/pnas.1332806100.PMCID: PMC164599 Retuning the misfiring brain Randolph J. Nudo Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7425–7427. Published online 2003 June 16. doi: 10.1073/pnas.1533210100.PMCID: PMC164600 Replication of the herpes simplex virus genome: Does it really go around in circles? Rozanne M. Sandri-Goldin Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7428–7429. Published online 2003 June 16. doi: 10.1073/pnas.1432875100.PMCID: PMC164601 Brain repair by cell replacement and regeneration Olle Lindvall and Ron McKay Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7430–7431. Published online 2003 June 16. doi: 10.1073/pnas.1332673100.PMCID: PMC164602 Physical Sciences Applied Mathematics A pattern analysis of the second Rehnquist U.S. Supreme Court Lawrence Sirovich Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7432–7437. Published online 2003 June 23. doi: 10.1073/pnas.1132164100.PMCID: PMC164603 Applied Physical Sciences Prediction and measurement of an autoregulatory genetic module Farren J. Isaacs, Jeff Hasty, Charles R. Cantor, and J. J. Collins Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7714–7719. Published online 2003 June 13. doi: 10.1073/pnas.1332628100.PMCID: PMC164653 Geology Nanobacteria-like calcite single crystals at the surface of the Tataouine meteorite Karim Benzerara, Nicolas Menguy, François Guyot, Christian Dominici, and Philippe Gillet Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7438–7442. Published online 2003 June 5. doi: 10.1073/pnas.0832464100.PMCID: PMC164604 Statistics Modeling of DNA microarray data by using physical properties of hybridization G. A. Held, G. Grinstein, and Y. Tu Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7575–7580. Published online 2003 June 13. doi: 10.1073/pnas.0832500100.PMCID: PMC164628 Biological Sciences Agricultural Sciences Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle O. Hanotte, Y. Ronin, M. Agaba, P. Nilsson, A. Gelhaus, R. Horstmann, Y. Sugimoto, S. Kemp, J. Gibson, A. Korol, M. Soller, and A. Teale Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7443–7448. Published online 2003 June 12. doi: 10.1073/pnas.1232392100.PMCID: PMC164605 Applied Biological Sciences Direct molecular haplotyping of long-range genomic DNA with M1-PCR Chunming Ding and Charles R. Cantor Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7449–7453. Published online 2003 June 11. doi: 10.1073/pnas.1232475100.PMCID: PMC164606 Biochemistry Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells Yasuko Nagatsuka, Miki Hara-Yokoyama, Takeshi Kasama, Masataka Takekoshi, Fumiko Maeda, Seiji Ihara, Shigeyoshi Fujiwara, Eriko Ohshima, Kumiko Ishii, Toshihide Kobayashi, Kazufumi Shimizu, and Yoshio Hirabayashi Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7454–7459. Published online 2003 June 11. doi: 10.1073/pnas.1232503100.PMCID: PMC164607 Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae Hyun Kim, Qi Yan, Gunnar von Heijne, Gregory A. Caputo, and William J. Lennarz Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7460–7464. Published online 2003 June 16. doi: 10.1073/pnas.1332735100.PMCID: PMC164608 Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes Brian C. Beard, Samuel H. Wilson, and Michael J. Smerdon Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7465–7470. Published online 2003 June 10. doi: 10.1073/pnas.1330328100.PMCID: PMC164609 RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase Magali Frugier, Richard Giegé, and Paul Schimmel Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7471–7475. Published online 2003 June 9. doi: 10.1073/pnas.1332771100.PMCID: PMC164610 Validation of the hexose transporter of Plasmodium falciparum as a novel drug target Thierry Joët, Ursula Eckstein-Ludwig, Christophe Morin, and Sanjeev Krishna Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7476–7479. Published online 2003 June 5. doi: 10.1073/pnas.1330865100.PMCID: PMC164611 Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice Ernie de Boer, Patrick Rodriguez, Edgar Bonte, Jeroen Krijgsveld, Eleni Katsantoni, Albert Heck, Frank Grosveld, and John Strouboulis Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7480–7485. Published online 2003 June 11. doi: 10.1073/pnas.1332608100.PMCID: PMC164612 Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissues Jackob Moskovitz and Earl R. Stadtman Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7486–7490. Published online 2003 June 5. doi: 10.1073/pnas.1332607100.PMCID: PMC164613 Membrane-binding and activation mechanism of PTEN Sudipto Das, Jack E. Dixon, and Wonhwa Cho Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7491–7496. Published online 2003 June 13. doi: 10.1073/pnas.0932835100.PMCID: PMC164614 High-resolution structure of RNase P protein from Thermotoga maritima Alexei V. Kazantsev, Angelika A. Krivenko, Daniel J. Harrington, Richard J. Carter, Stephen R. Holbrook, Paul D. Adams, and Norman R. Pace Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7497–7502. Published online 2003 June 10. doi: 10.1073/pnas.0932597100.PMCID: PMC164615 A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen Dahai Xue, Hong Shi, James D. Smith, Xinguo Chen, Dennis A. Noe, Tommy Cedervall, Derek D. Yang, Elizabeth Eynon, Douglas E. Brash, Michael Kashgarian, Richard A. Flavell, and Sandra L. Wolin Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7503–7508. Published online 2003 June 3. doi: 10.1073/pnas.0832411100.PMCID: PMC164616 The terminal nucleotide of the Mu genome controls catalysis of DNA strand transfer Ilana Goldhaber-Gordon, Michael H. Early, and Tania A. Baker Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7509–7514. Published online 2003 June 9. doi: 10.1073/pnas.0832468100.PMCID: PMC164617 Human acetyl-CoA carboxylase 1 gene: Presence of three promoters and heterogeneity at the 5′-untranslated mRNA region Jianqiang Mao, Subrahmanyam S. Chirala, and Salih J. Wakil Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7515–7520. Published online 2003 June 16. doi: 10.1073/pnas.1332670100.PMCID: PMC164618 Small nucleolar RNA interference induced by antisense or double-stranded RNA in trypanosomatids Xue-hai Liang, Qing Liu, and Shulamit Michaeli Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7521–7526. Published online 2003 June 13. doi: 10.1073/pnas.1332001100.PMCID: PMC164619 The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes Yong Jiang and Russell F. Doolittle Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7527–7532. Published online 2003 June 13. doi: 10.1073/pnas.0932632100.PMCID: PMC164620 Direct activation of the apoptosis machinery as a mechanism to target cancer cells Jack T. Nguyen and James A. Wells Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7533–7538. Published online 2003 June 13. doi: 10.1073/pnas.1031631100.PMCID: PMC164621 An unusual type IB topoisomerase from African trypanosomes Annette L. Bodley, Asit K. Chakraborty, Suji Xie, Christian Burri, and Theresa A. Shapiro Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7539–7544. Published online 2003 June 16. doi: 10.1073/pnas.1330762100.PMCID: PMC164622 A simple energy-conserving system: Proton reduction coupled to proton translocation Rajat Sapra, Karine Bagramyan, and Michael W. W. Adams Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7545–7550. Published online 2003 June 5. doi: 10.1073/pnas.1331436100.PMCID: PMC164623 Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation Arnold Kristjuhan, Birgitte Ø. Wittschieben, Jane Walker, Douglas Roberts, Bradley R. Cairns, and Jesper Q. Svejstrup Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7551–7556. Published online 2003 June 9. doi: 10.1073/pnas.1332299100.PMCID: PMC164624 A multistep mechanism for the activation of rearrangement in the immune system Yanhong Ji, Jianmin Zhang, Alfred Ian Lee, Howard Cedar, and Yehudit Bergman Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7557–7562. Published online 2003 June 11. doi: 10.1073/pnas.0932635100.PMCID: PMC164625 Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation A. Oganesian, M. Poot, G. Daum, S. A. Coats, M. B. Wright, R. A. Seifert, and D. F. Bowen-Pope Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7563–7568. Published online 2003 June 11. doi: 10.1073/pnas.1336511100.PMCID: PMC164626 Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing Zhen Y. Jiang, Qiong L. Zhou, Kerri A. Coleman, My Chouinard, Queta Boese, and Michael P. Czech Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7569–7574. Published online 2003 June 13. doi: 10.1073/pnas.1332633100.PMCID: PMC164627 Biophysics Modeling of DNA microarray data by using physical properties of hybridization G. A. Held, G. Grinstein, and Y. Tu Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7575–7580. Published online 2003 June 13. doi: 10.1073/pnas.0832500100.PMCID: PMC164628 From the Cover: The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility John van Noort, Thijn van der Heijden, Martijn de Jager, Claire Wyman, Roland Kanaar, and Cees Dekker Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7581–7586. Published online 2003 June 12. doi: 10.1073/pnas.1330706100.PMCID: PMC164629 Understanding folding and design: Replica-exchange simulations of ``Trp-cage'' miniproteins Jed W. Pitera and William Swope Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7587–7592. Published online 2003 June 13. doi: 10.1073/pnas.1330954100.PMCID: PMC164630 The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment Carlos J. Bosques and Barbara Imperiali Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7593–7598. Published online 2003 June 12. doi: 10.1073/pnas.1232504100.PMCID: PMC164631 Developing an energy landscape for the novel function of a (β/α)8 barrel: Ammonia conduction through HisF Rommie Amaro, Emad Tajkhorshid, and Zaida Luthey-Schulten Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7599–7604. Published online 2003 June 10. doi: 10.1073/pnas.1331150100.PMCID: PMC164632 Single-molecule detection of DNA hybridization Mukta Singh-Zocchi, Sanhita Dixit, Vassili Ivanov, and Giovanni Zocchi Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7605–7610. Published online 2003 June 13. doi: 10.1073/pnas.1337215100.PMCID: PMC164633 Fast gating in the Shaker K+ channel and the energy landscape of activation Daniel Sigg, Francisco Bezanilla, and Enrico Stefani Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7611–7615. Published online 2003 June 12. doi: 10.1073/pnas.1332409100.PMCID: PMC164634 Tetraspanin CD151 regulates α6β1 integrin adhesion strengthening Jan Lammerding, Alexander R. Kazarov, Hayden Huang, Richard T. Lee, and Martin E. Hemler Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7616–7621. Published online 2003 June 12. doi: 10.1073/pnas.1337546100.PMCID: PMC164635 Allosteric control of internal electron transfer in cytochrome cd1 nitrite reductase Ole Farver, Peter M. H. Kroneck, Walter G. Zumft, and Israel Pecht Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7622–7625. Published online 2003 June 11. doi: 10.1073/pnas.0932693100.PMCID: PMC164636 Cell Biology TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation Quan Lu, Lila Weiqiao Hope, Michael Brasch, Christoph Reinhard, and Stanley N. Cohen Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7626–7631. Published online 2003 June 11. doi: 10.1073/pnas.0932599100.PMCID: PMC164637 Synthetic small molecules that control stem cell fate Sheng Ding, Tom Y. H. Wu, Achim Brinker, Eric C. Peters, Wooyoung Hur, Nathanael S. Gray, and Peter G. Schultz Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7632–7637. Published online 2003 June 6. doi: 10.1073/pnas.0732087100.PMCID: PMC164638 The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase Emmanuelle Six, Delphine Ndiaye, Yacine Laâbi, Christel Brou, Neetu Gupta-Rossi, Alain Israël, and Frédérique Logeat Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7638–7643. Published online 2003 June 6. doi: 10.1073/pnas.1230693100.PMCID: PMC164639 Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin–actin interactions in budding yeast Jason M. Singer and Janet M. Shaw Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7644–7649. Published online 2003 June 13. doi: 10.1073/pnas.1232343100.PMCID: PMC164640 Ecology Additive effects of simulated climate changes, elevated CO2, and nitrogen deposition on grassland diversity Erika S. Zavaleta, M. Rebecca Shaw, Nona R. Chiariello, Harold A. Mooney, and Christopher B. Field Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7650–7654. Published online 2003 June 16. doi: 10.1073/pnas.0932734100.PMCID: PMC164642 Masquerading as self? Endoparasitic Strepsiptera (Insecta) enclose themselves in host-derived epidermal bag Jeyaraney Kathirithamby, Larry D. Ross, and J. Spencer Johnston Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7655–7659. Published online 2003 June 3. doi: 10.1073/pnas.1131999100.PMCID: PMC164643 Nutrient loading and consumers: Agents of change in open-coast macrophyte assemblages Karina J. Nielsen Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7660–7665. Published online 2003 June 9. doi: 10.1073/pnas.0932534100.PMCID: PMC164644 Evolution Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs Katsuhiko Mineta, Masumi Nakazawa, Francesc Cebrià, Kazuho Ikeo, Kiyokazu Agata, and Takashi Gojobori Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7666–7671. Published online 2003 June 11. doi: 10.1073/pnas.1332513100.PMCID: PMC164645 Human and mouse genomic sequences reveal extensive breakpoint reuse in mammalian evolution Pavel Pevzner and Glenn Tesler Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7672–7677. Published online 2003 June 16. doi: 10.1073/pnas.1330369100.PMCID: PMC164646 From the Cover: Lateral gene transfer and the evolution of plastid-targeted proteins in the secondary plastid-containing alga Bigelowiella natans John M. Archibald, Matthew B. Rogers, Michael Toop, Ken-ichiro Ishida, and Patrick J. Keeling Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7678–7683. Published online 2003 May 30. doi: 10.1073/pnas.1230951100.PMCID: PMC164647 Genera of the human lineage Camilo J. Cela-Conde and Francisco J. Ayala Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7684–7689. Published online 2003 June 6. doi: 10.1073/pnas.0832372100.PMCID: PMC164648 Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects Thomas Weber, Martin C. Göpfert, Harald Winter, Ulrike Zimmermann, Hanni Kohler, Alexandra Meier, Oliver Hendrich, Karin Rohbock, Daniel Robert, and Marlies Knipper Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7690–7695. Published online 2003 June 2. doi: 10.1073/pnas.1330557100.PMCID: PMC164649 Genetics End-sequence profiling: Sequence-based analysis of aberrant genomes Stanislav Volik, Shaying Zhao, Koei Chin, John H. Brebner, David R. Herndon, Quanzhou Tao, David Kowbel, Guiqing Huang, Anna Lapuk, Wen-Lin Kuo, Gregg Magrane, Pieter de Jong, Joe W. Gray, and Colin Collins Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7696–7701. Published online 2003 June 4. doi: 10.1073/pnas.1232418100.PMCID: PMC164650 Detailed map of a cis-regulatory input function Y. Setty, A. E. Mayo, M. G. Surette, and U. Alon Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7702–7707. Published online 2003 June 12. doi: 10.1073/pnas.1230759100.PMCID: PMC164651 Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence Tatsuya Anzai, Takashi Shiina, Natsuki Kimura, Kazuyo Yanagiya, Sakae Kohara, Atsuko Shigenari, Tetsushi Yamagata, Jerzy K. Kulski, Taeko K. Naruse, Yoshifumi Fujimori, Yasuhito Fukuzumi, Masaaki Yamazaki, Hiroyuki Tashiro, Chie Iwamoto, Yumi Umehara, Tadashi Imanishi, Alice Meyer, Kazuho Ikeo, Takashi Gojobori, Seiamak Bahram, and Hidetoshi Inoko Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7708–7713. Published online 2003 June 10. doi: 10.1073/pnas.1230533100.PMCID: PMC164652 Prediction and measurement of an autoregulatory genetic module Farren J. Isaacs, Jeff Hasty, Charles R. Cantor, and J. J. Collins Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7714–7719. Published online 2003 June 13. doi: 10.1073/pnas.1332628100.PMCID: PMC164653 piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila Udo Häcker, Sverker Nystedt, Mojgan Padash Barmchi, Carsten Horn, and Ernst A. Wimmer Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7720–7725. Published online 2003 June 11. doi: 10.1073/pnas.1230526100.PMCID: PMC164654 Germ-line transgenesis of the Tc1/mariner superfamily transposon Minos in Ciona intestinalis Yasunori Sasakura, Satoko Awazu, Shota Chiba, and Nori Satoh Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7726–7730. Published online 2003 June 3. doi: 10.1073/pnas.1230736100.PMCID: PMC164655 Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis Eilon Woolf, Cuiying Xiao, Ofer Fainaru, Joseph Lotem, Dalia Rosen, Varda Negreanu, Yael Bernstein, Dalia Goldenberg, Ori Brenner, Gideon Berke, Ditsa Levanon, and Yoram Groner Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7731–7736. Published online 2003 June 9. doi: 10.1073/pnas.1232420100.PMCID: PMC164656 From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression Oleg Schmidt-Kittler, Thomas Ragg, Angela Daskalakis, Martin Granzow, Andre Ahr, Thomas J. F. Blankenstein, Manfred Kaufmann, Joachim Diebold, Hans Arnholdt, Peter Müller, Joachim Bischoff, Detlev Harich, Günter Schlimok, Gert Riethmüller, Roland Eils, and Christoph A. Klein Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7737–7742. Published online 2003 June 13. doi: 10.1073/pnas.1331931100.PMCID: PMC164657 Targeted cytosine methylation for in vivo detection of protein–DNA interactions Christopher D. Carvin, Archana Dhasarathy, Laurie B. Friesenhahn, Walter J. Jessen, and Michael P. Kladde Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7743–7748. Published online 2003 June 13. doi: 10.1073/pnas.1332672100.PMCID: PMC164658 Immunology T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells Geanncarlo Lugo-Villarino, Roberto Maldonado-López, Richard Possemato, Cristina Peñaranda, and Laurie H. Glimcher Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7749–7754. Published online 2003 June 11. doi: 10.1073/pnas.1332767100.PMCID: PMC164659 Differential proteasomal processing of hydrophobic and hydrophilic protein regions: Contribution to cytotoxic T lymphocyte epitope clustering in HIV-1-Nef Maria Lucchiari-Hartz, Viv Lindo, Niclas Hitziger, Simone Gaedicke, Loredana Saveanu, Peter M. van Endert, Fiona Greer, Klaus Eichmann, and Gabriele Niedermann Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7755–7760. Published online 2003 June 16. doi: 10.1073/pnas.1232228100.PMCID: PMC164660 Mast cells disrupt epithelial barrier function during enteric nematode infection Jacqueline R. McDermott, Ruth E. Bartram, Pamela A. Knight, Hugh R. P. Miller, David R. Garrod, and Richard K. Grencis Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7761–7766. Published online 2003 June 9. doi: 10.1073/pnas.1231488100.PMCID: PMC164661 Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing Christoph Wülfing, Bozidar Purtic, Jennifer Klem, and John D. Schatzle Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7767–7772. Published online 2003 June 11. doi: 10.1073/pnas.1336920100.PMCID: PMC164662 Inducible nitric oxide synthase expression inhibition by adenovirus E1A Wangsen Cao, Clare Bao, and Charles J. Lowenstein Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7773–7778. Published online 2003 June 13. doi: 10.1073/pnas.1337185100.PMCID: PMC164663 Genes encoding putative natural killer cell C-type lectin receptors in teleostean fishes Akie Sato, Werner E. Mayer, Peter Overath, and Jan Klein Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7779–7784. Published online 2003 June 11. doi: 10.1073/pnas.1235938100.PMCID: PMC164664 Medical Sciences Regression of established tumors and metastases by potent vascular endothelial growth factor blockade Jianzhong Huang, Jason S. Frischer, Anna Serur, Angela Kadenhe, Akiko Yokoi, Kimberly W. McCrudden, Tamara New, Kathleen O'Toole, Stephanie Zabski, John S. Rudge, Jocelyn Holash, George D. Yancopoulos, Darrell J. Yamashiro, and Jessica J. Kandel Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7785–7790. Published online 2003 June 12. doi: 10.1073/pnas.1432908100.PMCID: PMC164665 Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling Joe V. Chakkalakal, Mark A. Stocksley, Mary-Ann Harrison, Lindsay M. Angus, Julie Deschênes-Furry, Simon St-Pierre, Lynn A. Megeney, Eva R. Chin, Robin N. Michel, and Bernard J. Jasmin Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7791–7796. Published online 2003 June 13. doi: 10.1073/pnas.0932671100.PMCID: PMC164666 Caspase 8 small interfering RNA prevents acute liver failure in mice Lars Zender, Sebastian Hütker, Christian Liedtke, Hans Ludger Tillmann, Steffen Zender, Bettina Mundt, Morlen Waltemathe, Thomas Gösling, Peer Flemming, Nisar Peter Malek, Christian Trautwein, Michael Peter Manns, Florian Kühnel, and Stefan Kubicka Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7797–7802. Published online 2003 June 16. doi: 10.1073/pnas.1330920100.PMCID: PMC164667 Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function Lin Pei, Ofer Wiser, Anthony Slavin, David Mu, Scott Powers, Lily Yeh Jan, and Timothy Hoey Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7803–7807. Published online 2003 June 2. doi: 10.1073/pnas.1232448100.PMCID: PMC164668 Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host Bertrand Léobon, Isabelle Garcin, Philippe Menasché, Jean-Thomas Vilquin, Etienne Audinat, and Serge Charpak Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7808–7811. Published online 2003 June 12. doi: 10.1073/pnas.1232447100.PMCID: PMC164669 Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells Zsuzsa Szondy, Zsolt Sarang, Péter Molnár, Tamás Németh, Mauro Piacentini, Pier Giorgio Mastroberardino, Laura Falasca, Daniel Aeschlimann, Judit Kovács, Ildikó Kiss, Éva Szegezdi, Gabriella Lakos, Éva Rajnavölgyi, Paul J. Birckbichler, Gerry Melino, and László Fésüs Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7812–7817. Published online 2003 June 16. doi: 10.1073/pnas.0832466100.PMCID: PMC164670 Epigenetic inactivation of CHFR in human tumors Minoru Toyota, Yasushi Sasaki, Ayumi Satoh, Kazuhiro Ogi, Takefumi Kikuchi, Hiromu Suzuki, Hiroaki Mita, Nobuyuki Tanaka, Fumio Itoh, Jean-Pierre J. Issa, Kam-Wing Jair, Kornel E. Schuebel, Kohzoh Imai, and Takashi Tokino Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7818–7823. Published online 2003 June 16. doi: 10.1073/pnas.1337066100.PMCID: PMC164671 Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis Tao Su, Masumi Suzui, Lei Wang, Chyuan-Sheng Lin, Wang-Qiu Xing, and I. Bernard Weinstein Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7824–7829. Published online 2003 June 16. doi: 10.1073/pnas.1332160100.PMCID: PMC164672 Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome John H. Griffin, Joey Leung, Rebecca J. Bruner, Michael A. Caligiuri, and Roger Briesewitz Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7830–7835. Published online 2003 June 13. doi: 10.1073/pnas.0932698100.PMCID: PMC164673 CD40 ligand is a critical effector of Epstein–Barr virus in host cell survival and transformation Ken-Ichi Imadome, Masaki Shirakata, Norio Shimizu, Shigeaki Nonoyama, and Yuji Yamanashi Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7836–7840. Published online 2003 June 12. doi: 10.1073/pnas.1231363100.PMCID: PMC164674 Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model Pradip K. Majumder, Jen Jen Yeh, Daniel J. George, Phillip G. Febbo, Jennifer Kum, Qi Xue, Rachel Bikoff, Hongfeng Ma, Philip W. Kantoff, Todd R. Golub, Massimo Loda, and William R. Sellers Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7841–7846. Published online 2003 June 10. doi: 10.1073/pnas.1232229100.PMCID: PMC164675 Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis Michael L. Cher, Hector R. Biliran, Jr., Sunita Bhagat, Yonghong Meng, Mingxin Che, Jaron Lockett, Judith Abrams, Rafael Fridman, Michael Zachareas, and Shijie Sheng Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7847–7852. Published online 2003 June 3. doi: 10.1073/pnas.1331360100.PMCID: PMC164676 Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements T. Rozovskaia, O. Ravid-Amir, S. Tillib, G. Getz, E. Feinstein, H. Agrawal, A. Nagler, E. F. Rappaport, I. Issaeva, Y. Matsuo, U. R. Kees, T. Lapidot, F. Lo Coco, R. Foa, A. Mazo, T. Nakamura, C. M. Croce, G. Cimino, E. Domany, and E. Canaani Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7853–7858. Published online 2003 June 2. doi: 10.1073/pnas.1132115100.PMCID: PMC164677 Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene María Elena Martínez, Thomas G. O'Brien, Kimberly E. Fultz, Naveen Babbar, Hagit Yerushalmi, Ning Qu, Yongjun Guo, David Boorman, Janine Einspahr, David S. Alberts, and Eugene W. Gerner Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7859–7864. Published online 2003 June 16. doi: 10.1073/pnas.1332465100.PMCID: PMC164678 Microbiology From the Cover: Division site selection in Escherichia coli involves dynamic redistribution of Min proteins within coiled structures that extend between the two cell poles Yu-Ling Shih, Trung Le, and Lawrence Rothfield Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7865–7870. Published online 2003 May 23. doi: 10.1073/pnas.1232225100.PMCID: PMC164679 Relationship of herpes simplex virus genome configuration to productive and persistent infections Sara A. Jackson and Neal A. DeLuca Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7871–7876. Published online 2003 June 9. doi: 10.1073/pnas.1230643100.PMCID: PMC164680 The complete genome sequence of Mycobacterium bovis Thierry Garnier, Karin Eiglmeier, Jean-Christophe Camus, Nadine Medina, Huma Mansoor, Melinda Pryor, Stephanie Duthoy, Sophie Grondin, Celine Lacroix, Christel Monsempe, Sylvie Simon, Barbara Harris, Rebecca Atkin, Jon Doggett, Rebecca Mayes, Lisa Keating, Paul R. Wheeler, Julian Parkhill, Bart G. Barrell, Stewart T. Cole, Stephen V. Gordon, and R. Glyn Hewinson Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7877–7882. Published online 2003 June 3. doi: 10.1073/pnas.1130426100.PMCID: PMC164681 Gene function analysis in environmental isolates: The nif regulon of the strict iron oxidizing bacterium Leptospirillum ferrooxidans Víctor Parro and Mercedes Moreno-Paz Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7883–7888. Published online 2003 June 13. doi: 10.1073/pnas.1230487100.PMCID: PMC164682 Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ Suzanne C. Cordell, Elva J. H. Robinson, and Jan Löwe Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7889–7894. Published online 2003 June 13. doi: 10.1073/pnas.1330742100.PMCID: PMC164683 Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein Daniel D. Pinschewer, Mar Perez, Ana B. Sanchez, and Juan Carlos de la Torre Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7895–7900. Published online 2003 June 13. doi: 10.1073/pnas.1332709100.PMCID: PMC164684 The complete genome sequence of the carcinogenic bacterium
Helicobacter hepaticus Sebastian Suerbaum, Christine Josenhans, Torsten Sterzenbach, Bernd Drescher, Petra Brandt, Monica Bell, Marcus Dröge, Berthold Fartmann, Hans-Peter Fischer, Zhongming Ge, Andrea Hörster, Rudi Holland, Kerstin Klein, Jochen König, Ludwig Macko, George L. Mendz, Gerald Nyakatura, David B. Schauer, Zeli Shen, Jacqueline Weber, Matthias Frosch, and James G. Fox Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7901–7906. Published online 2003 June 16. doi: 10.1073/pnas.1332093100.PMCID: PMC164685 Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms Daniel J. Wozniak, Timna J. O. Wyckoff, Melissa Starkey, Rebecca Keyser, Parastoo Azadi, George A. O'Toole, and Matthew R. Parsek Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7907–7912. Published online 2003 June 16. doi: 10.1073/pnas.1231792100.PMCID: PMC164686 A newly discovered cholesteryl galactoside from Borrelia burgdorferi Gil Ben-Menachem, Joanna Kubler-Kielb, Bruce Coxon, Alfred Yergey, and Rachel Schneerson Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7913–7918. Published online 2003 June 10. doi: 10.1073/pnas.1232451100.PMCID: PMC164687 Neuroscience Selective impairment of hippocampal neurogenesis by chronic alcoholism: Protective effects of an antioxidant Daniel G. Herrera, Almudena G. Yagüe, Siv Johnsen-Soriano, Francisco Bosch-Morell, Lucía Collado-Morente, Maria Muriach, Francisco J. Romero, and J. Manuel García-Verdugo Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7919–7924. Published online 2003 June 5. doi: 10.1073/pnas.1230907100.PMCID: PMC164688 From the Cover: Evidence for neurogenesis in the adult mammalian substantia nigra Ming Zhao, Stefan Momma, Kioumars Delfani, Marie Carlén, Robert M. Cassidy, Clas B. Johansson, Hjalmar Brismar, Oleg Shupliakov, Jonas Frisén, and Ann Marie Janson Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7925–7930. Published online 2003 June 5. doi: 10.1073/pnas.1131955100.PMCID: PMC164689 Reset of human neocortical oscillations during a working memory task D. S. Rizzuto, J. R. Madsen, E. B. Bromfield, A. Schulze-Bonhage, D. Seelig, R. Aschenbrenner-Scheibe, and M. J. Kahana Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7931–7936. Published online 2003 June 5. doi: 10.1073/pnas.0732061100.PMCID: PMC164690 Connectivity optimization and the positioning of cortical areas Vitaly A. Klyachko and Charles F. Stevens Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7937–7941. Published online 2003 June 9. doi: 10.1073/pnas.0932745100.PMCID: PMC164691 From the Cover: Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization Victor Candia, Christian Wienbruch, Thomas Elbert, Brigitte Rockstroh, and William Ray Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7942–7946. Published online 2003 May 27. doi: 10.1073/pnas.1231193100.PMCID: PMC164692 Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 Catherine Abbadie, Jill A. Lindia, Anne Marie Cumiskey, Larry B. Peterson, John S. Mudgett, Ellen K. Bayne, Julie A. DeMartino, D. Euan MacIntyre, and Michael J. Forrest Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7947–7952. Published online 2003 June 13. doi: 10.1073/pnas.1331358100.PMCID: PMC164693 Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum A. M. Ghoumari, I. Dusart, M. El-Etr, F. Tronche, C. Sotelo, M. Schumacher, and E.-E. Baulieu Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7953–7958. Published online 2003 June 16. doi: 10.1073/pnas.1332667100.PMCID: PMC164694 Male Japanese quails with female brains do not show male sexual behaviors Manfred Gahr Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7959–7964. Published online 2003 June 11. doi: 10.1073/pnas.1335934100.PMCID: PMC164695 Impairment of reward-related learning by cholinergic cell ablation in the striatum Yasuji Kitabatake, Takatoshi Hikida, Dai Watanabe, Ira Pastan, and Shigetada Nakanishi Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7965–7970. Published online 2003 June 11. doi: 10.1073/pnas.1032899100.PMCID: PMC164696 Pharmacology A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses Tamas Bartfai, M. Margarita Behrens, Svetlana Gaidarova, Janell Pemberton, Alexander Shivanyuk, and Julius Rebek, Jr Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7971–7976. Published online 2003 June 10. doi: 10.1073/pnas.0932746100.PMCID: PMC164697 Systematic discovery of multicomponent therapeutics Alexis A. Borisy, Peter J. Elliott, Nicole W. Hurst, Margaret S. Lee, Joseph Lehár, E. Roydon Price, George Serbedzija, Grant R. Zimmermann, Michael A. Foley, Brent R. Stockwell, and Curtis T. Keith Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7977–7982. Published online 2003 June 10. doi: 10.1073/pnas.1337088100.PMCID: PMC164698 Evidence that mouse brain neuropathy target esterase is a lysophospholipase Gary B. Quistad, Carrolee Barlow, Christopher J. Winrow, Susan E. Sparks, and John E. Casida Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7983–7987. Published online 2003 June 12. doi: 10.1073/pnas.1232473100.PMCID: PMC164699 Physiology INAUGURAL ARTICLE by a Recently Elected Academy Member: Mechanotransduction and flow across the endothelial glycocalyx Sheldon Weinbaum, Xiaobing Zhang, Yuefeng Han, Hans Vink, and Stephen C. Cowin Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7988–7995. Published online 2003 June 16. doi: 10.1073/pnas.1332808100.PMCID: PMC164700 Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts Craig S. Stump, Kevin R. Short, Maureen L. Bigelow, Jill M. Schimke, and K. Sreekumaran Nair Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7996–8001. Published online 2003 June 13. doi: 10.1073/pnas.1332551100.PMCID: PMC164701 Structural determinant of TRPV1 desensitization interacts with calmodulin Mitsuko Numazaki, Tomoko Tominaga, Kumiko Takeuchi, Namie Murayama, Hidenori Toyooka, and Makoto Tominaga Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8002–8006. Published online 2003 June 13. doi: 10.1073/pnas.1337252100.PMCID: PMC164702 Plant Biology Comparative genomics of Physcomitrella patens gametophytic transcriptome and Arabidopsis thaliana: Implication for land plant evolution Tomoaki Nishiyama, Tomomichi Fujita, Tadasu Shin-I, Motoaki Seki, Hiroyo Nishide, Ikuo Uchiyama, Asako Kamiya, Piero Carninci, Yoshihide Hayashizaki, Kazuo Shinozaki, Yuji Kohara, and Mitsuyasu Hasebe Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8007–8012. Published online 2003 June 13. doi: 10.1073/pnas.0932694100.PMCID: PMC164703 Function and glycosylation of plant-derived antiviral monoclonal antibody Kisung Ko, Yoram Tekoah, Pauline M. Rudd, David J. Harvey, Raymond A. Dwek, Sergei Spitsin, Cathleen A. Hanlon, Charles Rupprecht, Bernhard Dietzschold, Maxim Golovkin, and Hilary Koprowski Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8013–8018. Published online 2003 June 10. doi: 10.1073/pnas.0832472100.PMCID: PMC164704 Control of in vitro organogenesis by cyclin-dependent kinase activities in plants Masatoshi Yamaguchi, Hisashi Kato, Shigeo Yoshida, Saburo Yamamura, Hirofumi Uchimiya, and Masaaki Umeda Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8019–8023. Published online 2003 June 10. doi: 10.1073/pnas.1332637100.PMCID: PMC164705 Physical interaction between RRS1-R, a protein conferring resistance to bacterial wilt, and PopP2, a type III effector targeted to the plant nucleus Laurent Deslandes, Jocelyne Olivier, Nemo Peeters, Dong Xin Feng, Manirath Khounlotham, Christian Boucher, Imre Somssich, Stéphane Genin, and Yves Marco Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8024–8029. Published online 2003 June 3. doi: 10.1073/pnas.1230660100.PMCID: PMC164706 Psychology Social interaction shapes babbling: Testing parallels between birdsong and speech Michael H. Goldstein, Andrew P. King, and Meredith J. West Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8030–8035. Published online 2003 June 13. doi: 10.1073/pnas.1332441100.PMCID: PMC164707 Social Sciences Anthropology Genera of the human lineage Camilo J. Cela-Conde and Francisco J. Ayala Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7684–7689. Published online 2003 June 6. doi: 10.1073/pnas.0832372100.PMCID: PMC164648 Corrections Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8036. doi: 10.1073/pnas.1432848100.PMCID: PMC164708 Corrects: Christine Lonjou, et al. Linkage disequilibrium in human populations. Proc Natl Acad Sci U S A. 2003 May 13; 100(10): 6069–6074. Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8036. doi: 10.1073/pnas.1332736100.PMCID: PMC164709 Corrects: Alfred H. Schinkel, et al. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting)P-glycoproteins. Proc Natl Acad Sci U S A. 1997 April 15; 94(8): 4028–4033. Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8036. doi: 10.1073/pnas.1332662100.PMCID: PMC164710 Corrects: Éva Mezey, et al. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci U S A. 2003 February 4; 100(3): 1364–1369. Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8037. doi: 10.1073/pnas.1432896100.PMCID: PMC164711 Corrects: Sudarshan Rajagopal, et al. Crystal structure of a photoactive yellow protein from a sensor histidine kinase: Conformational variability and signal transduction. Proc Natl Acad Sci U S A. 2003 February 18; 100(4): 1649–1654. |