| | This journal provides immediate access to some articles. Commentaries The persistence of alien genomes Peter Tattersall Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6239–6241. PMCID: PMC33992 Glioblastoma multiforme: The terminator Eric C. Holland Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6242–6244. PMCID: PMC33993 A multiplicity of muscarinic mechanisms: Enough signaling
pathways to take your breath away Neil M. Nathanson Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6245–6247. PMCID: PMC33994 LINE-1 elements and X chromosome inactivation: A function for
“junk” DNA? Mary F. Lyon Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6248–6249. PMCID: PMC33995 Retrotransposon-mediated genome evolution on a local
ecological scale Jonathan F. Wendel and Susan R. Wessler Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6250–6252. PMCID: PMC33996 Physical Sciences Applied Mathematics Optimal prediction of stiff oscillatory mechanics Anton P. Kast Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6253–6257. PMCID: PMC18588 Subjective surfaces: A method for completing missing boundaries Alessandro Sarti, Ravi Malladi, and James A. Sethian Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6258–6263. Published online 2000 May 23. PMCID: PMC18589 Applied Physical Sciences The complete optical spectrum of liquid water measured by inelastic x-ray scattering Hisashi Hayashi, Noboru Watanabe, Yasuo Udagawa, and C.-C. Kao Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6264–6266. Published online 2000 May 30. PMCID: PMC18590 Temperature profiles and bathymetry of some high mountain lakes Luna B. Leopold Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6267–6270. PMCID: PMC18591 Chemistry Synthetic receptors as models for alkali metal cation-π binding sites in proteins Stephen L. De Wall, Eric S. Meadows, Leonard J. Barbour, and George W. Gokel Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6271–6276. PMCID: PMC18592 Control of protein crystal nucleation around the metastable liquid–liquid phase boundary Oleg Galkin and Peter G. Vekilov Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6277–6281. Published online 2000 May 23. PMCID: PMC18593 INAUGURAL ARTICLE by a Recently Elected Academy Member: Retrostructural analysis of metalloproteins: Application to the design of a minimal model for diiron proteins Angela Lombardi, Christopher M. Summa, Silvano Geremia, Lucio Randaccio, Vincenzo Pavone, and William F. DeGrado Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6298–6305. PMCID: PMC18597 Unfolding proteins by external forces and temperature: The importance of topology and energetics Emanuele Paci and Martin Karplus Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6521–6526. Published online 2000 May 23. PMCID: PMC18644 Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor Simon P. Gough, Bent O. Petersen, and Jens Ø. Duus Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6908–6913. PMCID: PMC18774 Physics Atomic force microscopy captures quantized plastic deformation in gold nanowires Piotr E. Marszalek, William J. Greenleaf, Hongbin Li, Andres F. Oberhauser, and Julio M. Fernandez Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6282–6286. PMCID: PMC18594 Biological Sciences Applied Biological Sciences Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1 Sharon Lafferty Doty, Tanya Q. Shang, Angela M. Wilson, Jeff Tangen, Aram D. Westergreen, Lee A. Newman, Stuart E. Strand, and Milton P. Gordon Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6287–6291. PMCID: PMC18595 Biochemistry Synthetic receptors as models for alkali metal cation-π binding sites in proteins Stephen L. De Wall, Eric S. Meadows, Leonard J. Barbour, and George W. Gokel Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6271–6276. PMCID: PMC18592 Rational design of nascent metalloenzymes David E. Benson, Michael S. Wisz, and Homme W. Hellinga Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6292–6297. PMCID: PMC18596 INAUGURAL ARTICLE by a Recently Elected Academy Member: Retrostructural analysis of metalloproteins: Application to the design of a minimal model for diiron proteins Angela Lombardi, Christopher M. Summa, Silvano Geremia, Lucio Randaccio, Vincenzo Pavone, and William F. DeGrado Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6298–6305. PMCID: PMC18597 Crystal structure of RPB5, a universal eukaryotic RNA polymerase subunit and transcription factor interaction target Flavia Todone, Robert O. J. Weinzierl, Peter Brick, and Silvia Onesti Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6306–6310. PMCID: PMC18598 Solution structure of the RNA polymerase subunit RPB5 from
Methanobacterium thermoautotrophicum Adelinda Yee, Valerie Booth, Akil Dharamsi, Asaph Engel, Aled M. Edwards, and Cheryl H. Arrowsmith Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6311–6315. PMCID: PMC18599 Zinc-bundle structure of the essential RNA polymerase subunit
RPB10 from
Methanobacterium thermoautotrophicum Cameron D. Mackereth, Cheryl H. Arrowsmith, Aled M. Edwards, and Lawrence P. McIntosh Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6316–6321. PMCID: PMC18600 Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ Bruno P. Klaholz, André Mitschler, Makonen Belema, C. Zusi, and Dino Moras Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6322–6327. PMCID: PMC18601 Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP George Minasov, Marianna Teplova, George C. Stewart, Eugene V. Koonin, Wayne F. Anderson, and Martin Egli Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6328–6333. PMCID: PMC18602 Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase Gilda Tachedjian, Hans-Erik G. Aronson, and Stephen P. Goff Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6334–6339. PMCID: PMC18603 Nutrient regulation of gene expression by the sterol regulatory element binding proteins: Increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo Mary K. Bennett and Timothy F. Osborne Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6340–6344. PMCID: PMC18604 Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA Ernst Schönbrunn, Susanne Eschenburg, Karolin Luger, Wolfgang Kabsch, and Nikolaus Amrhein Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6345–6349. Published online 2000 May 23. PMCID: PMC18605 A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing Alexandros D. Polydorides, Hirotaka J. Okano, Yolanda Y. L. Yang, Giovanni Stefani, and Robert B. Darnell Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6350–6355. Published online 2000 May 30. PMCID: PMC18606 Molecular modeling and in vitro activity of an HIV-1-encoded glutathione peroxidase Lijun Zhao, Arthur G. Cox, Jan A. Ruzicka, Ajita A. Bhat, Weiqing Zhang, and Ethan Will Taylor Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6356–6361. PMCID: PMC18607 Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates Tibor Farkas, Klara Kitajka, Elfrieda Fodor, István Csengeri, Eila Lahdes, Young K. Yeo, Zoltán Krasznai, and John E. Halver Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6362–6366. Published online 2000 May 23. PMCID: PMC18608 Analysis of telomerase catalytic subunit mutants in
vivo and in vitro in
Schizosaccharomyces pombe Christian H. Haering, Toru M. Nakamura, Peter Baumann, and Thomas R. Cech Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6367–6372. Published online 2000 May 30. PMCID: PMC18609 Catalytic role of enzymes: Short strong H-bond-induced partial
proton shuttles and charge redistributions Kwang S. Kim, Kyung Seok Oh, and Jin Yong Lee Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6373–6378. PMCID: PMC18610 The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development Jianming Xu, Lan Liao, Guang Ning, Hiromi Yoshida-Komiya, Chuxia Deng, and Bert W. O'Malley Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6379–6384. Published online 2000 May 23. PMCID: PMC18611 Copy-choice recombination by reverse transcriptases: Reshuffling of genetic markers mediated by RNA chaperones Matteo Negroni and Henri Buc Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6385–6390. Published online 2000 May 30. PMCID: PMC18612 Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors Antonio A. Postigo and Douglas C. Dean Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6391–6396. PMCID: PMC18613 Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter Natalia G. Denissova, Celio Pouponnot, Jianyin Long, Dongming He, and Fang Liu Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6397–6402. Published online 2000 May 23. PMCID: PMC18614 Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism Jay A. White, Heather Ramshaw, Mohammed Taimi, Wayne Stangle, Anqi Zhang, Stephanie Everingham, Shelly Creighton, Shui-Pang Tam, Glenville Jones, and Martin Petkovich Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6403–6408. Published online 2000 May 23. PMCID: PMC18615 A mechanistic basis for Mre11-directed DNA joining at microhomologies Tanya T. Paull and Martin Gellert Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6409–6414. Published online 2000 May 23. PMCID: PMC18616 Unpaired terminal nucleotides and 5′ monophosphorylation govern 3′ polyadenylation by Escherichia coli poly(A) polymerase I Yanan Feng and Stanley N. Cohen Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6415–6420. Published online 2000 May 23. PMCID: PMC18617 Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway Frédéric Beaudoin, Louise V. Michaelson, Sandra J. Hey, Mervyn J. Lewis, Peter R. Shewry, Olga Sayanova, and Johnathan A. Napier Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6421–6426. Published online 2000 May 30. PMCID: PMC18618 Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1 Yi Zhang, Eric C. Griffith, Julien Sage, Tyler Jacks, and Jun O. Liu Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6427–6432. PMCID: PMC18619 Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development Jean-Luc Desseyn, Kimberly A. Burton, and G. Stanley McKnight Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6433–6438. PMCID: PMC18620 The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation Tomoyuki Shishido, Tsuyoshi Akagi, Toru Ouchi, Maria-Magdalena Georgescu, Wallace Y. Langdon, and Hidesaburo Hanafusa Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6439–6444. Published online 2000 May 30. PMCID: PMC18621 The preaggregated state of an amyloidogenic protein: Hydrostatic pressure converts native transthyretin into the amyloidogenic state Astria D. Ferrão-Gonzales, Sandro O. Souto, Jerson L. Silva, and Débora Foguel Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6445–6450. PMCID: PMC18622 Biosynthesis of terpenoids: 4-Diphosphocytidyl-2C-methyl-d-erythritol synthase of Arabidopsis thaliana Felix Rohdich, Juraithip Wungsintaweekul, Wolfgang Eisenreich, Gerald Richter, Christoph A. Schuhr, Stefan Hecht, Meinhart H. Zenk, and Adelbert Bacher Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6451–6456. PMCID: PMC18623 Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein Timothy R. Hughes, Rodney G. Weilbaecher, Monika Walterscheid, and Victoria Lundblad Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6457–6462. PMCID: PMC18624 Thiol–disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase W. Todd Lowther, Nathan Brot, Herbert Weissbach, John F. Honek, and Brian W. Matthews Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6463–6468. PMCID: PMC18625 Cockroach diuretic hormones: Characterization of a
calcitonin-like peptide in insects Kenji Furuya, Richard J. Milchak, Kathleen M. Schegg, Jinrui Zhang, Stephen S. Tobe, Geoffrey M. Coast, and David A. Schooley Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6469–6474. PMCID: PMC18626 Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization Jochen Kuper, Tracy Palmer, Ralf R. Mendel, and Günter Schwarz Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6475–6480. Published online 2000 May 23. PMCID: PMC18627 CpG methylation as a mechanism for the regulation of E2F activity Miguel R. Campanero, Monica I. Armstrong, and Erik K. Flemington Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6481–6486. Published online 2000 May 23. PMCID: PMC18629 Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants Anders Dahlqvist, Ulf Ståhl, Marit Lenman, Antoni Banas, Michael Lee, Line Sandager, Hans Ronne, and Sten Stymne Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6487–6492. Published online 2000 May 30. PMCID: PMC18631 Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 Sandra E. Nicholson, David De Souza, Louis J. Fabri, Jason Corbin, Tracy A. Willson, Jian-Guo Zhang, Anabel Silva, Maria Asimakis, Alison Farley, Andrew D. Nash, Donald Metcalf, Douglas J. Hilton, Nicos A. Nicola, and Manuel Baca Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6493–6498. Published online 2000 May 30. PMCID: PMC18633 Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways James C. Clemens, Carolyn A. Worby, Nancy Simonson-Leff, Marco Muda, Tomohiko Maehama, Brian A. Hemmings, and Jack E. Dixon Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6499–6503. Published online 2000 May 23. PMCID: PMC18635 The Bloom's syndrome gene product promotes branch migration of Holliday junctions Julia K. Karow, Angelos Constantinou, Ji-Liang Li, Stephen C. West, and Ian D. Hickson Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6504–6508. Published online 2000 May 23. PMCID: PMC18638 Biophysics Investigation of routes and funnels in protein folding by free energy functional methods Steven S. Plotkin and José N. Onuchic Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6509–6514. PMCID: PMC18640 Modeling RNA folding paths with pseudoknots: Application to
hepatitis delta virus ribozyme Hervé Isambert and Eric D. Siggia Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6515–6520. Published online 2000 May 23. PMCID: PMC18642 Unfolding proteins by external forces and temperature: The importance of topology and energetics Emanuele Paci and Martin Karplus Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6521–6526. Published online 2000 May 23. PMCID: PMC18644 Atomic force microscopy reveals the mechanical design of a modular protein Hongbin Li, Andres F. Oberhauser, Susan B. Fowler, Jane Clarke, and Julio M. Fernandez Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6527–6531. Published online 2000 May 23. PMCID: PMC18646 Cell Biology Regulation of the actin cycle in vivo by actin filament severing James L. McGrath, Eric A. Osborn, Yanik S. Tardy, C. Forbes Dewey, Jr., and John H. Hartwig Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6532–6537. Published online 2000 May 23. PMCID: PMC18648 Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I Mamoru Ikemoto, Hiroyuki Arai, Dongdong Feng, Kazumi Tanaka, Junken Aoki, Naoshi Dohmae, Koji Takio, Hideki Adachi, Masafumi Tsujimoto, and Keizo Inoue Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6538–6543. Published online 2000 May 30. PMCID: PMC18651 Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence Elizabeth A. Sweeney, Gregory V. Priestley, Betty Nakamoto, Robert G. Collins, Arthur L. Beaudet, and Thalia Papayannopoulou Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6544–6549. PMCID: PMC18653 Down-regulation of iron regulatory protein 1 gene expression by nitric oxide Leonor Oliveira and Jean-Claude Drapier Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6550–6555. Published online 2000 May 23. PMCID: PMC18655 Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+,K+-ATPase α subunit and regulates its trafficking Guillermo A. Yudowski, Riad Efendiev, Carlos H. Pedemonte, Adrian I. Katz, Per-Olof Berggren, and Alejandro M. Bertorello Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6556–6561. Published online 2000 May 23. PMCID: PMC18657 Ecology Long-term impacts of the Exxon Valdez oil spill on sea otters, assessed through age-dependent mortality patterns Daniel H. Monson, Daniel F. Doak, Brenda E. Ballachey, Ancel Johnson, and James L. Bodkin Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6562–6567. Published online 2000 May 23. PMCID: PMC18659 Defense by foot adhesion in a beetle (Hemisphaerota cyanea) Thomas Eisner and Daniel J. Aneshansley Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6568–6573. PMCID: PMC18661 Evolution Olenid trilobites: The oldest known chemoautotrophic symbionts? Richard Fortey Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6574–6578. PMCID: PMC18664 Decoupled evolution of coding region and mRNA expression patterns after gene duplication: Implications for the neutralist-selectionist debate Andreas Wagner Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6579–6584. Published online 2000 May 23. PMCID: PMC18666 From the Cover: Convergent adaptive radiations in Madagascan and Asian ranid frogs reveal covariation between larval and adult traits Franky Bossuyt and Michel C. Milinkovitch Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6585–6590. PMCID: PMC18667 Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum Reinhard Schröder, Christoph Eckert, Christian Wolff, and Diethard Tautz Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6591–6596. Published online 2000 May 23. PMCID: PMC18669 Adaptive variation in lactate dehydrogenase-B gene expression: Role of a stress-responsive regulatory element Patricia M. Schulte, Hélène C. Glémet, Aline A. Fiebig, and Dennis A. Powers Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6597–6602. PMCID: PMC18671 From the Cover: Genome evolution of wild barley (Hordeum spontaneum) by BARE-1 retrotransposon dynamics in response to sharp microclimatic divergence Ruslan Kalendar, Jaakko Tanskanen, Sirkka Immonen, Eviatar Nevo, and Alan H. Schulman Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6603–6607. Published online 2000 May 23. PMCID: PMC18673 Selection–mutation balance in polysomic tetraploids: Impact of double reduction and gametophytic selection on the frequency and subchromosomal localization of deleterious mutations D. V. Butruille and L. S. Boiteux Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6608–6613. Published online 2000 May 23. PMCID: PMC18675 Identification of phylogenetic footprints in primate tumor necrosis factor-α promoters Jessica Y. Leung, F. Ellis McKenzie, Adele M. Uglialoro, Pedro O. Flores-Villanueva, Barbara C. Sorkin, Edmond J. Yunis, Daniel L. Hartl, and Anne E. Goldfeld Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6614–6618. PMCID: PMC18676 Genetics Anopheles gambiae pilot gene discovery project: Identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines George Dimopoulos, Thomas L. Casavant, Shereen Chang, Todd Scheetz, Chad Roberts, Micca Donohue, Jörg Schultz, Vladimir Benes, Peer Bork, Wilhelm Ansorge, Marcelo Bento Soares, and Fotis C. Kafatos Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6619–6624. PMCID: PMC18678 A protein required for prion generation: [URE3] induction requires the Ras-regulated Mks1 protein Herman K. Edskes and Reed B. Wickner Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6625–6629. Published online 2000 May 23. PMCID: PMC18680 The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations David O. Ferguson, JoAnn M. Sekiguchi, Sandy Chang, Karen M. Frank, Yijie Gao, Ronald A. DePinho, and Frederick W. Alt Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6630–6633. Published online 2000 May 23. PMCID: PMC18682 From the Cover: Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: The Lyon repeat hypothesis Jeffrey A. Bailey, Laura Carrel, Aravinda Chakravarti, and Evan E. Eichler Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6634–6639. PMCID: PMC18684 One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products Kirill A. Datsenko and Barry L. Wanner Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6640–6645. Published online 2000 May 30. PMCID: PMC18686 The SOS response regulates adaptive mutation Gregory J. McKenzie, Reuben S. Harris, Peter L. Lee, and Susan M. Rosenberg Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6646–6651. Published online 2000 May 30. PMCID: PMC18688 Operons in Escherichia coli: Genomic analyses and predictions Heladia Salgado, Gabriel Moreno-Hagelsieb, Temple F. Smith, and Julio Collado-Vides Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6652–6657. Published online 2000 May 23. PMCID: PMC18690 A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family Jeffrey S. Smith, Carrie Baker Brachmann, Ivana Celic, Margaret A. Kenna, Shabazz Muhammad, Vincent J. Starai, Jose L. Avalos, Jorge C. Escalante-Semerena, Charles Grubmeyer, Cynthia Wolberger, and Jef D. Boeke Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6658–6663. PMCID: PMC18692 Immunology Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice Lisa K. Petiniot, Zoë Weaver, Carrolee Barlow, Rhuna Shen, Michael Eckhaus, Seth M. Steinberg, Thomas Ried, Anthony Wynshaw-Boris, and Richard J. Hodes Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6664–6669. PMCID: PMC18695 Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains Laurence Morel, Byron P. Croker, Kim R. Blenman, Chandra Mohan, Guanling Huang, Gary Gilkeson, and Edward K. Wakeland Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6670–6675. PMCID: PMC18697 A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge Georgia Deliyannis, Jefferey S. Boyle, Jamie L. Brady, Lorena E. Brown, and Andrew M. Lew Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6676–6680. Published online 2000 May 23. PMCID: PMC18699 A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy Simon P. Hogan, Anil Mishra, Eric B. Brandt, Paul S. Foster, and Marc E. Rothenberg Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6681–6686. PMCID: PMC18701 A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase Anne B. Satterthwaite, Fiona Willis, Prim Kanchanastit, David Fruman, Lewis C. Cantley, Cheryl D. Helgason, R. Keith Humphries, Clifford A. Lowell, Melvin Simon, Michael Leitges, Alexander Tarakhovsky, Thomas F. Tedder, Ralf Lesche, Hong Wu, and Owen N. Witte Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6687–6692. Published online 2000 May 30. PMCID: PMC18703 Medical Sciences Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein Karin Butz, Claudia Denk, Angela Ullmann, Martin Scheffner, and Felix Hoppe-Seyler Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6693–6697. Published online 2000 May 30. PMCID: PMC18705 Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model Frank Griscelli, Hong Li, Chiat Cheong, Paule Opolon, Annelise Bennaceur-Griscelli, Gilles Vassal, Jeannette Soria, Claudine Soria, He Lu, Michel Perricaudet, and Patrice Yeh Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6698–6703. Published online 2000 May 23. PMCID: PMC18707 Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: An adaptive response induced by the fly? Yasmine Belkaid, Jesus G. Valenzuela, Shaden Kamhawi, Edgar Rowton, David L. Sacks, and José M. C. Ribeiro Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6704–6709. PMCID: PMC18709 Shear stress-induced apoptosis of adherent neutrophils: A mechanism for persistence of cardiovascular device infections Matthew S. Shive, Mariah L. Salloum, and James M. Anderson Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6710–6715. Published online 2000 May 23. PMCID: PMC18711 From the Cover: Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy Ziying Yan, Yulong Zhang, Dongsheng Duan, and John F. Engelhardt Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6716–6721. PMCID: PMC18714 Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia Matthew A. Nugent, Helen M. Nugent, Renato V. Iozzo, Kristian Sanchack, and Elazer R. Edelman Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6722–6727. PMCID: PMC18716 Extensive neurite outgrowth and active synapse formation on
self-assembling peptide scaffolds Todd C. Holmes, Sonsoles de Lacalle, Xing Su, Guosong Liu, Alexander Rich, and Shuguang Zhang Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6728–6733. PMCID: PMC18719 Prothrombotic phenotype of protein Z deficiency Zheng-Feng Yin, Zhong-Fu Huang, Jisong Cui, Ryan Fiehler, Nina Lasky, David Ginsburg, and George J. Broze, Jr. Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6734–6738. Published online 2000 May 30. PMCID: PMC18721 Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy Volker Heiser, Eberhard Scherzinger, Annett Boeddrich, Eckhard Nordhoff, Rudi Lurz, Nancy Schugardt, Hans Lehrach, and Erich E. Wanker Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6739–6744. Published online 2000 May 30. PMCID: PMC18723 Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy Carl J. Friddle, Teiichiro Koga, Edward M. Rubin, and James Bristow Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6745–6750. Published online 2000 May 30. PMCID: PMC18725 Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D Gesine Hansen, S.-L. Catherine Jin, Dale T. Umetsu, and Marco Conti Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6751–6756. PMCID: PMC18727 The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion Florence Salomon-Nguyen, Véronique Della-Valle, Martine Mauchauffé, Maryvonne Busson-Le Coniat, Jacques Ghysdael, Roland Berger, and Olivier A. Bernard Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6757–6762. Published online 2000 May 30. PMCID: PMC18730 The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription Joan S. Steffan, Aleksey Kazantsev, Olivera Spasic-Boskovic, Marilee Greenwald, Ya-Zhen Zhu, Heike Gohler, Erich E. Wanker, Gillian P. Bates, David E. Housman, and Leslie M. Thompson Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6763–6768. Published online 2000 May 23. PMCID: PMC18731 Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes M. F. Hammer, A. J. Redd, E. T. Wood, M. R. Bonner, H. Jarjanazi, T. Karafet, S. Santachiara-Benerecetti, A. Oppenheim, M. A. Jobling, T. Jenkins, H. Ostrer, and B. Bonné-Tamir Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6769–6774. Published online 2000 May 9. PMCID: PMC18733 Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation Shengkan Jin, Barbara Gorfajn, Glynn Faircloth, and Kathleen W. Scotto Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6775–6779. PMCID: PMC18735 Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743 Mario Minuzzo, Sergio Marchini, Massimo Broggini, Glynn Faircloth, Maurizio D'Incalci, and Roberto Mantovani Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6780–6784. PMCID: PMC18737 Microbiology Characterization of the 1918 “Spanish” influenza virus neuraminidase gene Ann H. Reid, Thomas G. Fanning, Thomas A. Janczewski, and Jeffery K. Taubenberger Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6785–6790. Published online 2000 May 23. PMCID: PMC18739 Ordered intracellular RecA–DNA assemblies: A potential site of in vivo RecA-mediated activities Smadar Levin-Zaidman, Daphna Frenkiel-Krispin, Eyal Shimoni, Ilana Sabanay, Sharon G. Wolf, and Abraham Minsky Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6791–6796. Published online 2000 May 30. PMCID: PMC18741 In vitro correlates of HIV-2-mediated HIV-1 protection Efi G. Kokkotou, Jean-Louis Sankalé, Indu Mani, Aissatou Guèye-Ndiaye, David Schwartz, Myron E. Essex, Souleymane Mboup, and Phyllis J. Kanki Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6797–6802. PMCID: PMC18743 Intergeneric poliovirus recombinants for the treatment of malignant glioma Matthias Gromeier, Sylvie Lachmann, Myrna R. Rosenfeld, Philip H. Gutin, and Eckard Wimmer Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6803–6808. PMCID: PMC18745 Neurobiology Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice James A. Bibb, Zhen Yan, Per Svenningsson, Gretchen L. Snyder, Vincent A. Pieribone, Atsuko Horiuchi, Angus C. Nairn, Anne Messer, and Paul Greengard Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6809–6814. Published online 2000 May 30. PMCID: PMC18747 Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors Yan Sun, Lily Yeh Jan, and Yuh Nung Jan Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6815–6819. Published online 2000 May 23. PMCID: PMC18750 Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis Arthur E. Warrington, Kunihiko Asakura, Allan J. Bieber, Bogoljub Ciric, Virginia Van Keulen, Srini V. Kaveri, Robert A. Kyle, Larry R. Pease, and Moses Rodriguez Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6820–6825. PMCID: PMC18751 Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice Simona Capsoni, Gabriele Ugolini, Alessandro Comparini, Francesca Ruberti, Nicoletta Berardi, and Antonino Cattaneo Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6826–6831. PMCID: PMC18754 Auditory processing parallels reading abilities in adults Merav Ahissar, Athanassios Protopapas, Miriam Reid, and Michael M. Merzenich Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6832–6837. PMCID: PMC18757 Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate Ingrid Bureau, Stéphane Dieudonné, Françoise Coussen, and Christophe Mulle Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6838–6843. PMCID: PMC18759 Mouse numb is an essential gene involved in cortical neurogenesis Weimin Zhong, Ming-Ming Jiang, Marcus D. Schonemann, Juanito J. Meneses, Roger A. Pedersen, Lily Yeh Jan, and Yuh Nung Jan Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6844–6849. PMCID: PMC18761 Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism Christine Saunders, Jasmine V. Ferrer, Lei Shi, Jiayun Chen, Gerald Merrill, Maria E. Lamb, L. M. Fredrik Leeb-Lundberg, Lucia Carvelli, Jonathan A. Javitch, and Aurelio Galli Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6850–6855. Published online 2000 May 23. PMCID: PMC18764 Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus Thomas Krucker, George R. Siggins, and Shelley Halpain Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6856–6861. Published online 2000 May 23. PMCID: PMC18765 Pharmacology A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor α chains Bruce P. England, Palaniappan Balasubramanian, Iain Uings, Sue Bethell, Min-Jia Chen, Peter J. Schatz, Qun Yin, Yao-Fen Chen, Erik A. Whitehorn, Alexander Tsavaler, Christine L. Martens, Ronald W. Barrett, and Murray McKinnon Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6862–6867. Published online 2000 May 23. PMCID: PMC18766 Physiology Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system Iori Ueki, Guck T. Ooi, Michel L. Tremblay, Kelley R. Hurst, Leon A. Bach, and Yves R. Boisclair Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6868–6873. Published online 2000 May 23. PMCID: PMC18767 Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 Didier Marguet, Laurie Baggio, Takashi Kobayashi, Anne-Marie Bernard, Michel Pierres, Per F. Nielsen, Ulla Ribel, Takeshi Watanabe, Daniel J. Drucker, and Nicolai Wagtmann Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6874–6879. Published online 2000 May 23. PMCID: PMC18768 Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR Beat M. Jucker, Sylvie Dufour, Jianming Ren, Xueying Cao, Stephen F. Previs, Brian Underhill, Kevin S. Cadman, and Gerald I. Shulman Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6880–6884. Published online 2000 May 23. PMCID: PMC18769 Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils T. E. DeCoursey, V. V. Cherny, W. Zhou, and L. L. Thomas Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6885–6889. Published online 2000 May 23. PMCID: PMC18770 Plant Biology A unique virus complex causes Ageratum yellow vein disease Keith Saunders, Ian D. Bedford, Rob W. Briddon, Peter G. Markham, Sek Man Wong, and John Stanley Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6890–6895. PMCID: PMC18771 The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter Huazhong Shi, Manabu Ishitani, Cheolsoo Kim, and Jian-Kang Zhu Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6896–6901. Published online 2000 May 23. PMCID: PMC18772 An acyltransferase catalyzing the formation of diacylglucose is a serine carboxypeptidase-like protein Alice X. Li and John C. Steffens Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6902–6907. Published online 2000 May 30. PMCID: PMC18773 Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor Simon P. Gough, Bent O. Petersen, and Jens Ø. Duus Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6908–6913. PMCID: PMC18774 Population Biology Changes in period mRNA levels in the brain and division of labor in honey bee colonies Dan P. Toma, Guy Bloch, Darrell Moore, and Gene E. Robinson Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6914–6919. PMCID: PMC18775 Correction Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6920. PMCID: PMC55994 Corrects: Jing Huang, et al. Role of calpain in skeletal-muscle protein degradation. Proc Natl Acad Sci U S A. 1998 October 13; 95(21): 12100–12105. |